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269 records · Page 15Linked to original sources
PubMedDate not supplied

[Zollinger-Ellison syndrome associated with Cushing's syndrome in a child (author's transl)].

The Zollinger-Ellison syndrome with characteristic symptoms is described in an 11 year old girl. Coeliac and mesenteric arteriography showed a pancreatic gastrin-secreting tumor. After total gastrectomy the condition improved but the associated Cushing's syndrome deteriorated. Surgical removal of the tumor was not possible and the child was treated with chemotherapy (5-fluorouracil and cyclophosphamide) and OP'DDD.

Celiac Artery↗
PubMed1994

The effect of L-carnitine, administered through intravenous infusion of glucose, on both glucose and insulin levels in healthy subjects.

The goal of the present study was to evaluate the effect of L-carnitine on plasma glucose and insulin levels. Two parallel studies were set-up, of 40 and 20 healthy volunteers, respectively. Each group received 500 cc of 10% glucose or 5% glucose, to which were randomly added 4 g or 2 g of L-carnitine and administered a week apart. Results showed that L-carnitine was able to reduce the increase in glucose plasma levels induced by infusion of the glucose solution. This finding was not dependent on an insulin-dependent mechanism.

Adult↗
PubMedDate not supplied

Is intraoperative ultrasonography useful in pancreatic cancer surgery?

Preoperative staging of pancreatic cancer represents a major challenge for a suitable surgical management of the disease. In a consistent number of patients laparotomy is still necessary in order to decide whether the tumor is resectable or not. In the present paper the Authors report their experience with intraoperative ultrasonography (IOU) in evaluating pancreatic cancer resectability. Very important data for intraoperative decision making were obtained in 37.9% of the patients, useful information in 31%, while in 31% IOU may be looked forward to as an important aid in decision making and for a safely guided dissection.

Aged↗
PubMed1993

[The drug treatment of postoperative pain].

The study, conducted on 40 patients with pain resulting from "minor" general surgery, for the purpose of evaluating the efficacy and tolerability of ST-679 (administered in a single oral dose of 1200 mg in 20 patients) and to compare them with those of paracetamol (administered in a single oral dose of 1000 mg in 20 patients), demonstrated that the new drug was active on all recorded parameters and superior to the reference drug. The evaluation of the evolution of pain, performed using the Scott-Huskisson visual analog scale, evidenced that the maximum analgesic efficacy of ST-679 is reached after 1 hour and 15 minutes from assumption and remains unaltered until the final observation (6 hours). The paracetamol registers maximum analgesic efficacy after 30 minutes, but does not remain constant for the entire observation period. All the other parameters evaluated (variation in pain intensity, peak of analgesic activity and total remission of pain) are significantly favorable to ST-679. The tolerability of ST-679 was very good and better than the reference drug.

Acetaminophen↗
PubMed1993

[The treatment of postoperative pain in obstetrical-gynecologic surgery. A comparative study between ST-679 and paracetamol].

In double-blind conditions, ST-679 (a single oral 1200 mg dose in 20 patients), or paracetamol (a single oral dose of 1000 mg in 20 patients) was administered to forty patients who presented pain as a result of obstetrical-gynecological surgery. The study proposed to evaluate the analgesic efficacy and tolerability of ST-679, a new non-steroid antiphlogistic drug, as compared to a reference drug amply utilized in clinical practice such as paracetamol. The average estimation of tolerability, with regard to paracetamol, was significantly in favor of ST-679.

Acetaminophen↗
PubMed1993

[An evaluation of the analgesic activity and tolerance of ST-679 in patients with pain following orthopedic and traumatological interventions].

The analgesic efficacy and tolerability of ST-679 (administered in a single oral dose of 1200 mg) was evaluated in a double-blind parallel-group study, as compared with paracetamol (administered in a single oral dose of 1000 mg) on 40 patients with pain following orthopedic or traumatological surgery. ST-679 was shown to possess better analgesic qualities with respect to paracetamol, in that the effect establishes itself more quickly and, moreover, both the maximum analgesic activity performed as well as the constant level on which such activity tends to stabilize is greater. No adverse reaction was recorded for either treatment, but ST-679 demonstrated a better tolerability with regard to paracetamol.

Acetaminophen↗
PubMed1998

Evaluating privilege requests from mentally ill prisoners.

Psychiatrists working in prisons are frequently presented with inmate requests for special privileges and living arrangements. Although recommendations to reduce stress are often indicated for seriously mentally ill prisoners, the injudicious use of special privileges can interfere with treatment and with the functioning and security of the prison environment. Guidelines are suggested for evaluating privilege requests that include exploring alternatives to granting requests; reserving privileges primarily for individuals with serious mental disorders; relying upon objective findings; and utilizing a multidisciplinary decision-making process.

Forensic Psychiatry↗