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PubMed1995

[The biological effects of heavy charged particles. The main results and prospective research in the context of interplanetary flights].

In experiments with biological objects varying in levels of their organization, comprising protozoa and cells and total bodies of large laboratory animals, the relative biological effectiveness (RBE) of accelerated charged particles in a wide range of doses and LET, i.e. high energy protons, heavy ions with energies up to 10 MeV/nucleon, charged particles of high and relativistic energies simulating individual components of GCR and SCR has been estimated. Early and delayed radiation effects were also studied. RBEs of protons in the energy interval of 50-660 MeV and standard radiation were shown to be equal, whereas RBE factors of heavier particles are a function of LET and many other physical and biological agents. Discussed are the specific properties of biological agents of heavy charged particles and the prospects for investigations in view of long-term interplanetary missions.

Animals↗
PubMed1976

Morphologic and morphometric analysis of the early effects of x-ray and heavy-ion irradiation of hamster lung.

Morphometric methods were to used to compare the early effects of graded single doses of x-rays with accelerated heavy particle (helium or neon) irradiation of hamster lung. Increased values in the volume densities of both capillary lumina and inflammatory cells at 2 weeks postirradiation were observed. Neon-ion irradiation wes statisically different from x-irradiation at all dose levels, while helium-ion irradiation showed significant increases only at higher doses (1000 to 1500 rads). At 1 month post-irradiation, the volume densities of capillary lumina after heavy particle irradiation began to return to control values, while those in x=irradiated lungs continued to be elevated. The volume density of inflammatory cells remained increased for all types of irradiation, and the highest values were obtained in neon-ion irradiated lungs. Accelerated heavy particle irradiation would therefore appear to elicit a more intense early radiation than does x-irradiation but the chronic significance of these findings is not yet known.

Animals↗