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At least 271 records · Page 15Linked to original sources
PubMed2001

Frequency and spectrum of Malassezia yeasts in the area of the prepuce and glans penis.

OBJECTIVE: To investigate the frequency and spectrum of lipophilic Malassezia yeasts within the area of the glans penis and preputial space in healthy men, most of whom were uncircumcised. SUBJECTS AND METHODS: As the glans penis and the prepuce are abundant in sebaceous glands, 130 clinically healthy men were examined for the presence of Malassezia spp. Two impression preparations each were made on modified Dixon (mDixon) and Leeming-Notman agar. The media were used with no added cycloheximide to allow the identification of the full spectrum of Candida yeasts. After 10 days of incubation at 32 degrees C Malassezia and Candida yeasts were differentiated by micromorphological and biochemical criteria. RESULTS: Malassezia spp. were found as part of the microflora of the glans penis in 49% of the men. The two media yielded comparable results for isolation frequency and spectrum: On mDixon agar, 47.6% of the isolates were identified as M. sympodialis, 42.8% as M. globosa, 4.8% as M. pachydermatis and 2.4% as M. furfur. Candida spp. (especially C. albicans) were found in 20.8%. There were no significant differences in the distribution of different Malassezia spp with age. CONCLUSIONS: Malassezia yeasts may belong to the resident microflora of the male genital region, which is supported by the finding that free sebaceous glands ('Tyson's glands') normally occur at this site. They may also be involved in pathological processes of the glans penis, e.g. balanitis, seborrheic eczema or psoriasis.

Adolescent↗
PubMed2004

Leiomyosarcoma of the penis: a clinicopathologic study of 14 cases with review of the literature and discussion of the differential diagnosis.

Primary leiomyosarcomas of the penis are very rare. To date, less than 30 have been documented in the English language literature. In this report, we describe the clinical, histopathologic, and immunohistochemical findings in 14 cases retrieved from our files. The patients ranged in age from 43 to 62 years (mean age, 51 years) at the time of initial surgical resection. The tumors involved the prepuce (n = 1), prepuce and distal shaft (n = 1), circumcision scar line (n = 2), circumcision scar line and distal shaft (n = 1), shaft (n = 5), base of the penis (n = 3), and penis, not otherwise specified (n = 1). The lesions ranged in size from 0.5 to 6.0 cm (median size, 1.5 cm) in greatest dimension. Nine tumors were superficially located, two were of indeterminate depth, and three were deep-seated. The superficial tumors were relatively asymptomatic, and seven were reportedly present for 1 year to more than 20 years (median duration, 5 years) before medical attention was sought. In contrast, one deep-seated lesion caused dysuria and difficulty voiding, prompting the patient to seek a clinical opinion within only a few months of the apparent onset. Histologically, all tumors contained smooth muscle cells with both cytologic atypia and mitotic activity. Immunohistochemical studies were available for nine tumors, and immunoreactivity for desmin was present in all instances. All patients were initially treated with a local procedure. Follow-up information is available for 9 of the 14 patients (64%), with a median follow-up interval of 12 years 11 months. Three patients had multiple (two to four) local recurrences. Two of these patients were ultimately treated with a wide local excision or partial penectomy, and both were alive and well at last follow-up. In contrast, one patient, who had four local recurrences and refused a penectomy, developed a distant metastasis 10 months after the fourth recurrence. The best predictors of outcome are tumor depth and tumor size. Superficial leiomyosarcomas of the penis are optimally managed by wide local excision whenever this is technically feasible. Tumors with a deep-seated component may require more aggressive intervention to ensure complete removal.

Adult↗
PubMed2001

Laser therapy for carcinoma in situ of the penis.

PURPOSE: Carcinoma in situ of the penis, also referred to as Bowen's disease or erythroplasia of Queyrat, may lead to invasive squamous cell carcinoma. We assessed the results of laser therapy for carcinoma in situ of the penis. MATERIALS AND METHODS: From 1986 to 2000 we treated 19 patients with carcinoma in situ of the penis with the neodymium:YAG or carbon dioxide laser. Treatment was assessed retrospectively. No patient was lost to followup. RESULTS: No complications developed and cosmesis was excellent. After 2 to 4 months 3 patients (16%) received repeat treatment because of incomplete disappearance of the lesion. Mean followup was 32 months. True carcinoma in situ recurrent in 5 patients (26%) at an average followup of 25 months (range 6 to 75), while 1 had infiltrating carcinoma. All patients with carcinoma in situ underwent repeat laser treatment. CONCLUSIONS: In our experience laser therapy is appropriate initial treatment for carcinoma in situ of the penis with excellent cosmetic and functional results. This therapy is also suited for recurrence without the need for more mutilating therapy. However, the high incidence of recurrence indicates the need for careful followup and patient self-examination.

Adult↗
PubMed2005

The use of betamethasone to manage the trapped penis following neonatal circumcision.

PURPOSE: The trapped penis results from cicatricial scar formation over the glans after circumcision. Management of this problem has been surgical either by incision of the cicatrix or formal surgical reconstruction. We report a series of neonates with trapped penises which were effectively managed primarily with topical steroid cream with operative intervention reserved for failed cases. MATERIALS AND METHODS: A retrospective study of 14 neonates who presented with a trapped penis treated with topical betamethasone cream was performed. Each child underwent topical application of 0.05% betamethasone 3 times daily for 3 weeks in conjunction with manual retraction that continued after the steroid course. The need for surgical intervention was assessed during and after the treatment period. RESULTS: All 14 boys were evaluated by the pediatric urologist within 4 weeks of circumcision. Each child had a trapped penis with a dense cicatrix of the residual foreskin distal to the glans. All parents were compliant with the regimen. There were no untoward effects of topical steroid application. Following therapy 11 boys (79%) demonstrated softening of the cicatrix with easy exposure of the glans in 2 and mild persistence of the cicatrix amenable to vertical relaxation incision in 2. The cicatrix persisted in 3 boys (14%) who required formal operative repair at ages 5 to 8 months. CONCLUSIONS: The combination of topical betamethasone and manual retraction is effective in managing the trapped penis. This combination may affect complete resolution of the condition in the majority of patients. Otherwise, this regimen may release the closing cicatrix and allow for simple incision of the constricting phimotic ring, thus reducing the need for formal surgical repair.

Administration, Topical↗
PubMed1992

Epidemiological aspects of cancer of the penis in Finland.

The purpose of this study was to characterize the epidemiological features of cancer of the penis in Finland. After histological re-examination and exclusions, the final series comprised 269 patients with cancer of the penis diagnosed and reported to the Finnish Cancer Registry between 1955 and 1977. The age-adjusted incidence rate of cancer of the penis decreased slightly from the 1960s onwards and was on the order of 0.5 per 100,000 person-years in the 1970s. Cancer of the penis was a disease of elderly males, which showed no systematic geographical variation in Finland in terms of risk. The most frequent predisposing factors were phimosis, in 44% of the cases, and condylomatous lesions, in 20% of the cases. The general survival (all patients, all stages) was favourable; the 5-, 10-, and 20-year relative survival rates were 71, 69 and 78%, respectively.

Adult↗
PubMed1979

Primary malignant melanoma of the penis. Two cases and a review of the literature.

Two cases of primary malignant melanoma of the penis are reported and 35 cases from the world literature are reviewed. The tumour most commonly started in the glans penis and less frequently from the prepuce. The microscopic appearances were identical with those of tumours arising elsewhere in the skin. A comparison is made between the incidence of melanoma of the penis and melanoma occurring elsewhere on the body surface. Evaluation of the best treatment was difficult because the total number of cases was small and the methods of treatment and results so variable. It would seem that the prognosis of malignant melanoma of the penis is generally poor, although there are sufficient examples of long-term survival after total amputation in Stage I disease to suggest that this radical treatment is justified.

Adult↗
PubMed1983

Treatment of penis carcinoma.

Amputation of the penis is by no means the quickest and least invasive of the surgical methods of treating penis carcinoma. Radiation therapy has the advantage of preserving the integrity of the penis and does not render a later operation of the penis impossible. Regional lymph node metastases should be removed surgically whenever possible; their radical extirpation, especially total lymphadenectomy, should not be too vigorous because it is essential to avoid any complications, and irradiation of the inguinal and iliac lymph node regions by modern methods of radiation therapy is acceptable to the patient and can still be helpful even in more advanced cases. We do not yet have enough experience with cytotoxic therapy, bleomycin or laser coagulation to alter our present method of treatment.

Adult↗
PubMed2006

Langerhans cell histiocytosis on the penis: a case report.

BACKGROUND: Langerhans cell histiocytosis affects mainly young children and features an accumulation of CD1a+ dendritic Langerhans cells in the bone, skin, and other organs. A few cases of Langerhans cell histiocytosis on the penis have been reported in the literature. We present a case of Langerhans cell histiocytosis on the penis and review the similar cases in the literature. CASE PRESENTATION: The patient was a 13-year-old boy who had a history of lymph node, femur bone, and pituitary-thalmic axis lesions from Langerhans cell histiocytosis who noticed a painful nodule on the prepuce of his penis. The histological and immunohistochemical examination fulfilled the criteria of Langerhans cell histiocytosis. CONCLUSION: We herein describe the case reported of Langerhans cell histiocytosis on the penis.

Adolescent↗
PubMed2001

Penis size: Survey of female perceptions of sexual satisfaction.

BACKGROUND: Does the size of the male penis, in terms of length or width, make a difference in female sexual satisfaction? METHOD: To study the effect of penis width vs. length on female sexual satisfaction, 50 sexually active female undergraduate students were asked which felt better, i. e., was penis width or length more important for their sexual satisfaction. RESULTS: None reported they did not know, or that width and length were equally satisfying. A large majority, 45 of 50, reported width was more important (p <.001). CONCLUSION: Implications are discussed, including the fact that the data seem to contradict Masters and Johnson about penis size having no physiological effect on female sexual satisfaction.

Journal Article↗
PubMed2006

[Verrucous carcinoma of the penis arising from a lichen planus. A true preneoplastic lesion?].

INTRODUCTION: Up to 30% of squamous cell carcinomas of the penis arise from a lichen sclerosus, but very few reports in which lichen planus was the preexisting lesion have been published. We report a male with verrucous carcinoma of penis that developed in an area of lichen planus. CLINICAL CASE: A 53-year-old male presented with an exophytic tumor on the glans penis that had been present for about 6 months. The lesion developed in a previously biopsied area of lichen planus hypertrophicus. After excision, histological diagnosis was verrucous carcinoma. COMMENT: The development of any subtype of squamous cell carcinoma of penis in a lichen planus can be coincidental, or a neoplastic transformation of lichen planus can take place.

Carcinoma, Verrucous↗
PubMed2003

[Epidermoid cyst of the penis: a case report].

A 62-year old man presented with a painless, slowly growing mass of the penis, which had been noted since childhood. A cystic mobile mass about 2.5 cm in diameter was found at the ventral aspect of the glans penis. Excision of the mass was performed to confirm the diagnosis. There was no communication with the urethra. The pathological diagnosis was epidermoid cyst of the penis. Epidermoid cysts of the penis are rare, and many of them arise on the penile raphe, which are thought to be one of the type of rapheal cyst. To our knowledge, this is the 7th case in the Japanese literature.

Epidermal Cyst↗
PubMedDate not supplied

[Palisading granuloma of the penis: a variant of subcutaneous granuloma annulare].

INTRODUCTION: Subcutaneous granuloma annulare on the penis has only been reported exceptionally. OBSERVATION: A 41 year-old man presented with four small, asymptomatic nodules on the glans penis. Histological examination of a biopsy revealed a deep palisading granuloma progressing not only around the alcian-blue necrobiosis areas but also around the smooth muscle fibers. The lesion regressed spontaneously after two years of progression. DISCUSSION: Palisading granuloma of the penis appears to be a most particular clinical form of subcutaneous granuloma annulare. It is characterized by small single or multiple nodules localized on the penis. On histological examination, the granuloma is deep and concentrates around the network of smooth muscle fibers of dartoic origin.

Adult↗
PubMed2003

[Squamous carcinoma of the penis with a rhabdoid phenotype].

OBJECTIVE: To describe a squamous cell carcinoma of the penis with rhabdoid phenotype. We believe that only three squamous cell carcinomas with rhabdoid cells have been previously published and none of them was located in the penis. METHODS AND RESULTS: A 76 year old man presented a tumoral lesión in his penis, which had all the light microscopic and immunohistochemical features of a squamous cell carcinoma with rhabdoid phenotype. Rhabdoid cells were mainly located in areas with an alveolar pattern, most of them being isolated and intermixed with necrotic cells and necrotic debris. CONCLUSIONS: First case of rhabdoid squamous cell carcinoma located in the penis. We suggest that rhabdoid phenotype could represent a type of degeneration, or a preliminary stage before apoptosis or cell necrosis occurs, instead of a specific differentiation. The most important prognostic factors in extrarenal tumors with rhabdoid features are stage and histologic type of tumors.

Aged↗
PubMed2003

[Verrucous carcinoma of the penis].

OBJECTIVE: The objective of the present retrospective research is to examine cases of verrucous carcinoma of the penis, an uncommon variant of squamous cell carcinoma, as well as to examine the localisation, evolvement and the ways of treatment. METHODS: Patients, treated for carcinoma of the penis at the Clinic of Urology, have been examined for a 13-year interval. From 80 cases of cancer localized in the penis, in only 3 of these verrucous carcinoma has been histologically proved, accounting for 2.4 per cent of the penile cancers. A rare case of a hybrid tumor between verrucous carcinoma and invasive squamous cell carcinoma, which is compared to similar finding as described by other authors. RESULTS: Slow and continuous evolvement of the disease has been observed, which has been followed by periods of aggressive development. The average age of the patients has been specified to be 52.7 years. The tumor has been mainly localized on the surface of the Glans penis. The results have been compared to those described in the literature. CONCLUSION: Wide surgical excision, usually requiring partial or total penectomy, is the treatment of choice. Radiotherapy and chemotherapy have proved to be unsuccessful.

Adult↗
PubMed2004

A case of tumor of the penis: interstitial brachitherapy after conservative surgical therapy.

The neoplasms of the penis are extremely rare and have an incidence of 1400 new cases for year in the United States. Higher is the percentage of incidence in Africa and Asia (10-20%) and in some areas of Brasil where the cancer of the penis constitutes 17% of all the male tumors. In Israel this neoplasm is rare, less than 0.1/100000 menfor year, because in Jewish population men are circumcised prematurely. Recently it has been placed attention to the possible aetiologic role of human papillomavirus (HPV-16 and HPV-18) in penis carcinoma. In fact, in the tumoral cells, DNA of this virus has been found with a percentage that varies from the 30 to 82%. Traditional surgical approach is total or partial penis resection basing on the extension of the disease. This procedure is associated to remarkable psycosessuals problems that greatly affect the quality of life. We bring back a case with organ sparing conservative treatment.

Aged↗
PubMed2005

Epidemiology, diagnostic and therapeutic problems for carcinoma of the penis in the regions of Plovdiv, Pazardzhik and Smolyan between 1993 and 2002.

INTRODUCTION: Carcinoma of the penis is a malignant tumour which is uncommon in the male population of the Plovdiv, Pazardzhik and Smolyan regions. Recently however, its occurrence in the clinical practice has been on the increase. In the present study we analyse the incidence of penile carcinoma in these regions and address some problems related to late diagnosing of the condition and its therapy. MATERIAL AND METHODS: The study included fifty one patients newly diagnosed with carcinoma of the penis between 1993 and 2002. The patients were registered in the Plovdiv Oncological Centre database. The available data were studied in detail analysing the incidence and mortality rates of the disease. RESULTS: The incidence and mortality rates carried by carcinoma of the penis showed a tendency to simultaneous increase with time--by 0.1355 and 0.0392 per 100000 men per annum, respectively. There is a relatively high number of patients diagnosed with carcinoma of the penis in the stage of invasive local tumor (82.35%). The distribution of the cases by stages is highly unfavourable--over 33% of them were diagnosed very late (stage III and IV). The greatest number of cases (70.59%) received only surgical treatment. The 5-year survival rate of the diagnosed patients is only 58.86%. CONCLUSION: These data about the incidence of the disease and the diagnosis and treatment of penile cancer in the studied regions are indicative of highly unfavourable tendencies for this disease which are reflected in the low efficaciousness of cancer control in the studied localisation.

Adult↗
PubMed1991

Penis envy: libidinal metaphor and experiential metonym.

The subjective narrative employed by the little girl to account for her femininity draws on her primary sense of femaleness, as well as on any secondary elaborations. The secondary nature of femininity is highlighted by the Freudian view wherein femininity is thought to be achieved through changes in libidinal aims and objects. The primary nature of femininity is highlighted by current views elaborating on ego development. An examination of the subjective role of the phallus in a number of clinical reports reveals that envy of the penis may represent the intersection of several associative chains. For example, the girl's castration reaction could result from a condensation of the libidinal theme of not having a penis as Freud argued. However, Freud's reliance on the phallus as a metaphoric representation of instinctual vicissitudes is not an end point. In addition to Freud's elaborations of the phallic theme, the desire to possess the penis may represent the girl's associations to contiguous events. That is, through the process of displacement, the phallus also functions as a metonymic symbol. To fully appreciate penis envy, both the metaphoric and metonymic meanings assigned to femininity must be analysed.

Body Image↗
PubMed1990

Laser surgery for the treatment of squamous cell carcinoma of the penis.

We describe our experience with six cases of squamous cell carcinoma of the penis treated with the carbon dioxide and neodymium yttrium aluminum garnet (Nd:YAG) lasers. One patient had carcinoma in situ. One patient had a T1 tumor. Two patients had T2 disease and two patients had T3 carcinoma of the penis when seen. The patients were followed up from 13 to 64 months. The patients with carcinoma in situ and T1 carcinoma of the penis were tumor-free at a mean follow-up of 45 months. One patient with T2 carcinoma apparently had a complete response to surgery; however, he was seen 56 months after the initial laser treatment with a new invasive penile tumor located at a different site that failed to respond to laser treatment and required a penectomy. Another man with T2 carcinoma as well as the two men with T3 carcinoma failed to respond to laser treatment and required a penectomy. It appears that laser surgery offers the potential for cure in patients with carcinoma of the penis with superficial involvement.

Aged↗