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At least 271 records · Page 15Linked to original sources
PubMed1988

Generation of nitro radical anions of some 5-nitrofurans, and 2- and 5-nitroimidazoles by rat hepatocytes.

Nitrofurantoin, nifurtimox, nifuroxime, nitrofurazone, misonidazole, benznidazole, ronidazole, and ornidazole were reduced to their respective nitro radical anions by intact rat hepatocytes at pH 7.4. The nitrofurantoin radical anion and other nitro anion radicals generated inside these cells were detected with ESR spectroscopy. Broadening of the signals from nitrofurantoin anion radicals was accomplished with paramagnetic transition metals, implying that the radicals were outside the cell in the medium. Rat hepatocytes are well suited for in situ electron spin resonance investigations of free radical metabolites and represent a model for the as yet unobtained direct detection of free radical metabolites in liver.

Animals↗
PubMed1987

DNA damage by 5-nitro-2-furylacrylic acid, a nitrofuran derivative.

5-Nitro-2-furylacrylic acid (5-NFA) caused dose dependent inhibition of growth of Escherichia coli K-12 strain AB 2480 (uvr-, rec-), the 37% (D37) and 10% (D10) survival doses being 1.0 microgram/ml.h and 1.75 micrograms/ml.h, respectively. Although much higher doses of drug were required to achieve comparable inhibition of growth of E. coli strain 1157 (repair proficient), significant filamentation of these cells was produced by treatment with 1.0 microgram/ml 5-NFA for 4 hr. Ultraviolet absorption data and thermal chromatography through hydroxyapatite (HAP) column revealed that 5-NFA treatment of E. coli strain AB 2480 produced more than 80% of DNA reversibly bihelical due to the formation of interstrand cross-links and the initial part of the reaction obeyed a first order relation. 5-NFA also produced dose-dependent increase of prophage induction in E. coli strain GY 5027: envA, uvrB, ampA1, strA (lambda). The implications of the action of 5-NFA on DNA in relation to the induction of 'SOS' functions and carcinogenesis were discussed.

Acrylates↗