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PubMed2001

Breast-feeding among women exposed to polybrominated biphenyls in Michigan.

In the early 1970s, the largest industrial accident in the United States resulted in widespread contamination of the food supply in Michigan with polybrominated biphenyls (PBBs). The chemical similarity of PBBs to compounds implicated as endocrine disruptors has raised the question of whether PBBs could affect the reproductive system. In the present analysis we examine the relation between serum measurements of PBBs and the frequency and duration of lactation. Persons who lived on or received food from farms exposed to PBBs were enrolled in a registry by the Michigan Department of Public Health. Female members of the cohort were invited to participate in a telephone survey of reproductive outcomes. The three outcomes of interest in the present analysis were a) the decision to breast-feed (yes/no); b) the duration, in months, of breast-feeding as the main source of nutrition; and c) the total duration, in months, of breast-feeding. None of the three outcomes was significantly associated with serum PBB levels, even after controlling for maternal age, previous history of breast-feeding, body mass index, maternal education, household income, history of smoking in the year before pregnancy, consumption of alcohol during the first trimester of pregnancy, history of thyroid disorder, gestational age of the infant in weeks, time to pregnancy, and year of birth.

Accidents, Occupational↗
PubMed1978

Comparison of findings among residents on Michigan dairy farms and consumers of produce purchased from these farms.

Consumers who had purchased farm products from both quarantined and nonquarantined farms were examined during the cross-sectional clinical survey of 1,029 Michigan residents. Since PBB had inadvertently contaminated cattle and other farm animals, ingestion of meat, milk, eggs and other farm products was thought to have possibly resulted in significant PBB body burdens in some consumers. Findings were considered in comparison with those made among farm residents. Prevalence of symptoms in consumers of farm products from quarantined farms (CQ) was similar to that found in farmers on quarantined farms (FQ); the prevalence was lower in consumers of products from nonquarantined farms (CNQ). Liver function abnormalities were found with similar prevalence in dairy farmers and consumers. Distribution, mean and median values of PBB serum levels in consumers were found to be similar to those of dairy farmers. These results indicate that significant body burdens of PBB had been accumulated by some consumers of farm products in Michigan and that prevalence of symptoms and liver function abnormalities resembled those found among dairy farm residents.

Biphenyl Compounds↗
PubMed1978

Relation of DDE and PBB serum levels in farm residents, consumers, and Michigan Chemical Corporation employees.

Results of serum PBB determinations on 524 Michigan diary farm residents and consumers of products from the farms, 55 chemical workers, and 56 Wisconsin farm residents are reported. Mean and median values were highest for the chemical workers, followed by consumers from and residents of quarantined and nonquarantined farms. Serum DDE was higher among chemical workers, but was similar for all other groups. Statistical analysis of serum of PPB and serum DDE levels was done with respect to quarantine status, age, sex, and obesity. The most significant correlate with PBB was quarantine status. Serum DDE, age, sex, or obesity were not consistently correlated with serum PBB. For DDE, age was invariably the most significant correlate. Both serum PBB and DDE were higher in males than females in husband-wife pairs in most cases, although the differences occurred less frequently among older age groups. These results support the hypothesis that PBB exposure was a recent interim exposure whereas DDE exposure has been cumulative throughout a person's lifetime. Higher PBB and DDE mean concentrations in serum of Michigan Chemical workers suggests an occupational exposure to these chemicals.

Adolescent↗
PubMed1978

Investigation of the health status of Michigan chemical corporation employees.

Clinical findings are reported for a group of 55 employees of the Michigan Chemical Corporation which manufactured FireMaster BP-6 from 1970 to 1974, in addition to a variety of other halogenated fire retardant chemicals. The results are compared with those from a group of male farm residents and consumers from Michigan examined at the same time. An increased prevalence of chest and skin symptoms was observed, compared with farmers. Skin symptoms were more prevalent among former PBB production personnel. Musculosketal symptoms were less prevalent among these workers than among farmers. Serum PBB concentrations are signicantly higher than among farmers. Blood chemistry results were similar for workers and farmers. However, both groups exhibited a significantly higher prevalence of elevated liver function tests (SGOT, SPGT) than a control population of nonexposed farmers. Both farmers and chemical workers showed an association of elevated CEA with serum PBB greater than 10 ppb.

Adult↗
PubMed1985

Overview of Michigan prevention programming.

The Michigan Department of Mental Health's prevention programming has centered around the development of community service models through pilot demonstration projects. A systems approach has resulted in the formulation of departmental guidelines and policies. Pilot demonstration projects have been directed primarily at enhancing coping skills of high risk populations. Collaborative interagency efforts have provided an additional dimension to Michigan prevention programming.

Forecasting↗
PubMed2003

Anthropology at the University of Michigan in the late 1950s.

By 1958, the Anthropology Department at the University of Michigan had emerged as a major center in the discipline. Its excellence derived from a strong faculty, commitment to an integrated view of the field, and broader support from a rising national tide of scholarship. While many new intellectual currents developed, among the strongest was biological-behavioral theory--somewhat ironically flourishing in a biological anthropology program that viewed itself as a nexus of population genetics. The biological anthropology faculty thought like anthropologists. From this environment, Frank Livingstone not only drew intellectual support, but also became a key player in demonstrating the importance of historical and cultural factors to shaping biological patterns. A biocultural perspective is evident in Michigan research to this day.

Anthropology↗
PubMed2006

Utilizing multilevel partnerships to build the capacity of community-based organizations to implement effective HIV prevention interventions in Michigan.

The Michigan Department of Community Health (MDCH), utilizing the expertise of public and private, federal, state, and local partners, increased the proportion of state health department-funded community-based organizations implementing effective behavioral interventions (EBIs) from .05 (1:18) in 2002 to .78 (14:18) in 2004. As the stewards of nearly two thirds of the HIV prevention funds awarded annually by the Centers for Disease Control and Prevention, state health departments occupy an important position in diffusing the science of EBIs to their grantees. This article describes the strategies and partners employed by Michigan's state health department to build the capacity of community-based providers to implement effective behavioral interventions. Additionally, lessons learned by the MDCH are highlighted and challenges to the long-term sustainability of these interventions are also discussed.

Community Networks↗
PubMed2003

Impact of the thimerosal controversy on hepatitis B vaccine coverage of infants born to women of unknown hepatitis B surface antigen status in Michigan.

OBJECTIVE: Hepatitis B vaccine is recommended for all infants, and the series may be started during the delivery admission. For infants who are born either to women who are positive for hepatitis B surface antigen (HBsAg) or to women whose HBsAg status is unknown, vaccination should be started within 12 hours of birth to prevent perinatal and early childhood hepatitis B virus infection. Because of concerns about mercury exposures from vaccines that contain thimerosal, the United States Public Health Service (USPHS) and the American Academy of Pediatrics (AAP) recommended in July 1999 that the first dose of hepatitis B vaccine be deferred until 2-6 months of age but only for infants who are born to HBsAg-negative women. To assess the impact on birth-dose vaccine coverage for infants who are born to women with unknown HBsAg status, we measured coverage before and after July 1999. METHODS: A sample of Michigan infants who were born to women whose HBsAg status was either unknown or missing were identified by reviewing newborn screening cards for infants who were born during 1) March-April 1999 (before recommendation changes [T1]); 2) July 15-September 15, 1999 (immediately after recommendation changes [T2]); and 3) March-April 2000 (6 months after resumption of pre-1999 practices were recommended [T3]). We verified maternal HBsAg screening and newborn hepatitis B vaccination by reviewing infant and maternal hospital records. RESULTS: Of 1201 infants who were born to women whose HBsAg status was indicated as unknown or missing on the newborn screening card during the 3 time periods, 216 (18%) were born to women whose status was truly unknown at the time of delivery, as determined by medical record review. During T1, 53% of these 216 infants received hepatitis B vaccine before hospital discharge, compared with 7% of infants who were born during T2 and 57% of infants who were born during T3. During T1, 19% of these infants received hepatitis B vaccine within 12 hours of birth compared with 1% of infants who were born during T2 and 14% of infants who were born during T3. CONCLUSIONS: Hepatitis B vaccine birth-dose coverage for infants who were born to women whose HBsAg status was unknown at the time of delivery was already low in Michigan before the July 1999 USPHS/AAP Joint Statement but decreased significantly during the 2 months after the USPHS/AAP Joint Statement. Abrupt changes in established vaccination recommendations for lower risk children may lead to decreased coverage among higher risk children. Increases in hepatitis B vaccine coverage at birth are necessary to reduce the risk of perinatal infection for infants who are born to women with unknown HBsAg status.

Contraindications↗
PubMedDate not supplied

Environmental controls of UV-B radiation in forested streams of northern Michigan.

We examined UV-B radiation flux and its environmental control within and among streams of northern Michigan. UV-B flux was estimated in streams by plastic dosimetry strips, which allow for the simultaneous and repeated in situ measurement of solar radiation. During the summer of 2004, UV-B flux was measured across depth gradients and along longitudinal transects in seven streams, which were chosen to encompass a range of dissolved organic carbon (DOC) concentrations and canopy cover. Attenuation coefficients of UV-B (K(d) (UV-B)) were estimated using plastic dosimeters placed along a depth gradient. K(d UV-B) were positively correlated with DOC concentration and similar to values obtained with laboratory and in situ spectrometry. Along 100 m longitudinal transects, UV-B flux varied along all streams regardless of their canopy cover and DOC concentration. Within-stream fluxes of UV-B were correlated to canopy cover in the only two streams that both had relatively low DOC concentration and variable canopy cover. Large differences were found among streams in the average UV-B flux (corrected for incident solar flux) reaching the dosimeters at 5 cm depth. These among-stream differences were largely accounted for by the stream width, canopy cover, and DOC concentration. Our results illustrate an inherent variability in UV-B flux within and among streams of northern Michigan that is strongly tied to the interactions of DOC concentration, stream size and riparian vegetation.

Environmental Exposure↗
PubMed2004

Parasitism of obliquebanded leafroller (Lepidoptera: Tortricidae) in commercially managed Michigan apple orchards.

The obliquebanded leafroller, Choristoneura rosaceana (Harris), is one of the major arthropod pests of apple in the United States. In 1999 and 2000, a survey of the obliquebanded leafroller parasitoid complex in commercially managed apple orchards in Michigan's two largest fruit production regions was conducted to determine the species present and their importance to obliquebanded leafroller population management. In total, 8,961 obliquebanded leafroller larvae were collected of which 2,174 were parasitized. Parasitism increased from the overwintering generation to the summer generation for both regions and both years. In 1999, 11% of the 1,126 overwintering obliquebanded leafrollers collected were parasitized, whereas 28% of the 3,669 summer generation were parasitized. In 2000, 8% of the 489 overwintering obliquebanded leafrollers collected were parasitized, whereas 26% of the 3,677 summer generation obliquebanded leafrollers collected were parasitized. In total, 20 species of hymenopteran and dipteran parasitoids from seven families were recovered from obliquebanded leafroller larvae over the course of the study. The most abundant hymenopteran parasitoids were Bassus dimidiator Nees (Braconidae) comprising 48% of the total parasitoids, followed by Colpoclypeus florus (Walker) (Eulophidae) (8% of the total) and Macrocentrus linearis (Nees) (Braconidae) (2% of the total). Dipteran parasitoids (Tachinidae) accounted for 36% of the parasitism and were largely comprised of Nilea erecta (Coquillett) (5%) and Actia interrupta Curran (13%). These collections represent new host records for B. dimidiator, Bassus annulipes (Cresson) Hyphantrophaga blanda (Osten Sacken), and Compsilura concinnata (Meigen). The parasitoid C. florus is also reported from Michigan for the first time.

Agriculture↗
PubMed2003

Examination of reproductive endpoints in goldfish (Carassius auratus) exposed in situ to municipal sewage treatment plant effluent discharges in Michigan, USA.

Effects of representative mid-Michigan (USA) wastewater treatment plant (WWTP) effluents on the reproductive physiology of common goldfish (Carassius auratus) were assessed in situ by measuring plasma concentrations of vitellogenin (VTG), 17 beta-estradiol (E2), and testosterone (T), and evaluating gonad histology. Caged adult male and female goldfish were exposed for six weeks to WWTP effluents. One riverine site and one lacustrine site were included as references for comparison to WWTP sites. There was differential growth and gonadal development among locations, which confounded the interpretation of biomarker responses. A linear contrast model was developed by analysis of covariance, and adjusted values were developed for concentrations of VTG, E2, and T in the plasma of both male and female fish. In general, VTG concentrations were significantly less in male than in female goldfish. Most concentrations of VTG in male goldfish were less than the method detection limit. There were no significant differences in plasma VTG of either male or female goldfish among locations or between sites at WWTPs and reference sites. Concentrations of E2 in the plasma of female goldfish were similar among WWTP sites, all of which were less than in females at a pond reference location. Concentrations of E2 in the plasma of male goldfish were similar at all WWTP locations, except for one, where they were greater. No consistent trends in hormone concentrations or gonadal histology could be attributed to putative endocrine disrupter exposure in WWTP effluents. The results indicate that the risk for estrogen agonist exposure below these mid-Michigan WWTPs is small.

Animals↗
PubMed1980

Height, weight and skinfold thickness of Michigan adults.

Height, weight, and selected skinfold measurements were taken on 544 Michigan males and 557 females age 18 and over. Mean body weight showed a tendency to increase with age for both sexes up to age 64 while mean height progressively decreased from its maximum at age 18-24 years. Between ages 18 and 64 years, mean triceps skinfold thickness of men increased 10 per cent, female triceps skinfolds 50 per cent. Mean subscapular skinfold values rose consistently with age for both sexes. Comparison of these findings with those from earlier national studies suggest that Michigan adults are heavier and fatter but no taller than other US adults.

Adolescent↗
PubMed1981

Polychlorinated biphenyl contamination of nursing mothers' milk in Michigan.

The problem of environmental contamination by toxic substances and human exposure to these substances has attracted increased attention in recent years. Particular concern has centered on polychlorinated biphenyls (PCBs), which have become widespread environmental pollutants as well as contaminants of the human population. This paper reports data from a study of PCB contamination of nursing mothers' breast milk in Michigan. During 1977 and 1978, breast milk samples of 1,057 nursing mothers residing in Michigan were tested for PCB residues. All of the 1,057 samples collected from 68 of the state's 83 counties contained PCB residues ranging from trace amounts to 5,100 parts per million (fat weight basis). The mean level was 1,496 parts per million (ppm), with 49.5 per cent of the samples having PCB levels of 1-2 ppm, 17.4 per cent had 2-3 ppm, and 6.14 per cent had more than 3 ppm. There was no consistent trend in the level of PCB contamination over the 24 months of monitoring. The mean PCB level for the eighth quarter of monitoring was slightly higher than for the first quarter. The public health significance of PCB contamination in human populations and its effects on breast-fed for eight months by a woman with the average PCB level in this sample would have an estimated body burden of approximately 0.89 ppm of PCBs. The implications of PCB contamination of human milk with regard to current breast-feeding practices are discussed and several precautionary measures are recommended.

Adolescent↗
PubMed1993

HIV-related knowledge and precautions among Michigan nurses.

OBJECTIVES: The present study examined human immunodeficiency virus (HIV)-related knowledge and precautionary behaviors in a large random sample of registered nurses in all regions of the state of Michigan, allowing for comparisons among nurses in a wide range of occupational experiences, exposures, and backgrounds related to HIV. METHODS: A random sample of all registered nurses living in Michigan completed surveys in the fall of 1989. RESULTS: Although nearly all respondents indicated a high level of knowledge of known viable routes of HIV transmission, many respondents also reported misconceptions about several unverified nonviable routes of HIV transmission. Of the respondents who were involved in situations with potential risk of exposure to HIV, many failed to consistently use the universal precautions recommended by the Centers for Disease Control and Prevention. The respondents also reported significant barriers in applying infection control procedures. CONCLUSIONS: The findings of the present study support the need for continued and intensified efforts to ensure that nurses have the knowledge necessary to provide quality care, are aware of the risk of potential exposures to HIV, and are engaging in appropriate precautionary behaviors.

Adult↗
PubMed1998

The impact of mammography quality improvement legislation in Michigan: implications for the National Mammography Quality Standards Act.

OBJECTIVES: This study examined the impact of state legislation on mammography quality and access in Michigan. METHODS: The impact of state legislation was analyzed with respect to utilization, numbers of machines and facilities, and image quality. RESULTS: The legislation had a positive effect on image quality improvement, had no impact on utilization by women aged 50 years and above, and resulted in few facility closures. CONCLUSIONS: Michigan's legislative intervention appears to have had a positive effect on efforts to improve mammography quality assurance with implications for other federal and state efforts to achieve quality assurance in health care delivery.

Aged↗
PubMed1985

The PBB episode in Michigan: an overall appraisal.

Polybrominated biphenyls (PBB) were used as a fire retardant. In common with other halogenated hydrocarbons, PBBs are lipophilic and resistant to chemical and metabolic degradation. Cattle on about 25 Michigan farms were exposed to as much as 250 g per head of PBB when it was accidentally mixed in cattle feed in 1973 to 1974. Livestock exposures several orders of magnitude lower occurred on several hundred other farms because of carryover and equipment contamination in feed mills. Approximately 85% of the Michigan population received some exposure to PBB because dairy product marketing involves mixing milk from many farms. A few cases of high human exposure, which may have been as great as 10 g, occurred when residents of the more highly exposed farms consumed their own products. Although numerous clinical signs and pathological changes were reported in exposed cattle, only anorexia, lacrimation, emaciation, hyperkeratosis, and kidney damage were confirmed in controlled studies. The acute toxicity of PBB in laboratory animals is low, but a variety of subacute effects have been reported. Induction of microsomal enzymes, enlargement and histopathological changes of the liver, fetotoxicity, and immunosuppression are among the more significant. Epidemiological studies of exposed humans have revealed no pattern of clinical signs or symptoms that were related to PBB exposure. A complete evaluation of the human consequences of exposure to PBB await the conclusion of long-term epidemiological studies.

Animal Feed↗
PubMed2004

Insights into the future generation of veterinarians: perspectives gained from the 13- and 14-year-olds who attended Michigan State University's veterinary camp, and conclusions about our obligations.

Veterinary medicine is at a crossroads: the future of the profession will be determined by those who join it and by those who select who will join it. Veterinary schools are the gatekeepers of the profession, and the entire veterinary profession is responsible for ensuring that the image it presents to those who will join it matches the social needs that it must serve. The application process for a Michigan State University College of Veterinary Medicine (MSUCVM) academic summer camp provided an opportunity to discern attributes of the 314 eighth-grade students who attended in 2000-2002. A re-reading of their application essays allowed clustering of similar descriptions and comments about motivations to attend the camp, interests in science, interactions with animals, and exposure to veterinarians and veterinary medicine. Many veterinary camp attendees will be undergraduate students by 2005/2006 and will be applying to colleges of veterinary medicine between 2008 and 2010. There-fore, an understanding of their attributes is germane to discussions about desirable characteristics of veterinary college applicants. Although the camp was designed to attract eighth graders interested in science and curious about veterinary medicine, attendees frequently described veterinary medicine as their career goal. These students (89.5% female, 95.6% residents of Michigan) enjoyed science, but their interest in veterinary medicine related to emotions such as a love of animals and sympathy for sick or injured animals (96.1%). They discussed having pets in their homes (75.5%), involvement with horseback riding (20.7%), experiences with animal-related projects and activities in 4-H (17.2%), and husbandry experience at farms or stables (16.2%). Although 22.6% had already shadowed a veterinarian and 12.8% described receiving other forms of veterinary mentoring, 22.9% commented on their inability to gain shadowing exposures prior to age 16. Based on the results of this survey and years of working with adolescents interested in veterinary medicine, the author offers conclusions about mentoring youth with an interest in veterinary careers.

Adolescent↗
PubMed2005

Practice-based education at Michigan State University.

Practice-based large animal education at Michigan State University (MSU) was initiated in 1995. Urbanization of the area surrounding MSU and the declining number of livestock and farms to provide clinical experience under field conditions were the major reasons for adopting this educational model. Veterinary students, as a requirement for graduation from the professional program, must successfully complete a three-week clerkship in a private practice that has either a food animal or an equine emphasis. The objective of the practice-based program is to provide students with introductory on-the-farm experience, with emphasis on examination, diagnosis, treatment, and prevention of common medical and surgical conditions of horses and/or food animals. Participating practices must be located in Michigan, have a sufficient case load, be interested in teaching senior veterinary students, and be willing to interact with the program coordinator and attend annual meetings. Sixty-nine practices are currently participating. The program coordinator matches students to practices based on the students' species interest and background, the personalities of the student and practitioner, and any special concerns or needs of the students (health conditions, child care). Assessment of students includes a practitioner's performance evaluation and review of written assignments (case log, clinical case reports, and a practice management assessment report) by campus faculty. A pass/no pass grading system is used. Overall, the Practice-Based Ambulatory Program represents a successful model for meeting the clerkship objectives. Additionally, exposing students to a high volume of commonly encountered conditions in a private business setting complements the referral cases seen in our large animal teaching hospital.

Animals↗