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At least 271 records · Page 15Linked to original sources
PubMed1979

Dynamics of cerebrospinal fluid circulation evaluated by metrizamide CT cisternography.

Cerebrospinal fluid (CSF) circulation has been analyzed by metrizamide computed tomography (CT) cisternography in 46 patients. Included were 7 patients without any clinical evidence of impaired CSF circulation, and 39 with hydrocephalus due to various causes. CT cisternography delineated the anatomical structures of the CSF pathways clearly and accurately and enabled us to analyze ventricular filling in a quantitative manner. As a result, a new, more precise CT cisternographic classification of the CSF flow patterns has been established. On the basis of the presence of ventricular reflux and stasis, extent of ventricular filling, and convexity flow of metrizamide, seven groups of flow patterns have been defined.

Adult↗
PubMed1979

Intrathecal metrizamide enhancement of the optic nerve sheath.

The subarachnoid space continues into the orbit as part of the optic nerve sheath. This space varies in size but is usually tiny. Occasionally, prominent (one case in our experience) enhancement of the optic nerve as part of metrizamide computed tomography (CT) cisternography is seen on transverse and coronal scans presumably because of a patulous optic subarachnoid space. In five cases, we have appreciated minimal enhancement of optic nerves with metrizamide only by close comparison of CT numbers with base-line scans. One of these patients had a tiny meningioma removed successfully from the optic sheath, with return to normal vision of a previously blind eye.

Adult↗
PubMed1984

Metrizamide meningitis.

A 39-year-old man had fever, nuchal rigidity, vomiting, and mental confusion within 24 hours after myelography with metrizamide, a water-soluble contrast medium. Cloudy cerebrospinal fluid showing pleocytosis, a significantly elevated level of protein, and a low glucose value suggested septic meningitis, but rapid resolution of signs of meningeal irritation and negative spinal fluid cultures made chemical meningitis due to the metrizamide the likely diagnosis.

Adult↗
PubMed1986

Nerve root cut-off on metrizamide-enhanced computerized tomography.

The "wink" sign of nerve root cut-off seen on metrizamide-enhanced computerized tomography correlates well with compression of a lumbar nerve by a herniated disk. Seven of 46 patients had normal or equivocal myelograms, but had definite nerve root cut-off on metrizamide-enhanced CT scan. All seven patients were found to have a herniated lumbar disk at operation or a diskogram positive for herniation at the time of chymopapain injection. The wink sign is an additional objective finding that can be used in assessing the patient with sciatica.

Adult↗
PubMedDate not supplied

Brain changes on computed tomography following metrizamide myelography. Significance and therapeutic implications.

Three cases of seizures and marked behavioral changes that occurred after intrathecal metrizamide administration are reported. In each case a cranial computed tomographic scan obtained within 24 hours of the ictus showed hyperdensity of the gray matter, and created an optical illusion of diffuse white matter edema. The literature on adverse reactions and their pathogenesis and on brain parenchymal penetration of metrizamide is reviewed.

Adult↗
PubMed1987

Combined CT metrizamide syringography and needle aspiration of cystic intramedullary spinal cord lesions.

A modified spinal cord puncture technique that was combined with CT metrizamide syringography for the evaluation of potentially cystic spinal cord lesions has been used in 5 patients. This procedure proved to be safe and efficacious in the preoperative differentiation of cystic neoplasms from syringohydromyelia. It also aided in planning a surgical approach by revealing details of the tumor location and/or syrinx dynamics. Spinal cord puncture associated with CT metrizamide syringography has a role in the diagnosis and therapy of patients with cystic spinal cord lesions.

Adult↗
PubMedDate not supplied

Metrizamide myelography in patients with iodine allergy or previous adverse reactions to iodinated contrast media.

Twenty-seven metrizamide myelographies were performed in 26 patients who had a history of iodine allergy or adverse reactions to iodinated contrast media. Three of the patients had had adverse reactions from a previous myelography procedure. All patients received atropine, diazepam, and metoclopramide as premedication. In ten examinations corticosteroids were also given. No patient, during or after myelography, had any reaction that could be related to hypersensitivity to the contrast medium. The incidence of headache, the most frequent side effect, was almost the same in patients who had corticosteroids in their premedication (30%) as in patients without (35%). These observations indicate that metrizamide myelography may be performed despite previous adverse reactions to contrast media.

Adrenal Cortex Hormones↗
PubMed1990

The effect of ambulation on post-myelography headache in patients injected with metrizamide.

This study was conducted to determine whether prescribed ambulation in post-myelography patients injected with metrizamide would significantly decrease the incidence of post-myelography headache. Eighty patients undergoing metrizamide lumbar myelography were assigned to two groups of 40 patients each. The control group was restricted to complete bedrest for the immediate 24-hour period following myelography. The experimental group participated in a prescribed regimen of ambulation every four hours following myelography. Data were collected during the immediate 24 hours post-myelography. Subjects were assessed as to the presence or absence of headache at four-hour intervals during data collection. At the end of the 24-hour period post-myelography, the Visual Analogue Pain Intensity Scale was administered to subjects with documented subjective complaints of headache pain. The nonambulatory group had a 62.5% incidence of headache while the ambulatory group revealed only a 42.5% incidence of post-myelography headache. The z test was used to test the first research hypothesis that there would be a higher incidence of post-myelography headache in the nonambulatory group than in the ambulatory group. The calculated z = 1.79, p less than .05; therefore, it was possible to conclude that the number of nonambulatory patients with headache was significantly higher than the number of ambulatory patients with headache. The second research hypothesis, that the severity of post-myelography headache would be greater in the nonambulatory group than in the ambulatory group, was tested using the Student's t test. The calculated t = .6492, p greater than .05. The subjects' self-perception of the severity of headache was not significantly different in the nonambulatory than in the ambulatory subjects.

Adult↗
PubMed1980

Isolation of Dane particles containing a DNA strand by metrizamide density gradient.

Dane-particle cores labelled with [3H]TTP were subjected to ultracentrifugation in a metrizamide density gradient. Two populations of core particles with different densities were obtained, and radioactivity was found only in the cores that sedimented at the lower density (1.19-1.23 g/cm3). All the cores in this group, when spread in a monolayer, were found to expel a closed circular double-stranded DNA molecule. In contrast, the core particles that sedimented at the higher density (1.23-1.27 g/cm3) were not associated with radioactivity, nor was any DNA strand extruded from them. These results show that metrizamide density gradients allow the separation of complete hepatitis B virions for the study of viral DNA.

Centrifugation, Density Gradient↗
PubMed1981

Myelography with metrizamide--an analysis of the complications encountered in cervical, thoracic and lumbar myelography.

Detailed analysis of complications in 363 patients undergoing myelography with metrizamide is presented. Patients have been separated into three groups: those who had lumbar myelograms via lumbar puncture; patients who had cervical myelograms via lumbar route and patients who had cervical myelograms via cervical puncture (lateral C1/C2. approach). Analysis has revealed that the incidence of minor complications like headaches, nausea, and vomiting is higher than that associated with myodil myelography. Nevertheless, it is concluded that because of lack of long term disability of arachnoiditis, and because of greater diagnostic accuracy, metrizamide represents the best contrast medium for myelography currently available.

Adolescent↗
PubMed1984

The effect of metrizamide on regional brain glucose metabolism in the rat.

The X-ray contrast material metrizamide is structurally related to 2-deoxyglucose and inhibits brain glucose phosphorylation in vitro. In vivo, the present autoradiographic study with labeled 2-deoxyglucose revealed a global reduction of brain glucose phosphorylation after metrizamide administration in the cisterna magna of rats. The reduction averaged 18% of all regions.

Animals↗
PubMed1975

Thoracic and cervical myelography with metrizamide. Clinical experiences with a water-soluble, non-ionic contrast medium.

One hundred cervical and thoracic myelographies were performed with the non-ionic, water-soluble contrast medium metrizamide. Good myelograms were obtained in almost all cases, adverse effects were minor, no serious complications occurred, and no convulsions were seen. Metrizamide is better than gas or isophendylate for demonstrating intraspinal expansive lesions of affections of the root sleeves.

Aminoglycosides↗
PubMed1976

Computed tomography of spinal cord after lumbar intrathecal introduction of metrizamide (computer-assisted myelography).

Computed tomography (CT) of the thoracic and cervical spine was carried out after lumbar intrathecal introduction of a water-soluble radiographic contrast medium (metrizamide). By choice, no head-down position of the patient was used to facilitate craniad movement of the contrast medium; rather, advantage was taken of the normal CSF flow. This technique, referred to as computer-assisted myelography (CAM), permits the demonstration of the metrizamide-containing subarachnoidal spaces surrounding the thoracic and cervical cord. Some examples of the diagnostic possibilities of the method are discussed.

Computers↗
PubMed1976

Adhesive arachnoiditis following lumbar radiculography with water-soluble contrast agents. A clinical report with special reference to metrizamide.

The frequency of adhesive arachnoiditis following lumbar radiculography with methiodal sodium (95 patients), methylglucamine iocarmate (20 examinations in 18 patients), and metrizamide (77 examinations in 73 patients) was found to be 29% in patients who were not operated on between methiodal studies and 48% in those who were operated on. With both methylglucamine iocarmate and metrizamide the frequency was very low. No changes indicating adhesive arachnoiditis were seen with these media in patients who were not operated on between radiographic examinations.

Arachnoiditis↗
PubMed1977

Metrizamide--CSF contrast medium. Analysis of clinical application in 215 patients.

Two-hundred-fifteen patients were evaluated with metrizamide, a new water-soluble contrast agent for use in the subarachnoid spaces. Side effects were reported in 67% of these; 39% were moderate or severe. Cervical injections monitored by fluoroscopy provide the most precise positioning of the medium. The benefits of metrizamide use outweigh its risk.

Cerebrospinal Fluid↗
PubMed1977

Metrizamide computed tomography cisternography: pediatric applications.

The methodology and clinical use of metrizamide (Amipaque) computed tomography (CT) cisternography are described as applied in the cases of 22 children with morphologic and physiologic abnormalities affecting the cranial portion portion of the central nervous system. In contrast to pneumoencephalography, CT cisternography affords equivalent or superior visualization of the basal cranal subarachnoid spaces with simpler technique and low morbidity. Intrathecal metrizamide enchancement in children causes a very low incidence of side effects.

Adenoma, Chromophobe↗
PubMed1977

Metrizamide in pediatric myelography.

Metrizamide, a new water-solution iodinated contrast medium, was evaluated in 63 infants and children, most of whom had lumbosacral or low thoracic lesions. The diagnostic quality was found to be good, and no serious complications or permanent sequelae were encountered. Chief complications were headache, nausea, vomiting and fever. No myoclonic spasms or convulsions were seen. The advantages and disadvantages of metrizamide are discussed.

Adolescent↗