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At least 271 records · Page 15Linked to original sources
PubMed2001

Connection between the inner ear and the lymphatic system.

OBJECTIVE: The aim of this study was to identify the lymphatic drainage of the inner ear in guinea pigs. STUDY DESIGN: Prospective study. METHODS: The prospective study was performed in guinea pigs by injection of keyhole limpet hemocyanin (KLH) into either the right-side scala tympani or the middle ear cavity. The left side was not injected and served as a control. Fifteen minutes after injection, the animals were killed by intracardiac perfusion with paraformaldehyde and tissue specimens (right and left temporal bones, cervical lymph nodes, and the spleen) were collected. The presence of KLH in each specimen was determined by immunohistochemical assay of frozen sections using polyclonal mouse anti-KLH antibodies. RESULTS: After injection into the middle ear, labeled cells were identified in the parotid, superficial ventral, mandibular, and deep cranial cervical lymph nodes. However, after inner ear injections KLH was present in only the parotid and superficial ventral cervical nodes. The spleen contained KLH-positive cells following injection into either the middle or inner ear, but not all animals contained labeled spleen cells. CONCLUSIONS: The inner ear has a connection to the lymphatic drainage system. Because fewer lymph nodes contained labeled cells after inner ear injection than after middle ear injection, it is concluded that the inner ear does not simply drain to the middle ear and subsequently to the lymph nodes but seems likely to have its own connections.

Animals↗
PubMed1993

Porphobilinogen deaminase activity in malignant proliferative disorders of the lymphatic system and bone marrow.

Porphobilinogen deaminase activity was studied in the erythrocytes of 73 women and 35 men with various malignant proliferative disorders of the lymphatic system and bone marrow, and, for comparison, in the erythrocytes of 34 women and 14 men with non malignant diseases of the haemopoietic system, and in those of 20 healthy women and 20 healthy men. The activity of the enzyme was determined by the Hsiao et al. method, using porphobilinogen as a substrate. Statistical analysis showed a significant decrease of porphobilinogen deaminase activity in the erythrocytes of men with Hodgkin's disease and women with plasmocytoma and with myeloblastic leukemia; an increased activity of the studied enzyme was found only in men with lymphocytic leukemia.

Adult↗
PubMed1979

Distribution and density of the canine renal cortical lymphatic system.

The pattern, distribution, and extent of the lymphatic circulation in the canine renal cortex was studied with light and electron microscopy, in two groups of animals, one with and one without ipsilateral ureteric obstruction for 3 days. Recognition of lymphatics in tissue sections was facilitated by mild dilatation, induced in both groups by ligation of the renal collecting vessels for 4 to 6 hours, and by retrograde injection of tracer in a third group. Of 77 lymphatics present in 180 blocks from six kidneys, approximately one third were intralobular, the remainder being primarily associated with interlobular blood vessels. The cross-sectional area of interlobular lymphatics was almost twice that of intralobular lymphatics. The relationships of these lymphatics were analyzed quantitatively. Intralobular lymphatics had primary relationships with terminal arteries, arterioles, renal corpuscles, and tubular elements. Both inter- and intralobular lymphatics had secondary relationships with a small proportion of all components of the cortical parenchyma including juxtaglomerular complexes. The most common association was between lymphatics and elements of the vascular tree. Morphometric analysis was used to obtain volume density data on the composition of the renal cortex. The volume density of lymphatics was 0.0026 in ureter-obstructed kidneys and 0.0017 in nonobstructed kidneys. The cross-sectional surface area of lymphatics in ureter-obstructed kidneys was significantly larger than those in nonobstructed kidneys. The volume density of other cortical components was found to be in good agreement with published data. From the volume density data, it was concluded that the volume of lymph in the renal cortex, under conditions of mild lymphatic dilatation, was about 1% that of the volume of blood in the cortical peritubular capillaries.

Animals↗
PubMedDate not supplied

[Effect of brown enriched Livex on the general condition of patients with proliferative diseases of the bone marrow and lymphatic system].

Brown Livex, a preparation of animal blood in doses of 5.0 g twice daily was given to 33 patients with proliferative diseases of bone marrow and lymphatic system during and after treatment with cytostatic agents. The course of treatment was 3 months. The effect of the preparation was studied on the wellbeing of the patients, body weight, general fitness (Karnofsky scale) and the levels of haemoglobin, haematocrit and beta-lipoproteins. The control groups comprised 20 patients with similar diseases and similar cytostatic treatment. In the studied group a positive effect was observed of the preparation on weight gain (26 out of 33 patients), well-being (24 of 33) and general fitness (17 of 33). In the control group during the same-time of observation weight loss was noted in 11 of 20 cases, well-being deterioration in 7 of 20, and decreased general fitness in 7 of 20. Livex treatment had no effect on haemoglobin level, haematocrit value, total serum protein, albumins and beta-lipoproteins.

Adult↗