Solitary pyogenic liver abscess in patients with diabetes mellitus.
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For the therapy planning of liver abscesses both etiological factors and clinical symptoms have to be evaluated, with visualization via ultrasound, CT, or MRI. The indication for a percutaneous abscess drainage (PAD) is a solitary or complicated abscess with a safe drainage access. The success rate varies between 70 and 93%, the mortality rate between 1 and 11%. For complex abscesses, surgical therapeutic techniques (OSD) or liver resection have to be discussed. The OSD success rate varies between 51 and 70%, the mortality rate between 11 and 43%. In summary PAD is characterized by low complication and mortality rates, reduced risk of anesthesia, low cost, and short stay in the hospital.
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Acute Budd-Chiari syndrome caused by compression of the inferior vena cava by a space-occupying lesion in the liver is rare in children. We report a case where the compression was due to a large staphylococcal abscess in the right lobe of the liver. A high index of suspicion in such a case ensures early intervention and saves life.
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We report a case of isolated hepatic actinomycosis and review 35 previously reported cases. Three-fourths of the reported patients were male, and more than one-half were between 30 and 50 years of age. Although some patients had oral disease or intraabdominal infections, the majority of cases were cryptogenic. Common presenting symptoms included fever, abdominal pain, and anorexia with weight loss. Findings on physical examination included pyrexia, abdominal tenderness, and hepatomegaly. Leukocytosis with a left shift, anemia, an elevated serum erythrocyte sedimentation rate, and an elevated level of alkaline phosphatase were almost universally present. Diagnosis was frequently made at the time of exploratory laparotomy, but percutaneous diagnostic procedures obviated the need for surgery in many recent cases. Microbiological diagnosis involved visualization of branching gram-positive Actinomyces organisms or recovery of organisms in anaerobic culture. Treatment most commonly consisted of prolonged administration of penicillin or tetracycline and was associated with an excellent outcome in the majority of cases.
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Computed tomography (CT) was used to evaluate 15 rabbits with experimentally induced liver abscesses. The animals were examined both before and after intravenous contrast injection. After sacrificing the animals, postfreeze CT scans were made to mark the abdomen for 1-cm thick whole body sections for correlating the gross pathology with the results of the CT scans. CT detected 15 abscesses in 13 of the 14 rabbits with true positive lesions. Ten abscesses less than 1.4 cm in diameter were not detected by CT. Contrast agent enhancement was helpful in 70% of the studies. These abscesses have characteristics similar to human liver abscesses, but there was more gas and calcium in the experimentally induced abscesses than is encountered in humans with hepatic abscesses. The model and its CT characteristics appear well suited for future studies in the diagnosis and treatment of liver abscesses.
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