Multiple primary neoplasms in identical twins.
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BACKGROUND: The radial forearm flap has been a workhorse flap for soft-tissue or coverage reconstruction in the head and neck area. Although it has several major advantages, it requires sacrifice of the radial artery. In this article, the authors present their modification of harvesting a forearm flap based on a large septocutaneous branch of the radial artery in the proximal forearm with or without sacrificing the main radial artery. They name it the proximal radial forearm flap. METHODS: From September of 2003 to March of 2004, a total of 14 free proximal radial forearm flaps were used for head and neck reconstruction in 12 patients. There was one female patient and 11 male patients. Their ages ranged from 32 to 85 years. The skin flap size ranged from 2.0 x 6.0 cm to 4.5 x 18 cm. RESULTS: All free proximal radial forearm flap reconstructions had immediate success. There were one delayed flap loss caused by wound infection and one death attributable to advanced medical disease. Six flaps were harvested with preservation of the radial artery trunk. Six of the eight radial arteries that were killed during flap harvest were repaired with a short segment (3 to 4 cm) of vein graft. The average diameter and length of the septocutaneous vessel of the proximal radial forearm flap was 0.73 mm and 3.3 cm, respectively. Two flaps were harvested in conjunction with the conventional free radial forearm flaps. Nine donor sites were closed primarily and five donor sites required skin grafts. CONCLUSIONS: The proximal radial forearm flap can be used successfully in head and neck reconstruction with the advantages of moving the donor site to the proximal forearm for better scar concealment and possible preservation of the radial artery trunk. The disadvantages of this flap are short pedicle length and small pedicle diameter when the radial artery is to be preserved.
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In 72 basal-cell epitheliomas, the clinical extension and the actual extension of the defect measured by complete tumor removal by Mohs' chemosurgery were compared. Subclinical extension depends on the type of basal-cell epithelioma (primary, recurrent), on case history, location, clinical diameter, number of previous treatments and histological type. It is remarkably great in large (diameter more than 20 mm), in morphea-like basal-cell epitheliomas on the forehead, temple and scalp, especially following several previous treatments. In such cases the excision should include at least a 5-10 mm margin of "normal tissue." Present results again show that "histographic," that is, Mohs' chemosurgery is the method of choice for the treatment for these tumors.
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The principles of radiotherapy for the common cutaneous carcinomas of the skin are discussed and results illustrated. Shorter accounts of X-ray therapy of other, less common malignancies are also presented.
Six cases of advanced head and neck cancer in young patients, who were regular marijuana users, are presented. Numerous carcinogens, as well as respiratory irritants, are found in marijuana smoke. The active euphoria-producing agent, delta-9 tetrahydrocanabinol, has been implicated in altered DNA, RNA, and protein synthesis and consequent chromosomal aberrations.
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Of 124 patients with oral squamous cell carcinomas treated during the past 14 years, 13 developed second primary cancers with clinical symptoms in the same tissues or in organs different from those of the initial lesions during follow-up. The second primary tumors also appeared in the oral cavity in 3 of the patients, the hypopharynx in 1, the esophagus in 2, the stomach in 2, the colon in 1, the thyroid gland in 2 and the lung in 2. Of the 3 patients with second tumors in the oral cavity, 1 underwent surgery after chemo- and radiotherapy and 2 underwent laser surgery or chemo- and radiotherapy only. The second primary cancers appeared on the contralateral or ipsilateral side, completely separate from the sites of the primary lesions during a period of 1 to 3 years. One patient with triple cancers involving the oral cavity, esophagus and hypopharynx is still alive after 15 years. The other two patients died of cervical or lung metastases after 3 years.
On the basis of results and check-ups gained at the clinic of Zurich, it can be demonstrated, once more, that radiotherapy of precancerous lesions and tumors, even critically considered, is still a very valuable and safe method of treatment with lasting success in 90 to 99% of the cases. At the same time this method safeguards the essential functions, even in the case of particularly difficult areas.
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Effective reconstructive techniques are available for immediate, primary repair of surgical defects caused by extensive ablation for malignant conditions of the head and neck. Primary repairs rely heavily on the principle of 'axial-based' skin flaps which can be transposed into the defects without delay. Three cases are presented to illustrate the method.