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PubMed2003

Shackling the shoulders of giants. A report on excerpts from the National Academies' Symposium on the Role of Scientific and Technical Data and Information in the Public Domain, Washington, DC, September 5-6, 2002.

This paper informally summarizes a two-day symposium held at the U.S. National Academy of Sciences in Washington, D.C., September 5-6, 2002. The issue was to what extent the progress of science and societal capacity for continued technological innovation are threatened by excessive protection of intellectual property. Excessive protection creates disadvantages not only for scientists and inventors but also for educators/students and for librarians/clientele. Speakers from a variety of disciplines and institutions agreed unanimously that scientific and technological progress is, indeed, under serious threat. Various opinions were expressed about the degree of threat, currently and prospectively, as well as what counter-measures are best suited to resist undue restrictions on creative uses of scientific and technical data and information. This summary is based entirely on the author's notes from the symposium, and the commentary offered is his alone. My apologies to the speakers if this paper does not accurately reflect the primary intent of their presentations. The "Suggested Readings" offered at the end are not specific to the speakers' statements but rather are offered as a general resource to aid further research. The definitive record of the symposium is planned to be available from the National Academies Press as a Proceedings publication in the summer of 2003.

Copyright↗
PubMed2005

Surgical patents and patients--the ethical dilemmas.

It is obvious that every inventor should be rewarded for the intellectual effort, and at the same time be encouraged to successively improve his or her discovery and to work on subsequent innovations. Patents also ensure that patent owners are officially protected against intellectual piracy, but protection of intellectual property may be difficult to accomplish. Nevertheless, it all comes down to this basic question: Does a contradiction exist between medical ethics and the "Medical and Surgical Procedure Patents" system? It may well turn out that medical-procedure patents can have a negative influence on the standard of medical care. Medical-method patents may also interfere with the physician-patient relationship. At present, physicians do not question the usefulness of patent protection for medicines, biotechnology, equipment and devices, but they strongly oppose it for surgical procedures.

Ethics, Medical↗
PubMed1989

Heart valve legislation and regulation.

During 13 years of regulation by the FDA under the Medical Device Amendments of 1976, the process by which replacement heart valves have been developed and modified has changed. Some of these changes have been good for the public, whereas other changes are of questionable value. Conditions will never be as they were 25 years ago, but they could be closer to what was expected in 1976. As the FDA constantly seeks to improve its performance and Congress focuses on possible changes to the Act, the cardiovascular community of practitioners, inventors, and manufacturers should offer their assistance. I believe the creative spirit that enables you as pioneers to reflect on your accomplishments and contemplate even greater innovations for the future should again be applied to the process of helping the FDA improve the way it serves us--the public.

Heart Valve Prosthesis↗
PubMed1994

Chevalier Jackson: the father of American bronchoesophagoscopy.

Chevalier Jackson was involved with bronchoesophagoscopy from the late 1800s until shortly before his death in 1958. A pioneer in the field, he developed numerous instruments used in peroral endoscopy and taught their safe and effective use. Most of the next generation of leaders in the field of bronchoesophagoscopy were trained in his clinics in Pittsburgh and in Philadelphia, where he held academic appointments at the six leading medical institutions of these cities. He was a keen observer, inventor, prolific writer, and humanitarian.

Bronchoscopy↗
PubMed1992

The physical and functional behavior of capture antibodies adsorbed on polystyrene.

Six monoclonal and two polyclonal antibodies to fluorescein (FLU) were affinity purified and immobilized on Immulon 2 polystyrene as capture antibodies (CAbs): (a) by passive adsorption at pH 9.6, (b) via a streptavidin bridge to a biotinylated carrier molecule, and (c) via an antiglobulin which had been previously adsorbed passively to the polystyrene. Data show that less than 3.0% of the binding sites of monoclonal CAbs and approximately 5-10% of those of polyclonal CAbs were capable of capturing antigen (FLU4.2-BSA) after passive adsorption. Immobilization of CAbs via an antiglobulin or a streptavidin bridge, resulted in the preservation of antibody binding sites to greater than 70% for some monoclonals although immobilization via the streptavidin bridge resulted in the highest number of functional sites/well. The data presented are consistent with studies on other adsorbed proteins which demonstrate that passive adsorption on polystyrene results in the loss of protein function. Furthermore, these data show that generally less than half of the binding sites of antibodies available in solution are available after solid-phase immobilization even when non-adsorptive methods are employed. Some polyclonal anti-FLU also have lower average avidity following passive adsorption compared with CAbs immobilization via a streptavidin bridge. Immunochemical studies revealed that adsorbed polyclonal-CAbs performed like monoclonals when tested with multivalent antigens (FLU10-IgA) but in an expected heterogeneous manner in Scatchard plots when tested using univalent FLU-insulin. This observation implied cross-linking of immobilized CAbs by the multivalent antigen. Because only 5-10% of adsorbed polyclonal CAbs are active, the survivors must be non-randomly distributed in clusters to explain the cross-linking. This was confirmed by scanning electron microscopy which gave rise to the hypothesis that antibodies which retain activity after adsorption, are those present in clusters, i.e., the functional adsorbed CAb is an antibody cluster. Data presented in this report on the behavior of adsorbed CAbs, and reviewed from the work of others for various adsorbed proteins, indicate that the method of passive adsorption at pH 9.6, which is widely used in popular microtiter ELISAs, and which has in many ways revolutionized immunoassay, is a method of protein denaturation. Assayists that utilize passive adsorption of proteins on hydrophobic supports as part of their research need to be cognizant of this phenomenon, while inventors of immunoassay should develop alternative methods of immobilization which do not destroy 90% of the functional activity of solid-phase reactant.

Adsorption↗
PubMed1986

The peritoneal cell carcinogenicity test.

The peritoneal cell carcinogenicity test, which is a new short-term in vivo-in vitro transformation test invented by Nashed (1981), was evaluated in the present report. The experimental design and materials used were as close as possible to those used by Nashed (1981). Test compounds were the two carcinogenic/non-carcinogenic analog pairs benzo[a]pyrene/pyrene and 2-acetylamidofluorene/4-acetylamidofluorene. All 4 compounds were administered orally. Al(OH)3 was injected intraperitoneally to act as mitogen for peritoneal macrophages. The criterium for transformation was colony growth of macrophages in soft agar. Two transformed cell types formed colonies under the conditions used. Pulmonary and peritoneal macrophages formed colonies when colony-stimulating factor was added. No colony growth was observed on plates with macrophages from 256 animals tested (100 carcinogen treated, 80 treated with noncarcinogenic analogs and 76 untreated controls). Thus we were not able to confirm results published previously by the inventor of this test (Nashed, 1981).

Animals↗
PubMed1995

Davy comes to America: Woodhouse, Barton, and the nitrous oxide crossing.

In the final decade of the eighteenth century, a new method of medical treatment appeared in England when physician Thomas Beddoes developed a systematic application of Joseph Priestley's "factitious airs", or gases, to treat consumptive patients. Supported by peers such as Erasmus Darwin and using applications designed for him by James Watt and other inventors, Beddoes combined technological innovation and gas inhalation in an attempt to cure his patients. Late in the decade Beddoes hired young Humphry Davy as his assistant; Davy quickly added nitrous oxide to the armamentarium. The prominent group Davy assembled to help him test nitrous oxide and record their experiences has seldom been equaled in medical history as a research population. Davy left the Pneumatic Institution in March 1801 and joined the staff of the infant Royal Institution in London, but news of the nitrous oxide soon reached American. Physician James Woodhouse, a professor of chemistry at the University of Pennsylvania since July 1795, left in early 1802 for England, where he met Davy. A few years later one of his chemistry students preserved an account of the extensive nitrous oxide trials that took place in Woodhouse's classroom throughout 1807. In that work William Barton discussed and replicates Davy's research and agrees with his conclusions. Such intermittent experimentation continued in the United States and Europe until Horace Well's public demonstration of ether inhalation in January 1845. This paper describes how nitrous oxide inhalation survived in America through the work of Woodhouse and Wells. Traveling showmen like Samuel Colt and Gardner Quincy Colton demonstrated the gas' effects at popular lectures.(ABSTRACT TRUNCATED AT 250 WORDS)

Anesthesiology↗
PubMed1995

Desperately seeking sensors.

The list of biologically active small molecules for which fluorescent sensors would be desirable is enormous. The list of sensors actually available is surprisingly small. The reason derives in part from a lack of communication between chemistry inventors and biology end-users. A new World Wide Web board has been created to address this need.

Animals↗
PubMed2006

Synergy between Competitive Intelligence (CI), Knowledge Management (KM) and Technological Foresight (TF) as a strategic model of prospecting--the use of biotechnology in the development of drugs against breast cancer.

The aim of this paper is to demonstrate the synergy between Competitive Intelligence, Knowledge Management and Technological Foresight, and to emphasize the proposal of a strategic model of data prospecting as a mechanism to support decision-making in regard to three approaches for sustainable development and innovation: technological, social and economic. The use of biotechnology in the development of drugs against breast cancer is the case study. The article shows the results of data and text mining in specialized medical and patent databases, identifying the most frequently cited drugs, as well as the authors of research, and the inventors of new technology at the beginning of the 21st century. In addition, the study includes reference to Brazilian competence in breast cancer area, the international trends in drugs for treatment of this cancer, leading international institutions and Brazilian competencies. A framework is presented, which could serve as a guide and support for the decision-making process.

Biotechnology↗
PubMed2004

Cross your heart: Some historical comments about fibrinous pericarditis.

This article briefly describes the origin of one of the more common (food-related) pathologic terms--"bread and butter pericarditis." The eminent French physician, Laennec, the inventor of the stethoscope amongst several other important medical contributions, can be credited for having coined the term that is still in common usage amongst pathologists.

Auscultation↗
PubMed2006

Design of a monitoring network and assessment of the pollution on the Lerma river and its tributaries by wastewaters disposal.

While the 2005 progress report of the United Nations Millennium Development Goals stresses out the need of a dramatic increase in investment to meet the sanitation target in the third world, it is important to anticipate about some parallel negative impacts that may have this optimistic programme (extension of sewer networks without sufficient treatment works). Research was initiated on Lerma River (Mexico), subjected to many rejects disposal, to design a monitoring network and evaluate the impact of wastewaters on its water quality. The discharges was inventorized, geo-positioned with a GPS and mapped, while the physico-chemical characteristics of the river water, its tributaries and main rejects were evaluated. Microtox system was used as an additional screening tool. Along the 60 km of the High Course of Lerma River (HCLR), 51 discharges, with a diameter or width larger than 0.3 m (including 7 small tributaries) were identified. Based on the inventory, a monitoring network of 21 sampling stations in the river and 13 in the important discharges (>2 m) was proposed. A great similitude was found between the average characteristics of the discharges and the river itself, in both the wet and dry seasons. Oxygen was found exhausted (<0.5 mg/L) almost all along the high course of the river, with COD and TDS average levels of 390 and 1980 mg/L in the dry season, against 150 and 400 mg/L in the wet season. In the dry season, almost all the sites along the river revealed some toxicity to the bacteria test species (2.9 to 150 TU, with an average of 27 TU). Same septic conditions and toxicity levels were observed in many of the discharges. Four of the six evaluated tributaries, as well as the lagoon (origin of the river), were relatively in better conditions (2 to 8 mg/L D.O., TU<1) than for the Lerma, acting as diluents and renewal of the HCLR flow rate. The river was shown to be quite a main sewer collector. The high surface water contamination by untreated wastewaters that is depicted in this research should be taken into account in the Millennium Goals strategies, by promoting treatment plan works simultaneously, when sewer networks in the third world would extend.

Aliivibrio fischeri↗
PubMed2004

Patenting for the research scientist: an update.

Academic institutional research constantly produces results worthy of patent protection, but coping with the demands of patent law presents considerable challenges to bioscientists working in these institutions. Inventors need, however, to be aware of recent patent office guidelines and court decisions if they are to seek useful intellectual property as a basis for technology transfer to industry.

Animals↗
PubMed2004

Technologies that make administration of vaccines safer.

There is an ever-expanding technology that is aimed at making the administration of vaccines safer. Conventional ways of administering vaccines are being upgraded, modified or replaced by a wide variety of innovations. The paradigm of liquid vaccines, needles and syringes is slow to change, but already developments are occurring that will change for ever the way vaccines are administered and will improve the safety record of immunization. The oral route of vaccine administration has generally been thought of as safe, but until now only the polio vaccine has been widely used in this way. The conventional method of vaccine administration is by injection. Many ingenious devices have become available that now make injecting safer. Inventors are now looking imaginatively to alternative routes and technologies for delivering vaccines. Vaccines are generally manufactured to extremely high standards and rarely are shown to be the cause of safety issues. People remain the weakest safety link is vaccine administration. Technologies that bypasses the ability of man to make bad decisions or to behave incorrectly are of tremendous value. The vaccine world is in the middle of a radical re-think about how vaccines might best be administered. The presentation of the vaccine can be altered to fit new technologies such as powder jet guns, or skin patches. Even the conventional needle and syringe have evolved to much safer versions, and are set to continue this evolution. All this means even safer vaccines and their delivery.

Drug Compounding↗
PubMed1997

The device with a name on it.

Conflict of interest is a significant problem in interventional cardiology that can potentially affect how data are presented and evaluated. Creative inventor clinicians and scientists should rely on investigators without conflict of interest to evaluate and report on new devices and outcomes.

Cardiology↗
PubMed2003

The use of peptidomics in endocrine research.

In 2002, the Nobel Prize for chemistry was awarded to the inventors of two novel ionization techniques in mass spectrometry, MALDI and ESI. These techniques, often in combination with data from genomic databases, represent an extremely powerful tool in analytical (bio)chemistry, with many applications, e.g., in the field of proteomics. Peptides, which are small proteins, have, despite their importance as controlling agents in numerous physiological processes, as yet been much less intensively studied by these novel techniques than larger proteins. The term peptidomics, i.e., the study of all peptides expressed by a certain cell, organ or organism was only introduced in 2001. In neuroendocrinology, spectacular progress could already be realized and the future looks bright. In this minireview we discuss the different methodologies that are used in peptidomics and give an overview of the wide range of applications.

Animals↗
PubMed2001

Pre-clinical validation of a new partially cemented femoral prosthesis by synergetic use of numerical and experimental methods.

The present work reports the pre-clinical validation of an innovative partially cemented femoral prosthesis called cement-locked uncemented (CLU) prosthesis. The inventors of the device under investigation claimed that, when compared to a comparable fully cemented stem, the new stem would present various advantages. Two previous experimental studies confirmed that primary stability and stress shielding were comparable to those of cemented stems. Aim of the present study was to investigate if the remaining claims were confirmed as well. A complete finite element model of the bone-implant complex was created from CT data. The model was validated against in vitro measurements of bone surface strains as well as against primary stability measurements. The peak stresses predicted in the CLU cement mantle were not found significantly lower than those reported in other studies on fully cemented stems. However, once the cement inlet geometry is optimised and the associated stress risers are eliminated, the CLU cement mantle should be subjected to much lower stresses. The stress induced in the stems by both load cases was well below the fatigue limit of the Ti6Al4V alloy. Finite element models predicted for all load cases relative motion between cement and metal lower than 60 microm. This amplitude may be fully accommodated by elastic deformations of the cement micro-ridges. The experimental and numerical results showed the validity of the new fixation concept, although a further optimisation of the geometry of the cement pockets is needed in order to further reduce the stresses in the cement.

Alloys↗
PubMedDate not supplied

Aloys Alzheimer, a coworker of Emil Kraepelin.

In the last 10 years most people in the western world have become fully aware of the medical and social dimensions of Alzheimer's disease. One might conclude, therefore, that the life of Aloys Alzheimer (1864-1915) would be an object of intensive study. However, compared to other scientists from the turn of the century, our knowledge of Alzheimer is still limited. One of the most decisive factors in his life was Emil Kraepelin, the real "inventor" of the Alzheimer dementia. A critical-historical attitude should be especially maintained if one looks at Alzheimer's dementia, Alzheimer's famous "discovery". Many of today's psychiatrists would assume that the description of Alzheimer's disease was the scientific climax of Alzheimer's professional life and the ultimate aim of his research. However, this view is the result of our modern knowledge. Kraepelin's creation of Alzheimer's disease in 1909 was not based on a large number of "objective" findings, but on his idea of "nosological entities". Alzheimer's disease is a striking example of the fact that a new medical idea must comprise conceptual prerequisites, clinical observations and innovative technologies.

Alzheimer Disease↗