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Results for “Immunologic Memory”

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At least 271 records · Page 15Linked to original sources
PubMed1980

Immune interferon secretion as an expression of immunological memory to transplantation antigens: in vivo generation of long-lived, recirculating memory cells.

Leukocytes from C57Bl/6 mice immunized against DBA/2 strain antigens by intraperitoneal injection of mastocytoma P 815 cells produced, when stimulated in the mixed leukocyte reaction assay with DBA/2 spleen cells, an earlier and more intense secretion of immune interferon than leukocytes from untreated mice. This secondary-type interferon response was independent of cell proliferation. The memory phenomenon was induced by long-lived, recirculating lymphocytes found in spleen, lymph nodes and thoracic duct, but not in the thymus. Memory cells could be recruited into inflammatory sites. They were shown to be specific for H-2 alloantigens, although some cross-reactivity with stimulating cells bearing unrelated H-2 antigens was observed. The possible anti-tumor, antiviral and immunoregulatory roles of this memory phenomenon, and its significance in transplantation immunity are discussed.

Animals↗
PubMed1975

Immunological memory: stable IgG patterns determine in vivo responsiveness at the clonal level.

Immune responsiveness to the streptococcal group polysaccharides at the clonal level can conveniently be monitored by analytical isoelectric focusing combined with autoradiography. The parameters investigated in this paper can be summarized as follows: [1] Within the first week after injection antistreptococcal p0lysaccharide responses are characterized by IgM antibodies, followed by subclass restriction in Balb/c mice to IgG2a antibodies. [2] The clonal pattern of specific IgG2a antibodies established in the second week after immunization does not change within the following 6 weeks. [3] Persistence of a specific response pattern established within a primary immunization course holds for Balb/c mice and rabbits for as long as 12 to 13 months. [4] Repeated immunization courses in mice and rabbits maintain established clonal antibody patterns in toto. Temporal variations of clonal expression are generally quantitative rather than qualitative. B-cell memory within this system is therefore stable and long-lived.

Animals↗