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Integrated Academic Information Management Systems (IAIMS). Part III. Implementation of integrated information services. Clinical linkages: IAIMS at the University of Utah.

The IAIMS project at the University of Utah has focused on clinical linkages to facilitate the research, teaching, and service mission of the Medical Center. The planning phase focused on the relationship among ther users and providers of the system and developed a scenario describing the professor and clinical clerk making rounds in the bedside setting. The prototype Health Evaluation through Logical Processes (HELP) system brings together three sources necessary to solve a medical problem: the patient database, the medical literature, and an expert in the subject. Microcomputers provide access to the HELP system and a complementary literature knowledge database.

Academic Medical Centers↗

Integrated Academic Information Management Systems (IAIMS). Part III. Implementation of integrated information services. Medical informatics education.

Medical informatics is still in its early stages of evolution and definition. If informatics is to obtain the status of a specialized field of study within the health science curriculum, its ambiguity must be eliminated. This article discusses the term "medical informatics" and the impact of the new field of study on curriculum, education, and training of health care professionals, and health care information systems research and development.

Academic Medical Centers↗

Genomic occurrence of microsatellites containing integral and non-integral repeat numbers.

We calculated occurrences of all dinucleotide and trinucleotide microsatellites in the human, mouse, and yeast genomes. The microsatellites were considered separately not only according to the repeated dinucleotide or trinucleotide and the microsatellite length but also according to the starting/terminal nucleotide. The analysis showed that dramatically non-equal amounts occurred in the human genome of microsatellites that differed only by the terminal nucleotides. For example, the 23-mer (TTG)(7)TT occurs 635 times in the human genome whereas (GTT)(7)GT is present only three times in the human genome though the two 23-mers share a 22 nucleotide sequence. The dramatically non-equal occurrences of microsatellites differing only by the terminal nucleotides are observed for most dinucleotide and trinucleotide microsatellites and in all analyzed genomes. We suppose that the strikingly non-equal genomic occurrences of these closely related microsatellites originate from conformational properties of DNA.

Animals↗