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PubMed1996

Morphometric evaluation of immunoglobulin A-containing and immunoglobulin G-containing cells and T cells in duodenal mucosa from healthy dogs and from dogs with inflammatory bowel disease or nonspecific gastroenteritis.

OBJECTIVE: To investigate the distribution of IgA- and IgG-containing cells and T cells in the villi of duodenal mucosa from healthy dogs and from dogs with inflammatory bowel disease (IBD) of gastroenteritis. DESIGN: Case-control study. ANIMALS: 28 dogs, grouped according to clinical and histologic criteria: 11 dogs with IBD, 8 dogs with non-specific gastroenteritis, and 9 healthy dogs. PROCEDURE: Endoscopic biopsy specimens of duodenal mucosa from each dog were stained specifically for IgA and IgG heavy chains and pan T-cell (CD3) antigen, using immunoperoxidase techniques. Morphometric analysis, performed via an image-analysis system, was used to count IgA- and IgG-containing cells and T cells within paired contiguous villi from each dog. RESULTS: cells were the predominant immune cell type in all groups of dogs. Significant differences in the villus distribution of IgA- and IgG-containing cells and T cells were not observed. Healthy dogs had significantly higher T-cell counts than had dogs with IBD or gastroenteritis. Dogs with nonspecific gastroenteritis had a significantly higher concentration of IgA-containing cells than the other groups of dogs had. Significant group differences for IgG-containing cells also were evident, with dogs with IBD having the lowest cell counts. CONCLUSIONS AND CLINICAL RELEVANCE: High concentrations of IgA- and IgG-containing cells and T cells in the villus lamina propria cannot be reliably used to distinguish IBD from other intestinal disorders in dogs. Evaluation of T cells may be the most discriminatory method for differentiating dogs with IBD from clinically normal dogs via examination of intestinal biopsy specimens.

Animals↗
PubMed1997

Gastroenteritis in children under 5 years of age in England and Wales.

Gastroenteritis is a major cause of illness in young children worldwide. The magnitude of this problem is underestimated, as many cases may not present for medical treatment and many that do present are not asked to provide a faecal specimen. In this study, laboratory reports of pathogens responsible for gastroenteritis in children under 5 years in England and Wales reported to the PHLS Communicable Disease Surveillance Centre from January 1990 to December 1994 were analysed. These reports were compared with food poisoning notifications and mortality attributable to gastroenteritis collated by the Office of Population Censuses and Surveys in the same age group over the same period. Thirty-nine per cent of the 167630 laboratory faecal identifications were of rotavirus. Reports were commonest in children under 1 year of age during the winter months. Salmonellas and campylobacters were isolated from 16% and 15% of the specimens reported respectively. During the study period salmonella reporting rates rose by 48% in this age group. Improving the microbiological quality of food and raising standards of food hygiene, together with increasing parental awareness of the possibility of food poisoning in young children, will help to reduce morbidity in this age group. The majority of childhood deaths attributable to gastroenteritis were associated with rotavirus infection. The introduction of recently developed vaccines against rotavirus could substantially reduce the level of morbidity in this age group.

Bacterial Infections↗
PubMed1980

[Comparison of the effects of gastroenteric and parenteral saline loading on kidney function after inhibition of prostaglandin synthesis (author's transl)].

UNLABELLED: We inhibited the prostaglandin synthesis with indomethacin in rats during a 7-h (periods: 1--4h; 4--5.5h; 5.5--7h) gastroenteric and parenteral infusion of isotonic saline. Indomethacin was given in a dosis of 10 mg/kg of b. wt. by stomach tube after 5.5-h infusion of saline. We studied how far prostaglandins are involved in the different function of the kidney by measuring the water and sodium excretion and the cortico-medullary osmotic and albumin concentrations of the kidney. RESULTS: 1. a) Studies Without Indomethacin. As compared to infusion of isotonic saline into the stomach water excretion is decreased by 30% (P less than 0.02) and 35% (P = n.s.) in the second and third 90 min period during parenteral infusion of saline. As compared to gastroenteric infusion we found an increase of the total osmolarity by 13% (P less than 0.02) in the cortex of the kidney. b) Studies with Indomethacin. As compared to saline infusion into the stomach indomethacin-treated rats decrease their urinary flow rates in 90 min by 26% (P = n.s.) in the presence of equivalent saline infusion into the aorta. Total osmolarity of the parenteral loaded rats increases by 17% (P less than 0.01) in the cortex of the kidney. 2. Indomethacin leads to an increased concentrating ability of the kidney in both gastroenteric and parenteral loaded rats. 3. In the presence of indomethacin plasma albumin of the kidney increases in the cortex and in the outer medulla of the kidney. In the inner medulla, and in the papillary tip, however, albumin concentration decreases significantly. As compared to gastroenteric saline infusion, the osmolarity of the kidney tissue increases and the urinary flow rate decreases during equivalent parenteral infusion of isotonic saline. The prostaglandins are not responsible for the pronounced diuresis during infusions of isotonic saline into the stomach.

Animals↗
PubMed2007

Quantitative analysis of lymphangiogenic markers in human gastroenteric tumor.

BACKGROUND: Lymphatic spread of gastroenteric tumor cells to regional lymph nodes is one of the early events in metastatic cancers and is often associated with distant metastatic spread and poor prognosis. Expression levels of newly described lymphatic endothelial markers, LYVE-1, VEGF-C, VEGF-D and the VEGF receptors VEGFR-3 were assessed in our study. METHODS: Paired (tumor and corresponding normal tissue) samples were obtained. The expression level of each factor was determined using RT-PCR and quantified by using a real-time quantitative PCR (RT-QPCR) technique, with respective cloned cDNA plasmids as internal standards. RESULTS: The expression of VEGF-C and lymphatic endothelial marker VEGFR-3 was significantly greater in patients with lymph node metastasis than in those without metastasis, but no different expression level of VEGF-D and LYVE-1 was detected in both groups of patients. Lymphatic vessel density (LVD), which was assessed by immunohistochemistry for LYVE-1, was correlated with lymphangiogenesis factors and lymph node metastasis. Expression of VEGF-C and VEGFR-3 was significantly associated with higher peritumoral LVD than normal group, and LVD was found greater in the node-positive group than in the node-negative group. CONCLUSIONS: These results indicate that quantitative analysis of lymphangiogenic marker VEGF-C and VEGFR-3 in gastroenteric specimens may be useful in predicting metastasis of gastroenteric cancer to regional lymph nodes, but the role of LYVE-1 in predicting metastasis of gastroenteric cancer requires further analysis.

Biomarkers, Tumor↗
PubMed1993

Fat absorption and gastroenteric pH profile in postsurgical pancreatic insufficiency: role of the association of H2-receptor antagonists with pancreatic enzymes.

The complete control of steatorrhea in post-surgical exocrine pancreatic insufficiency is difficult. The aim of this study was to evaluate the effect of the association of ranitidine with pancrelipase om fecal fat excretion in patients who had undergone a pancreatoduodenectomy with suppression of the exocrine pancreatic secretion by Neoprene injection. Ten patients were studied 1 year after surgery. Steatorrhea was measured as an integrated test of 3-day stools, while patients were kept on a diet of 100 g lipid/day, with their usual enzyme supplementation therapy (16,050 USP units of lipase/meal). A basal 24-h gastroenteric pH profile was also obtained. In the following month, patients had ranitidine (150 mg twice a day) in addition to pancrelipase. Then steatorrhea and gastroenteric pH were reassessed. Mean fecal fat was 26.9 (SD 13.7) g/day without ranitidine and 30.5 (SD 13.9) g/day during combined treatment. Body weight and nutritional parameters did not show any significant variation after ranitidine administration. Even in the absence of ranitidine, postprandial gastroenteric pH values were always > 4; the H2-receptor antagonist only reduced fasting gastric acidity. In conclusion, the gastroenteric pH and fecal fat determinations showed that ranitidine is not useful in patients with total postsurgical exocrine pancreatic insufficiency.

Adult↗
PubMed1978

Effects of ambient temperatures on induction of transmissible gastroenteritis in feeder pigs.

Experiments were carried out to investigate the effects of ambient temperatures on the induction of transmissible gastroenteritis in feeder pigs 2 to 3 months old. Pigs maintained at a high temperature (30 +/- 2 degrees C) and exposed to the virulent transmissible gastroenteritis virus did not show clinical signs of the disease during their maintenance at the high temperature. On the other hand, a sudden decrease in the ambient temperature, either before or after virus inoculation, induced severe disease in feeder pigs exposed to the virus. However, continuous maintenance of pigs at the low temperature (4 +/- 1 degrees C) tended to somewhat reduce the frequency of occurrence of signs in proportion to the length of the maintenance periods at that temperature. Pigs raised at temperatures that fluctuated between 20 +/- 2 and 4 +/- 1 degrees C every 24 h developed profuse diarrhea. The duration of clinical signs was longer in pigs maintained under the fluctuating temperatures than in those at the constantly low temperature. With one exception, antibody against transmissible gastroenteritis virus was demonstrated in sera collected from pigs both with and without clinical signs. Antibody titers obtained, however, were somewhat higher in sera collected from pigs that had developed clinical signs than in those from pigs that had endured the infection without showing signs.

Animals↗
PubMed2006

Multiplex reverse transcription-PCR for rapid differential detection of porcine epidemic diarrhea virus, transmissible gastroenteritis virus, and porcine group A rotavirus.

A novel multiplex reverse transcription polymerase chain reaction (multiplex RT-PCR) that can detect porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine group A rotavirus (GAR) was developed. The 3 viruses (PEDV, TGEV, and porcine GAR) are major agents in viral enteric diseases of piglets. As the clinical signs of these diseases are similar, including watery diarrhea, differential detection is required for etiologic diagnosis. A mixture of 3 pairs of published primers was used for amplification of viral nucleic acids, yielding 3 different amplicons with sizes of 859 bp, 651 bp, and 309 bp for TGEV, PEDV, and porcine GAR, respectively. A total of 157 specimens (78 fecal and 79 intestinal samples) from piglets with acute gastroenteritis were collected in Korea between January 2004 and May 2005. They were tested for the presence of 3 viruses by multiplex RT-PCR. Coinfections with PEDV and porcine GAR were identified in 16 farms (43.2%). PEDV, porcine GAR, and TGEV infection were 26.3%, 13.2%, and 2.7% respectively. The relative sensitivity and specificity of multiplex RT-PCR were evaluated, with results suggesting that this assay is equal in quality to conventional single-agent RT-PCR assays (sensitivity:100%, 92.9%, 100% for TGEV, PEDV, GARs; specificity: 100% for all 3 viruses). This multiplex RT-PCR is a simple assay and may be a potentially useful for rapid, sensitive, and cost-effective etiological diagnostic tool for acute viral gastroenteritis in piglets.

Animals↗
PubMed1977

Transmissible gastroenteritis: demonstration of the virus from field specimens by means of cell culture and pig inoculation.

Isolation of transmissible gastroenteritis virus was attempted from segments of jejunum collected from piglets submitted for diagnosis of transmissible gastroenteritis. The virus was isolated more frequently in susceptible piglets than in pig kidney or pig thyroid cells. Practically, both cell systems were equally capable of demonstrating the virus when the tissue suspensions were sonicated. The pig thyroid cells prepared with glands collected from minimal disease pigs were preferred to the pig kidney cells for initial virus isolation because of their ability to respond to transmissible gastroenteritis virus with a progressive cytopathic effect. However, the pig thyroid cells, prepared from pool of glands collected in abattoirs, were often contaminated with parvoviruses and could not be used for diagnostic work. Controlled ultrasound treatments of the inoculum increased the frequency of virus isolation in both cell systems.

Animals↗
PubMed1985

[Demonstration of a transmissible gastroenteritis virus by contrast immunofluorescence].

Tested were a number of procedures to employ the immunofluorescence method for diagnosing transmissive gastroenteritis in pigs--impression preparations, frozen cross-sectioned material, and infected cell cultures of the established cell line SPEV. It was found that immunofluorescence microscopy was a dependable method for the express diagnosis of transmissive gastroenteritis. It could be employed in its three variants. The use of impression preparations, however, did not prove as dependable as the remaining ways of applying the method, and this drawback had to be compensated for with the study of a greater number of impression preparations taken from more pigs that had contracted the disease. It was also established that most promising and effective was to apply the method with the use of cell cultures infected with suspensions of organs. Cell cultures of the established SPEV cell line infected with material that contained the virus could produce dependable positive results in immunofluorescence investigations at the 24th hour following inoculation. This method could be employed for the express diagnosis of transmissive gastroenteritis.

Animals↗
PubMed2004

Enteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials.

OBJECTIVE: To review the relative efficacy and safety of enteral vs intravenous (IV) rehydration therapy in treating childhood gastroenteritis. DATA SOURCES: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register databases were searched. Known investigators and expert bodies were contacted to locate unpublished and ongoing studies. STUDY SELECTION: Studies were selected based on the following criteria: randomized or quasi-randomized trials; children younger than 15 years with a clinical diagnosis of gastroenteritis of less than 1-week duration; interventions comprising enteral and IV treatment arms; and at least 1 of the following: major adverse event rates, treatment failure rates, weight gain with treatment, measurement of ongoing losses, length of hospital stay, costs of treatment, and satisfaction with treatment. DATA EXTRACTION: Data were extracted from eligible studies, which were then combined using a random-effects model. DATA SYNTHESIS: Sixteen trials involving 1545 children and conducted in 11 countries were identified. Compared with children treated with IV rehydration, children treated with oral rehydration had significantly fewer major adverse events, including death or seizures (relative risk, 0.36; 95% confidence interval [CI], 0.14-0.89), and a significant reduction in length of hospital stay (mean, 21 hours; 95% CI, 8-35 hours). There was no difference in weight gain between the 2 groups (mean, -26 g; 95% CI, -61 to 10 g). The overall failure rate of enteral therapy was 4.0% (95% CI, 3.0%-5.0%). CONCLUSIONS: For childhood gastroenteritis, enteral rehydration is as effective if not better than IV rehydration. Enteral rehydration by the oral or nasogastric route is associated with significantly fewer major adverse events and a shorter hospital stay compared with IV therapy and is successful in most children.

Child↗
PubMed1977

Viruses associated with acute gastroenteritis in young children.

Conventional virologic investigations generally failed to implicate viruses as a cause of acute gastroenteritis in young children. When negative-contrast stain electron microscopy was used for the examination of stool samples from affected patients, several candidate etiologic agents were discovered. Rotavirus (otherwise known as orbivirus, reo-like agent, and infantile gastroenteritis virus) emerged as an important causative agent. In a considerable number of patients, however, no causative agent was identified. Several other candidate etiologic viruses now "stand in the wings" awaiting additional evidence as to their role in the pathogenesis of acute gastroenteritis. In a study period of 12 months, 669 patients were found to be shedding virus in association with symptoms of diarrhea, vomiting, and temperature elevation. Approximately one third of these patients acquired their infection in hospital.

Acute Disease↗
PubMed1981

Campylobacter gastroenteritis in neonates.

Campylobacter fetus enteritis is thought to be an unusual infection in the newborn. We describe eight term neonates with gastroenteritis caused by C fetus subspecies jejuni who were seen during a two-year period. Symptoms of bloody diarrhea (7/8) and irritability (6/8) began between 2 and 11 days of age. None of the infants was seriously ill; only one infant was febrile. None of the seven infants who had blood cultures drawn had bacteremia with C fetus, and none of the infants had complications. The infants were treated with antimicrobial agents and recovered rapidly. Five mothers had Campylobacter cultured from the stool or vagina. The cases were not related epidemiologically. We concluded that Campylobacter gastroenteritis in the newborn clinically resembles Campylobacter gastroenteritis in older children and adults, except that it is generally an afebrile illness. The bacterium most likely is acquired from the mother during or shortly after delivery.

Age Factors↗
PubMed2006

Oral versus intravenous rehydration for treating dehydration due to gastroenteritis in children.

BACKGROUND: Dehydration associated with gastroenteritis is a serious complication. Oral rehydration is an effective and inexpensive treatment, but some physicians prefer intravenous methods. OBJECTIVES: To compare oral with intravenous therapy for treating dehydration due to acute gastroenteritis in children. SEARCH STRATEGY: We searched the Cochrane Infectious Diseases Group Specialized Register (March 2006), CENTRAL (The Cochrane Library 2006, Issue 1), MEDLINE (1966 to March 2006), EMBASE (1974 to March 2006), LILACS (1982 to March 2006), and reference lists. We also contacted researchers, pharmaceutical companies, and relevant organizations. SELECTION CRITERIA: Randomized and quasi-randomized controlled trials comparing intravenous rehydration therapy (IVT) with oral rehydration therapy (ORT) in children up to 18 years of age with acute gastroenteritis. DATA COLLECTION AND ANALYSIS: Two authors independently extracted data and assessed quality using the Jadad score. We expressed dichotomous data as a risk difference (RD) and number needed to treat (NNT), and continuous data as a weighted mean difference (WMD). We used meta-regression for subgroup analyses. MAIN RESULTS: Seventeen trials (1811 participants), of poor to moderate quality, were included. There were more treatment failures with ORT (RD 4%, 95% confidence interval (CI) 1 to 7, random-effects model; 1811 participants, 18 trials; NNT = 25). Six deaths occurred in the IVT group and two in the ORT groups (4 trials). There were no significant differences in weight gain (369 participants, 6 trials), hyponatremia (248 participants, 2 trials) or hypernatremia (1062 participants, 10 trials), duration of diarrhea (960 participants, 8 trials), or total fluid intake at six hours (985 participants, 8 trials) and 24 hours (835 participants, 7 trials). Shorter hospital stays were reported for the ORT group (WMD -1.20 days, 95% CI -2.38 to -0.02 days; 526 participants, 6 trials). Phlebitis occurred more often in the IVT group (NNT 50, 95% CI 25 to 100) and paralytic ileus more often in the ORT group (NNT 33, 95% CI 20 to 100, fixed-effect model), but there was no significant difference between ORT using the low osmolarity solutions recommended by the World Health Organization and IVT (729 participants, 6 trials). AUTHORS' CONCLUSIONS: Although no clinically important differences between ORT and IVT, the ORT group did have a higher risk of paralytic ileus, and the IVT group was exposed to risks of intravenous therapy. For every 25 children (95% CI 14 to 100) treated with ORT one would fail and require IVT.

Administration, Oral↗
PubMed2002

Molecular epidemiology of human calicivirus gastroenteritis outbreaks in Hungary, 1998 to 2000.

Between November 1998 and November 2000, 196 stool specimens from 21 outbreaks of acute nonbacterial gastroenteritis occurring in 11 of the 19 counties of Hungary were collected and tested for human caliciviruses. Human caliciviruses were detected and characterized by a type-common enzyme-linked immunosorbent assay (EIA) and reverse transcription-polymerase chain reaction (RT-PCR) followed by cloning and sequencing. Twenty (95%) and 14 (67%) outbreaks were positive by EIA and RT-PCR, respectively, and 12 RT-PCR-positive outbreaks were also confirmed by sequencing. Comparative sequence analysis revealed 13 Norwalk-like virus sequences in the 12 outbreaks, including 11 Norwalk-like virus genogroup II (seven in Hawaii-like, two Lordsdale-like, one Melksham-like, and one Hillingdon-like) and two Norwalk-like virus genogroup I (related to Southampton-like and Desert Shield-like clusters) viruses. Multiple Norwalk-like virus clusters, with a predominance of Hawaii-like viruses, played an important role in nonbacterial gastroenteritis outbreaks during the study period. This is the first country-wide molecular epidemiological investigation of human calicivirus-associated, gastroenteritis outbreaks in Hungary and Central-Eastern Europe.

Adolescent↗
PubMed2003

Incidence and characteristics of endemic Norwalk-like virus-associated gastroenteritis.

Endemic gastroenteritis associated with the Norwalk-like viruses (NLVs) is little understood. This study tested for NLV in gastroenteritis cases in 257 households in Melbourne, Australia, for the period September 1997 to February 1999 by a reverse transcription hemi-nested polymerase chain reaction. Positive samples were studied by nucleotide sequencing and phylogenetic analysis. NLV was detected in 73 (11.4%) of 638 faecal specimens tested. Twelve (1.9%) were NLV genogroup 1 (G1) and 61 (9.6%) NLV genogroup 2 (G2). Gastroenteritis symptoms associated with NLV G2/no other pathogens were significantly more severe than where no NLV was detected. NLV G1 and NLV G2 were detected in adults and children, males and females. NLV G2 incidence showed a marked seasonal periodicity with significant peaks in the Australian late spring/early summer periods. NLV G1 seasonality was significantly different from that of NLV G2. Seven major NLV clusters were identified by phylogenetic analysis.

Adolescent↗
PubMed2003

Persistent gastroenteritis in children infected with astrovirus: association with serotype-3 strains.

The relationship between cases of persistent diarrhoea and the levels and type of human astrovirus was investigated. The potential correlation between human astrovirus excretion levels and the occurrence of protracted gastroenteritis was elucidated after quantifying astroviruses in faecal samples by a competitive RT-PCR. This assay was developed employing an internal RNA standard constructed for this purpose and showed a threshold of positivity of 3.4 x 10(4) genomes per gram of faeces. By this procedure, the levels of astrovirus, belonging to serotypes 1, 2, 3, 4, and 8, in faecal samples could be ascertained to range from 3.4 x 10(8) to 1 x 10(13) per gram of faeces. The mean viral titre in the serotype 3-containing faeces was higher than in any of the other serotype-containing samples. In children with no background disease, persistent gastroenteritis cases were detected in 8.5% of the astrovirus infections, and 37.5% of those were associated with astrovirus type 3 infection. In addition, 42.9% of astrovirus 3 isolates were implicated with persistent cases, some of them lasting for 3 months. Other type 3 isolates, detected in the faeces in very large numbers, caused severe gastroenteritis.

Astroviridae Infections↗
PubMed1993

Comparative epidemiology of rotavirus, subgenus F (types 40 and 41) adenovirus and astrovirus gastroenteritis in children.

We report a 5 year prospective study of episodes of rotavirus, subgenus F adenovirus, and astrovirus gastroenteritis diagnosed by electron or immune electron microscopy in a single regional virology laboratory. Of 1426 total infections, the numbers in each category were 1117 (78.3%), 254 (17.8%), and 20 (7.9%), respectively. Using restriction endonuclease analysis or immune electron microscopy, all but 20 of the subgenus F adenovirus strains were classified as type 40 (n = 50) or type 41 (n = 184). Rotavirus and astrovirus infections were more prevalent in winter than summer, whereas subgenus F (either type 40 and 41) adenoviruses showed no seasonal variation in prevalence. The ratio of type 40 to all typable subgenus F adenoviruses declined between 1984 and 1986 and then increased again. Adenoviruses were relatively more important as causes of viral gastroenteritis in infants aged less than 6 months than in toddlers aged 12 months or more, but even in young infants more rotavirus than adenovirus infections were diagnosed. Our data confirmed the epidemiological differences between rotavirus, subgenus F adenovirus and rotavirus gastroenteritis and documented the shared epidemiological characteristics of type 40 or 41 adenovirus infections.

Adenovirus Infections, Human↗
PubMed1995

Local succession of adenovirus strains in pediatric gastroenteritis.

Assessment of the current incidence of different adenovirus types in local gastroenteritis involved the examination of over 1,000 stool specimens annually from 1988-1992. Adenoviruses were detected by electron microscopy and/or cell culture in 32% of the specimens in which a viral pathogen was detected. The identification of every adenovirus isolate to type by neutralization with specific antisera against the first 6 types and by restriction analysis of nonneutralized isolates was started in 1990. Samples from 1988 and 1989 were examined retrospectively. Adenovirus strains were compared to those isolated in a study between 1980-1983. Enumeration of individual adenovirus types revealed a number of trends, demonstrating that rapid changes in the local incidence of several strains were occurring in Manitoba. The incidence of adenovirus type 40 (Ad40) as a cause of gastroenteritis was found to have fallen dramatically in recent years. The predominant cause of gastroenteritis in Manitoba is a variant strain of Ad41, increasing in predominance each year and now responsible for over a third of the symptomatic cases examined since 1990. The majority of restriction site differences of the Ad41 variant strain from the prototype strain Tak were mapped to the hexon and fiber genes, both of which code for the neutralizable external viral epitopes. The probability of the observed pattern of mutations occurring by chance was calculated as P < 0.0005, indicating a strong pressure for selection of these immunologically significant alterations to the viral proteins responsible for cell attachment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenovirus Infections, Human↗