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PubMedDate not supplied

Delayed T-cell maturation and suppression of mitogen-induced blastogenesis in turkey poults fed cortisone acetate and furazolidone.

The effect of cortisone acetate (CA) on the immune response of control and furazolidone (FZ)-fed turkey poults was investigated. CA, fed at a dose of 500 mg/kg of ration beginning at 1 week of age, decreased mortality but had little effect on the development of FZ-induced cardiomyopathy. When poults were 2 weeks of age, the in vitro stimulation of lymphocytes by phytohemagglutinin (PHA) and concanavalin A (Con A) was significantly depressed (P less than or equal to 0.001 and P less than or equal to 0.05, respectively) in cortisone-treated poults. The time of the peak response of lymphocytes from poults 2-5 weeks of age to in vitro stimulation by PHA was significantly delayed (P less than or equal to 0.01) and the magnitude of the response was significantly depressed (P less than or equal to 0.001) in cortisone-treated poults compared with control poults. Cortisone treatment had no effect on time of peak response to Con A stimulation but significantly depressed (P less than or equal to 0.05) the magnitude of the response. Poults receiving FZ administered by gastric tube showed a peak response to PHA stimulation significantly (P less than or equal to 0.05) earlier and significantly (P less than or equal to 0.05) greater than did control poults.

Animals↗
PubMed1984

[Pathomorphology of acute furazolidone poisoning in calves].

Studied was the morphologic picture in a total of 13 calves spontaneously intoxicated with furazolidon following its overrating and use once and severalfold as a therapeutic means against infectious enteritis. There were hemorrhages in the subcutaneous tissue and the muscles, kidneys, abomasum, spleen, and heart as well as liver dystrophia and hyperemia and edema of the leptomeninges and the brain cortex. Histologically, there were hyperemia, strong and diffuse pericellular and perivascular edema of the cerebrum and the cerebellum with degenerative changes in the Purkinje layer, fatty degeneration and biliary thrombi in the liver, hemorrhages and activation of the endothelial cells and glomeruli of the kidneys, hyperemia and fatty infiltration of the myocardium, and hemorrhages in the spleen.

Acute Disease↗
PubMed1983

Furazolidone-induced congestive cardiomyopathy in ducklings: myocardial ultrastructural alterations.

Newly hatched male White Pekin ducklings were fed furazolidone (FZ) at dosage of 750 mg/kg of feed for 4 weeks. Selected ducklings with advanced lesions of FZ-induced congestive cardiomyopathy were used for ultrastructural study of the myocardial alterations. Semithin sections of plastic-embedded blocks of myocardium from these dilated hearts revealed diffuse myocytolysis, characterized by pale sarcoplasm and lack of cross-striations in affected myocytes. Evidence of myocardial necrosis, inflammation, or fibrosis was not observed. Ultrastructural study revealed that the principal alteration in cardiac muscle cells was diffuse myofibrillar lysis. The sarcoplasm of affected myocytes had scattered masses of free thick and thin myofilaments, clumps of Z-band material, and accumulations of cytoskeletal filaments. Numerous polyribosomes were present in the areas of lysis of contractile material, as were other normal-appearing organelles. Myofibrillar lysis may have resulted from FZ-induced decreased synthesis, increased degradation, or disaggregation of contractile proteins. Ducklings with FZ-induced congestive cardiomyopathy offer an attractive model for studies of the biochemical and ultrastructural alterations of myofibrillar lysis and drug-induced cardiac failure.

Animals↗
PubMed1983

Furazolidone-induced congestive cardiomyopathy in ducklings: lack of protection from selenium, vitamin E, and taurine supplements.

Newly hatched male White Pekin ducklings (n = 108) were allotted to 6 groups of 18 each and were fed for 4 weeks diets containing 750 mg of furazolidone (FZ)/kg of feed either alone or with supplements of vitamin E (250 IU of dl-alpha-tocopheryl acetate/kg), selenium (2.5 mg as selenite/kg) or taurine (1%). Control groups were fed diets without FZ and with or without added taurine (1%). Ducklings in the 4 FZ-fed groups had retarded growth, mortality, ascites, and cardiac alterations of congestive cardiomyopathy. Supplements of vitamin E, selenium, or taurine did not protect against the development of the cardiac and extracardiac alterations of FZ toxicosis. These findings could indicate that the development of FZ-induced congestive cardiomyopathy is not mediated by low tissue concentrations of selenium, vitamin E, or taurine.

Animals↗
PubMed1981

Failure of furazolidone in the treatment of onchocerciasis.

12 adult onchocerciasis patients from the rain forest zone of Nigeria were treated with furazolidone in divided daily doses ranging from 5--15 mg per kg body weight for 7--21 days to a maximum total dose of 6.3 g. The drug showed neither micro- nor macrofilaricidal activity against Onchocerca volvulus.

Adolescent↗
PubMedDate not supplied

A morphometric study of myocardial mitochondria and myofibrils in turkey poults during development of furazolidone-induced cardiomyopathy.

Furazolidone (FZ) at a dose of 700 ppm was fed to turkey poults 2-5 weeks posthatching. At 3, 4, and 5 weeks of age, six poults each were sacrificed from control and FZ-fed groups. Samples of tissue from the outer free walls of the ventricles and the interventricular septum were removed and processed for electron microscopy. Volumetric density of mitochondria and myofibrils was determined by the point-counting technique. Significant reductions (p less than or equal to .05) in the volumetric density of mitochondria were observed at 5 weeks of age in the ventricular free walls of round-heart poults, and at 4 and 5 weeks of age in the interventricular septum. Significant reductions (p less than or equal to .05) in the volumetric density of myofibrils were noted at 4 weeks of age in the left ventricular free wall of FZ-fed normal poults and in the interventricular septum of round-heart poults. At 5 weeks of age, a significant increase (p less than or equal to .05) in myofibrils was observed in the left ventricular free wall of FZ-fed normal poults. Data confirms that the volumetric densities of mitochondria and myofibrils are significantly altered during development of FZ-induced hypertrophy.

Animals↗
PubMedDate not supplied

The production of cardiomyopathy in turkey poults by the oral administration of furazolidone.

Furazolidone (FZ) was given to turkey poults two weeks post-hatching by stomach tube in doses of 60 and 80 mg/kg per day, and via the feed at a concentration of 700 ppm. Oral doses were given either as one dose at 8 a.m. or as two equal doses given at 8 a.m. and 4 p.m. Electrocardiographic (ECG) recordings were used to monitor the development of round-heart disease (RHD) and necropsies were performed on all poults to corroborate the ECG findings. All poults receiving FZ gained significantly less weight (p less than or equal to .05) than control poults. At oral doses of 80 mg/kg per day, the apparent acute toxicity of FZ resulted in high mortality during the first week of the experiment. At necropsy there were no signs of RHD in these poults. Most of the poults given FZ orally in doses of 60 mg/kg per day or at 700 ppm in the feed survived to the termination of the experiments. The majority of these poults showed ECG patterns that are typical of RHD. Myocardial lesions indicative of RHD were present at necropsy.

Administration, Oral↗
PubMed1995

Experimental furazolidone toxicosis in broiler chicks: effect of dosage, duration and age upon clinical signs and some blood parameters.

Groups of broiler chicks of one day and three weeks of age were given feeds containing 0, 400, 800 and 1000 mg furazolidone (Fz)/kg for three weeks. The age of the birds and the dose and duration of Fz treatment significantly (P < or = 0.05) influenced the parameters studied. Clinical signs of Fz toxicosis included ascites, leg weakness and nervous derangement like convulsions and torticollis. The body weight also decreased. Ascites and nervous derangement was not observed in birds fed 400 mg Fz from one day of age. Fz-fed birds developed anaemia and had lower plasma total protein and albumin levels than those fed no Fz. The decrease in body weight was related to reduced feed intake. Decreases found in the haematological parameters and plasma proteins showed no correlation with the chicks' age but were related to the dose and duration of Fz treatment.

Anemia↗
PubMedDate not supplied

Liquid chromatographic determination of furazolidone in swine serum and avian egg.

A rapid, simple, and accurate method for determination of furazolidone (FZ) in swine serum and avian egg using liquid chromatography (LC) with a 358 nm ultraviolet-visible spectrophotometric detector is described. After liquid-liquid extraction of sample with ethyl acetate using Extrelut-3, the extract is evaporated, redissolved in 40% acetonitrile, and injected directly into the chromatograph. The antibiotic can be analyzed within 30 min. Within-day recoveries for swine serum and avian egg spiked with FZ at 1 ppm were 90.0 and 88.1%, respectively, with coefficients of variation of 3.52 and 3.88%, respectively. Between days recoveries for the 1 ppm samples were 87.2 and 87.0%, with coefficients of variation of 3.10 and 4.29%, respectively. Determination of FZ also was performed by LC/mass spectrometry (MS) with an atmospheric-pressure chemical-ionization interface (APCI) system. The LC/MS-APCI system is more applicable for qualitative analysis than quantitative analysis because the drug detection limit (about 0.1 microgram/L) is almost the same as that of the LC-UV detector.

Animals↗
PubMedDate not supplied

Simultaneous determination of nitrofurazone, nitrofurantoin, and furazolidone in channel catfish (Ictalurus punctatus) muscle tissue by liquid chromatography.

A liquid chromatographic (LC) method was developed for the simultaneous determination of nitrofurazone (NFZ), nitrofurantoin (NFT), and furazolidone (FZD) in catfish muscle tissue. The drugs were extracted from the tissue with acetonitrile, and the lipids were removed from the extract with hexane. The acetonitrile extract was evaporated by rotary evaporation, and the resultant drug residues were dissolved with LC mobile phase. The mixture was sonicated, centrifuged, and filtered. The drugs were determined by using LC with a C18 reversed-phase (ODS Hypersil) column, a mobile phase of acetonitrile-1% aqueous acetic acid (25 + 75), and a photodiode array ultraviolet detector at 375 nm. NFZ, NFT, and FZD were each determined in catfish tissue at 5 fortification levels (80, 40, 20, 10, and 5 ng drug/g tissue). Average recoveries of each of the 3 drugs at each level ranged from 70.7 to 101.5%, and relative standard deviations ranged from 2.2 to 18.6%. The limit of detection of each drug was approximately 1 ng drug/g tissue, and the limit of quantitation was 5 ng drug/g tissue. In the second part of the study, the method was used to determine nitrofuran residues incurred in catfish tissue. Live channel catfish were intravascularly doses (10 mg/kg body wt) with NFZ to generate drug-incurred fish muscle tissue. Incurred NFZ levels exceeded 400 ng drug/g tissue at 2 h after dosing but decreased rapidly to approximately 1 ng drug/g tissue by 8 h after dosing, as determined by this method.

Animals↗
PubMedDate not supplied

Simultaneous determination of nitrofurazone and furazolidone in shrimp (Penaeus vannamei) muscle tissue by liquid chromatography with UV detection.

A liquid chromatographic (LC) method was developed for the simultaneous determination of nitrofurazone (NFZ) and furazolidone (FZD) in shrimp muscle tissue. The drugs are extracted from the tissue with acetonitrile, and the lipids and lipophilic pigments are removed from the extract with hexane. The remaining acetonitrile extract is evaporated by rotary evaporation, and the resultant residues are dissolved with LC-grade water, applied to a preconditioned C18 solid-phase extraction column, and eluted with acetonitrile. The acetonitrile eluant is then dried under nitrogen, and the resultant drug residues are dissolved with mobile phase and filtered. The drugs are determined by LC by using a C18 reversed-phase (octyldecylsilyl Hypersil) column, a mobile phase of acetonitrile--1% aqueous acetic acid (25 + 75, v/v), and a photodiode array UV detector at 375 nm. NFZ and FZD were determined in shrimp tissue at each of 5 spiking levels (64, 32, 16, 8, and 4 ng drug/g tissue). Absolute recoveries ranged from 70.6 to 78.4%, and relative standard deviations ranged from 4.0 to 13.6%. The limit of detection of pure standard of each drug was approximately the equivalent of 1 ng drug/g tissue, and the limit of determination in a sample was 4 ng drug/g tissue.

Animals↗
PubMed1993

[Basic reproductive toxicological studies of the effect of furazolidone on the hypothalamo-hypophyseo-gonadal axis of male rats].

The reproductive-toxic effects of furazolidone on testis, epididymis and selected nuclei of the hypothalamus of male wistar rats were investigated. After a dosage of 50 mg/kg b.w. daily over five days no changes of testis and epididymis were detected in relation to controls by means of light microscope. Using morphometric methods a significant increase of the nucleus volume of the measured nuclei of the hypothalamus (Ncl. ventromedialis, Ncl. praeopticus medialis, Ncl. infundibularis) could be shown. After the high dosage of 200 mg/kg b.w. daily for five days testis and epididymis showed marked signs of atrophy and the volume of the investigated nuclei of the hypothalamus was significantly increased. These results suggest that--contrary to the wide spread opinion the testis would react most sensitive to chemical agents--more attention should be directed to the hypothalamus in reproductive-toxicological studies.

Animals↗
PubMed1995

Furazolidone toxicosis in young broiler chicks: morphometric and pathological observations on heart and testes.

Broiler chicks 1 d and 3 w of age were given 0, 400, 800, or 1000 mg furazolidone (Fz)/kg feed for 4 w. Bi-ventricular heart dilatation (as measured by increases in ventricular diameter and thinning of the ventricular walls) was present in 1-d-old chicks fed 800 mg Fz, whereas in 3-w-old groups these changes occurred at 1000 mg Fz. There was no heart hypertrophy. Microscopic changes in the heart were not discernible in and Fz-fed birds. The liver had congestion and cytoplasmic vacuolation of hepatocytes. About 37-50% of the male birds in the different Fz-fed groups had testicular degeneration varying from mild to cystic enlargement. The degenerated testes had dilatation of seminiferous tubules; in cystic testes the seminiferous tubules were extremely dilated and had flattened epithelium. The interstitial tissue between the dilated tubules was compressed and atrophic.

Administration, Oral↗
PubMed1996

Reversibility of furazolidone-induced changes in testes and secondary sex characters of White Leghorn cockerels.

Furazolidone (Fz) was fed to 4 groups of cockerels 15 w of age at 0, 400, 800 and 1200 mg/kg feed for 3 w and then was withdrawn for another 3 w. In a second experiment conducted simultaneously cockerels were fed these same Fz levels for 6 w and then were withdrawn from Fz feed for 4 w. In both experiments, 800 and 1200 mg Fz/kg feed resulted in decreases in comb and wattle size and in the weight of testes. The testes had smaller seminiferous tubule diameters and increased relative and decreased absolute volumes of interstitium. Spermatogenesis was not observed in cockerels fed 800 and 1200 mg Fz/kg feed. Withdrawal of Fz resulted in increased comb and wattle size, weight of testes and diameter of the seminiferous tubules. There was also an increase in absolute volume of interstitium along with decreased relative interstitium volume. Spermatogenesis was restored.

Administration, Oral↗
PubMedDate not supplied

Five day and ten day triple therapy (amoxicillin, furazolidone and metronidazole) in the treatment of duodenal ulcer.

This investigation aimed to compare bacterial eradication and healing in patients with active duodenal ulcer treated with a combination of furazolidone 600 mg/day and metronidazole 750 mg/day and amoxicillin 1.5 and g/day for 5 (TT5) or 10 (TT10) days. Fifty four (TT5 = 28 and TT10 = 26) patients were included in the study. Ulcer healing was observed in 77.8% of TT5 Group and in 75% of TT10 Group at week 4. H pylori eradication was observed in 51.9% and 65% respectively (p > 0.05). When all patients were grouped, a significantly healing rate was observed in those eradicated as compared to those not eradicated (p = 0.03). We concluded that extending the treatment to 10 days did not significantly influence the results of ulcer healing and eradication of Helicobacter pylori.

Adolescent↗
PubMed1998

Furazolidone toxicosis in female Japanese quail (Coturnix coturnix japonica): pathomorphological changes in reproductive tract and reversibility of the induced changes.

Female Japanese quail (Coturnix coturnix Japonica) placed in 3 equal groups were given 600, 400 or 0 mg furazolidone (Fz)/kg feed for 4 w and then withdrawn for another 4 w. Another (pair-fed) group of same size was given basal feed as much as was consumed by the quail fed 600 mg Fz/kg feed. Fz feeding decreased body weight, feed intake and egg production. Ovaries of the Fz-fed quail decreased in weight and size and were studded with small follicles. Magnum, isthmus and uterus in Fz-fed groups had decreased area, height and number of mucosal folds compared with the control group. Microscopically, in Fz-fed groups, the mucosal glands in magnum and isthmus had decreased cell height with centrally located nuclei and foamy cytoplasm. In the 600 mg Fz-fed group, some birds had atrophy of the glandular tissue in the mucosa and infiltration of mononuclear cells and fibroblasts. Upon cessation of the Fz feeding, all parameters reversed gradually and became non-significantly different from control quail. These observations suggested that Fz-induced changes in mature female quail were reversible.

Animals↗
PubMed1998

Furazolidone treatment suppresses pubertal testosterone secretion in male broiler breeder birds (Gallus domesticus).

We determined the effect of chronic administration of furazolidone (Fz) on sexual maturation of male broiler breeder birds (Ross 308; Gallus domesticus). A total of 20 15-w-old birds were randomly assigned to receive 0, 150, 250 or 350 mg Fz/kg feed daily for 5-w. Blood samples were taken at weekly intervals. The birds were challenged with 500 IU human chorionic gonadotropin (hCG) i.v. at the age of 24 w before slaughtering. Concentration of testosterone in the plasma was measured by a specific radioimmunoassay. Testicular tissue was processed for morphometric studies. Testicular weights of the groups fed 250 or 350 mg Fz/kg feed/d were decreased (P < 0.05). Plasma testosterone levels were affected by age (P < 0.001) and dose of Fz (P < 0.001). Mean plasma testosterone levels during and after drug administration were reduced (P < 0.05) by all Fz doses. Human chorionic gonadotropin administration led to poor testosterone response (P < 0.05) in all Fz-dosed groups, but not the control group (P < 0.05). As compared to the control, Fz-dosing reduced the seminiferous tubule diameter (P < 0.05) at the 350 mg/kg feed dose, seminiferous epithelial height (P < 0.05) at the 250 and 350 mg/kg feed doses, and Leydig cell nuclear diameter (P < 0.05) at the 350 mg/kg feed dose. This data suggest that sexual maturation in male broiler breeder birds is adversely affected by chronic Fz-administration. Actions of Fz on sexual maturation probably involve a direct effect at the testicular level.

Animals↗