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PubMed1998

Effects of pirfenidone and dermoid cyst fluid on adhesion formation.

OBJECTIVE: To evaluate the effects of pirfenidone and human dermoid cyst fluid on adhesion formation in a rat model. DESIGN: A prospective, blinded, controlled study. SETTING: Sprague-Dawley white rats in a conventional laboratory setting. INTERVENTION(S): Rats were divided into four groups according to the type of solution tested (dermoid fluid, 0.05 mg of pirfenidone, normal saline, and a combination of dermoid fluid and pirfenidone). In the first experiment, the solution (0.5 mL) was injected intraperitoneally. In the second experiment, the solution was instilled intraperitoneally after a standardized injury to the right uterine horn. The degree of adhesion formation was evaluated 2 weeks after the initial surgery. RESULT(S): Human dermoid cyst fluid caused adhesion in 4 of 10 intact rats and in 9 of 10 standardized injured rats. Pirfenidone did not decrease adhesion formation. No adhesion was found after injection of saline or pirfenidone in intact rats. The mean +/- SEM adhesion score in standardized injured rats was higher in the dermoid group (4.6 +/- 0.6) than in the pirfenidone group (2.8 +/- 0.7) or the saline group (3.8 +/- 0.5). The mean +/- SEM adhesion score in intact rats was 0.6 +/- 0.3 after dermoid fluid injection and after dermoid instillation in standardized injured rats was 4.6 +/- 0.6. CONCLUSION(S): Human dermoid fluid causes adhesion formation even in intact rats, and the adhesion is worse in the presence of serosal injury. Intraperitoneal pirfenidone does not decrease adhesion formation.

Animals↗
PubMed2002

Peritoneal implantation of squamous cell carcinoma following rupture of a dermoid cyst during laparoscopic removal.

BACKGROUND: In recent years, there has been a move toward using laparoscopy in the management of presumed benign ovarian masses. This paper discusses the use of laparoscopy for ovarian masses (particularly dermoid cysts). The focus is on the implications for unexpected malignancies. CASE: We report here a case involving a dermoid cyst that was removed at laparoscopy and was subsequently found to contain a squamous cell carcinoma. Spillage of the cyst's contents occurred at the time of removal. At staging laparotomy, peritoneal implants of the tumor were found, upgrading the tumor from FIGO stage Ia to IIc. CONCLUSION: Spillage rates of dermoid cyst content with laparoscopic removal are inevitably higher than with excision at laparotomy. It remains controversial whether upstaging from FIGO stage Ia to IIc affects prognosis; however, in this case it led to aggressive adjuvant therapy which imposed significant additional morbidity, including loss of fertility, on the patient. One should be aware of the possibility of unexpected malignancy when the decision to manage an ovarian mass laparoscopically is made.

Adult↗
PubMed1990

Dermoid cyst of the auricle: report of two cases.

Dermoid cyst of the auricle is a very rare lesion in Japan. The cysts studied for this report demonstrated a benign clinical course with a tendency to become larger. The clinical and pathological characteristics of these cysts are reviewed.

Adolescent↗
PubMed1991

Squamous cell carcinoma arising in a subcutaneous dermoid cyst.

A case of malignant transformation to a squamous cell carcinoma in a long-standing subcutaneous dermoid cyst in a 44 year old man is presented. Malignant transformation in dermoid cysts is extremely uncommon and has never previously been recorded at this site. The need for adequate investigation and treatment of superficial midline lesions presenting in childhood is emphasized.

Adult↗
PubMed1983

[Cytogenetic studies of multiple ovarian dermoid cysts in a single host].

To investigate the pathogenesis of gonadal teratoma, sixteen ovarian dermoid cysts obtained from four patients were examined by using chromosomal Q and R heteromorphisms, HLA antigens and enzyme polymorphisms of phosphoglucomutase-1 and esterase-D. The results obtained were as follows: 1) Karyotypes of 16 tumors were 46,XX. 2) In thirteen tumors, chromosomal heteromorphisms were homozygous for the homologous chromosomes, being heterozygous in the hosts. In 9 of them, all gene markers analyzed were also homozygous, but in the remaining 4 tumors some gene markers showed heterozygous combination. These findings indicate that these 13 tumors arose from a germ cell after the first meiotic division by suppression of the second meiotic division or by fusion of polar body II with the oocyte. 3) In three tumors, chromosomal heteromorphisms showed heterozygous patterns as in the hosts. In 2 of them, some gene markers were homozygous, and in the remaining one tumor the gene markers were all heterozygous. These findings suggest that these three tumors arose from a germ cell before the first meiotic division. It is concluded that multiple ovarian dermoid cysts in a single host originate from different germ cells with diverse mechanisms.

Adult↗
PubMed1983

A case of ovarian dermoid cyst with malignant transformation perforated into the rectosigmoid colon and small intestine.

A 72-year-old female was admitted to hospital with diarrhea containing hair. The abdominal plain film showed teeth-like structures in the right lower quadrant. Barium enema and endoscopic examination were performed, and the results indicated a possible dermoid cyst perforated into the rectosigmoid colon and small intestine. The operation revealed a dermoid cyst of the right ovary perforated into the rectosigmoid colon and small intestine. Histopathologically, a dermoid cyst and in part well-differentiated squamous cell carcinoma invading the rectosigmoid and small intestine were demonstrated.

Aged↗
PubMed1996

A comparative study of laparoscopy and colpotomy for the removal of ovarian dermoid cysts.

OBJECTIVE: To compare laparoscope-assisted transvaginal removal of dermoid cysts to more standard laparoscopic cystectomy techniques. METHODS: We conducted a retrospective review of 44 laparoscopic dermoid removals performed at Olive View-UCLA Medical Center between 1992 and 1995. Cases were divided into three groups based on surgical approach: 1) conventional laparoscopic ovarian cystectomy, 2) laparoscopic ovarian cystectomy and removal of the freed mass via colpotomy, and 3) laparoscopic inspection, then transvaginal cystectomy via colpotomy. Surgical time, estimated blood loss, cyst spillage, and complications were compared. RESULTS: There were 11-19 patients in each group. The groups were similar in patient age, parity, and weight. Larger cysts tended to be removed by the laparoscopy-colpotomy techniques (mean diameter 10 cm) rather than by the purely laparoscopic approach (mean diameter 7 cm, P < .05). Cyst spillage occurred less often (43%, P < .05) and surgical time was shortest (mean 81 minutes, P < .05) with laparoscope-assisted transvaginal ovarian cystectomy compared with conventional laparoscopic techniques. Disposable laparoscopic instruments were used less often with transvaginal cystectomy (7%) than with conventional laparoscopic cystectomy (77%, P < .01). The difference in mean estimated blood loss in the cases using colpotomy (89 mL) compared with cases that did not (65 mL) was not statistically significant. Among the three groups, there were four major operative complications related to blood loss and infection. CONCLUSION: Laparoscope-assisted transvaginal ovarian cystectomy allows the removal of larger dermoid cysts, with less cyst spillage and savings in operative time and equipment compared with conventional laparoscopic cystectomy.

Adult↗
PubMedDate not supplied

Brucella-infected ovarian dermoid cyst causing initial treatment failure in a patient with acute brucellosis.

A 37-year-old woman was diagnosed with acute brucellosis. Despite appropriate antimicrobial therapy, high fever persisted. A contrast enhanced CT scan of the abdomen and pelvis revealed a left ovarian dermoid cyst. On the first postoperative day after left ovariectomy and right ovarian cystectomy were performed, the patient defervesced abruptly and continued to be completely afebrile. Cultures from bone marrow and dermoid cyst grew Brucella melitensis. The observation of a Brucella-infected ovarian dermoid cyst, which has not been previously reported, illustrates the importance of localized brucellosis as a cause of persistent infection despite appropriate antimicrobial therapy.

Adult↗
PubMed1996

Gorlin syndrome associated with midline nasal dermoid cyst.

Gorlin syndrome is an autosomal dominant multisystem disorder characterised by multiple basal cell naevi, cysts of the jaw, pits of the palms and soles, skeletal anomalies, and various other defects. Patients with Gorlin syndrome have a predisposition to basal cell carcinomas and other neoplasms. This is the first report to describe the coexistence of Gorlin syndrome and a nasal dermoid cyst. A 4 year old girl was diagnosed with medulloblastoma and treated with surgery and radiation therapy. A genetic evaluation was sought because of the brain tumour, multiple small naevi localised mostly on the upper torso, and rib abnormalities. Biopsies of several naevi showed naevoid basal cell carcinoma. Past medical history was significant for a midline nasal punctum noted at birth. The significance of this finding was unrecognised until the dermoid cyst enlarged, just before the diagnosis of her brain tumour. A common tissue of origin exists between basal cell naevi, cysts of the jaw, and dermoid cysts. We propose that the association of these two rare conditions in one patient is not a chance occurrence.

Basal Cell Nevus Syndrome↗
PubMed1982

[The value of tomodensitometry in the diagnosis of dermoid cysts. Apropos of 5 cases].

Results of computed tomography before operation in 5 cases of dermoid cysts (mediastinal: 3; retroperitoneal: 1; ovarian: 1) are employed to assess the contribution of this technique, and to define its place in relation to other diagnostic radiological procedures (straight radiographs and ultrasonography). The CT scan enables three morphological types to be distinguished, and also supplies very precise data on the extension, limits, and relationships of the tumor. The effective place of this examination in the diagnosis of dermoid cysts depends upon two factors: data obtained from the straight radiograph and the initial site of the lesion. When the former supplies specific information, the only role of the CT scan and ultrasonography is to determine the precise extent of the tumor pre-operatively, the CT scan being superior to ultrasonography for this purpose. When straight radiographs do not reveal characteristic signs, the diagnostic assistance of the scanner appears to be irreplaceable, even in those abdominal or pelvic regions where ultrasonography is best conducted.

Adult↗
PubMed1986

Congenital dermoid cysts of the tongue.

A case of large dermoid cyst in the tongue in a 3 1/2-month-old child is presented. Histologically it was an epidermoid cyst. Typically corresponding cysts are diagnosed during the first four months of life. When the cyst was punctured, some keratin escaped and caused a granulation tissue reaction with granulocytes between the muscles of the tongue. The cyst was treated by marsupialization. No abnormality in the shape or function of the tongue was seen after 24 months.

Dermoid Cyst↗
PubMed1998

[Chemical peritonitis after iatrogenic rupture of a dermoid cyst of the ovary treated by coelioscopy. Apropos of a case and review of the literature].

Dermoid cyst is the most frequent benign ovarian tumor. Its intraperitoneal rupture may lead to a peritoneal reaction known as chemical peritonitis. It is a rare but a potentially dangerous issue. Its treatment may need one or more reoperations. We report here the case of a patient operated on in emergency for a torsion of an ovarian dermoid cyst, with peritoneal spillage of its content during coeliosurgery. The prolonged contact between the sebaceous material and the peritoneum has led to a chemical peritonitis. Two more laparoscopic interventions, associated with a systemic anti-inflammatory treatment, were necessary to relieve symptoms. We propose the following attitude to avoid this complication: (1) puncture and drainage of the cyst with a trocar; (2) extraction of the cyst in an endobag, and (3) abundant washout of the peritoneal cavity.

Adult↗
PubMed1978

Congenital inclusion dermoid cyst of the anterior fontanel.

An unusual type of dermoid cyst is reported in 10 African infants. In these cases a soft, cystic mass located over the anterior fontanel was noted shortly after birth and gradually enlarged. The cyst had no intracranial extension and was easily excised intact. The clinical and x-ray findings of the cyst are described and compared with the usual dermoids. The histology and the contents of the cyst are detailed and some peculiarities of this lesion pointed out.

Dermoid Cyst↗
PubMed1986

Intraconal dermoid cyst. A case report.

We report an unusual dermoid cyst that was located entirely within the muscle cone. The delineation of the tumor was enhanced preoperatively by using an MRI scan in conjunction with the CT scan and ultrasonography.

Adult↗
PubMed1980

Dermoid cyst of the mandible.

A mid-line cyst of the mandible is described which possessed the histological features of a dermoid cyst. This appears to be the first fully documented example of a totally intra-osseous dermoid cyst in the mandible. The pathogenesis of the present lesion is discussed in relation to both the odontogenic and the non-odontogenic cysts that may occur in the mandibular mid-line.

Adult↗
PubMed1996

Intradermal dermoid cyst associated with occult spinal dysraphism.

A 2-year-old boy with congenital lumbosacral skin lesions is described. He presented with associated occult spina bifida and a sagittal cleft of the vertebral body deep in the skin lesions. The skin lesions presented as a combination of a lipoma, telangiectasia, mild hypertrichosis, and a dermoid cyst. Magnetic resonance imaging (MRI) revealed that the lipoma extended to the spina bifida region, but that it did not connect to the dura. MRI also demonstrated no other spinal lesions requiring surgical treatment. The intradermal location of the dermoid cyst observed in our patient was unusual. We discuss the location of dermoid cysts in the lumbosacral region associated with spinal dysraphism.

Dermoid Cyst↗
PubMed1980

Intracranial dermoid cyst in Goldenhar's syndrome. Case report.

A patient with Goldenhar's syndrome and an ipsilateral intracranial dermoid cyst is reported. It is suggested that the combination of both entities may not be coincidental but due to their related embryological origin. This report also reemphasizes the value of computerized tomography in the preoperative diagnosis of intracranial dermoid cysts.

Adult↗