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The importance of temporal structure in analyzing schizophrenic behavior: some theoretical and diagnostic implications.

THEME, a new method for analyzing the temporal structure of responding on a two-choice task, is described. This method reveals the time relationships (temporal patterns) between all response events, even those not occurring in direct sequence. It selects those temporal patterns that are significantly different (p < 0.0001) from the patterns found in a random Poisson distribution of the same events. The method was applied to data from Lyon et al. (1986) in which n = 17 outpatient schizophrenics were compared with n = 17 age-, sex-, and education-matched normal control subjects. Results revealed that responding of schizophrenic outpatients, in comparison to control subjects, had a larger number of significant temporal patterns, more different types of patterns, and more branching (connectivity) of patterns at a higher level. The latter indicates a higher degree of internal structure. These results are not predicted by standard (DSM-III-R) diagnostic procedures, but are in agreement with studies of two-choice behavior in schizophrenia based on the Lyon-Robbins (1975) theory of behavioral change, which has possible relationship to dopamine/acetylcholine imbalance in the brain. Diagnostic procedures in schizophrenia might benefit from tests oriented toward these findings, which are also consistent with Bleuler's original descriptions of schizophrenic symptomatology.

Adult↗

Determinants of suckling versus drinking in weanling albino rats: influence of hydrational state and maternal contact.

Preferences of weanling albino rats (15, 20, and 25 days of age) for nonnutritive suckling or drinking were determined using a Y-maze. Age, hydrational state, and the opportunity to contact the mother all influenced choice behavior. When tested in a maze that allowed continuous maternal contact in the "drinking-goal box," dehydrated rats chose to drink, while nondehydrated rats chose to suckle. Testing dehydrated rats in a maze that precluded maternal contact in the "drinking-goal box" eliminated drinking preference at all ages. These observations identify maternal presence as an important condition for the expression of drinking behavior during the weaning period and confirm our previous demonstration of dehydration's inhibition of suckling behavior.

Animals↗

Effects of ovariectomy and calcium deficiency on learning and memory of eight-arm radial maze in middle-aged female rats.

There is increasing evidence that estrogen and calcium ion are involved in learning and memory. In the present study, to examine the effect of estrogen deficiency and low-calcium diet on learning and memory, middle-aged female Wistar rats (50 weeks old) were fed either a low-calcium (0.02% Ca) or a normal-calcium (1.25% Ca) diet throughout the experiment. Rats were ovariectomized (OVX) or sham-operated (Sham). These animals were divided into four groups: 1) Sham group with normal-calcium diet [Sham-normal Ca group], 2) OVX group with normal-calcium diet [OVX-low Ca group], 3) Sham group with low-calcium diet [Sham-low Ca group], 4) OVX group with low-calcium diet [OVX-low Ca group]. Seventy-seven days after the OVX or Sham operation, the learning and memory abilities in the female rats were examined by using a radial maze task according to the method of Olton and Samuelson (regular trials) and using a delay-interposed task following regular trials. During regular trials and delay-interposed tasks, the OVX-low Ca group was inferior to all the other groups in accuracy of choice behavior. Both Sham-normal Ca and Sham-low Ca groups showed more accurate choices than the OVX-low Ca group, but were less accurate than the Sham-normal Ca group. In addition, there was no significant difference in locomotor activity between any of the groups. These results suggest that OVX or low-calcium diet may impair learning and memory, and that the combination of these factors impaired more markedly when the rats were tested in the eight-arm radial maze. These results may also imply the possibility that a woman in menopause or post-menopause suffers impairment of learning and/or memory when intakes low-calcium diet.

Age Factors↗

Variables influencing food perception reviewed for consumer-oriented product development.

Consumer wishes have to be translated into product characteristics to implement consumer-oriented product development. Before this step can be made, insight in food-related behavior and perception of consumers is necessary to make the right, useful, and successful translation. Food choice behavior and consumers' perception are studied in many disciplines. Models of food behavior and preferences therefore were studied from a multidisciplinary perspective. Nearly all models structure the determinants related to the person, the food, and the environment. Consequently, the overview of models was used as a basis to structure the variables influencing food perception into a model for consumer-oriented product development. To this new model, referred to as food perception model, other variables like time and place as part of consumption moment were added. These are important variables influencing consumers' perception, and therefore of increasing importance to consumer-oriented product development nowadays. In further research, the presented food perception model is used as a tool to implement successful consumer-oriented product development.

Choice Behavior↗

Risk-taking behavior: effects of ethanol, caffeine, and basal sleepiness.

STUDY OBJECTIVES: This study examined the effects of ethanol, caffeine, and basal sleepiness on a laboratory measure of risk-taking behavior, the Stop Light Task. The aims were to determine whether sleepiness and ethanol degrade psychomotor speed and risky choice and whether caffeine attenuates these effects. DESIGN: Mixed design with participants chosen for basal level of sleepiness and each assessed under 4 conditions presented in a Latin-square crossover design. PARTICIPANTS: Thirteen healthy adult volunteers aged 21 to 35 years. INTERVENTIONS: Participants received ethanol 0.5 g/kg and caffeine placebo, ethanol 0.5 g/kg and caffeine 150 mg, ethanol 0.5 g/kg and caffeine 300 mg, or a dual (ethanol-caffeine) placebo between 9:00 am and 9:30 am. MEASUREMENTS: The Multiple Sleep Latency Test (MSLT) was used to determine basal level of sleepiness. Subjects completed the Stop Light Task about 60 to 90 minutes after drug administration to assess psychomotor speed and risky choices. RESULTS: Seven subjects were classified as Alert (MSLT = 12.6 +/- 2.0 minutes) and 6 Sleepy (MSLT = 8.1 +/- 1.0 minutes). Sleepy compared to Alert subjects did not differ in psychomotor speed overall. Ethanol significantly slowed psychomotor speed relative to placebo, and ethanol-caffeine combinations attenuated this effect. Consistent with previous studies using the Stop Light Task, higher response requirements (FR15-FR50) and higher point loss probability (12.5%, 37.5%, 100%) significantly decreased risky choice, across sleepiness and treatment conditions. Alert subjects made "go" (primary measure of risk-taking) choices more often at lower response requirements and less often at higher response requirements, relative to Sleepy subjects. Ethanol did not significantly affect "go" choices but did produce changes in "go" choices as a function of response requirement. Given their more optimal pattern of choice behavior, Alert subjects gained significantly more money than Sleepy subjects; ethanol and caffeine combinations did not significantly affect money earned. CONCLUSIONS: These data suggest that sleepiness moderates risky choice such that Alert subjects have improved choice "acuity." Also, under conditions where risk-taking depends on responding rapidly (like the Stop Light Task), ethanol may also impair responding and caffeine may attenuate this effect.

Adult↗

Single units in the pigeon brain integrate reward amount and time-to-reward in an impulsive choice task.

BACKGROUND: Animals prefer small over large rewards when the delays preceding large rewards exceed an individual tolerance limit. Such impulsive choice behavior occurs even in situations in which alternative strategies would yield more optimal outcomes. Behavioral research has shown that an animal's choice is guided by the alternative rewards' subjective values, which are a function of reward amount and time-to-reward. Despite increasing knowledge about the pharmacology and anatomy underlying impulsivity, it is still unknown how the brain combines reward amount and time-to-reward information to represent subjective reward value. RESULTS: We trained pigeons to choose between small, immediate rewards and large rewards delivered after gradually increasing delays. Single-cell recordings in the avian Nidopallium caudolaterale, the presumed functional analog of the mammalian prefrontal cortex, revealed that neural delay activation decreased with increasing delay length but also covaried with the expected reward amount. This integrated neural response was modulated by reward amount and delay, as predicted by a hyperbolical equation, of subjective reward value derived from behavioral studies. Furthermore, the neural activation pattern reflected the current reward preference and the time point of the shift from large to small rewards. CONCLUSIONS: The reported activity was modulated by the temporal devaluation of the anticipated reward in addition to reward amount. Our findings contribute to the understanding of neuropathologies such as drug addiction, pathological gambling, frontal lobe syndrome, and attention-deficit disorders, which are characterized by inappropriate temporal discounting and increased impulsiveness.

Animals↗

Voluntary task switching: chasing the elusive homunculus.

In the voluntary task switching procedure, subjects choose the task to perform on a series of bivalent stimuli, requiring top-down control of task switching. Experiments 1-3 contrasted voluntary task switching and explicit task cuing. Choice behavior showed small, inconsistent effects of external stimulus characteristics, supporting the assumption of top-down control of task choice. Switch costs were smaller when subjects chose to switch tasks than when instructed by an external cue. Experiments 4-6 separated choice costs from switch costs. These findings support models of task switching that incorporate top-down processes in accounts of switch costs. The degree to which task switching procedures capture top-down versus bottom-up processes may depend on the extent of environmental support provided by the procedure.

Attention↗

Determinants of adaptive behavior among older persons: self-efficacy, importance, and personal dispositions as directive mechanisms.

Successful aging calls for effective adaptation, which in turn implies flexible use of coping strategies to optimize personal functioning and well-being. The present paper studied adaptive choice behavior of older, independently living persons faced with complications in their houses. The goal was to gain insight into the concrete coping process and its outcome-in terms of the choice of assimilative vs. accommodative strategies-and in the role of three determinants on this process. The determinants were perceived self-efficacy, importance of the problem, and personal dispositions (flexibility and tenacity). A sample of 199 independently-living older persons participated in an experiment that was based on a scenario and questionnaire method, with problems stemming from the domain of independent living. Results mainly underlie the crucial role of perceived self-efficacy and are discussed in view of the concept of successful aging.

Activities of Daily Living↗

Structural equation modeling of paired-comparison and ranking data.

L. L. Thurstone's (1927) model provides a powerful framework for modeling individual differences in choice behavior. An overview of Thurstonian models for comparative data is provided, including the classical Case V and Case III models as well as more general choice models with unrestricted and factor-analytic covariance structures. A flow chart summarizes the model selection process. The authors show how to embed these models within a more familiar structural equation modeling (SEM) framework. The different special cases of Thurstone's model can be estimated with a popular SEM statistical package, including factor analysis models for paired comparisons and rankings. Only minor modifications are needed to accommodate both types of data. As a result, complex models for comparative judgments can be both estimated and tested efficiently.

Choice Behavior↗

How to resist temptation: the effects of external control versus autonomy support on self-regulatory dynamics.

The purpose of the present study (N=80 undergraduate students) was to examine two issues: first, does external control lead to an increase in resistance to temptation more than the use of autonomy support? Second, what are the long-term effects of these types of educational style? Based on the Personality Systems Interaction (PSI) theory, external control was expected to increase resistance to temptation for those participants who lack initiative and self-motivation (i.e., state-oriented participants). Consistent with expectations, resistance to temptation was greater for state-oriented participants with externally controlled instructions than for individuals who received autonomy-supportive instructions. This was reflected by their performance on a visual discrimination task during distracter, compared to baseline, episodes. However, external control had negative long-term effects on state-oriented participants as indexed by alienation from their own preferences in free-choice behavior. Action-oriented participants were less influenced by experimental conditions.

Adult↗

Smoked heroin in rhesus monkeys: effects of heroin extinction and fluid availability on measures of heroin seeking.

The purpose of the present study was to evaluate the reinforcing effects of smoked heroin in nonopioid-dependent nonhuman primates when an alternative reinforcer, sweetened fluid, was made available. Four adult male rhesus monkeys lived in three chambers, with heroin self-administration (0, 0.3, and 0.6 mg/kg) specific to one end of the chamber, oral sweetened fluid self-administration specific to the other end chamber, and no commodity available in the middle chamber. The length of time monkeys spent in the drug-associated chamber provided one measure of drug seeking (i.e., location preference). During self-administration sessions, a second-order schedule of reinforcement was used, with responding during the first component maintained by a brief presentation of the stimuli associated with reinforcement. Responding during the second component was maintained by a delivery of the reinforcer, and the associated stimuli. Responding during the first component provided a second measure of drug seeking. Monkeys also had choice trials each day, when they could choose to work for either commodity. Choice behavior provided a third measure of drug seeking. Each experimental day consisted of a smoking session (four smoking trials), a sweetened fluid session (four fluid trials), and a choice session (four choice trials). Monkeys typically completed all four smoking trials each day when either of the active heroin doses was available. They chose both heroin doses over fluid on 3.5 of the four choice trials, and they had a location preference for the heroin chamber. Under baseline conditions, the number of acquisition responses and the number of consumption responses (inhalations) were greater for the high dose of heroin compared to the low dose of heroin. Further, it took longer to extinguish the responding for the high dose of heroin compared to the low dose of heroin when a vehicle was substituted. During heroin extinction, acquisition responding for fluid increased, the number of fluid choices increased, and location preference shifted to the fluid chamber. These data suggest that in nondependent rhesus monkeys, measures of heroin seeking decreased when heroin was not available and seeking behavior shifted to the available alternative commodity.

Animals↗

An information processing view of framing effects: the role of causal schemas in decision making.

People prefer a sure gain to a probable larger gain when the two choices are presented from a gain perspective, but a probable larger loss to a sure loss when the objectively identical choices are presented from a loss perspective. Such reversals of preference due to the context of the problem are known as framing effects. In the present study, schema activation and subjects' interpretations of the problems were examined as sources of the framing effects. Results showed that such effects could be eliminated by introducing into a problem a causal schema that provided a rationale for the reciprocal relationship between the gains and the losses. Moreover, when subjects were freed from framing they were consistently risk seeking in decisions about human life, but risk averse in decisions about property. Irrationality in choice behaviors and the ecological implication of framing effects are discussed.

Adult↗

Contribution of area MT to stereoscopic depth perception: choice-related response modulations reflect task strategy.

Due to the diversity of tuning properties in sensory cortex, only a fraction of neurons are engaged in a particular task. Characterizing the tuning properties of neurons that are functionally linked to behavior is essential for understanding how activity is "read out" from sensory maps to guide decisions. We recorded from middle temporal (MT) neurons while monkeys performed a depth discrimination task, and we characterized the linkage between MT responses and behavioral choices. Trial-to-trial response fluctuations of MT neurons with odd-symmetric ("Near," "Far") disparity tuning were predictive of monkeys' choices, whereas responses of neurons with even-symmetric tuning were not. This result cannot be explained by neuronal sensitivity or any other response property of MT neurons that we examined but is simply explained by the task strategy that monkeys learned during training. We suggest that this approach provides a physiological means to explore how task strategies are implemented in the brain.

Animals↗

Directional signals in the prefrontal cortex and in area MT during a working memory for visual motion task.

Neurons in the middle temporal visual area (MT) have been implicated in the perception of visual motion, whereas prefrontal cortex (PFC) neurons have been linked to temporary storage of sensory signals, attentional and executive control of behavior. Using a task that placed demands on both sets of neurons, we investigated their contribution to working memory for visual motion. Monkeys compared the direction of two moving random-dot stimuli, sample and test, separated by a brief memory delay. Neurons in both areas showed robust direction-selective activity during all phases of the task. During the sample, approximately 60% of task-related PFC neurons were direction selective, and this selectivity emerged 40 ms later than in MT. Unlike MT, the PFC responses to sample did not correlate with behavioral choices, but their selectivity was modulated by task demands and diminished on error trials. Reliable directional signals were found in both areas during the memory delay, but these signals were transient rather than sustained by neurons of either area. Responses to the test in both areas were modulated by the remembered sample direction, decreasing when the test direction matched the sample. This decrease arose in the PFC 100 ms later than in MT and was predictive of the forthcoming decision. Our data suggest that neurons in the two regions are functionally connected and make unique contributions to different task components. PFC neurons reflect task-related information about visual motion and represent decisions that may be based, in part, on the comparison in MT between the remembered sample and test.

Action Potentials↗

Effects of the nicotinic receptor blocker mecamylamine on radial-arm maze performance in rats.

Lesions of cholinergic neurons have been found by many investigators to impair choice accuracy in the radial arm maze. Because muscarinic receptor blockers, such as scopolamine, have also repeatedly been found to impair choice accuracy in the radial-arm maze, it has generally been thought that the critical effect of cholinergic lesions is the deafferentation of muscarinic receptors. The possible involvement of nicotinic receptors in the cholinergic bases of cognitive performance in the radial-arm maze has not been as well investigated. The present study examined the effects of the blockade of nicotinic receptors on performance of female Sprague-Dawley rats in the radial-arm maze. Acute administration of the the nicotinic receptor blocker, mecamylamine (10 mg/kg) was found to significantly impair radial-arm maze choice accuracy. This dose also caused a significant increase in response latency in the maze. The effect on choice behavior but not locomotor speed seemed to be due to the central effects of mecamylamine, because administration of the peripheral nicotine receptor blocker, hexamethonium (20 mg/kg), did not impair choice accuracy, even though it did increase response latency to a similar degree as the 10-mg/kg dose of mecamylamine. Lower doses of mecamylamine (2.5 and 5 mg/kg) did not impair choice accuracy. These results indicate that central nicotinic as well as muscarinic cholinergic receptors are involved with cognitive functioning.

Animals↗

Can fruits and vegetables and activities substitute for snack foods?

This study investigated the choice of snack foods versus fruits and vegetables and enjoyable sedentary behaviors using a computerized behavioral choice task. Thirty-nine participants were provided the choice of earning points for snack foods or fruits and vegetables (Condition 1) or snack foods or enjoyable sedentary behaviors (Condition 2). The behavioral cost to gain access to snacks increased across trials, whereas the behavioral costs to obtain alternatives to snack foods remained constant across trials. Results showed that when costs for snack foods and alternatives were equal, participants chose snack foods, but as the behavioral costs increased, participants shifted choice to the alternatives. The switch point for both alternatives was equal. Results suggest that fruits and vegetables and sedentary activities can substitute for snack foods when the behavioral cost for snack foods is increased.

Adult↗