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At least 271 records · Page 15Linked to original sources
PubMed1996

Crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma mimicking Weber-Christian disease: immunohistochemical, ultrastructural, and gene-rearrangement studies.

A case of crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma is presented. Unlike previous cases, this patient presented with signs and symptoms suggestive of Weber-Christian disease. Biopsy of subcutaneous nodules showed numerous deposits of crystal-storing histiocytes with lymphoplasmacytic cells, the latter exhibiting light chain restriction (lambda-chain) with a predominance of immunoglobulin (Ig)G heavy chain. Polymerase chain reaction (PCR) analysis of CDR-II* region of the immunoglobulin heavy chain locus confirmed monoclonality of the lymphoplasmacytic cells in the nodule. Electron microscopy showed polygonal-shaped amorphous crystals, characteristic of immunoglobulin in the histiocytic cells. Crystal-storing histiocytosis should be examined by immunohistochemical and DNA analysis to confirm or exclude the possibility of lymphoplasmacytic lymphoma.

Adult↗
PubMed2003

Surgical-site infections at Kilimanjaro Christian Medical Center.

A five-month prospective survey of surgical-site infections (SSI) was conducted in the department of general surgery at Kilimanjaro Christian Medical Center, Tanzania. SSI were classified according to Centers for Disease Control and Prevention (CDC) criteria and identified by bedside surveillance and post-discharge follow-up. This study showed that 77 (19.4%) of the patients developed SSI. Twenty-eight (36.4%) of these infections were apparent only after discharge from hospital. Eighty-seven percent of those who developed SSI had received antibiotic prophylaxis. Significant risk factors for developing SSI during hospital stay were: operations classified as contaminated or dirty, operations lasting for more than 50 min and the length of preoperative stay. The only significant risk factor for those who developed SSI after discharge was having undergone a clean-contaminated operation. Staphylococcus aureus was the most frequently isolated micro-organism followed by Escherichia coli and Klebsiella spp., most of which were multi-resistant. An exception was S. aureus where 54.5% of the isolates were fully susceptible. The incidence of SSI and the prevalence of antibiotic resistance in this teaching and tertiary care hospital are high. The risk factors were similar to those reported from countries with more resources. The findings suggest that infection prevention measures, particularly antibiotic prophylaxis, should be re-evaluated.

Adolescent↗
PubMed2003

Christian Doppler is 200 years young.

Christian Doppler was born 200 years ago in Salzburg, Austria, on November 29, 1803, worked in Prague and Vienna and died 150 years ago in Venice. In an article of eight pages he described the principle, which made him famous. It appeared in 1842 with the exotic title: "On the Coloured Light of the Double Stars and Certain Other Stars of the Heaven". The validity of his principle for velocity measurement was confirmed by trumpet sounds produced on a train moving towards and away from the observer. Around 1960 Japanese scientists suggested that flow velocity in blood vessels could be determined by analysing the difference of frequency between emitted and backscattered ultrasound. Rushmer and coworkers built machines suitable for medicine in Seattle, where Eugene Strandness recognized their potential and applied them in first studies. In 1967 the technique jumped to Europe and started to be used worldwide. Already by using continuous wave ultrasound it was possible to diagnose occlusive disease of neck and limb arteries, venous thrombosis and valvular insufficiency with accuracy. Measurements of postestenotic ankle blood pressure were facilitated by Doppler sensing. Over the years more sophisticated instruments were developed. Pulsed emission of ultrasound waves opened a way to study flow velocity profiles across large vessels. By combining the method with A or B mode ultrasound blood flow could be quantified and finally perfused segments of blood vessels visualized. Duplex scanning in its simple and then in its colour coded version is nowadays the standard non-invasive technique that nobody would like to miss. Vascular territories like intracranial, renal and intestinal arteries can also be explored. For the assessment of microvascular flow in skin and mucosae laser Doppler instruments were introduced.

Austria↗
PubMed2006

A case of Weber-Christian disease with collapsing glomerulopathy.

We report a case of Weber-Christian disease confirmed by skin biopsy in a patient who presented with collapsing glomerulopathy and lipophagic interstitial nephritis. On renal biopsy, glomerular visceral epithelial cells, tubular cells, and interstitial macrophages were loaded with inclusions that were morphologically consistent with oxidized lipoproteins, suggesting that lipids derived from the panniculitis may have an etiopathogenic role.

Adult↗
PubMed1999

[100 years of the Otto Körner ENT Clinic, Rostock. The merits of Christian Lemcke and Otto Körner in the development of ENT specialty].

BACKGROUND: The first special ENT hospital in Germany and northern Europe, the Department of Otorhinolaryngology, Head- and Neck-Surgery "Otto Körner" in Rostock is celebrating its 100th anniversary on October 25, 1999. METHODS: There is a presentation on the efforts in the ENT-specialty from the beginning considering the special situation at the university of Rostock. RESULTS: The efforts of Christian Lemcke (1850-1894), who associated the three sections Otology, Laryngology and Rhinology are appreciated, Otto Körner (1859-1935) continued this development. He achieved the building of a special ENT-hospital by his excellent knowledge and surgical skills. The opening date was October 25, 1899, Körner became the first full professor in Otology and Laryngology in Germany in 1901. His "Textbook Of Otology And It's Bordering Specialties" was published in 1906. As one of the first, he supported the independence of ENT-medicine as a separate field in the course of medicine. CONCLUSION: Today, Otto Körner's claims are more relevant than ever before, because the today's students in their practical course of medicine and even young doctors at the hospitals obviously show a lack of knowledge in the ENT-field. The current "multiple choice" type of examinations could be one of the main reasons.

Germany↗
PubMed2004

["I am rather satisfied with this interpretation of my dreams." -- real-life and work-related encounters between psychiatrist Johann Christian August Heinroth and poet Johann Wolfgang von Goethe].

Apart from being a major pioneer of modern psychiatry, Johann Christian August Heinroth (1773 - 1843) is foremost famous as the first academic teacher, professor of this subject at Leipzig University. Despite his theoretical concepts being thoroughly investigated by medical historians, the fact that his scientific work also brought him in contact with Weimar poet and scientist Johann Wolfgang von Goethe (1749 - 1832) has up to now not been acknowledged. This paper analyses for the first time the manifold points of contact between the two geniuses. Starting off with a retrospective on Goethe's relationship towards psychiatry in his day, this paper investigates the mutual interconnections and influences between the two. This is achieved by an analysis of yet unknown primary sources as well as Goethe's literary and scientific works. A main emphasis is also placed on Heinroth's Textbook of Anthropology of 1822 in which the psychiatrist laid out his understanding of 'relational thinking' (gegenständliches Denken), a key concept for both. This theory developed from Heinroth's dealing with Goethe's concept of "anschauung" and was to gain major importance not only for his way of gaining knowledge in general but also for his psychiatric concept. Goethe's influence on Heinroth is particularly revealed in the latter's holistic views on mental illnesses. Heinroth's visit to Goethe on 15 September 1827 can be earmarked as a sign of their mutual esteem.

Dreams↗
PubMed1992

[Christian Gerhard Leopold (1846-1911)].

Christian Gerhard Leopold was one of the outstanding German gynaecologists at the turn of this century. Although interested in the entire discipline of obstetrics and gynaecology including related areas, he is merely known today for his obstetrical manoeuvres. Under his chairmanship, the Dresden Royal Gynaecological Infirmary developed into a leading hospital in Germany. Leopold died on September 12, 1911, following a heart attack.

Germany↗
PubMed2006

Hans Christian Jacobaeus: Inventor of human laparoscopy and thoracoscopy.

Hans Christian Jacobaeus performed the first clinical laparoscopic surgery in Stockholm. This pioneering procedure was based on the animal experiments of Georg Kelling (1866-1945), a German physician from Dresden, who performed the first laparoscopic intervention in 1901 using a Nitz cystoscope in a dog. In 1910, Jacobaeus published his initial experiences with laparoscopic surgery in the Münchner Medizinischen Wochenschrift under the title "The Possibilities for Performing Cystoscopy in Examinations of Serous Cavities." He used this technique for diagnostic purposes in undefined abdominal complaints and functional impairment. Jacobaeus was the first who pointed out the possibility of injuring organs, especially the intestines, by inserting the trocar. In 1910, Jacobaeus recognized the immense diagnostic and therapeutic possibilities of laparoscopic surgery, as well as its difficulties and limits. He also was the first to realize the need for initial endoscopic training in animals and corpses. He promoted the development of special laparoscopic instruments to optimize and simplify the procedure.

Animals↗
PubMed1988

Relapsing polychondritis and Weber-Christian disease.

A patient with classical relapsing polychondritis in whom abdominal pain was a prominent symptom is described. Histological examination of skin and mesenteric biopsies confirmed the diagnosis of Weber-Christian disease (systemic panniculitis) suggested by clinical features. The prognostic and therapeutic implications of this unusual disease association are discussed.

Adult↗
PubMed2002

A rare condition of Hand-Schüller-Christian disease.

The authors present the clinical case of a 61-year-old patient with Hand-Schüller-Christian disease associated with multisystemic involvement. The onset of such puzzling symptoms and the extremely rarity of this disease in a patient of such advanced age resulted in a delayed diagnosis and subsequently delayed treatment of the patient.

Anti-Inflammatory Agents↗
PubMed1997

Imaging of Hand-Schüller-Christian syndrome by a monoclonal antibody.

PURPOSE: Multifocal eosinophilic granuloma (Hand-Schüller-Christian syndrome) consists of localized lesions of histiocytosis X originating from proliferating Langerhans' cells involving male children and young adults. MATERIALS: The authors present the first case of multifocal eosinophilic granuloma that was imaged by Tc-99m monoclonal antibody BW250/183 recognizing NCA-95 antigen on granulocytes. A 30-year-old man had a diagnosis of histiocytosis X for 16 years. RESULTS: All active known lesions were visualized. The previous radiotherapy fields were also accurately demonstrated as areas with no antibody accumulation. Bone marrow biopsy taken 30 hours after injection showed no infiltrations, but mild hypoplasia suggesting chronic disease was demonstrated. Retrospectively, the authors performed digital autoradiography from tissue samples and found specific targeting with the same BW250/183 antibody. CONCLUSION: Their results indicate that antibody targeting is possible in multifocal eosinophilic granuloma, probably even allowing radioimmunotherapy.

Adult↗
PubMed1998

The mystery of angiography and the "unawarded" Nobel Prize: Egas Moniz and Hans Christian Jacobaeus.

OBJECTIVE: To investigate the circumstances surrounding why Egas Moniz was not awarded the Nobel Prize for his contribution of angiography, provide a synopsis of Moniz's political and medical careers, and present a biographical sketch of Hans Christian Jacobaeus, the neurologist who evaluated Moniz's Nobel Prize nominations, as well as to dispel long-standing misconceptions concerning Moniz's recognition and to acknowledge the contributions of other researchers. HISTORICAL PERSPECTIVE: In 1936, António Caetano de Abreu Freire Egas Moniz published the results of a radical treatment for mental illness, a surgical procedure he termed prefrontal leucotomy. Moniz achieved such remarkable results with mental patients who suffered from conditions previously deemed incurable that many physicians throughout the world immediately embraced the procedure. In 1949, the Nobel Prize Committee recognized Moniz's contribution with the Nobel Prize in Physiology and Medicine. Why Moniz's earlier major contribution to medicine, the discovery and development of angiography, was not acknowledged in like fashion has remained a mystery. Nobel Prize documents reveal that Moniz was nominated for the award on two separate occasions; both times, Jacobaeus, Chairman of the Department of Neurology at Karolinska Institute and a member of the Nobel Prize Committee, evaluated the nominations and recommended against awarding Moniz the prize. CONCLUSION: The development of imaging techniques was not isolated to any one individual's contribution. Several persons, including Walter Dandy and Jacobaeus, were leading figures.

Angiography↗
PubMed2002

Successful treatment of idiopathic febrile panniculitis (Weber-Christian disease) with thalidomide in a patient having failed multiple other medical therapies.

The authors describe a case of idiopathic nodular panniculitis (Weber-Christian disease) with recurrent febrile episodes resistant to glucocorticosteroids and methotrexate (MTX) in various combinations with hydroxychloroquine, azathioprine, cyclosporine, colchicine, and doxycycline. Thalidomide at 100 mg/day has induced a remission for 3 years.

Journal Article↗
PubMed2000

Neighbors in time: development and use of some values for intergenerational justice from the Jewish and Christian religious traditions.

The overlapping understandings of Jewish and Christian traditions (the Traditions), both influencing and reincorporating Western culture from the Greeks to the present, underpin many of the ethical constructs of present society, in ways both obvious and subtle. The concept of justice is central to the ethical outlooks of both religious traditions. This article systematically develops values related to justice from within the Traditions and extends them to the question of intergenerational equity as proposed precepts for assessment and action. Many of the results seem familiar because they are deeply embedded in our culture. They are assertions that transcend time-the value of human life; an obligation to support the necessary interests of others, especially the powerless; the concepts of brotherhood, the common good, and stewardship of resources; and the transmission of knowledge, resources, and values through the vehicles of families and communities. Other ideas from within the Traditions, such as giving beyond the requirements of equity and the connection of human life with God whose abilities are unbounded by time, continue to draw people beyond the limits of culture. These outlooks are organized into 17 statements or proposals constitutive of this view of justice. These summary statements are used as the basis for comparing a system of principles proposed by a panel of the National Academy of Public Administration for intergenerational decision making with the views represented by the Traditions. This broaches a broader question of fairness in resource distribution. The article concludes with reference to some developed resources of the Traditions from which further insight can be drawn, and another illustration related to resource allocation. It is hoped that the article helps stimulate wider analysis of the values on which our decisions are made.

Journal Article↗
PubMed1984

Airway deadspace, end-tidal CO2, and Christian Bohr.

In order to calculate alveolar deadspace, an important measure of ventilation/perfusion mismatching, it is necessary to measure airway or anatomical deadspace (VDaw) and physiological deadspace. VDaw is usually measured graphically or by similar means, but sometimes it is estimated from a formula, based on Christian Bohr's work, in which end-tidal PCO2 is used as a measure of alveolar PCO2. In 58 patients undergoing anaesthesia and positive pressure ventilation, there were large errors in this estimate of VDaw compared to a graphical method. At tidal volumes of 400-500 ml, the median error was 34 ml; at larger tidal volumes, the median error increased to 74 ml (P less than 0.001). The size of the error was correlated to the slope of phase III, the part of the CO2 tracing representing alveolar CO2, at both ventilator settings (P less than 0.01). It is concluded that estimates of VDaw based on end-tidal PCO2 are unreliable, and their use will lead to a large part of the alveolar deadspace being wrongly accredited to VDaw.

Adolescent↗
PubMed1976

An ultrastructural and histochemical study on bone lesions of Hand-Schüller-Christian disease.

A correlated light microscopical, histochemical and ultrastructural study was made on bone lesions repeatedly biopsied from three patients with Hand-Schüller-Christian disease. The histiocytic cells proliferating in the early lesions had a markedly indented nucleus and contained in their cytoplasm varying numbers of Langerhans cell granules and round or irregular-shaped lipid droplets. Histochemically, the lipid droplets were verified to the lipo-protein rich in fatty acids. Such histiocytic cells differ from highly phagocytic histiocytes or macrophages because of indistinct phagocytotic activity, and are regarded as a metabolic type of histiocytes. The late lesions were mostly dominated by a xanthogranulomatous tissue chiefly comprised of xanthoma cells and collagen fibers. The xanthoma cells were usually filled with numerous lipid vacuoles which were histochemically proved to mainly contain cholesterol. Almost all the xanthoma cells were closely attached to collagen fibers and often had well-developed rough endoplasmic reticula. Ultrastructurally, it is suggested that the xanthoma cells are originated from fibroblasts or fibrocytes. As an important factor to induce proliferation and xanthoma cell transformation of fibroblasts in the late phase, the presence of such a lipoprotein produced in the histiocytic cells of the early phase is emphasized.

Adenosine Triphosphatases↗