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PubMed1998

Endogenous opioids and the first suckling episode in the rat.

Endogenous activity at opioid receptors affects the appetitive behavior of Caesarean-delivered rat pups during presentation of a surrogate nipple that provides milk. Blockade of opioid receptors by peripheral injection of naloxone has no effect on responses evoked by the surrogate nipple. Similarly, blockade of caudal brain opioid receptors by injection of naloxone into the cisterna magna has no effect on the pup's behavior in response to the surrogate nipple. However, blockade of rostral opioid receptors by injection of naloxone into the cerebral ventricles increases the latency to the first oral grasp response, decreases total time on the nipple, and virtually eliminates ingestion of milk from the surrogate nipple (Experiment 1). Blockade of endogenous opioid activity does not affect responses to a nipple that provides distilled water (Experiment 2) or to an empty surrogate nipple (Experiment 3). These data indicate that during the initial suckling episode endogenous opioids in rostral brain regions affect the pup's behavioral responses to the nipple. The results are consistent with the hypothesis that milk engages opioid systems during the first suckling and that endogenous opioids play a role in early suckling.

Analysis of Variance↗
PubMed2005

Effects of dietary and pharmacological manipulations on appetitive and consummatory aspects of feeding in non-human primates.

This study examined how pharmacological and behavioral manipulations affect appetitive and consummatory aspects of feeding of baboons. Baboons have access to food 24 h each day, but they must complete a two-phase operant procedure in order to eat. Responding on one lever during a 30-min appetitive phase was required before animals could start a consumption phase, i.e. a meal, where responding on another lever led to food delivery. Responding during the appetitive phase resulted in presentations of food-related stimuli only. Decreasing session length, increased appetitive behavior and increased meal size. Limiting the number of meals to a single 90 min meal each day but increasing the number of food pellets the animals received increased the size of meal, but did not increase appetitive behavior. These findings suggest that time since the previous meal has a greater effect on appetitive behavior than the size of the previous meal. Amphetamine (AMPH), which increases dopamine, decreased food intake at doses that did not affect appetitive behavior, indicating that appetitive and consummatory aspects of eating can be pharmacologically differentiated. Increasing how frequently animals could earn food-related stimuli in the appetitive phase and food in the consummatory phase increased both appetitive and consumatory behavior. Under these conditions, AMPH nearly doubled appetitive behavior at doses that decreased food intake by nearly 50 percent. When animals had one meal, of self-determined duration, meal size increased without affecting appetitive behavior, further demonstrating that appetitive behavior can be independent of the size of the previous meal and not predictive of the size of the subsequent meal. Under these conditions, AMPH decreased food intake at doses that did not affect appetitive behavior. In contrast, dexfenfluramine (DFEN), which increases serotonin, decreased both appetitive and consumatory behavior. Thus, it is possible to independently manipulate the appetitive and consummatory aspects of eating using both pharmacological and behavioral interventions indicating that it may be possible to develop medications that selectively affect appetitive or consummatory aspects of eating.

Amphetamine↗
PubMed2003

Effects of self-administered ethanol or water preloads on appetitive and consummatory behavior in the alcohol-preferring (P) rat.

OBJECTIVE: Ethanol intake control in the selected alcohol-preferring lines of rats appeared to have shifted in some lines for both increased ethanol seeking and increased consumption once ethanol was available. It was unknown whether a small preload of ethanol would alter either the seeking or the consumption in a selected line. This study examined this issue. METHOD: Alcohol-preferring (P) rats from Indiana University School of Medicine were initiated to drink ethanol using a sucrose-substitution procedure and a single daily limited-access trial. Following 30 responses on a lever, a sipper tube containing 10% ethanol extended into the operant chamber for 20 minutes. Self-administered ethanol and water preloads were tested prior to either a regular session or an extinction session. In extinction sessions, no access to the sipper tube occurred, and the number of responses occurring during 20 minutes was taken as a measure of ethanol seeking. RESULTS: The ethanol and water preloads had no effect on the following ethanol consumption at any time during the experiment. However, the first two ethanol preloads significantly reduced extinction responding, which did not recover to the levels observed prior to the preload tests. CONCLUSIONS: The data support the conclusion that ethanol seeking in the P rat can be influenced by environmental history, whereas consummatory behavior appears to be under more explicit genetic control. This gene-environment interaction suggests that, in the P rat, seeking behavior, initially set at higher levels than observed for nonselected lines, can be modified by certain environmental experiences.

Animals↗
PubMed2002

Evidence that appetitive responses for dehydration and food-deprivation are learned.

Rats do not seek water when cellularly dehydrated until they are about 4 weeks of age. This lack of appetitive 'seeking' behavior in young rats differs from their precocious ingestive responses such as an increased intake of solutions infused into their mouths when they are dehydrated as young as 2 days of age. Using video analysis of appetitive behavior in a structured environment, we document this early absence of appetitive responding and the subsequent acquisition of dehydration-elicited appetitive behavior. Weaning age pups were separated into four conditions: (i) experienced, dehydrated; (ii) experienced, nondehydrated; (iii) inexperienced, dehydrated; and (iv) inexperienced, nondehydrated. 'Experienced' rats received a dehydration and drinking experience prior to the test, and 'dehydrated' rats were dehydrated (by injection of a salt load) at the time of test. At the test, all water and food was removed from the test cages, eliminating the confounding of appetitive and consummatory measures. Despite the fact that pups in all conditions had experience with water and had previously drunk, only the 'experienced' pups differentially sought water when dehydrated. Parallel experiments with food deprivation produced similar results. Pups did not exhibit food-seeking behavior when food-deprived unless they had previous experience with food deprivation and eating. The appetitive 'seeking' behavior for feeding also appears to be learned. Directed appetitive behavior in general may thus be acquired.

Animals↗
PubMed1960

Simultaneous generalization gradients for appetitive and aversive behavior.

In the presence of a bright light five monkeys were trained to press a lever to avoid shock and to pull a chain for food reward. When tested with a series of lights dimmer than the conditioning stimulus, the monkeys showed a sharp gradient of effect for the rewarded response, in contrast to a very flat gradient for the avoidance response.

Animals↗
PubMed2001

Role of various types of serotonin receptors in regulation of drinking behavior and salt appetite in vasopressin-deficient brattleboro rats.

Serotonin 5-HT(1A)receptor agonist 8-OH DPAT suppressed drinking behavior in Brattleboro and Wistar rats. 5-HT(1B)agonist CGS-12066A and 5-HT(2A)antagonist ketanserin did not affect drinking behavior in Brattleboro rats; 5-HT(3)antagonist ondansetron suppressed water consumption and 5-HT(1A)agonist stimulated salt appetite in Brattleboro, but not in Wistar rats. Presumably, vasopressin regulates thirst and salt appetite by modulating sensitivity/density of various types of 5-HT receptors.

8-Hydroxy-2-(di-n-propylamino)tetralin↗
PubMed2001

[Participation of various types of serotonin receptors in the regulation of drinking behavior and salt appetite in rats].

The 5-HT1A agonist 8-OH-DPAT was shown to diminish the water and 1.8% NaCl solution consumption, whereas its antagonist pMPPI--to enhance the water intake in rats. Another agonist: CGS-12066A enhanced water intake or exerted no effect on drinking behaviour and diminished salt intake. Other substances under study exerted various effects. The data obtained suggest that the 5-HT receptors are involved in regulation of water and salt intake, even though the mechanisms of the effects are different. Apparently 5-HT1B and 5-HT2A receptors play an activating role in regulation of water intake, whereas 5-HT1A, 5-HT2C and 5-HT3 receptors act as inhibitory ones. Only three of the receptors under study seem to regulate salt intake by inhibiting the salt appetite.

Animals↗
PubMed1979

Modulation of behavioral inhibition in appetitive extinction following manipulation of adrenal steroids in rats: implications for involvement of the hippocampus.

Corticosterone, the principal glucocorticoid in the rat, binds selectively to the CA1 pyramidal neurons of the hippocampus where the hormone has been demonstrated to exert a moderate chronic suppression of spontaneous activity. In the first experiment of the current study, the functional behavioral significance of this hormone--brain interaction was investigated in the extinction of an appetitive runway response in normal rats and those with lesions of the hippocampus. During extinction, half of the animals in each group were given daily subcutaneous injections of corticosterone. Whie the classical retardation effect of hippocampal lesions on appetitive extinction was replicated, hormone treatment was without effect in normal or hippocampally damaged subjects. The absence of a hormone effect in normals was primarily attributed to a saturated limited-binding system operating in the normal animal. Experiment 2 tested this notion, repeating the first experiment, with adrenal-ectomized (ADX), ADX + corticosterone replacement, and normal groups of animals. Adrenalectomy produced a striking facilitation of extinction which was speculated to be the result of a hyperactive inhibitory neural organ free from an inhibitory endocrine feedback. Corticosterone treatment normalized the progress of extinction in ADX animals, providing support for the afore-mentioned speculation. In the normal animal, it appears that a stress-induced surge in hormone level interacts with a limited-capacity neural binding to produce a transient dynamic range of behavioral disinhibition, perhaps promoting persistence during initial stages of frustrative nonreward in moderate stress tasks.

Animals↗
PubMed2001

[Physiology of appetite and feeding behavior: introduction].

Food intake is regulated by the central nervous system depending on macronutrients and environmental changes. The hypothalamus is the target of hunger and satiety signals arising from the peripheral organs and the brain. Noradrenaline-neuropeptide Y and opioid-galanine are involved in carbohydrate and fat intake, respectively, while serotonin-CCK-insulin and dopamine-cyclic dipeptides systems inhibit them. Histamine and proinflammatory cytokines are involved in stress- and sickness-induced anorexia. Leptin accelerated intrahypothalamic anorexic mechanisms executed by POMC/CART and CRH but suppresses orexigenic mechanisms promoted by NPY and orexin. Although these mechanisms elegantly regulate appetite and feeding behavior, disruption of weight control has been accelerated and the incidence of obesity and eating disorder are dramatically increasing recent years in our modern society. New approach may be necessary to solve the problems of weight control.

Appetite↗
PubMed1998

A behavioral economic analysis of fat appetite in rats.

A behavioral economic analysis of rats' consumption of various fat and sweet solutions was conducted in order to assess whether rats' fat appetite is readily modifiable. According to economic demand theory, changes in the price of a reinforcer will produce substantial changes in its consumption under conditions in which a substitutable reinforcer is available. Results from income-compensated price changes revealed that sucrose, mineral oil and saccharin solutions substituted for a corn oil solution: increases in the price of the corn oil led to large decreases in its consumption and sizable increases in consumption of these alternatives. On the other hand, plain water did not substitute for the corn oil solution: increasing the price of the corn oil did not result in nearly as marked a change in its consumption nor in consumption of the water. Neither the strength of preference for the corn oil under baseline conditions nor the caloric content of the alternative solution predicted whether the alternative reinforcer substituted for the corn oil. Rather, palatability appeared to be a dimension along which substitution was based. These results suggest that fat appetite is modified when palatable alternatives are available, independent of how strongly the fat is preferred.

Animals↗
PubMed2005

Rapid effects of aromatase inhibition on male reproductive behaviors in Japanese quail.

Non-genomic effects of steroid hormones on cell physiology have been reported in the brain. However, relatively little is known about the behavioral significance of these actions. Male sexual behavior is activated by testosterone partly through its conversion to estradiol via the enzyme aromatase in the preoptic area (POA). Brain aromatase activity (AA) changes rapidly which might in turn be important for the rapid regulation of behavior. Here, acute effects of Vorozole, an aromatase inhibitor, injected IP at different doses and times before testing (between 15 and 60 min), were assessed on male sexual behavior in quail. To limit the risk of committing both types of statistical errors (I and II), data of all experiments were entered into a meta-analysis. Vorozole significantly inhibited mount attempts (P < 0.05, size effect [g] = 0.527) and increased the latency to first copulation (P < 0.05, g = 0.251). The treatment had no effect on the other measures of copulatory behavior. Vorozole also inhibited appetitive sexual behavior measured by the social proximity response (P < 0.05, g = 0.534) or rhythmic cloacal sphincter movements (P < 0.001, g = 0.408). Behavioral inhibitions always reached a maximum at 30 min. Another aromatase inhibitor, androstatrienedione, induced a similar rapid inhibition of sphincter movements. Radioenzyme assays demonstrated that within 30 min Vorozole had reached the POA and completely blocked AA measured in homogenates. When added to the extracellular milieu, Vorozole also blocked within 5 min the AA in POA explants maintained in vitro. Together, these data demonstrate that aromatase inhibition rapidly decreases both consummatory and appetitive aspects of male sexual behavior.

Animals↗
PubMed2001

Carbohydrates, appetite and feeding behavior in humans.

The view of carbohydrates in relation to obesity has changed over the past few decades from being conducive to overconsumption and weight gain to being protective. This article reviews the mechanisms by which carbohydrate is purported to protect against weight gain. Although carbohydrate is metabolized and stored in the body less efficiently than fat, when de novo lipogenesis is invoked on very high carbohydrate diets, the beneficial effect on energy balance is likely to be minimal when typical high fat Western diets are consumed. However, it has been suggested that high carbohydrate foods may influence energy balance by reducing food intake through greater satiety effects, reducing energy density and displacing fat from the diet-the fat-sugar seesaw effect. To date, there seem to be few differences between sugars and starches on satiety and energy intake, but few studies have examined this. Some reduced-fat, and, therefore, higher carbohydrate, foods are highly energy dense. High carbohydrate foods do not necessarily have a low energy density. Evidence from recent studies suggests that adding carbohydrate, and especially sugar, to the diet neither displaces fat from the diet nor protects against elevated energy intake. Although it is easier to overeat on high fat than low fat foods, simply replacing fat with carbohydrate in the diet may not be as protective against overconsumption as the energy density or fat-sugar seesaw arguments suggest.

Appetite↗
PubMed1995

Appetite and eating behavior in children.

The authors propose that individual differences among children in the controls of food intake can be viewed in terms of differences in balance of power in feeding. They also argue that the individual differences in styles of intake control that emerge by adolescence and adulthood, including chronic dieting, eating disorders, and out-of-control eating, begin in the early balance of control in the feeding context. Limited evidence suggests that the course of development of shared control differs for intermeal interval, food selection, and meal size.

Appetite↗
PubMed2001

The hippocampus and motivation revisited: appetite and activity.

After reviewing the available data regarding the various effects of manipulating (e.g. lesions, chemical or electrical stimulation) the hippocampal formation, Jarrard concluded that this structure likely played a role in motivated behaviors, specifically in general behavioral activation and incentive motivation. Since that time there have been technical advances in lesion techniques and conceptual advances in theories of motivation and learning. Here, we present more recent data that demonstrates the effects of hippocampal lesions on general activity, the utilization of interoceptive state cues, ingestive behaviors, and appetitive responding. We critically evaluate several theories of hippocampal function that have been proposed to explain these data, including the hippocampus as an inhibitor of general activation, as a processor of energy state signals and as a mediator of reward valuation. Finally, we propose that these findings may also be accounted for based on a role for the hippocampus in the learned inhibition of appetitive behaviors. We conclude that, while the specific mechanism of hippocampal involvement may not yet be determined, it is clear that this structure is involved in food-related behaviors and we caution researchers to consider this as a possible confound in studies of learning and memory processes.

Animals↗
PubMed2005

Sea hares use novel antipredatory chemical defenses.

Numerous studies have demonstrated that chemical defenses protect prey from predation and have often assumed that these defenses function by repelling predators. Surprisingly, few have investigated the mechanisms whereby predators are affected by these defenses. Here, we examine mechanisms of chemical defense of sea hares (Aplysia californica), which, when attacked by spiny lobsters (Panulirus interruptus), release defensive secretions from ink and opaline glands. We show that ink-opaline facilitates the escape of sea hares by acting through a combination of novel and conventional mechanisms. Ink-opaline contains millimolar quantities of amino acids that stimulate chemoreceptor neurons in the spiny lobster's nervous system. Ink stimulates appetitive and ingestive behavior, opaline can elicit appetitive behavior but can also inhibit ingestion and evoke escape responses, and both stimulate grooming. These results suggest that these secretions function by "phagomimicry," in which ink-opaline stimulates the feeding pathway to deceive spiny lobsters into attending to a false food stimulus, and by sensory disruption, in which the sticky and potent secretions cause high-amplitude, long-lasting chemo-mechanosensory stimulation. In addition, opaline contains a chemical deterrent that opposes appetitive effects. Thus, chemical defenses may act in more complex manners than palatability assays of prey chemistry may suggest.

Amino Acids↗