[Angioscopy--future method in diagnosis and treatment of cardiovascular diseases].
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Efficacy of percutaneous treatments of arterial affections requires the correct choice of indications, necessitating precise knowledge of elementary arterial lesions. Arterial endoscopy appears to be more specific than angiography for this use, since it allows direct vision in vivo of the lesion, a histopathologic approach compared with the non univocal images produced by angiography (for example, an arterial obstruction can result from varied causes). Different accidents to the endothelial surface can be observed: golden yellow atheromatous elevations on a straw yellow background, intimal flaps, mobile intra-luminal vegetations. Established atheromatous stenosis are smooth and regular, or on the contrary ulcerated and edged with irregular flaps capable of provoking an eccentric residual lumen. The vegetating atheromatous lesions may project into the lumen, often as calcified and thus pearly white scales adhering to the wall, or as larger occlusive lesions. When capable of being isolated, a thrombus often completes the stenosis: its recognition is therefore fundamental since its removal exposes the subjacent lesions to be treated. The fresh clot is coral shaped, bright red and mobile in the blood flow. Established clots are compact and greenish brown. At an advanced stage of atheroma the surface of the occluding clot is covered with a regular straw yellow endothelium. In the presence of a dissecting vessel the fibroscope may be introduced into the false channel, no longer showing typical endothelium but a coagulated mass interspersed with fibrous bands. Prosthetic stenosis result from either intimal hyperplasia or a suturing fault with plication.
In all coronary arteries after failed PTCA with subsequent stent insertion the stenosed and dilated part of the vessels were inspected. We found dissections in 17/25 coronary lesions as well as thrombus adherent to the wall of the vessels in 8/25 cases. The morphology of the coronary stenosis was compared with the preoperative cine-angiogram. The angioscopic images after failed PTCA and subsequent stent-insertion showed severe wall dissections which were located beyond the inserted stent. In none of the cases was stent-implantation the sufficient treatment of coronary lesions. In all patients we performed coronary artery bypass grafting (CABG). Every coronary incision was used for peripheral anastomosis of the bypass grafts.
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The authors report on their experience with lower limb revascularization using the in-situ saphenous vein bypass grafting in four patients with angioscopically assisted valvulotomy. They describe the surgical technique employed and outcome of the procedure. The discussion section examines the pros and cons of the technique of in-situ saphenous vein bypass with angioscopically assisted valvulotomy (ISB + AV) compared with the standard technique of reversed bypass (RVB).
The angioscope catheter is 1.55 mm in outer diameter and 1.2 m in length. This distal end is tapered, therefore its outer diameter decreased to 1.1 mm. It has an inflatable balloon at the distal tip and four circular channels. Through one of the lumina, 0.014 inch PTCA guide wire can be used. The steerable guide wire enable the angioscope to be inserted to the target lesion safely and accurately. Recently we investigated the appearance of coronary artery in acute coronary syndromes. The results have indicated that thrombi, intimal irregularities, and xanthomatous atheromas were observed more frequently in patients with acute myocardial infarction, recent myocardial infarction and unstable angina. It is concluded that a thrombus overlying a rupture in the lining of plaque plays a major role in an acute coronary disorders, and that the fragile, lipid-rich gruel atheroma may procede its rupture. Coaxial alignments of the coronary artery were obtained in more than 80% of attempted patients. However, a finer controllable distal tip to allow good coaxial alignment and a larger balloon to reduce the coronary good flow and make the angioscopic catheter easier to track, are necessary for more complete visualization.
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Recent developments in optical instrumentation have made possible the direct, three-dimensional viewing of intravascular structures. Using an angioscope (the Trimedyne Optiscope, Trimedyne Inc., Santa Ana CA) and a xenon cold lamp (the Xenon Cold Light Fountain, Karl Storz Endoscopy America, Inc., Culver City, CA), the authors have visualized, without complications, the normal orifices of various arteries and their bifurcations in 12 dogs, the atherosclerotic aortas of eight post mortem humans, and the coronary arteries of six post mortem humans. Potential applications of the instruments include more accurate diagnosis of occlusive diseases of the blood vessels, evaluation of such interventional procedures as angioplasty, intraoperative assessment of anastomoses, and safer laser surgery. The angioscope also enables the physician to combine pressure recording and dye injection simultaneously with the visualization of the inner walls of the vessels.