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258 records · Page 15Linked to original sources
PubMed2005

Male aging and hormones: the adrenal cortex.

The hypothalamic-pituitary-adrenal (HPA) axis in the aging male (adrenopause) is characterized by an unexplained reduction of DHEA secretion while ACTH and cortisol show no major changes, except for a lower amplitude of 24-h fluctuations and a tendency to higher cortisol values in the evening and night (especially in dementia). As a consequence, the cortisol/DHEAS ratio tends to be higher. Adrenocortical morphology reveals an age-related reduction in the thickness of the zona reticularis, and an increase of microhemorrhagic events. This may be one of the underlying causes of the age-dependent high frequency of adrenal nodules incidentally found in the elderly, which may seldom be hormonally active.

Adrenal Cortex↗
PubMed2006

[Testosterone's role in regulating expression of genes of several proliferation factors].

This research work focuses on an important topic--the study of cause and effect links between partial androgen deficiency of ageing men (PADAM) and an increased expression of genes of a series of factors that make proliferate activity. The results of this research show that an increased expression of genes of several proliferation factors, and a decreased expression of the gene of the insulin receptor among men of older age groups are all connected to PADAM. The given changes are directed at compensation for testicular inadequacy, and are a particular expression of metabolic syndrome (X-syndrome); their effect can be inversed however by androgen-replacement therapy.

Actins↗
PubMed2006

[The influence of partial androgen deficiency of aging men (PADAM) on the impulse regime of incretion of several hormones and mitotic activity].

This research work is devoted to an important subject--study of the impulse regime of the incretion of a series of hormones among men with partial androgen deficience of aging men (PADAM). The results of this study suggest that PADAM leads to a breakdown of the impulse regime of incretion of a series of hormones, including luteinizing hormone (LH), follicle stimulating hormone (FSH), and somatotropic hormones (STH), as well as cortisol and insulin among men of older age groups. These changes accompany the development of metabolic syndrome (X-syndrome); their development can be inversed through androgen-replacement therapy.

Adult↗