Structure-activity relationship in halogen and alkyl substituted allyl and allylic compounds: correlation of alkylating and mutagenic properties.
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Alkylating Agents↗
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Reaction of alkylating mutagens and carcinogens with nucleic acids: N-3 of guanine as a site of alkylation by N-methyl-N-nitrosourea and dimethyl sulphate.
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Alkylating Agents↗
THE ACTION OF ALKYLATING AGENTS ON DEOXYRIBONUCLEIC ACID IN RELATION TO BIOLOGICAL EFFECTS OF THE ALKYLATING AGENTS.
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Alkylating Agents↗
Alkylation of coenzymes and the acute effects of alkylating hepatotoxins.
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Alkylating Agents↗
Liver production of N-alkylated porphyrins caused in mice by treatment with substituted dihydropyridines. Evidence that the alkyl group on the pyrrole nitrogen atom originates from the drug.
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Alkylation↗
Mutagenicity of alkyl and nitroso-alkyl compounds acting on tobacco mosaic virus and its RNA.
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Alkylating Agents↗
n-Propyldiazonium ion alkylates O6 of guanine with rearrangement, but alkylates N-7 without rearrangement.
Treatment of guanosine with n-propylnitrosourea yields 7-n-propylguanine (after acid hydrolysis) but O6-isopropylguanosine. Similarly, injection of [3H]di-n-propylnitrosamine into Sprague--Dawley rats resulted in isolation of 7-n-propylguanine from RNA, but O6-isopropylguanosine. The amounts of the different adducts indicate that attack at both N-7 and O6 of guanine proceed by bimolecular substitution (otherwise significant levels of 7-isopropylguanine should have been seen), but the observed rearrangement indicates that the transition state for reaction at O6 may be much looser than that for reaction at N-7.
Alkylation↗
Synthesis of S-alkyl-L-cysteine from pyruvate, ammonia and alkyl-mercaptan by cysteine desulfhydrase of Aerobacter aerogenes.
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Alkylation↗
Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.
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Alkylating Agents↗
Alkylation of cytochromes c. I. Properties of alkylated beef cytochrome c.
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Alkylation↗
O2- and O4-alkyl pyrimidine nucleosides: stability of the glycosyl bond and of the alkyl group as a function of pH.
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Alkylation↗
Reaction of DNA with alkylating agents. Quantitation of alkylation by ethylnitrosourea of oxygen and nitrogen sites on poly[dA-dT] including phosphotriester formation.
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Adenine↗
Reaction of DNA with alkylating agents. Differential alkylation of poly[dA-dT[ by methylnitrosourea and ethylnitrosourea.
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Alkylation↗
1-Alkyl-3-(3-alkyl-5-nitro-4-thiazolin-2-ylidene)ureas and related compounds as schistosomicides.
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Alkylation↗
N-alkylation of purines with alkyl esters of phosphorus oxy acids.
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Adenine↗
6-ALKYL PENICILLINS AND 7 ALKYL CEPHALOSPORINS.
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Alkylation↗
Alkylation by alcohols in the prescence of dicyclohexylcarbodiimide. Alkylation of thymine, uracil, thymidine, and uridine by alcohols.
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Alcohols↗
Mechanism of the cytotoxic action of alkylating agents in mammalian cells and evidence for the removal of alkylated groups from deoxyribonucleic acid.
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Alkylating Agents↗