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Results for “biological data”

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At least 253 records · Page 14Linked to original sources
PubMed1983

Synthesis, biological data and correlation analysis in a set of analgesic drugs.

A set of ortho-disubstituted benzene derivatives (2-X--C6H4NH--Y) designed as analgesics has been studied. Some physicochemical properties which are potentially correlated with the considered pharmacological activities are determined. Quantitative structure-activity relationships (QSAR) show that the analgesic potency (writhing test) is a function of the hydrophobic-lipophilic parameters associated with the structures under study. Since the derivatives are inactive or very poor inhibitors of prostaglandin biosynthesis, the appropriate modulation of substituents may maximize the differentiation between anti-nociceptive and analgesic activity.

Acetates↗
PubMedDate not supplied

[The adult respiratory distress syndrome. Clinical signs, radiology and biological data (author's transl)].

The etiology of shocklung is diverse. All causes lead to a lesion of the alveolar-capillary membrane with interstitial and subsequent alveolar edema. The clinical manifestations, although variable, are progressive and can be divided into 3 stages, which are the expression of a decrease in pulmonary compliance and of hypoxemia due to a ventilation-perfusion defect (shunt effect). The diagnosis of shocklung must be differentiated from pulmonary edema of cardiac origin by right heart catheterization and demonstrate a normal capillary pressure, a pulmonary hypertension with increased pulmonary resistance and a normal or increased cardiac output. A decreased PaO2 is the first sign of a ventilation-perfusion imbalance. The problem of alveolar-capillary O2 transfer is better defined by the alveolar-arterial O2 difference, the calculation of quantity of the intrapulmonary shunt and the hyperoxia curve. The daily analysis of the hyperoxia curve allows for a better appreciation of the clinical status than the clinical and radiological signs. The prognosis of the shockening is poor inspite of better reanimation technics. The mortality is about 50% and depends on 3 factors: etiology, early diagnosis and correction of the primary insult.

Adult↗
PubMed1976

[Urinary infection and its development. Current diagnostic biological data].

The main object of the present article was to show that, independently of the clinical symptoms, the results of three laboratory examinations permit one to make the diagnosis of urinary infection and its degree of severity. 1) Bacteriuria equal or greater than 10(3) bacteria per ml is already significant of an urinary infection and infection of tissues of the urinary tree. If leukocyturia accompanies this bacteriuria, this does not necessarily show the degree of the infection. 2) The demonstration of specific serum antibodies of the bacterial species responsible for the infection (agglutination technique) is evidence of infection of tissues of the urinary tree, sometimes before the onset of radiological lesions. Furthermore, supervision of the course of the titer of these antibodies assesses the efficacy of the antibiotic treatment undertaken. 3) Using an immunofluorescent technique, the discovery of bacteria antibody immune complexes in the urinary sediment is also a sign of infection of the tissues of the urinary tree.

Agglutinins↗
PubMed2006

Bioinformatics for study of autoimmunity.

Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological data. Autoimmunity research stands to greatly benefit from this data so long as appropriate strategies are available to enable full access to and utilization of this data. The quantity and complexity of this biological data necessitates use of advanced bioinformatics strategies for its efficient retrieval, analysis and interpretation. Major progress has been made in development of specialized tools for storage, analysis and modeling of immunological data, and this has led to development of a whole new field know as immunoinformatics. With advances in novel high-throughput immunology technologies immunoinformatics is transforming understanding of how the immune system functions. This paper reviews advances in the field of immunoinformatics pertinent to autoimmunity research including databases, tools in genomics and proteomics, tools for study of B- and T-cell epitopes, integrative approaches, and web servers.

Allergy and Immunology↗
PubMed2005

Time microscopy for all kinds of data including circadian clock biology.

Data showing a rhythm to the naked eye prominently, barely or not at all were described as kinds A, B and C, respectively. Here, we document good agreement between estimates of maxima and minima with eyeballing and with the addition of point and interval estimates of parameters in kind A data. We also construct a chart that provides estimates of uncertainties that can be obtained objectively while they are more difficult to quantify subjectively; again there is agreement. Interval as point estimates of rhythm characteristics and parameter comparisons are useful in charting all kinds of data and become indispensable as we proceed from kind A to kind C data. Illustrations included herein from molecular biology apply equally to all aspects of transdisciplinary science.

ARNTL Transcription Factors↗
PubMed1984

Fitting a sinusoid to biological rhythm data using ranks.

Biological data are frequently collected with small numbers of observations from several subjects. Often a linear model is fitted to the data by averaging over subjects. Frequently there are considerable between-subject differences, and due allowance should be made for these when the model is fitted by parametric techniques. In this paper it is proposed that the model should be fitted by using the within-subject ranks of the observations. The technique is applied to the problem of estimating the 'cosinor' diagram for biological rhythm data. An example involving melatonin levels, in which there are considerable between-subject differences, is considered. The results obtained by use of the ranks are compared with those of a parametric analysis which makes allowance for the between-subject differences. The results are very similar, but the rank analysis requires much less computation.

Biometry↗
PubMed2005

Evolution of web services in bioinformatics.

Bioinformaticians have developed large collections of tools to make sense of the rapidly growing pool of molecular biological data. Biological systems tend to be complex and in order to understand them, it is often necessary to link many data sets and use more than one tool. Therefore, bioinformaticians have experimented with several strategies to try to integrate data sets and tools. Owing to the lack of standards for data sets and the interfaces of the tools this is not a trivial task. Over the past few years building services with web-based interfaces has become a popular way of sharing the data and tools that have resulted from many bioinformatics projects. This paper discusses the interoperability problem and how web services are being used to try to solve it, resulting in the evolution of tools with web interfaces from HTML/web form-based tools not suited for automatic workflow generation to a dynamic network of XML-based web services that can easily be used to create pipelines.

Computational Biology↗
PubMed1985

Development of hamster tracheal epithelium: III. Illustration of statistical methods for proportional data in biology.

The data in the two companion papers (McDowell et al., 1985a,b) are of a commonly occurring type in which the dependent variable takes on one of a small number of distinct values; we wish to compare the relative proportions in which these values occur. Student's test is inapplicable. We explain here in detail the linear logistic model that is appropriate, using our data as an example. Several reasonable models must first be fit. We did this by the maximum likelihood method, using a computer. We then used a chi 2 test to decide statistically between models. This process amounts to deciding directly which of the independent variables are important in determining the outcome, and thus it is the center of physiologic interest. The outcome depends on the initial choice of parametrization of the model. Generalizations are required in more complicated, but still commonly occurring, types of data.

Animals↗
PubMed1987

A method for simultaneously estimating plasma, erythrocyte, and leukocyte sodium, potassium, and magnesium: reference values and considerations from biological variation data.

We describe a method for measuring plasma, erythrocyte, and leukocyte sodium (Na+), potassium (K+), and magnesium (Mg2+) concentrations in 10-mL blood specimens. After separating cells with Ficoll-Hypaque and washing with isotonic choline chloride, erythrocytes and leukocytes are counted, so that results can be expressed as amount of substance per cell and also to monitor cell integrity and possible contamination. Plasma and cell lysates were analyzed (CV less than or equal to 7.0%) with flame photometry and atomic absorption spectrometry. Reference intervals for an elderly population with values for plasma electrolytes within reference intervals are similar to those for younger healthy subjects. From data on biological variation, reference values for erythrocyte cations are not of much use, and analytical goals for precision are not met, but the results might be useful for monitoring disease progression in individual patients. In contrast, reference values for leukocyte cations are theoretically of use and goals are achieved, but large changes are required before consecutive results can confidently be said to be significantly different.

Aged↗