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Advances in clinical vectorcardiography.

With use of the Frank lead system, still loop and timed vectorcardiograms were recorded in more than 5,000 patients sujected to complete right and left hear catheterization and selective coronary cine angiography. Data so obtianed demonstrated clincila superiority of the vectorcardiogram over the standard 12 lead scalar electrocardiogram. Specific advantages of the vectorcardiogram include (1) recognititin of undetected atrial and ventrcular hypertropy, (2) greater sensitivity in identification of myocardial infaraction, and (3) superior capability for diagnosis of multiple infaractions in the presnece of fascicular and burnany number of simultaneously recoreded electrocardiographic leadsfor the analysis of complex arrhythmias and beat to beat changes in intraventricula conduction. SINCE THE VALIDITY AND USEFULNESS OF THIS TECHNIQUE HAVE BEEN ESTABLISHED, IT SHOULD BECOME PART OF THE ROUTINE NONINVASIVE EVALUATION OF PATIENTS WITH CARDIOVASCULAR DISORDERS.

Adult↗

Analysis of bites on three-dimensional vectorcardiography after coronary artery ligation in dogs.

The serial changes in the QRS loops of vectorcardiograms were investigated following ligation of a branch of the left anterior descending artery (LAD) by the three-dimensional rotation method in 18 dogs. Concave inflections of the QRS loop, defined as "bites," were best delineated when the loop was viewed from a left cranial or right caudal direction. Bites appeared 48 +/- 8 minutes after LAD ligation in all of the dogs, and their development was closely related to the temporal changes in the % sigma R and QRS point score on a standard 12-lead electrocardiogram. Q waves were not observed on the electrocardiograms in 9 dogs. In the remaining 9, they appeared 117 +/- 18 minutes after LAD ligation. The bite duration, area, and amplitude were compared with the anatomical extent of the infarcts. A significant positive correlation was found between bite duration and infarct size. The detection of bites on the three-dimensionally rotated vectorcardiogram appears to have a high sensitivity for anterior myocardial infarction and could potentially become a useful diagnostic tool.

Animals↗

Quantitative electrocardiography and vectorcardiography in postnatally developing rats.

The aim of this study was to provide quantitative descriptions of developmental changes of the cardiac electrical activity of rats as background information useful for assessing abnormal development, for example, in spontaneously hypertensive rats. The data are based on the findings of serial examinations of 11 animals, slightly anesthetized by ether, on whom Frank-ECGs were recorded on days 6, 14, 21, 30, 38, and 53 of life. Typical features of the electrocardiograms during the physiologic development are P waves consisting of one positive deflection in all three leads (x, y, and z); and PQ intervals decreasing between days 6 and 14, whereas the heart rate increases during this period. QRS vector loops and the maximum spatial vector (R) shift to the left, whereas the amplitudes of R first increase but decrease with later age. The shape of the QRS magnitude curves is described, the peaks of which occur later during QRS in relation to increasing age. QRS intervals are considerably shorter than in the adult even at day 53. At this age rats have attained the adult configuration of the QRS loop. From day 30 onward, QRS frequency merges with the T wave. It is concluded that the ontogenetic development of the major electrical forces of the rat heart shows peculiarities compared to those seen with the development of other mammalian species. The most probable morphologic and functional postnatal adjustments are discussed with reference to the causes of the developmental electrocardiographic changes.

Aging↗