SEARCH · Search PubMed
Results for “UPS”
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
The ups and downs of Gs- to Gi-protein switching.
Explore the source record for details and available documents.
The ups and downs of Rho-kinase and penile erection: upstream regulators and downstream substrates of rho-kinase and their potential role in the erectile response.
In the absence of arousal stimuli, the activity of the Rho-kinase-mediated signaling pathway promotes vasoconstriction of the cavernosal arterioles and sinuses, keeping the penis in the nonerect state. Upon sexual arousal or during nocturnal tumescence, nitric oxide (NO), released from nonadrenergic/noncholinergic nerves or from local endothelial cells, induces cavernosal vasodilation, resulting in an elevation in blood flow and intracavernosal pressure to initiate the erectile response. Although NO is thought to be the principal stimulator of penile erection, the signaling mechanism(s) of NO-mediated cavernosal vasodilation is unknown. In this article, we will consider the novel hypothesis that NO induces penile erection through the inhibition of endogenous Rho-kinase-mediated vasoconstriction. Additionally, we will look downstream of Rho-kinase, introducing a potential role for various substrates in the mechanism of Rho-kinase-mediated constriction in the cavernosal vasculature.
The ups and downs of Wnt signaling in prevalent neurological disorders.
In order to function properly, the brain must be wired correctly during critical periods in early development. Mistakes in this process are hypothesized to occur in disorders like autism and schizophrenia. Later in life, signaling pathways are essential in maintaining proper communication between neuronal and non-neuronal cells, and disrupting this balance may result in disorders like Alzheimer's disease. The Wnt/beta-catenin pathway has a well-established role in cancer. Here, we review recent evidence showing the involvement of Wnt/beta-catenin signaling in neurodevelopment as well as in neurodegenerative diseases. We suggest that the onset/development of such pathological conditions may involve the additive effect of genetic variation within Wnt signaling components and of molecules that modulate the activity of this signaling cascade.
Insulin secretion--the ups and downs.
Explore the source record for details and available documents.
Living with the ups and downs of the two signal model.
Explore the source record for details and available documents.
Epidural bupivacaine/fentanyl infusions vs. intermittent top-ups: a retrospective study of the effects on mode of delivery in primiparous women.
This study was designed to determine whether the introduction of epidural infusions containing fentanyl and bupivacaine has affected the mode of delivery in primiparous women attending our maternity department. We reviewed retrospectively the computerized records of 4362 consecutive primiparous women in labour. All the women were admitted with the expectation of a vaginal delivery. The results were analysed using logistic regression analysis adjusted for age, weight, gestation, cervical dilatation at epidural insertion, use of oxytocin, the year of entry into the study and the type of epidural block received. In women receiving an epidural block at 3-6 cm cervical dilatation (n = 1534), those who received an infusion were significantly less likely to have an emergency Caesarean section than those having intermittent 'topups' (P = 0.0019). In the same subgroup of women, the Caesarean section rate specifically for failure to progress followed the same trend, but just failed to reach statistical significance (P = 0.058). This provides evidence to support the theory that epidural infusions containing a low dose bupivacaine/fentanyl combination may reduce the risk of Caesarean section in primiparous women.
An assessment measure to evaluate case write-ups in a medicine core clerkship.
Explore the source record for details and available documents.
UPs and downs in bacterial transcription initiation: the role of the alpha subunit of RNA polymerase in promoter recognition.
In recent years, it has become clear that promoter recognition by bacterial RNA polymerase involves interactions not only between core promoter elements and the sigma subunit, but also between a DNA element upstream of the core promoter and the alpha subunit. DNA binding by alpha can increase transcription dramatically. Here we review the current state of our understanding of the alpha interaction with DNA during basal transcription initiation (i.e. in the absence of proteins other than RNA polymerase) and activated transcription initiation (i.e. when stimulated by transcription factors).
Automatic sensor algorithms expedite pacemaker follow-ups.
OBJECTIVE: Automatic algorithms can be used to optimize settings and reduce the duration of pacemaker (PM) clinical follow-up. METHODS: This study prospectively evaluated 87 patients (74.2 +/- 10.7 years old, 52% men) who received PM with the Autoslope algorithm. Patients randomized to the manual group (group M, n = 43) performed a walk test and used sensor-indicated rate histograms to adjust the sensor, while in the automatic group (group A, n = 44) the sensor was automatically adjusted by the Autoslope. The patients were followed for 6 months. Follow-up time required for device interrogation and optimal sensor set-up, and the number of sensor parameters reprogramming were recorded. Changes in the patients' activity level were also evaluated. RESULTS: Group A required significantly less follow-up time than group M (9.4 +/- 5.7 min vs 13.5 +/- 8.5 min, P = 0.0002). The average number of sensor parameters reprogrammed during visits was significantly lower in group A than M (0.6 +/- 0.9 vs 0.9 +/- 1.3, P = 0.048). Threshold was adjusted 34.4% of the time in the sensor evaluations in group M versus 12.9% in group A (P = 0.0004). Although more patients in group A reported being more active, the changes in patients' activity level did not lead to increasing sensor setup time or number of parameter reprogramming in either group. CONCLUSIONS: Auto sensor adjustment required less time during routine PM clinical follow-up by reducing steps needed for manual sensor threshold adjustment.
Push-ups: a new technique in intravenous urography.
Explore the source record for details and available documents.
[Ups and downs of therapeutic cloning].
Explore the source record for details and available documents.
[Check-ups for malignant urologic tumors].
Explore the source record for details and available documents.
[Follow-ups after kidney transplantations].
Explore the source record for details and available documents.
Different accuracies of rapid enzyme-linked immunosorbent, turbidimetric, and agglutination D-dimer assays for thrombosis exclusion: impact on diagnostic work-ups of outpatients with suspected deep vein thrombosis and pulmonary embolism.
The requirement for a safe diagnostic strategy should be based on an overall posttest incidence of venous thromboembolism (VTE) of less than 1%, with a negative predictive value of more than 99 to 100% during 3-month follow-up. Compression ultrasonography (CUS) and spiral computed tomography (CT) currently are the methods of choice to confirm or rule out deep venous thrombosis (DVT) and pulmonary embolism (PE), respectively. CUS has a negative predictive value (NPV) of 97 to 98%, indicating the need to improve the diagnostic work-up of patients with suspected DVT by clinical score assessment and D-dimer testing. Spiral CT as a stand-alone method detects all clinically relevant PEs and a large number of alternative diagnoses. It rules out PE with a NPV of 98 to 99%. Spiral CT is expensive, emphasizing the need to improve the diagnostic work-up of patients with suspected PE by the use of clinical score assessment and D-dimer testing. Clinical score assessment for DVT and PE has not safely ruled out VTE in multicenter studies and in routine daily practices. Modification of the Wells clinical score assessment for DVT by elimination of the "minus 2 points" for alternative diagnosis will improve the reproducibility of the clinical score assessment. The combination of a first negative CUS and a negative SimpliRed or an enzyme-linked immunosorbent assay (ELISA) VIDAS D-dimer of < 1,000 ng/mL safely exclude DVT (NPV > 99%) irrespective of clinical score assessment and without the need to repeat CUS in approximately 60 to 70% of patients. The rapid quantitative and qualitative agglutination D-dimer assays for the exclusion of VTE are not sensitive enough as stand-alone tests and should be used in combination with clinical score assessment. A normal rapid ELISA VIDAS D-dimer test as a stand-alone test safely excludes DVT and PE, with a NPV of 99 to 100%, irrespective of clinical score, without the need of CUS or spiral CT. The combined strategy of a rapid ELISA VIDAS D-dimer followed by objective testing with CUS for DVT and by spiral CT for PE will reduce the need for noninvasive imaging techniques by 40 to 50%.
[Cataract extraction in chronic iridocyclitis. Long-term follow-ups].
Eighty-six patients with chronic anterior uveitis were followed up for an average of five years after cataract surgery. In most cases the course of the uveitis was favorably influenced: inflammatory signs were reduced in 70% and the frequency of recurrence in 94%. With regard to the postoperative course, there was no significant difference between the eyes in which an iris suture had been performed and those in which it had not. One should therefore not hesitate to remove cataracts in patients with chronic uveitis.
Varicella-zoster virus vaccine--grown-ups need it, too.
Explore the source record for details and available documents.
The ups and downs of face perception: evidence for holistic encoding of upright and inverted faces.
A visual-search task was used to investigate the influence of facial organisation on discrimination of an internal facial feature. Participants searched for a downturned mouth in arrays of one to six faces that differed only in the target feature, with distractor faces containing an upturned mouth. Feature search was tested in four different face contexts: upright unaltered faces, inverted unaltered faces, upright faces in which the internal features were scrambled, or inverted scrambled faces. Normal face organisation facilitated feature search in upright faces, but slowed it in inverted faces. These findings demonstrate an interdependence of features and their configuration in the perceptual analysis of both upright and inverted faces.