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At least 253 records · Page 14Linked to original sources
PubMed1986

Guinea pig complement fixation by tissues from hypocomplementaemic renal diseases.

Recently many studies have been done to identify complement pathway activation in renal tissue from patients with renal disease. We examined whether tissues obtained by renal biopsy from such patients would fix guinea pig complement. Nine out of 15 patients with systemic lupus erythematosus (SLE), 4 out of 7 patients with mesangiocapillary glomerulonephritis (MCGN), and 2 out of 7 cases with acute glomerulonephritis (AGN) fixed guinea pig C3. We found that tissues from 5 out of 9 guinea pig C3-positive SLE cases fixed guinea pig C4, while none of the guinea pig C3-positive tissues from patients with MCGN or AGN fixed guinea pig C4. These guinea pig C3-positive renal tissues were further studied for interaction with C4-deficient guinea pig serum, EDTA guinea pig serum, heated guinea pig serum, and EGTA Mg2+ guinea pig serum. The results indicated that activation of both the alternate and classical complement pathways occurred with tissues from patients with SLE, while activation of the alternate pathway occurred with MCGN and AGN. Results for tissues from AGN and MCGN patients indicated the presence of C3 convertase and protease which interacted with guinea pig C3.

Biopsy↗
PubMed2004

A biomechanical comparison of initial soft tissue tibial fixation devices: the Intrafix versus a tapered 35-mm bioabsorbable interference screw.

BACKGROUND: Biomechanical testing of the Intrafix device has not been performed using human tibiae. HYPOTHESIS: The Intrafix device would provide comparable or superior tibial fixation of a quadrupled hamstring tendon graft to a 35-mm-long bioabsorbable interference screw. STUDY DESIGN: In vitro, biomechanical study. METHODS: Eight paired human tibiae and 16 quadrupled hamstring tendon grafts were divided into 2 groups. Each quadrupled hamstring tendon graft was fixed in a tunnel sized to 0.5 mm graft diameter with either an Intrafix device or a screw. RESULTS: Displacement at failure was greater in the Intrafix group (17.3 +/- 4.6 mm versus 10.9 +/- 4.4 mm, P =.002). Load at failure (796 +/- 193 N versus 647 +/- 269 N), stiffness (49.2 +/- 21.9 N/mm versus 64.5 +/- 22 N/mm), and bone mineral density (0.74 +/- 0.15 gm/cm(3) versus 0.74 +/- 0.14 gm/cm(3)) did not display significant differences for the Intrafix device and the screw, respectively (P >.05). CONCLUSIONS: Displacement at failure was greater for the Intrafix device. CLINICAL RELEVANCE: Increased displacement at failure for the Intrafix group suggests slippage from sheath channel deployment. Concentric fixation may not occur when less than optimal tibial bone mineral density increases the difficulty of attaining precise sheath deployment and quadrupled hamstring tendon graft strand alignment.

Bone Screws↗