[Telepathology--a powerful diagnostic method for the 21st century].
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Progress in pathology is related to application of new biological techniques and impact of electronic devices affecting transfer of information and images. The increase of specification of all kinds of disease classification induces a specific need for data exchange and expert consultation. The momentary technical situation in communication lines connected with medical fields, especially pathology is characterized by parallel operation of two basically different communication systems, namely a) systems based upon computerized data exchange (E-mail, etc.), and b) systems working at public access, i.e. telephone lines and their successors (digitized network, satellite system). Practical use in telecommunication in pathology has been gathered nearly exclusively by use of the second (public) system, and includes intraoperative classification of histological images (frozen sections), expert consultations, panel discussions, quantitative measurements, and access to image data bank systems. The use of remote control microscopes has been reported to work without major errors from Norway and Switzerland. In Norway, images and diagnostic informations are transferred by use of broad band networks (satellite communication), whereas in Switzerland the digitized network ISDN is used. The experiences show clearly that remote control microscopes are practicable and reliable tools for daily diagnostic work of pathologists, and that the quality of the transferred images is sufficient to allow sophisticated diagnoses. Expert consultations are routinely performed by use of the common telephone network in lung pathology, and can not be underestimated in their impact on the daily work. Accuracy of diagnosis, quality of staining and tissue handling, and reliability of diagnosis are automatically improved besides the positive legal aspects.
At present, the exchange of information between clinicians and pathologists are limited to mail, telefax and telephone. The bi-directional video communication using at least two digitized phone lines (ISDN) is an additional medium for video-conference and for image exchange. The MECOM system (Medical Communication) has been set up in the department of pathology of Aixla-Chapelle Hospital (Germany) and has routinely used for two years between 4 local hospitals. Now it is mainly used for staff discussions between pathologists and practitioners involved in different oncological fields. Mecom can transmit any kind of high resolution images (x rays films, scanner images, histologic slides...) which are useful or necessary during medical staff discussions. This system requires only two phone lines to be operative. However it can turn on up to twelve parallel ISDN lines which allow to transmit 768 kbytes/sec. It manages the SG3, HVQ and H320 compression algorithms and allows the transmission of still images at a resolution varying from 256/240 to 512/480 pixels. Mecom is a modulable system which adapts to the needs. It has the following advantages. Emergency inter-disciplinary conferences. Real time images, discussion between a pathologist and an expert to confirm histo-pathological diagnosis. Abolition of distances. That is specially useful or necessary in countries with low medical population and poor transportation network.
The objective of this work was to compare diagnoses achieved through the traditional methods of current pathology practice versus diagnoses achieved through a selection of image on a telediagnostic TV-monitor. The Kappa coefficient between the two protocols of k = 0.26 SE(k) = 0.06 z = k/SE(k) = 4.3 (p < 0.001) allows us to conclude that there is a good reliability between video and glass slide diagnoses.
The histologic or cytologic diagnosis of a tumoral lesion may be sometimes very difficult to do even for a senior pathologist. Nevertheless, it is necessary to recognize a malignant process with reliability and security. The usual way to solve some difficult problems is firstly to search documentations in books or atlas and then to discuss the slides in common. Sometimes it is necessary to dispatch the original documents to a national or international expert. Now computers are used in any private or public department of Pathology. Some new informatics developments allow to send good digitized pictures to an expert and to discuss with him. It is also possible to elaborate a data base of digitized images which can be edited on CD-Rom. We describe the development and the use of these technics in France and elsewhere. It seems that they could have an increasing role for quality assurance in tumoral pathology.
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The identification of small cells in cervical/vaginal smears is usually considered as a difficult task, as well when they are examined through a classical light microscope or thanks to a teletransmission system. In this paper, we have compared both methods. 53 cases of smears with small cells were examined by two pathologists. The different types of small cells were described. The results and the discrepancies were studied. The reliability was rather good (45/53 cases, 84.6%). The main images were recorded onto a videotape for teaching purposes.
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Telemedicine is rather new activity covering various approaches in order to fulfill the main task which can be expressed in more comprehensive words such as "remote medicine" or "medicine on distance". One of definitions of telemedicine given by the European Commission for Telemedicine says that "telemedicine is fast access to distributed medical expert knowledge using telemedicine and information technologies regardless of actual location of a patient or relevant information". The first connection has been established with Zagreb, Croatia in September by means of PHAROS. In October 1996 the Institute of Pathology with the Radiology and Ophthalmology Clinics of University hospital of Sarajevo has joined the experimental project "SHARED" (a telemedicine initiative to support remote health care structure, proposed by the San Raffaele International Biomedical Science Park with Stato Maggiore della diffesa and European Space Agency). Due to problems in infrastructure and lack of experts, small country like Bosnia and Herzegovina (BiH) sees telemedicine as future in its health care organizing.
Long distance transmission by the telephone network have offered new facilities in transmitting images in real time. Pathologists and other specialists like radiologists are now using these transmissions of digitalised pictures, both for diagnostic support and for constituting image data base for teaching purposes. Haematological application of this new method is shown as a particularly good example.
The Virtual Microscope is being designed as an integrated computer hardware and software system that generates a highly realistic digital simulation of analog, mechanical light microscopy. We present our work over the past year in meeting the challenges in building such a system. The enhancements we made are discussed, as well as the planned future improvements. Performance results are provided showing the system scales well, so that many users can be adequately serviced by an appropriately configured data server.
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