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The effect of triglycyl-lysine-vasopressin (terlipressin INN, Glypressin) on skin blood flow, measured with laser Doppler flowmetry, thermography and plethysmography. A dose-response study.

Triglycyl-lysine-vasopressin (TGLVP) has been shown to reduce blood loss in connection with early excision of experimentally induced burns in pigs. In order to determine an appropriate dosage of TGLVP in patients with burns, a dose-response study was undertaken. TGLVP was administered intravenously in various doses to healthy volunteers, and skin blood flow was measured with laser Doppler flowmetry, thermography and plethysmography. Blood pressure, heart rate and electrocardiac activity were monitored as well as serum and urine changes. The doses of 5, 10 and 20 micrograms TGLVP/kg b.wt. caused statistically significant reduction of skin blood flow; minimal values were 35, 26 and 25% of predrug values for the three doses, respectively. Thermography and plethysmography were less sensitive for detecting effects of TGLVP than laser Doppler flowmetry. Minor effects on blood pressure and heart rate were recorded after TGLVP, but no disturbances in electrocardiac activity. Urinalyses revealed an antidiuretic action of TGLVP. The study supports earlier findings and suggests a dose level of TGLVP for the use in excision of burns.

Adult↗

Liquid crystal thermography of the spine and extremities. Its value in the diagnosis of spinal root syndromes.

Cholesteric liquid crystals are special compounds that display specific color changes in response to variations in temperature. Their responses can be graphically demonstrated by means of color thermography. A new color contract thermographic technique is described utilizing liquid crystals embedded in elastic flexible sheaths. These sheaths, when inflated, conform to the varied contours of the torso and extremities and, therefore, the new thermographic technique is especially well suited to the study of the skin dermatomes and myotomes. Typical heat patterns have been observed in root compression syndromes and particularly at the S-1, L-5, L-4, C-6, C-7, and C-8 levels. A high degree of anatomic accuracy can thus be achieved, comparable to or better than can be achieved by electromyography or myelography. Liquid crystal thermography can serve to screen patients for myelography and can complement myelography in identifying clinically significant abnormalities. The imaging technique correlates well with clinical and surgical findings, and constitutes one of the first attempts by means of a concomitant study of the body dermatomes to objectively document the subjective complaint of pain.

Adult↗

Thermography: a call for scientific studies to establish its diagnostic efficacy.

Thermography is reported to provide objective evidence of physiologic dysfunction in patients with low back pain and sciatica. This diagnostic test is appealing because it is painless, non-invasive, has no known adverse biologic effects, presents comprehensible graphic information, requires only a moderate investment in equipment, and should be an inexpensive procedure to perform. Unfortunately, the complete scientific information necessary to assess its diagnostic reliability is not available. This article discusses other experiments which have been performed to assess the diagnostic accuracy of tests for low back pain and sciatica and outline some features of an experimental protocol which would be essential to establish the reliability of thermography in the diagnosis of low back pain and sciatica due to herniated nucleus pulposus.

Back Pain↗

Thermography--wither the niche?

OBJECTIVE: To review the current medical and legal status and future directions of thermography. DATA SOURCES: Medical and legal journals published from 1956 onwards; report of the United States Office of Health Technology Assessment and personal communication with the author of that report; report of Australian Institute of Health and personal communication with the author; personal communication with members of the Therapeutics and Technology Assessment Subcommittee, American College of Neurology and with the Chairperson of the Commission of Technology Assessment and Efficacy Studies, American College of Radiology. STUDY SELECTION: Reports and position statements of statutory bodies and specialist colleges in the United States and Australia; legal judgments in both these countries. CONCLUSION: Acceptance of thermography is largely confined to those who use it and profit by its use.

Australia↗

[Thermography in sport injuries and lesions of the locomotor system due to sport].

Using the infrared-thermography a exact picture of the body surface can be obtained. Injuries are recognized by a local hyperthermy, if the impaired structures do not lie too deep under the body surface. In combination with anamnesis and clinical and radiological examination the infrared-thermography plays an important role in the diagnosis, management and control of therapy. The results of examinations of 82 patients with distorsions, ruptures of tendons or ligaments, injuries of the meniscus and tendo- and chondropathias as well as of 50 athletes are described. In all cases a hyperthermy was found in the area of injury. In those cases, in which an injury was not the cause of the hyperthermy, other processes could be found (furunculosis, phlebitis, tumor).

Athletic Injuries↗

Microwave thermography: a method of detecting subsurface thermal patterns.

A discussion has been given of the principles and techniques of microwave thermography. The method is analogous to infrared thermography in that it detects thermal radiation emitted by the body. It differs in that it is sensitive to temperatures several centimeters beneath the skin surface and has coarser spatial resolution. Results are shown of successful attempts to detect subsurface thermal gradients in feline and human tissue. Planned clinical evaluation is described.

Animals↗

Thermography in diagnosing deep venous thrombosis of the lower limb.

Phlebography and thermography of the lower limbs were performed on 58 patients suspected on the basis of clinical examination to have deep venous thrombosis of the lower limb. Both thermography and phlebography were consistently positive in 34 and negative in 17 cases. The skin temperature was lowered in four cases evidently because of an arterial spasm caused by deep venous thrombosis. No significant temperature elevation was established in three anamnestically and phlebographically older cases.

Humans↗

[Evaluation of efficacy of a disposable monitor for surface temperature (PROCHECKER) compared with thermography].

We evaluated efficacy of a disposable monitor for surface temperature (PROCHECKER) compared with thermography. Changes in surface temperature after epidural block with mepivacaine 1% were measured using both PROCHECKER and thermography. Measured areas were regions of bilateral Th 4, 6, 8, 10, 12 and along the midmammary line. The surface temperatures on all areas were measured before, 15 min after and 30 min after the epidural block. Discrepancies of the temperatures measured by the two methods were found in 16.7% of all measured areas, and discrepancies in changes in the temperature were found in 6.7%. In conclusion, a disposable monitor for surface temperature (PROCHECKER) is effective and sensitive to measure changes in the temperature.

Disposable Equipment↗

The objective corroboration of back pain through thermography.

The potential usefulness of thermography as an aid to the diagnosis of neuro-musculo-skeletal disease in occupational settings is discussed. The characteristics of the infrared spectrum are briefly outlinded, followed by a description of basic concepts and technics necessary to ensure reproducible results. A pilot study demonstrating the association between thermographic changes and back pain is presented. Findings are compared with normal thermograms and are statistically evaluated. Thermography seems to have the potential to be developed into a useful tool of occupational medicine in general.

Back Pain↗

[Analysis of physiologic and abnormal pictures of uterine cervix by means of infrared thermography].

RATIONALE FOR THE STUDY: Diagnosis of the uterine cervix lesions remains a key element of the women's health care especially in the context of the cervical carcinoma prophylaxis. The infrared mapping constitutes a new generation biophysical diagnostic method of potential application in medicine. OBJECTIVE: The study was planned to analyze uterine cervix thermograms in both physiology and pathology of this organ. An attempt was made to establish the standard thermographic pattern of the portion. MATERIAL AND METHODS: The study population consisted of 51 women aged from 20 do 70 years. In total, 109 thermographic patterns were analyzed by the computer processing of the thermovision data. In order to establish a physiologic standard, 14 thermograms of the normal cervix were analyzed in detail. Furthermore, thermograms of such cervical lesions as endocervical polyp (3 patients), erosion (PAP II) (11 cases), CIN I-III (9 patients) and invasive cancer (6 patients) were studied. The diagnosis was based on clinical, cytologic and colposcopic criteria as well as on the pathology report. The infrared camera AGEMA AGA-880 and the specialized software was used. The measurements were done in a standardized climatic environment. RESULTS: Comparisons between the studied groups revealed significant differences between invasive cervical cancer and benign lesions or healthy cervix. Significant were also differences in mean temperature and highest temperature for all the studied groups. The difference in mean whole portion temperature between the normal cervix and invasive planoepithelial cancer amounted to 1.4 degrees C while in comparison to other lesions it did not exceed 0.5 degree C. Statistical analysis of the averaged profiles of cervical temperatures has also shown significant differences between invasive cancer and the remaining groups--by 1.5 degrees C in average. Strong interrelationships (p < 0.001) were found among the single results of thermography measurements within all the groups. The thermographic profiles of all 14 thermograms of normal portion did not exceed the two standard deviations range of the established standard with the mean temperature of 36.56 degrees +/- 0.56 degree C. CONCLUSIONS: 1. The established thermographic mapping patterns of the normal cervix may form a basis for the future evaluation of the diagnostic application of computer thermography in gynecology. 2. Statistically significant differences were found in thermographic profiles of the portion between the normal cervix and such cervical lesions as endocervical polyp, erosion (PAP II), CIN and invasive cancer. 3. Invasive cervical cancer reveals thermographic pattern of relatively high specificity within the analyzed cervical lesions.

Adult↗

[Diagnostic value of thermography and endothelin concentration in serum of children with Raynaud's Syndrome].

OBJECTIVE: The primary Raynaud's Syndrome may occur in pubescent children, the secondary is connected with connective tissue diseases. The aim of this study was to evaluate the diagnostic value of thermography and endothelin concentration in patients with Raynaud's Syndrome (RS). MATERIAL AND METHODS: 49 patients aged 11 to 18 years with clinical symptoms of RS and 12 healthy children participated in the study. 17 patients had secondary and 32 primary RS. Thermography was conducted in all children. Vasomotor disturbances were diagnosed by Doppler ultrasonography. Palm temperature measurements were taken in room temperature before, directly after the cooling test and 4 minutes later. ET-1 serum concentration was tested by ELISA. RESULTS: The mean palm temperatures after the cooling test were significantly lower than in control group. (26.28 +/- 3.13C vs 30.26 +/- 1.11C p<0.001). There was no difference between primary and secondary RS. After cooling, the palm temperatures were statistically lower than before the test in all children (primary RS -19.56 +/- 1.68; secondary RS -18.7 +/- 1.02; control group -- 18.98 +/- 0.39). The warming up speed of palm after 4 minutes from the cooling test was similar in investigated and control groups. There was no statistically significant difference in the mean concentration values of ET-1 in sera of children with RS and the control group (1.62 +/- 0.86 pg/ml vs 1.27 +/- 0.4 pg/ml). CONCLUSIONS: 1. Thermographic estimation of palm temperatures in children with RS is a good diagnostic method of vasomotor disturbances. 2. Assay of ET-1 serum levels seem not to have significant diagnostic value.

Adolescent↗

[The usefulness of thermography in the diagnostics of dry eye syndrome].

PURPOSE: The aim of the study was to evaluate corneal temperature in patients with dry eye syndrome, and in normal subjects by measuring with infrared radiation thermography. MATERIAL AND METHODS: Each eye of 9 patients with dry eye syndrome and each eye of 13 normal subjects, were evaluated in this study. The corneal surface temperature was measured during 15 seconds after opening the eye. RESULTS: Mean corneal temperature was lower in the dry eye syndrome patients compared with the control group. Decrease in time of mean corneal temperature in patients with dry eye syndrome, was lesser than in the control group. CONCLUSIONS: The study shows the usefulness of thermography in the diagnosis of dry eye syndrome.

Adult↗

Thermography of the hand and wrist: practical applications.

Thermography is a noninvasive imaging technique that visualizes extremely small but significant cutaneous sensory segment temperature alterations, which reflect physiologic changes not depicted by static techniques including CT and MR imaging. The equipment in current use, techniques of upper extremity examination, criteria for interpretation, a classic body of thermographic patterns associated with sympathetic nerve dysfunction, and theories relating to their mechanisms have been summarized. The particular contributions of thermography in diagnosing and corroborating acute, recurrent, and chronic clinical symptoms related to the hand and wrist have been illustrated and discussed.

Adult↗

[The atypical vessels of the feminine breast in the plate-thermography (author's transl)].

In 215 atypical--including 109 carcinomas and 8 carcinomata in situ--as well as 294 verified benign histological evidences of the breast the value of the main clinical, mammographical and plate-thermographical symptoms is examined. The clinical palpable tumors, the mammographical irregular connective tissue and/or the homogenous opacity, as well as plate-thermographical atypical vessels proved to be a relatively insecure sign of a carcinoma. The individual characteristics of the atypical vessels in the plate-thermography according to Tricoire were worked out. The sudden and blunt breaking-off of a atypical vessel has to be considered the most suspicious sign for a carcinoma. The plate-thermography according to Tricoire is also usable as additive method for diagnosis of benign breast-tumors that don't have to be exstirpated.

Adenocarcinoma, Scirrhous↗

[Distant thermography in the diagnosis of digestive organ diseases in children].

The authors review the most urgent problems of alimentary diseases in children: diagnosis, differential diagnosis and early detection with the use of remote thermography, an up-to-date noninvasive and atraumatic research method. The method was demonstrated to be highly informative in diseases such as gastroduodenitis, peptic ulcer, chronic pancreatitis and others. The significance of remote thermography in revealing functional pathology of the alimentary organs in children is emphasized.

Age Factors↗

[Thermography in assessing the microcirculation of patients with acute and chronic viral hepatitis].

The important role is emphasized of microcirculatory disorders in the pathogenesis of viral hepatitis and the necessity of their early diagnosis. For this purpose the method of infrared thermography of the upper extremities (hands) was used that allowed to reveal pronounced disorders of the peripheral hemodynamics in a significant number of patients with acute and chronic viral hepatitis, in particular, hepatitis B that promoted a more severe, progressive course of the disease. It is concluded that for instituting pathogenetically substantiated treatment, prognosis and prevention of unfavourable outcomes it is necessary to supplement clinico-laboratory data by instrumental examination of the terminal blood flow, in particular, thermography of the extremities.

Acute Disease↗