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Results for “Splenic Neoplasms”

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At least 253 records · Page 14Linked to original sources
PubMed2003

[Mechanisms of inhibiting thymus endocrine function in tumor growth].

The experiments were conducted on a model of intraorganic growth of Geren carcinoma (GC) in spleen of non-linear mice. It has been shown that titer of thymic serum activity (TSA) decreased sharply in the blood at a stage of settling transplants down (7th day), while the level of an inhibitor for thymic serum factor (FTS) increased in a statistically significant way. At progressive tumor growth, the level of TSA in the circulation raised a little on the 10th day but it was still reduced in comparison with that before inoculation of GC. Traces of the inhibitor for FTS were detected only in 18 and 25 days of tumor growth. We have found resemblance between these substances and those in low-molecular extracts of lymphocytes (LEL). The LEL from cells of the spleen and the thymus of intact rats contained TSA and FTS inhibitor, both of T-cell origin, in ratio 1:1. Production of TCA and the FTS inhibitor was peculiar to immature cortisone-sensitive T-lymphocytes. Anti-FTS serum in vitro completely neutralized TSA in both the blood and an extract of thymocytes but it effected neither the contents of TSA in the LEL of the spleen nor the level of FTS inhibitor in all the samples investigated. The data received testify to an important role of FTS inhibitor in the pathogenesis of tumor progression.

Animals↗
PubMed2004

Anaplastic pancreatic carcinoma. A case report and review of literature .

CONTEXT: Anaplastic pancreatic carcinoma is an aggressive neoplasm with survival measurable in weeks. It presents as a large cystic mass with loco-regional and distant spread. Three histological types have been described: pleomorphic, spindle cell and sarcomatoid. CASE REPORT: We describe the case of a 74-year-old woman with pleomorphic anaplastic carcinoma of the pancreas diagnosed after laparoscopic biopsy. The patient had a rapid downhill course with progression of the disease and demise within 4 weeks after diagnostic laparoscopy. CONCLUSION: Due to the rapid spread of the disease, no effective cure exists for these tumors. A brief review of the histological and radiological findings and the possible mechanisms of the pathogenesis of anaplastic tumors is included in the discussion.

Adrenal Gland Neoplasms↗
PubMed1979

[The contribution of laparoscopy to diagnosis of malignant lymphomas (author's transl)].

Peritoneoscopy revealed in 15 patients with malignant lymphomas splenomegaly (13 patients), hepatomegaly (10 patients, 8 of them with impressive or suspicious alterations of the liver surface) and enlargement of retroperitoneal lymph nodes or localised infiltration of a jejunal loop (3 patients). Aimed biopsy of liver, spleen or lymph nodes frequently established the diagnosis definitively. The various features of malignant lymphomas observable at peritoneoscopy are described. Based on these experiences peritoneoscopy is recommended in suspected malignant lymphomas as a real diagnostic aid.

Humans↗
PubMed1992

Metastatic granulosa cell tumor in a mare.

A 5-year-old Quarter Horse mare was referred for evaluation of an acute non-weightbearing lameness of the left hind limb in which musculoskeletal abnormalities had not been detected. After admission, the mare had signs of colic. Exploratory laparotomy revealed the left ovary to be large, masses in the left sublumbar space, and diffuse infiltration of the mesentery, omentum, liver, and spleen with variably-sized masses. The mare was euthanatized, and granulosa cell tumor was identified on histologic examination of the left ovary, left sublumbar and cranial thoracic lymph nodes, omentum, mesentery, liver, spleen, and lung.

Animals↗
PubMed1992

Isolated traumatic accessory splenic rupture: a case report and literature review.

Although small and relatively protected, an accessory spleen can be the cause of acute intraabdominal symptoms following minimal trauma. Although a splenic fracture or laceration may not be apparent on by CT scan, the scan cannot rule out the possibility. The diagnosis of splenic injury should be entertained in light of appropriate history and physical findings. The case we present and prior similar cases are a useful review of isolated accessory splenic rupture due to blunt trauma.

Abdominal Injuries↗
PubMed1991

Rupture of the spleen caused by primary angiosarcoma. Case report.

Splenic angiosarcoma is rare with only about 60 reported cases. A case is presented in which the tumor caused spontaneous rupture of the spleen and showed characteristics of an infiltrating echinococcosis of the liver and spleen in ultrasound and computed tomography imaging. The literature is reviewed in regard to clinical features, diagnosis and management.

Diagnostic Errors↗
PubMed2006

Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon.

Epithelioid hemangioendothelioma is an extremely rare vascular bone tumor with a slow growth and poor prognosis. The term was designed to describe neoplasms that had an appearance in between hemangiomas and sarcomas. Various synonyms for epithelioid hemangioendothelioma are used clinically: low grade anaplastic angiosarcoma, cellular hemangioma, histiocytoid hemangioma and angioendothelioma. However, it represents 1% of all vascular neoplasms and is locally aggressive. We report the course of disease of a 47-year-old man who presented to our clinic with unspecific abdominal and back pain. Radiological findings revealed multiple lesions in the spine as well as liver and spleen involvement. Tumor histology of the bone and liver biopsies confirmed the diagnosis of epithelioid hemangioendothelioma. Although treatment was initiated with thalidomide, the patient developed multiple organ dysfunction syndrome (MODS) and succumbed to his disease. This case report may contribute to the data on clinical findings and natural history of this rare tumor.

Angiogenesis Inhibitors↗
PubMed2007

[A case of recurrent colon cancer with urinary bladder, para-aortic lymph nodes, and spleen metastases successfully treated with CPT-11].

The patient was a 71-year-old woman with sigmoid colon cancer with urinary bladder invasion, for which sigmoidectomy with D 3 lymphadenectomy and partial cystectomy was performed. After surgery, the patient was started on 4 courses of 6-week systemic chemotherapy (500 mg/m(2) 5-FU and 200 mg/m(2) l-LV weekly). However, 4 months later, CT revealed local recurrence in the urinary bladder and recurrence in the para-aortic lymph nodes and spleen. Therefore, low-dose CPT-11 therapy (40 mg/m(2) once per week) was instituted, which achieved a complete response as revealed by CT for response evaluation 5 months after the start of therapy. Up to the present, after 8 months no recrudescence or recurrent lesions in other organs have been observed. The patient developed mild side effects such as grade 1 nausea, anorexia, and leukopenia, but has a well-maintained QOL.

Adenocarcinoma↗
PubMed1978

[Angiography in abdominal diseases (author's transl)].

Angiography of arteries and veins in the abdominal and retroperitoneal compartement is a valuable routine roentgenologic procedure. Its value in the diagnosis of vascular disorders is apparent. Regarding space occupying lesions in the abdomen angiography is an aid in diagnosis and differential diagnosis and provides information on the curability. Visualization of the venous system will give mainly information on the extent of a tumor. For an evaluation of portal hypertension the arterial indirect visualization of the portal venous system is superior to the direct percutaneous splenoportography. In the acute gastrointestinal bleeding selective angiography is able to demonstrate the bleeding site.

Abdomen↗
PubMed1990

Vincristine sulfate as single-agent chemotherapy in a dog and a cat with malignant neoplasms.

A 12-year-old 4-kg spayed domestic shorthair cat with a poorly differentiated fibrosarcoma of the rostral aspect of the mandible and an 11-year-old 13-kg castrated dog of mixed breeding with pulmonary metastatic hemangiosarcoma were treated with 0.5 mg of vincristine sulfate/m2 of body surface, IV, weekly. Three months after beginning treatment, both animals had complete clinical remission. The role of this vinca alkaloid as a single agent for malignant neoplasms has seldom been discussed in the veterinary scientific literature. The results of these two cases indicate that single-agent vincristine sulfate chemotherapy is effective in the treatment of feline fibrosarcoma and canine hemangiosarcoma.

Animals↗