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At least 253 records · Page 14Linked to original sources
PubMed1983

Early exposure to sugars influences the sugar preference of the adult rat.

Female rats were maintained on either a High Sucrose or High Glucose diet during gestation and lactation. Their pups were continued on the same diet as their dam until they were 42 days of age; thereafter all animals were maintained on laboratory chow. From 21-84 days of age, each rat was given a weekly two-choice preference test between the High Sucrose and High Glucose diets. Rats that were fed the High Sucrose diet throughout their early development had heavier body weights and a greater preference for the High Sucrose diet beginning on Day 63 than did the rats that were fed the High Glucose diet. Rats fed the High Glucose diet demonstrated a greater preference for the High Glucose diet during adulthood. These data indicate that early dietary experience can modify the rat's subsequent preference for sugars.

Animals↗
PubMed1996

Nucleotide-sugar binding to ribosomes. Comparison of affinity and capacity of gastric mucosa and liver ribosomes to sugar-nucleotides.

Highly purified ribosomes from gastric mucosa and liver were isolated and tested for their affinity and capacity toward UDP- monosaccharide binding. Ribosomes from both tissues bind UDP-N-acetylglucosamine nearly at the same level with similar affinity, but binding capacity of gastric ribosomes to UDP-N-acetylgalactosamine was twice higher than in case of liver ribosomes, and with higher affinity than in case of UDP-N-acetylglucosamine. The binding of UDP-N-acetylgalactosamine to mucosa ribosomes requires the whole sugar-nucleotide structure.

Acetylgalactosamine↗
PubMed1986

The long-term effect of dietary administration of refined sugars and sugar alcohols on plasma biochemistry, urine biochemistry and tissue histology in mice given a limited degree of dietary self-selection.

A prototype animal feeding model is described in which mice were meal-fed a balanced diet but were given free access to water (controls) or 20% (w/v) solutions of glucose, sucrose, fructose, xylitol or sorbitol. Under these conditions it was found that the provision of an alternative energy source, in the form of a refined carbohydrate, produced marked effects on total energy intake, mouse cube (i.e. balanced energy) intake and body weight. There were also changes in the metabolic states of the animals as assessed by serum levels of glucose, urea and cholesterol, plasma levels of lactate and D-3-hydroxybutyrate, and urinary excretion of urea and oxalate. Histological examinations of tissue indicated that the sucrose-fed mice had a tendency to suffer from acute congestion of the lungs and liver steatosis. Given a limited degree of dietary self-selection it appears that mice are more likely to be at risk of excessive food consumption and obesity when given glucose- or sucrose-containing diets than they are when fructose-, xylitol- or sorbitol-containing diets are given.

Animals↗
PubMed1986

The effect of dietary refined sugars and sugar alcohols on renal calcium oxalate deposition in ethylene glycol-treated rats.

The effect of administering refined carbohydrates in the diet on calcium oxalate deposition in the kidneys of rats given 1% (v/v) ethylene glycol in their drinking-water was investigated. The rats were given 0, 2.5, 10, 30 or 60% sucrose in the feed (w/w) and/or drinking-water (w/v) or 20% (w/w) starch, glucose, sucrose, fructose, galactose, xylitol or sorbitol in the feed for 3 wk. All of the animals remained healthy over the test period as far as could be assessed by the measurement of 19 plasma biochemical parameters. The inclusion of 30 or 60% (w/w) sucrose in the diet resulted in a more than tenfold increase in the deposition of calcium oxalate in the kidneys. However, this deposition could not be predicted from data on urinary pH and urinary excretion of calcium, oxalate and urate, which have been reported to be risk factors for stone formation. There was no evidence of increased rates of oxalate production from ethylene glycol. The administration of fructose, xylitol or sorbitol was associated with the greatest renal deposition of calcium oxalate, and glucose was associated with by far the least.

Animals↗