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Juvenile onset ankylosing spondylitis (JAS) has less severe spinal disease course than adult onset ankylosing spondylitis (AAS): clinical comparison between JAS and AAS in Korea.

OBJECTIVE: To assess the frequency of juvenile onset ankylosing spondylitis (JAS) in Korean patients with AS and to differentiate the clinical characteristics of JAS from adult onset ankylosing spondylitis (AAS). METHODS: We studied 98 consecutive patients with AS who visited the rheumatology clinic of a tertiary referral center and compared clinical and radiographic features of JAS (n = 41) with those of AAS (n = 57). RESULTS: Median age at onset in JAS was 14 years (range 7-16) and in AAS 22 years (range 17-38) (p < 0.01). Patients with JAS at presentation showed fewer spinal symptoms and more frequent peripheral joint symptoms than those with AAS (41.5% vs 80.7% and 73.2% vs 36.8%, respectively; p < 0.01). Current cervical spine disease was more frequent in AAS (66.7% vs 43.9%; p = 0.02) and current knee disease in JAS (26.8% vs 8.8%; p = 0.02). Patients with JAS showed a shorter tragus-wall distance (mean +/- SD 10.6 +/- 1.7 vs 13.1 +/- 6.9 cm; p < 0.01), more mobility on the modified Schober test (5.7 +/- 2.0 vs 4.0 +/- 2.6 cm; p < 0.01) and chest expansion (4.4 +/- 1.7 vs 3.2 +/- 1.8 cm; p < 0.01), and a better forced vital capacity (75.1 +/- 14.1% vs 82.1 +/- 16.1% of predicted value; p = 0.03) than those with AAS. Totally ankylosed sacroiliitis and spinal syndesmophyte on radiographs were less frequent in JAS patients than in AAS (19.5% vs 47.4% and 17.1% vs 54.4%, respectively; p < 0.01). CONCLUSION: The frequency of JAS (41.3%) among Koreans was higher than that reported for Caucasians. General joint involvement pattern at disease onset in JAS was similar to previous reports. Our data suggest that clinically and radiographically JAS has a less severe spinal disease course than AAS.

Adolescent↗

Usefulness of functional outcome questionnaires in primary screening of spinal disease.

Back pain screening clinics are established to clinically screen patients with back pain for organic lumbar pathology. The aim of this study is to assess the relationship between clinical signs of organic pathology and the level of disability as measured by functional outcome scores. Sixty-nine patients who were found to have clinical signs of organic pathology and 69 age- and sex-matched patients from 512 patients who were found to have no signs of organic pathology in the same time period in the back pain screening clinic were selected. The Oswestry Disability, Short Form-36, and visual analogue (pain) scores between the two groups were statistically analyzed. We found a significant increase in the level of disability in the group with organic pathology; however, the variation in the scores makes them unspecific for use in screening of acute spinal pathology. We also found a strong relationship between psychologic disability and length of symptoms.

Activities of Daily Living↗

[Measuring the surface of the back. Value in diagnosis of spinal diseases].

X-ray study to verify clinical findings in patients with scoliosis and other deformities of the spine is associated with considerable radiation exposure as well as a variety of other problems, particularly as regards assessing disease progression. Hence, in the course of the past few years a number of alternative, supplementary spinal diagnostic procedures have been developed which are based on analysis of the surface of the back: Moiré topography, photogrammetry/raster stereometry, opTRImetric system, ISIS system, video raster stereometry (formetrics), ultrasound-guided spine analysis (Zebris) and ultrasound topometry. To assess the effectiveness of screening, diagnosis, and progression of scoliosis the formetric system of video raster stereometry and the Zebris system for ultrasound-guided spine analysis were tested. It was shown that the results of screening tests, diagnostic study, and progression evaluation of scoliosis and sagittal deformities were exact enough using these systems. Furthermore, the ultrasound-guided Zebris system offers the option of dynamic analysis of spinal movement. Limitations in measurement precision were found in obese patients, asymmetric muscle surfaces, and in patients who had undergone surgery, although in the latter group progression could be reliably monitored if the radiological angle was known. We can assume that surface analysis procedures will gain in importance clinically and in practice.

Adolescent↗

Surgery for metastatic spinal disease.

Cancer is a leading cause of death in the United States. Despite the development of advanced treatment for many malignancies, a large number of patients will require evaluation and possible surgical intervention for lesions which have metastasized to or directly invaded the spinal column. The recommendations for operative intervention on these patients should be made following evaluations by multiple specialties, both medical and surgical. An improved understanding of the pathophysiology of malignancy and the development of advanced adjunctive treatment modalities have improved the quality and duration of life in many patients. Recent studies have demonstrated the utility of early surgery when combined with other treatment modalities. Surgical techniques for tumor resection and spine stabilization have improved the outcome of patients reported in multiple surgical series. A multidisciplinary approach to treatment of cancer patients with spinal involvement affords the patient an optimal outcome.

Aged↗

[Pregnancy and delivery in a woman with neuromuscular disease. Spinal muscular atrophy and severely reduced pulmonary function].

Pregnancy and delivery are described in a 22-year-old woman suffering from spinal muscular atrophy. In spite of severe respiratory insufficiency with a vital capacity of 0.6 litre, pregnancy and planned caesarean section in general anaesthesia went without complications. Some explanations for this are presented. Teams involving respiratory centres specialized in the treatment of patients with neuromuscular diseases, obstetricians and neurologists are recommended. These teams may carry out individual counselling, frequent controls, respiratory support and planning of delivery.

Adult↗