Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “SENECIO”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 253 records · Page 14Linked to original sources
PubMed1982

Effect of feeding milk from goats fed tansy ragwort (Senecio jacobaea) to rats and calves.

Dried tansy ragwort, which contains pyrrolizidine alkaloids (PA), was fed to lactating dairy goats. Milk containing 7.5 ng of PA/g (dry weight basis) from these goats was fed to rats and calves. Rats fed a goats' milk diet for 180 days with a calculated total PA intake of 0.96 mg/rat had swollen hepatocytes of centrilobular distribution, and biliary hyperplasia, indicating PA involvement. Rats fed tansy ragwort at dietary levels of 1%, 0.1%, 0.01% and 0.001% (corresponding to PA intakes of 39.77, 5.04, 0.52, and 0.05 mg/rat) showed swollen hepatocytes, megalocytosis, biliary hyperplasia, and fibrosis. The histopathologic changes in the milk-fed rats and those given 0.001% tansy ragwort in the diet were similar. Definitive changes in 2 calves fed goats' milk were not detected. The results with rats indicate that PA are transferred in goats' milk and may produce hepatoxic effects.

Animals↗