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At least 253 records · Page 14Linked to original sources
PubMed1981

[Pathogenetic role of lipid peroxidation and the protective role of sodium selenite in ischemia and myocardial reperfusion].

The data obtained in experiments on 89 random bred male white rats indicate an important pathogenetic role of lipid peroxidation activation during ischemia of the myocardium and its further reperfusion. Inhibition of lipid peroxidation by sodium selenite was accompanied by increased resistance of the heart to its reversible ischemia. The evidence obtained documents a new principle of pathogenetic therapy of transitory coronary insufficiency with lipid peroxidation inhibitors, particularly sodium selenite. The data presented may be of importance for clinical practice since transitory myocardial ischemia in animals represents an experimental model of the forms of coronary heart disease of man which are accompanied by transient reduction of the coronary blood flow.

Animals↗
PubMedDate not supplied

Dimensions of the staff nurse role in ambulatory care: Part II--Comparison of role dimensions in four ambulatory settings.

Ambulatory care nursing is one of the fastest growing and least studied areas of nursing practice. Information from a national survey of ambulatory nurses has been used to delineate the core dimensions of the current staff nurse role. Comparison of practice patterns of ambulatory staff nurses employed in university hospitals, community hospitals, physician group practices, and health maintenance organizations can provide insights for nurse managers interested in improving ambulatory nursing care delivery. Part III of this series, which will be published in the July/August 1995 issue, will examine how to use research data to design new models of nursing care delivery.

Ambulatory Care↗
PubMed1994

Mice deficient in CD23 reveal its modulatory role in IgE production but no role in T and B cell development.

To assess roles of CD23 in lymphocyte development and immune function in vivo, CD23-deficient mice (CD23-/-) were generated. Mice heterozygous with respect to the defective allele (CD23+/-) display 50% reduced levels of CD23 expression on CD23+ cell types. This pattern is consistent with a lack of parental or tissue-specific imprinting of the CD23 gene. Neither a 50% reduced level nor a complete lack of CD23 caused profound changes in lymphocyte compartments (thymocytes, peripheral T cells, and B-1 and B-2 B cells). The lack of CD23 also did not significantly alter in vitro the proliferative response of B cells triggered via the Ag receptor in combination with CD40 ligand, IL-2, and/or IL-4. Effects on polyclonal Ig production were tested in a Th2 cell-driven immune response in vivo after infection with Nippostrongylus brasiliensis, a parasite that dramatically enhances CD23 expression on B cells. In both primary and secondary immune responses, heterozygous CD23+/- mice developed slightly higher and CD23-/- mice similar serum IgE and IgG1 levels as compared with CD23+/+ (wild-type) mice. The increase in blood eosinophil counts was similar in all three types of mice. These findings show that after N. brasiliensis infection 1) a complete lack of CD23 in vivo neither prohibits nor significantly alters quantitatively polyclonal IgE levels in serum, and 2) a 50% reduction in cell-surface CD23 expression (CD23+/- mice) correlates with slightly increased serum IgE levels.

Animals↗
PubMedDate not supplied

[Role of putrescine in the antiporter mechanism of potassium transport in Escherichia coli and its role in the regulation of intracellular pH].

The interrelation between the Escherichia coli transport processes of K+ and putrescine+2 was investigated under the inhibition and limitation of the main energy consuming potassium transport systems (Trk, Kdp). It was shown that the potassium addition to the potassium deprived putrescine loaded cells triggers the putrescine exit at the exchange on the potassium. The stoichiometry of putrescine +2/2K+ translocation provide the electroneutrality of this process. The putrescine gradient turnover changes the potassium transport direction on the opposite one. The submitted experimental data are the evidence of putrescine +2/2K+ antiporter existence. The role of this antiporter in the E. coli pH-homeostasis is discussed.

Biological Transport↗
PubMed1996

The semidominant Mi(b) mutation identifies a role for the HLH domain in DNA binding in addition to its role in protein dimerization.

The mouse microphthalmia (mi) locus encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor called MITF (microphthalmia transcription factor). Mutations at mi affect the development of several different cell types, including melanocytes, mast cells, osteoclasts and pigmented epithelial cells of the eye. Here we describe the phenotypic and molecular characterization of the semidominant Microphthalmia(brwnish) (Mi(b)) mutation. We show that this mutation primarily affects melanocytes and produces retinal degeneration. The mutation is a G to A transition leading to a Gly244Glu substitution in helix 2 of the HLH dimerization domain. This location is surprising since other semidominant mi mutations characterized to date have been shown to affect DNA binding or transcriptional activation domains of MITF and act as dominant negatives, while mutations that affect MITF dimerization are inherited recessively. Gel retardation assays showed that while the mutant MITF(Mi-b) protein retains its dimerization potential, it is defective in its ability to bind DNA. Computer modeling suggested that the Gly244Glu mutation might disrupt DNA binding by interfering with productive docking of the protein dimer onto DNA. The Mi(b) mutation therefore appears to dissociate a DNA recognition function of the HLH domain from its role in protein dimerization.

Animals↗
PubMed2002

The important role of pain in neurorehabilitation. The neurosurgeon's approach or (neurorehabilitation: the neurosurgeon's role with special emphasis on pain and spasticity).

Pain syndromes due to peripheral or central nervous system damage, or both, may hinder neurorehabilitation. Control of pain may be obtained by ablative or augmentative procedures. Of the ablative modes only DREZ and Cordectomy are still being employed in cases of pain due to Brachial Plexus Avulsion and conus and cauda damage at T9-L1: in both pain is not simply due to "deafferentiation". The augmentative procedures include spinal cord, deep brain and cortical stimulation. Subarachnoid infusion of drugs (midazolam, clonidine, baclofen, etc.) is a new avenue open to control pain. Indications, results and mechanisms of action of those procedures in neuropathic pain are discussed on the basis of literature and personal experience.

Electric Stimulation Therapy↗