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At least 253 records · Page 14Linked to original sources
PubMed1986

Therapeutic progress--review XXIII. Are we making progress in the treatment of acute stroke?

The principal purpose of the treatment of acute stroke is to ensure that the quality of life of those affected is returned to as near normal as possible. Early nursing and physiotherapy are important components of effective management of acute stroke. It is not the intention of this review to examine these aspects which are so well described elsewhere (1). Instead, the theoretical and clinical bases for the various specific treatments advocated in recent years to reduce brain damage after ischaemic insult will be considered to serve as a guide for clinicians. Areas in this field where further research may prove rewarding are highlighted.

Acute Disease↗
PubMed1990

Therapeutic progress--Review XXXVI. Are we making progress in the drug treatment of disorders of the bladder, prostate, and penis?

This paper discusses the novel application of drugs, many of which were first developed for, or have an established role in other indications, in the treatment of disorders of the bladder, prostate and penis. These novel applications have often followed on from an increase in the understanding of the pathophysiological processes involved in the urological condition. Urology also lends itself to novel routes of administration, such as intravesical and intracorporeal routes as well as the more conventional oral, parenteral, and intra-nasal routes.

Humans↗
PubMed1999

The dutch national alcohol and drugs database: progress in monitoring, monitoring in progress.

The Dutch Alcohol and Drug Information System (LADIS) has been operational since 1986 and covers 95% of all alcohol and drug treatment out-patient services in the Netherlands. From 1994 it has been operating as a population-based register in which contact episodes of individual clients can be linked over time with a unique code made anonymous by encryption methods. With the acceptance of the welfare law in 1998, the flow of various categories of data (diagnostic, demographic, treatment and evaluation) and the continuity of LADIS have been secured. Data capture, processing and quality control are highly automated. The information from LADIS concerns annual reports as well as numerous profiles of various groups of clients. The implementation of LADIS and the high degree of standardisation of the data collected have been strongly facilitated by the use of the underlying institutional application ADDICTIS. Within the LADIS framework, almost 95% of the (European) Treatment Demand Indicator Protocol data set on drugs can be collected.

Databases as Topic↗
PubMed1981

Progressive inhibition of human glandular (urinary) kallikrein by human serum and identification of the progressive antikallikrein as alpha 1-antitrypsin (alpha 1-protease inhibitor).

Human urinary kallikrein was inhibited by human alpha 1-antitrypsin (alpha 1-protease inhibitor) in a similar way as by equivalent amounts of human serum. The inhibitor present in the kallikrein-inhibitor complex formed was identified as alpha 1-antitrypsin by two-dimensional immunoelectrophoresis. Under the experimental conditions applied, 90 mIU (= 185 microgram) alpha 1-antitrypsin inhibits about 9 microgram of human urinary kallikrein in 24 h at 37 degrees C, 1 ml of human serum, containing 2-4 mg alpha 1-antitrypsin, inhibits about 70 microgram kallikrein. At an incubation temperature of 25 degrees C, the rate of inactivation is significantly lower than at 37 degrees C. No inhibition was observed at 0 degrees C or when alpha 1-antitrypsin was presaturated with trypsin.

Humans↗