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Results for “PHENYLPYRUVIC ACID”

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At least 253 records · Page 14Linked to original sources
PubMed1984

Inhibition of protein and aminoacyl-tRNA synthesis, and binding and transport sites for aromatic amino acids in the brain in vitro with aromatic acids.

The influx of [3H]phenylalanine, [3H]tyrosine and [3H]tryptophan into brain slices and synaptosomes, their binding to synaptic membranes and their incorporation into protein and aminoacyl-tRNA were studied in the presence of an excess of a second aromatic amino acid or some other aromatic acid, viz., phenylpyruvate, phenyllactate, phenylacetate, homogentisate, salicylate or benzoate. The influx into brain slices was strongly inhibited by a second aromatic amino acid and in general also by phenylpyruvate and homogentisate, but the effects of these substances upon the influx into synaptosomes were slight. The binding of phenylalanine and tyrosine to the synaptic membranes was affected mainly by phenylpyruvate and homogentisate, and these were also effective in preventing the formation of aminoacyl-tRNA, and thus apparently inhibited the biosynthesis of proteins and polyphenylalanine. In all cases phenyllactate, phenylacetate salicylate and benzoate had virtually no effect. Phenylalanine seemed to be a noncompetitive, and tyrosine a competitive inhibitor, while tryptophan had both properties, as was also the case with phenylpyruvate and homogentisate. Under phenylketonuric conditions high excesses of phenylalanine and phenylpyruvate, and also certain other aromatic compounds, seemed to occupy the cellular transport sites for amino acids on the cellular membranes and prevent the formation of aminoacyl-tRNAs, thus inhibiting brain protein synthesis. The reduced supply of intracellular amino acids and the inhibition of protein synthesis may constitute one reason for the development of biochemical phenylketonuric abnormalities.

Amino Acids↗
PubMed2002

Relapse in violent crime in relation to cerebrospinal fluid monoamine metabolites (5-HIAA, HVA and HMPG) in male forensic psychiatric patients convicted of murder: a 16-year follow-up.

OBJECTIVE: Our purpose was to investigate if low levels of cerebrospinal fluid (CSF) monoamine metabolites of 5-HIAA, HVA and HMPG predict relapse in violent crimes. METHOD: Relapse in crime and level of CSF monoamine metabolites (5-HIAA, HVA and HMPG) was studied in a group of 29 murderers. The follow-up was 16 years. RESULTS: Fourteen of the 29 murderers were convicted of crime; nine of them committed violent crimes; one was convicted of a new murder. The differences in mean CSF monoamine metabolites were lower in subjects who relapsed into any type of crime, but only the difference in mean CSF HVA was statistically significant. CONCLUSION: The risk to commit new murder is very small in males who earlier have been convicted of murder. Low levels of CSF HVA is associated with an increased risk for relapse in any type of crime.

Crime↗
PubMed1963

TYROSINOSIS.

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Alanine↗
PubMed1969

Investigation of ketoacidurias by two-dimensional paper chromatography.

A simple paper chromatographic method was found to be effective for the study of phenylketonuria and tyrosyluria. It proved to be much more reliable than conventional tests for the detection of abnormal amounts of ketoacids in urine and was suitable and convenient for following the effects of dietary variations on the excretion of these compounds. Information obtained about ketones other than those of primary importance to the conditions studied included confirmation of the excretion of p-hydroxyphenylpyruvic acid in phenylketonuria. A modification of the method applicable to histidinaemia was devised.

Amino Acid Metabolism, Inborn Errors↗