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PubMed2000

Disciplining social psychology: a case study of boundary relations in the history of the human sciences.

This paper explores the disciplinary status of social psychology through an analysis of the history of the boundary relations of psychology, sociology, and social psychology. After outlining some research on the nature of scientific disciplines, on the role of rhetoric in the constitution of disciplines, and on "boundary work," I consider the singular importance of social psychology as a discipline for the analysis of boundary relations, examining its units of analysis and its "disciplining." The boundaries of the disciplines of social psychology were seen as fluid, contingent, local, and contestable, reflecting the thematic preoccupations, disciplinary origins, and meta-theoretical commitments of social psychologists, of the parent disciplines, and of those who represent disciplinary practices.

Behavioral Sciences↗
PubMed2002

The construction of community participation: village family planning groups and the Indonesian state.

Indonesia's family planning program has been one of the most effective in the developing world in promoting contraceptive use and contributing to fertility transition. In evaluating why the program has worked, analysts have given much credit to a network of village family planning groups that developed from the 1970s to the 1990s and that blanketed the archipelago. These groups, composed primarily of female volunteers, made contraception available to women in even the most remote parts of the country, and acted as agents of family planning motivation. They have been labeled by the Indonesian state family planning agency as an example of effective community participation on a national scale. In this paper, I investigate this claim and find it to be simplistic. I provide extensive evidence that the creation of this network was orchestrated by the Indonesian state. On the other hand, I show that these groups are not fully state entities, as they have several characteristics that mark them as socially embedded institutions. They are best labeled as unusual state-society hybrids. In my investigation I draw on one of the newest paradigms in the discipline of political science--the state-society approach--to uncover the odd nature of this family planning network. More deeply, I argue that the state-society approach ought to be adopted in family planning analysis on a comprehensive basis. The traditional organizational and social-demographic approaches that have dominated the field offer only limited understanding of the nature of family planning programs in developing countries. The state-society approach is ideally suited to identifying how family planning programs are institutions of a political nature, embedded in states and societies, and transformed by and transformative of each.

Community Health Planning↗
PubMed2005

New prospects for the management of renal bone disease.

The last decade has been a remarkably productive one in the field of bone biology. New insights into the maintenance of a normal bone microenvironment have led to significant advances in our understanding of many important skeletal disorders, including renal osteodystrophy. Novel targets for therapeutic manipulation have been exposed and encouraging progress made towards new treatments. In addition, just as clinical studies have alerted us to the potential hazards of vascular calcification, basic science has unearthed the intimate nature of the relationship between the previously separate disciplines of bone and vascular biology. The clinical nephrologist, however, may be forgiven a little cynicism at this point. If such progress has been made, why do the same proverbial difficulties confront us in day-to-day practice? Control of phosphate remains inadequate, despite a literature which constantly reaffirms its crucial importance, and parathyroid hyperplasia seems inevitable in many patients. Furthermore, even the satisfaction of successful control of serum parathyroid hormone concentration must now be tempered by disquiet regarding the skeletal and cardiovascular consequences of oversuppression. This review aims to provide an update of the latest developments in relevant skeletal research and to assess how recently acquired knowledge may improve clinical nephrological practice over the next five years.

Animals↗
PubMed2003

Astrobiology, the transcendent science: the promise of astrobiology as an integrative approach for science and engineering education and research.

Astrobiology is rapidly gaining the worldwide attention of scientists, engineers and the public. Astrobiology's captivation is due to its inherently interesting focus on life, its origins and distribution in the Universe. Because of its remarkable breadth as a scientific field, astrobiology touches on virtually all disciplines in the physical, biological and social sciences as well as engineering. The multidisciplinary nature and the appeal of its subject matter make astrobiology ideal for integrating the teaching of science at all levels in educational curricula. The rationale for implementing novel educational programs in astrobiology is presented along with specific research and educational policy recommendations.

Biological Evolution↗
PubMedDate not supplied

Clinical medicine between science, ethics and economy: a complex activity.

Until recently the common opinion was that medicine was substantially a natural science. In recent years, this has completely changed because two non-naturalistic disciplines have become part of the physician's activity; ethics and economy. These new disciplines have evidenced many problems to which doctors did not pay much attention before; however, they had an impact on the clinician's sensibility. At present, clinical medicine represents a complex knowledge as well as an activity: it is both a "historical" and a "technological" science characterized by a specific goal, the recovery or maintenance of health, and by a series of values.

Bioethics↗
PubMedDate not supplied

How hardwired is human behavior?

Time and time again managers have tried to eliminate hierarchies, politics, and interorganizational rivalry--but to no avail. Why? Evolutionary psychologists would say that they are working against nature--emotional and behavioral "hardwiring" that is the legacy of our Stone Age ancestors. In this evolutionary psychology primer for executives, Nigel Nicholson explores many of the Science's central tenets. Of course, evolutionary psychology is still an emerging discipline, and its strong connection with the theory of natural selection has sparked significant controversy. But, as Nicholson suggests, evolutionary psychology is now well established enough that its insights into human instinct will prove illuminating to anyone seeking to understand why people act the way they do in organizational settings. Take gossip. According to evolutionary psychology, our Stone Age ancestors needed this skill to survive the socially unpredictable conditions of the Savannah Plain. Thus, over time, the propensity to gossip became part of our mental programming. Executives trying to eradicate gossip at work might as well try to change their employees' musical tastes. Better to put one's energy into making sure the "rumor mill" avoids dishonesty or unkindness as much as possible. Evolutionary psychology also explores the dynamics of the human group. Clans on the Savannah Plain, for example, appear to have had no more than 150 members. The message for managers? People will likely be most effective in small organizational units. As every executive knows, it pays to be an insightful student of human nature. Evolutionary psychology adds another important chapter to consider.

Biological Evolution↗
PubMed1980

From chemistry of life to chemistry of disease: the rise of clinical biochemistry.

Any young scientific discipline may experience difficulties in determining its position. For a young discipline placed at the juncture between potent branches of science with a long tradition, as is the case for Clinical Biochemistry, this is especially true. In such a situation, a look backwards to identify first origins and to follow trends of development can be helpful. Moreover, the close relationship between the history and the philosophy of science should provide insight into the nature of our present work and the potential for future work. Our discipline originated with the emergence of modern chemistry at the end of the 18th century. Methods for the chemical analysis of plant and animal material were developed first. The examination of chemical processes in living organisms followed. Only after these successes did chemical investigations of causes and mechanisms of human disease become possible. A few selected milestones in this evolution can illustrate the medical, philosophical, intellectual and social background which has shaped the rise of Clinical Biochemistry.

Biochemistry↗
PubMed2000

Societal and medical consequences of the Human Genome Project. Inter-disciplinary approaches to human genetics.

The Human Genome Project is a US-based molecular biological project, the results of which are likely to be implemented on humans. The sociopolitical dimension of this is highly neglected. The aim of the conference was to fill this gap by drawing together scientists of natural and political sciences to discuss the consequences of the Human Genome Project across the disciplines.

Ethics, Medical↗
PubMed2006

Tasks of research in forensic medicine - different study types in clinical research and forensic medicine.

In the last years the research output of forensic medicine has sometimes been regarded as insufficient and as of poor quality, especially when parameters as impact factors and external funding were taken into account. However, forensic medicine has different tasks compared to clinical medicine. The main difference between basic subjects, clinical and forensic medicine is not a lack of scientific efficiency in forensic medicine but is a result of the questions asked, the available methods and specific aims. In contrast to natural-scientific research, forensic science has furthermore important intersections with arts and socio-scientific disciplines. Etiologic and pathogenetic research is of only limited relevance in forensic medicine. Thus, forensic medicine is excluded from these research fields, which are mainly supported by external funding. In forensic medicine research mainly means applied research regarding findings, the probative value and reconstruction as well as examination at different points of intersection between medicine and law. Clinical types of research such as controlled randomised, prospective cross-sectional, cohort or case-control studies can only rarely be applied in forensic medicine due to the area specific research fields (e.g. thantatology, violent death, vitality, traffic medicine, analytical toxicology, hemogenetics and stain analysis). The types of studies which are successfully established in forensic medicine are comparison of methods, sensitivity studies, validation of methods, kinetic examinations etc. Tasks of research in forensic medicine and study types, which may be applied will be addressed.

Biomedical Research↗
PubMed1999

Macromolecular crystallography with a third-generation synchrotron source.

The European Synchrotron Radiation Facility (ESRF) at Grenoble, France, is a 6 GeV machine producing hard X-radiation that can be used for pure and applied research in a wide range of disciplines including physics, chemistry, structural biology, materials science, the earth sciences, engineering and medicine. The overall nature of the machine will be described, including the features that give rise to the notation 'third-generation source'. The ESRF is equipped with a number of beamlines which can be used for macromolecular crystallography. Applications include the use of very small crystals, large unit cells, data collection at high resolution, anomalous dispersion measurements for phase determination and time-resolved studies. Key features of these applications will be described.

Acetylcholinesterase↗
PubMed1987

Some perspectives on targeted delivery with prodrugs.

Targeted delivery using prodrugs is becoming an important means for studying approaches to the efficient delivery for complex and often toxic molecules to specific sites within the body. Especially true for polymeric prodrugs containing targeting moieties, the future offers many possibilities for improvement of the therapeutic ratio by delivering drugs exclusively to diseased cellular and subcellular components within the organism. The fact that this type of research is highly interdisciplinary in nature requires the creative input of the biology disciplines as well as chemistry and pharmaceutical science. Our perspective on what constitutes the true delivery system, as it applies to targeted delivery, needs to be redefined. The use of the prodrug to target drug molecules to specific sites is merely the chemical delivery device that has been conceived and designed after considering the implications of those biochemical, physiological, and immunological processes that ultimately affect the transport and distribution of the prodrug within the host organism.

Animals↗
PubMed2001

Backing into the future.

The professionalization of anthropology was grounded in a naturalistic tradition of field research. The empirical particularism of fieldwork wedded aesthetic and humanistic concerns with those of science in a discipline that assumed a species-wide and long-time perspective while focusing on the description and comparisons of local variations. Scientific progress has occurred in anthropology over the past century despite the distortions of colonialism, the Cold War, and other historical circumstances. Controversies about good and bad scientific work and about the humanistic character of anthropology have been an ongoing aspect of our discipline. The historical development of medical anthropology and important recent publications in this specialty illustrate the nature of the encompassing discipline and provide the ground on which 21st-century scholars will carry the science forward.

Anthropology, Cultural↗
PubMed1982

Concepts in causality: chemically induced human urinary bladder cancer.

A significant portion of the incidence of human urinary bladder cancer can be attributed to occupational and cultural (tobacco smoking) situations associated with exposures to various arylamines, many of which represent established human carcinogens. A brief historical overview of research in bladder cancer causality indicates that the identification of causal agents and causal mechanism has been approached and rests upon information gathered at the organismal (geographical/historical), cellular, and molecular levels of biologic organization. This viewpoint speaks of a natural evolution within the biomedical sciences; a natural evolution from descriptive approaches to mechanistic approaches; and a natural evolution from more or less independent discipline-oriented approaches to hierarchically organized multidisciplinary approaches. Available information relevant to bladder cancer causality can be readily integrated into general conceptual frameworks to yield a hierarchial view of the natural history of urinary bladder cancer, a view consistent with contemporary natural systems and information theory and perhaps relevant also to other chemically induced epithelial cancers. Such frameworks are useful in appreciating the spatial and temporal boundaries and interrelationships in causality and the conceptual interrelationships within the biomedical sciences. Recent approaches in molecular epidemiology and the assessment of relative individual susceptibility to bladder cancer indicate that such frameworks are useful in forming hypotheses.

Animals↗
PubMed1994

Nursing: an integration of art and science within the experience of the practitioner.

In this paper it is proposed that whilst nursing knowledge is underpinned by the philosophies of art and science they are integrated in such a way that nursing is greater than their sum and is thus a unique discipline. It begins with an exploration of the philosophies underpinning art and science, and their relationship to nursing. The discussion then moves on to examine critically the nature and development of theory in nursing with reference to art and science, the nursing knowledge thus generated and how that knowledge is learned and expressed. The paper concludes with an evaluation of how far the discipline of nursing lies within the paradigms of science and of art, and whether indeed art and science may be, to some extent, false distinctions. The authors conclude that nursing may be viewed as an integration of art and science, expressed through the practitioner's unique, yet also shared experience.

Clinical Competence↗
PubMed2003

At the crossroads of chemistry and biology.

The life sciences are molecular and the harnessing of information gleaned from genomics and proteomics will require interdisciplinary research integrating chemistry and biology. This approach is illustrated by the synthesis and biological evaluation of lipidated peptides and proteins and the delineation of a concept arguing for natural product guided combinatorial chemistry.

Biochemistry↗
PubMed2005

Excerpt from Medicinische Psychologie oder Physiologie der Seele by Dr Rudolph Hermann Lotze.

Hermann Lotze (1817-81) is a neglected figure in the history of psychiatry although it has been claimed that his early views were influential, for example, on the young Griesinger. Trained as a physician, psychologist and philosopher he saw better than many the impending epistemological crisis that was to affect disciplines such as psychology and medical psychology as they were being taken over by the natural sciences. The problem he endeavoured to resolve was double-headed. On the one hand, Lotze believed that the mechanisms proposed by physiology and other relevant natural sciences were essential to the explanation of human behaviour provided that its meaning and context were respected; on the other, he wanted to do away with the mysterious (metaphysical) explanations such as 'vital force' which in his time were still popular in biology. The solutions he eventually offered can understandably be seen as a weak compromise and one which statisfied no one. Materialists à outrance such as Vogt, Büchner, Lange and Ribot though he was too 'metaphysical'; spiritualist philosophers believed that he had surrendered too much to biology. It is likely that Lotze remained, in fact, a metaphysician as can be ascertained by studying his concept of Seele (soul, mind) into which he packed enough furniture to make many believe that he was an idealist thinker. This paper discusses some of these issues and justifies the choice of classic text, namely, Lotze's illuminating Introduction to his book Medicinische Psychologie oder Physiologie der Seele.

Germany↗
PubMed1994

Social science and psychiatric epidemiology. A difficult relationship.

The difficulty in the relationships among the social sciences, psychiatry and epidemiology is important because it inhibits incremental growth of scientific knowledge regarding human behavior. This in turn handicaps coping with social, psychological and cultural perturbations which currently threaten human existence. A major reason for the difficulty in the relationships is the presence of divergent views among the various relevant disciplines with regard to the nature of the scientific process. This article presents an outline of the scientific process modelled on those sciences which focus on living systems. Growth in scientific knowledge is seen to occur as a result of a spiral movement in which articulating conceptual and operational transactions alternate. A problem of our time is that parts of the spiral are often disengaged and conducted independently in a way that makes impossible the incremental synthesis of theory, hypotheses, premisses and data.

Anthropology, Cultural↗
PubMed1986

[Significance of a theoretical pathology for the scientific cognitive process in medicine].

A critical examination of current trends in medicine demonstrates the need for a deepened theoretical foundation. Of particular importance is the development of theoretical pathology. The goals, methods and content of theoretical pathology are discussed and contrasted with those of general and special pathology. Although general pathology incorporates some elements of theoretical pathology, the latter is based on the theory of cognition rather than empirical science. Dialectic materialism is an essential element of this discipline. The development of theoretical pathology demands an interdisciplinary approach on the part of physicians, natural and social scientists and must be based on a broad concept of human disease.

Cognition↗