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Effects of age on the ability to remember common and rare proper names.

Difficulties in remembering proper nouns increase with age. One factor is that names are arbitrary labels. Another is that because many people share the same names, mutual discriminability between names is less than than that between other words. Discriminability between names may reduce as the number of acquaintances increases. Also, most people have both a first and a second name. These have to be learned as a pair, but they may be of unequal distinctiveness and so be unequally well remembered. An experiment was designed to evaluate the relative effects of distinctiveness of first and second names on free and cued recall. Subjects (aged 60-69 or 70-79 years, matched on Mill-Hill vocabulary score) were asked to remember one of four lists of 16 names. Each was presented four times. The names were either common, rare, or a combination of the two--a common first name with a rare surname, or vice versa. Subjects first freely recalled the names. They were next cued by either first name or surname to recall the remaining half of name pairs. Interactions between effects on recall of subjects' ages and of the relative distinctiveness of first and second names provide partial support for a model incorporating "relative distinctiveness" as a factor in failures of name recall in old age.

Age Factors↗

Descriptiveness and proper name retrieval.

Cohen (1990) hypothesised that the retrieval of proper names is particularly difficult because proper names convey little information about their bearers' attributes. In the present study, this hypothesis was evaluated by using a face naming task. Faces were those of cartoon and comic-strip characters bearing either arbitrary names or descriptive names. Results unequivocally showed that retrieval blocks occurred more often in naming characters bearing arbitrary names than in naming characters bearing descriptive names. Moreover, retrieving arbitrary names that were also common names was as difficult as retrieving arbitrary names that were not common names. These results support Cohen's claim that arbitrariness plays a significant role in the relative vulnerability of proper name retrieval.

Adult↗

Naming famous faces and buildings.

Reports of a dissociation between impaired retrieval of people's names and spared retrieval of other categories of proper names have led to the suggestion that there are separate brain mechanisms for processing different categories of proper names. An alternative explanation states that geographical proper names (e.g. cities, countries) may be spared in patients with proper name anomia because they are easier to retrieve than people's names. Unlike people's names, geographical names are also used as adjectives. However, this explanation can not explain why retrieval of proper names that are never used as adjectives (e.g. buildings) was spared in some patients. This study investigated whether retrieving people's names is equally difficult as retrieving the names of buildings. Results from normal subjects and closed-head injured patients revealed no differences between retrieval of people's names and buildings' names, and suggested that both categories of proper names are equally vulnerable to brain injury.

Adult↗

Picture naming deficits in developmental dyslexia: the phonological representations hypothesis.

The picture and word naming performance of developmental dyslexics was compared to the picture and word naming performance of non-dyslexic ("garden variety") poor readers, reading age, and chronological age-matched controls. The stimulus list used for both tasks was systematically manipulated for word length and word frequency. In order to examine picture naming errors in more depth, an object name recognition test assessed each subject's vocabulary knowledge of those names which they were unable to spontaneously label in the picture naming task. Findings indicated that the dyslexic and the garden variety poor readers exhibited a picture naming deficit relative to both chronological and reading age-matched controls. Findings also indicated that both groups of impaired readers obtained superior scores in the word naming task than in the picture naming task, while both groups of controls showed no difference in performance across tasks. The dyslexics' picture naming errors, but not those of the garden variety poor readers, were particularly marked on polysyllabic and/or low frequency words, indicating a possible phonological basis to the picture naming deficit of the dyslexic children. These children also recognized significantly more unnamed target words than all comparison groups, suggesting a particular difficulty in retrieving the phonological codes of known picture names rather than a vocabulary deficit. Results are discussed in terms of dyslexics' difficulty in encoding full segmental phonological representations of names in long-term memory and/or in processing these representations in order to generate required names on demand.

Adolescent↗

Naming and grasping common objects: a priming study.

This study examined the effects of priming on response latency when participants named and/or grasped common objects. A repetition-priming paradigm was used. An object was presented during a study phase and then was presented again during testing along with other objects that had not been seen before. In experiment 1, the studied objects were either named twice or grasped twice, named first and then grasped, or grasped first and then named. We found a strong priming effect (i.e., decreased latency) when naming was preceded by naming, as well as by grasping, but no priming effect when grasping was preceded by either naming or grasping. In experiment 2, we investigated the effects of priming in naming-naming and grasping-grasping paradigms, with and without a change in object orientation from study to test. As expected, we found significant priming of naming by naming, and the effect was not reduced by orientation change. Again, we found no evidence of priming in grasping. Experiment 3 was designed to examine how different kinds of perceptual and visuomotor processing (naming, orientation matching, orientation discrimination, simple observation, and grasping) during the study phase affect naming at a later test phase. We found significant priming of naming following all study conditions. Notably, the effect differed depending on how much "perceptual" processing was involved in the study phase. The results clearly indicate that perceptual/semantic processing is more dependent on memory than visuomotor processing, which instead relies more on moment-to-moment computations.

Adolescent↗

Constraints in naming parts of the Tree of Life.

There are now overlapping codes of nomenclature that govern some of the same names of biological taxa. The International Code of Zoological Nomenclature (ICZN) uses the non-evolutionary concept of a "type species" to fix the names of animal taxa to particular ranks in the nomenclatural hierarchy. The PhyloCode, in contrast, uses phylogenetic definitions for supraspecific taxa at any hierarchical level within the Tree of Life (without associating the names to particular ranks), but does not deal with the names of species. Thus, biologists who develop classifications of animals need to use both systems of nomenclature, or else operate without formal rules for the names of some taxa (either species or many monophyletic groups). In addition, the ICZN does not permit the unique naming of many taxa that are considered to be between the ranks of genus and species. Hillis and Wilcox [Hillis, D.M., Wilcox, T.P., 2005. Phylogeny of the New World true frogs (Rana). Mol. Phylogenet. Evol. 34, 299-314] provided recommendations for the classification of New World true frogs that utilized the ICZN to provide names for species, and the PhyloCode to provide names for supraspecific taxa. Nonetheless, they created new taxon names that followed both sets of rules, to avoid conflicting classifications. They also recommended that established names for both species and clades be used whenever possible, to stabilize the names of both species and clades under either set of rules, and to avoid conflicting nomenclatures. Dubois [Dubois, A., 2006. Naming taxa from cladograms: a cautionary tale. Mol. Phylogenet. Evol., 42, 317-330] objected to these principles, and argued that the names provided by Hillis and Wilcox [Hillis, D.M., Wilcox, T.P., 2005. Phylogeny of the New World true frogs (Rana). Mol. Phylogenet. Evol. 34, 299-314] are unavailable under the ICZN, and that the two nomenclatural systems are incompatible. Here, I argue that he is incorrect in these assertions, and present arguments for retaining the established names of New World true frogs, which are largely compatible under both sets of nomenclatural rules.

Amphibians↗

The influence of learning style and cognitive ability on recall of names and faces in an older population.

The present study examined whether, for older adults, a verbal or imagery cognitive style is associated with recall of names and faces learned in an experimental condition. Cognitive abilities that are represented in current models of face recognition and name recall were also examined. Those abilities included picture naming, verbal fluency (i.e., naming items within a given category), vocabulary comprehension, visual memory, and the learning of unassociated word pairs. Fifty older adults attempted to learn first and last names of 20 student actors and actresses pictured on videotapes (40 names total). On average, participants learned the most first names, followed by last names, and the fewest full names. The greater the number of responses on a questionnaire associated with an imagery cognitive style, the more the names of faces were correctly identified by participants. There was no significant relationship between a verbal cognitive style and the number of names and faces recalled. As for cognitive abilities, all of the abilities measured--with the exception of vocabulary comprehension--were significantly associated with the number of names and faces learned. A regression analysis indicated that the best predictor of successful name-face learning was the participants' ability to learn and recall 5 unrelated word pairs. When that cognitive measure was deleted from the regression analysis, delayed visual memory and verbal fluency were the next best predictors of the older adults' ability to learn names and faces.

Aged↗

Action naming in dementia.

Recent studies of action naming in dementia report contradictory results. Some studies have shown that naming of pictured actions is impaired and indeed worse than naming of pictured objects, whereas other studies report the opposite result, i.e. action naming is better preserved than object naming. One reason for these conflicting results may be that actions vary in their relationships with object knowledge. Instrumental actions, e.g. hammering, require access to knowledge about a specific object (a tool), whereas non-instrumental actions can be named correctly without access to knowledge about a specific object, e.g. running. Moreover, many instrumental action names share a name relationship with the instrument used to perform the action (homophony), whereas other action names do not, e.g. digging. In this case report, we describe an anomic patient RS with dementia affecting his access to knowledge about objects from visual, verbal and tactile input. By contrast, RS displays relatively well-preserved knowledge and naming of actions. We found an effect of instrumentality on pictured action naming, i.e. actions that depict an actor using a tool are named less accurately than actions that depict an actor performing an action without a tool. We argue that the instrumentality effect is independent of the name relationship between the action and the object and also the visual complexity of the action. We consider several explanations of the instrumentality effect and conclude that an impairment to the areas underpinning sensory feature and sensorimotor information (specific to manipulation) can account for an effect of instrumentality on action naming in dementia.

Aged↗

Face-name interference.

Interference effects between the processing of simultaneously presented photographs of faces of familiar people and printed names of familiar people were investigated. Printed names interfered with identifying faces, whereas faces did not interfere with saying printed names (Experiments 1 and 3). In contrast, faces interfered more with name categorization than names interfered with face categorization (Experiments 2 and 4). Despite a priori reasons as to why faces might be thought to possess functional properties different from those of other visual objects, the observed effects are comparable to those found in object-word interference studies, with photographs of faces behaving like pictures of objects and printed people's names behaving like printed names of objects. In face naming tasks, the presence of related names produced more interference than did the presence of unrelated names (Experiment 1). This effect was examined in greater detail in Experiment 3, where we found that the effect arises when the face and the name belong to people of similar appearance. An effect of common category membership was not found in Experiment 3. Experiment 5, however, showed that names of people highly associated with the person whose face is presented also produce more interference than do names of unrelated people.

Association↗

The difficulty with recalling people's names: the plausible phonology hypothesis.

Recalling the name of a person is a simple, but often a problematic, everyday task. There are various explanations of this phenomenon, but here it is argued that the explanations offered so far, by failing to consider learning of names, have overlooked a simple account of name recall difficulty. The starting observation for this viewpoint is that names of people are often non-words, in that they have never been encountered before. This is not true of, say, names of professions. Not only does the relatively high rate of new exemplars mean that people's names are likely to be underlearned, but furthermore, even for equal degrees of learning, a person's name is at a disadvantage because of the high plausibility of most phonologies: "dreaner" is much more readily accepted as the name of a person than as the name of their profession. So specifying the phonology of people's names is inherently a more demanding task, compared to the phonology of other names. The implications of this view are explored with regard to explanations of empirically established name recall phenomena in normal subjects, the patterns of performance of anomic patients and the difficulty of name recall in different word domains. It is shown that these arguments, derived from a real world fact, account in a simple way for existing data and make predictions in different areas of research.

Age Factors↗

Regression of chronic L -NAME-treatment-induced left ventricular hypertrophy: effect of captopril.

Long-term administration of N(G)-nitro- L -arginine methyl ester (L -NAME) induces development of NO-deficient hypertension and left ventricular (LV) hypertrophy. In this work, we examined the effect of spontaneous and captopril-induced recovery on LV hypertrophy and protein composition in rats with developed L -NAME-induced hypertension. Four groups of rats were investigated: control L -NAME 40 mg/kg/day for 4 weeks (L -NAME) L -NAME 40 mg/kg/day for 4 weeks followed by 3-week spontaneous recovery (L -NAME+R) L -NAME 40 mg/kg/day for 4 weeks followed by 3 weeks of captopril treatment at a dose of 100 mg/kg/day (L -NAME+C). LV hypertrophy in the L -NAME group was associated with an increase in content and concentration of left ventricular DNA and RNA, concentration of metabolic proteins (MP) and soluble collagenous proteins (SCP). Spontaneous recovery period reduced the hypertension, without regression of LV hypertrophy. Left ventricular DNA and RNA content were increased in the L -NAME+R group. In this group, concentrations of MP, contractile proteins (CP), and collagenous proteins did not differ from those in the L -NAME group. Captopril treatment caused total regression of hypertension and LV hypertrophy and decreased both content and concentration of DNA and RNA, as well as the contents of MP, CP and SCP v the L -NAME group. However, after captopril treatment, concentration of collagenous and non-collagenous protein fractions remained increased v control. We conclude that spontaneous regression of L -NAME-induced hypertension is not associated with regression of LV hypertrophy. LV hypertrophy was regressed only in captopril-treated animals.

Angiotensin-Converting Enzyme Inhibitors↗

The relationship between naming and semantic knowledge for different categories in dementia of Alzheimer's type.

We studied the relationship between naming and semantic memory in a group of 10 patients with dementia of Alzheimer's type. In an extension to a previous cross-sectional study (Hodges, J. R. et al., Brain and Language, 1996, 54, 302-325), this relationship was investigated at two longitudinal points within each patient's cognitive decline. Two types of naming performance were compared: items that each patient named correctly at the first stage but failed to name at the second stage, as contrasted with items named correctly at both stages (thereby providing a control for cognitive decline in general). Semantic knowledge of the concepts represented by the pictures in the naming test was investigated at each stage using definitions to the spoken object name, scored particularly for the number of sensory and associative/functional features provided by the patient. At stage 2, an analysis of the definitions for named-->unnamed items as contrasted with named-->named objects revealed a significant loss of both sensory and associative information. A comparison between natural kinds (animals and birds) and artefacts (household objects, vehicles, etc.), however, demonstrated a striking interaction between category and type of information contained in the definitions. Specifically, stage 2 definitions of artefacts in the named-->unnamed set showed a disproportionate loss of associative/functional information, while definitions of animal names that patients failed to produce in response to the pictures were notably lacking in sensory features. This pattern supports the notion that successful naming relies on a subset of critical semantic features which vary somewhat across different categories of semantic knowledge. We suggest that these findings are best encompassed by a conception of semantic organization, Weighted Overlappingly Organized Features (WOOF), in which (i) knowledge about all objects is represented by a central, distributed network of features activated by both words and pictures, but (ii) natural kinds and artefacts are differentially weighted in favour of those features that are involved in learning about and experiencing different kinds of objects.

Aged↗

Effects of antihypertensive therapy on factors mediating endothelium-dependent relaxation in rats treated chronically with L-NAME.

OBJECTIVES: To evaluate the relative participation of endothelium-derived factors mediating relaxation in response to acetylcholine in isolated mesenteric vascular beds from rats treated chronically with N(G)-nitro-L-arginine methylester (L-NAME); and to compare the consequences of prolonged treatment with either an angiotensin converting enzyme inhibitor or a calcium channel blocker on the components of acetylcholine-induced relaxation in this vascular preparation. MATERIALS AND METHODS: Male Sprague- Dawley rats were treated for 8 weeks with L-NAME (40 mg/kg per day), quinapril (10 mg/kg per day), diltiazem (100 mg/kg per day), L-NAME + quinapril and L-NAME + diltiazem. Systolic blood pressure was estimated by a tail-cuff plethysmograph. Relaxing responses to acetylcholine (10(-12) to 10(-8) mol) in mesenteric vascular beds precontracted with phenylephrine (10(-5) mol/l) were studied in the presence and absence of L-NAME (10(-5) mol/l), L-NAME + indomethacin (10(-5) mol/l) or L-NAME + indomethacin + potassium chloride (6 x 10(-5) mol/l). The area under the dose- response curve was used to calculate the approximate participation of nitric oxide, prostaglandins or endothelium-derived hyperpolarizing factor in the acetylcholine-induced relaxation. RESULTS: Chronic administration of L-NAME increased blood pressure levels and vascular responsiveness to phenylephrine. Treatments with either quinapril or diltiazem reduced blood pressure levels and attenuated the increased response to phenylephrine. Relaxing responses to acetylcholine were similar in all groups, independently of the treatment received. The calculated participation of endothelium-derived hyperpolarizing factor in the acetylcholine-induced relaxation was higher than that of nitric oxide and prostaglandins in all groups, but was higher in L-NAME-treated than in untreated rats. In contrast, the participation of both nitric oxide and prostaglandins was higher in control than in L-NAME-treated rats. Quinapril increased the participation of prostaglandins in L-NAME-treated rats. Diltiazem increased the participation of nitric oxide in L-NAME-treated rats. CONCLUSIONS: The administration of L-NAME in Sprague-Dawley rats increased the production of endothelium-derived hyperpolarizing factor as a compensatory mechanism to maintain acetylcholine-induced relaxation. Antihypertensive therapy with either quinapril or diltiazem produced a selective redistribution of the endothelial factors mediating acetylcholine-induced relaxation.

Acetylcholine↗

Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine.

1. The L-arginine derivatives NG-nitro-L-arginine (L-NOARG) and NG-nitro-L-arginine methyl ester (L-NAME) have been widely used to inhibit constitutive NO synthase (NOS) in different biological systems. This work was carried out to investigate whether L-NAME is a direct inhibitor of NOS or requires preceding hydrolytic bioactivation to L-NOARG for inhibition of the enzyme. 2. A bolus of L-NAME and L-NOARG (0.25 micromol) increased coronary perfusion pressure of rat isolated hearts to the same extent (21 +/- 0.8 mmHg; n = 5), but the effect developed more rapidly following addition of L-NOARG than L-NAME (mean half-time: 0.7 vs 4.2 min). The time-dependent onset of the inhibitory effect of L-NAME was paralleled by the appearance of L-NOARG in the coronary effluent. 3. Freshly dissolved L-NAME was a 50 fold less potent inhibitor of purified brain NOS (mean IC50 = 70 microM) than L-NOARG (IC50 = 1.4 microM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. H.p.l.c. analyses revealed that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG. 4. Freshly dissolved L-NAME contained 2% of L-NOARG and was hydrolyzed with a half-life of 365 +/- 11.2 min in buffer (pH 7.4), 207 +/- 1.7 min in human plasma, and 29 +/- 2.2 min in whole blood (n = 3 in each case). When L-NAME was preincubated in plasma or buffer, inhibition of NOS was proportional to formation of L-NOARG, but in blood the inhibition was much less than expected from the rates of L-NAME hydrolysis. This was explained by accumulation of L-NOARG in blood cells. 5. These results suggest that L-NAME represents a prodrug lacking NOS inhibitory activity unless it is hydrolyzed to L-NOARG. Bioactivation of L-NAME proceeds at moderate rates in physiological buffers, but is markedly accelerated in tissues such as blood or vascular endothelium.

Animals↗

The superoxide dismutase mimetic, tempol, reduces the bioavailability of nitric oxide and does not alter L-NAME-induced hypertension in rats.

L-NAME-induced hypertension is characterized by chronic inhibition of nitric oxide synthesis. We have investigated if tempol, an agent mimicking superoxide dismutase might reduce hypertension and the increased vascular reactivity to pressor agents. Rats were divided into: Control, animals receiving L-NAME 50 mg kg(-1)day(-1), tempol 200 mg kg(-1)day(-1) and tempol plus L-NAME. Drugs were administrated in the drinking water for seven days. L-NAME increased mean arterial blood pressure (Control: 108+/-3 mmHg versus L-NAME 181+/-5 mmHg; P<0.05). Tempol did not change arterial pressure and heart rate in L-NAME and Control groups. The reactivity to phenylephrine increased in the L-NAME group (E(max) Control: 2.00+/-0.15 g versus L-NAME: 2.45+/-0.14 g); tempol+L-NAME (E(max): 2.55+/-0.15 g) and in the tempol group (E(max): 2.57+/-0.14 g). Maximal relaxation induced by acetylcholine was reduced in L-NAME group (60.9+/-3%) and tempol+L-NAME (37.4+/-6%) compared to Control (99.1+/-0.12%) and tempol groups (95.6+/-2.12%). All treated groups presented a reduction in the effects of L-NAME administration on basal vascular tone. Our results show that tempol, in the dose used in this study, did not change the effects of L-NAME on blood pressure which suggests that tempol reduces bioavailability of nitric oxide on aortic isolated ring.

Animals↗

Using stimulus equivalence procedures to teach name-face matching to adults with brain injuries.

On pretests, 3 men with brain injuries matched dictated names of three therapists to written names, but did not match dictated or written names to photos, produce correct names in response to photos, locate offices given written names, or name therapists on sight. Match-to-sample training established conditional relations between dictated names and photos. Posttests showed the emergence of untrained conditional relations involving photos and written names, indicating development of three classes of equivalent stimuli (each containing a dictated name, photo, and written name). For 1 participant, conditional relations involving photos of office nameplates were also examined, but did not emerge pre- or posttraining. Two participants produced names orally when given photos and sorted written names and faces together after training; the 3rd participant was unavailable for these posttests. After training, 1 participant located and named all three therapists in their offices.

Adult↗

L-NAME-induced protein remodeling and fibrosis in the rat heart.

The aim of the present study was to determine whether NO deficiency itself or rather the elevation of systolic blood pressure is responsible for the protein and structural remodeling of the heart during hypertension induced by long-term treatment by nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). Three groups of rats were investigated. The first group served as control. In the second group L-NAME was given in the dose of 20 mg/kg/day in the drinking water and in the third group L-NAME was given in the dose of 40 mg/kg/day during 4 weeks. While L-NAME treatment in both doses caused essentially the same increase in systolic blood pressure (SBP), NO synthase activity and cGMP concentration in the left ventricle decreased by 17% and 13%, respectively in the 20 mg/kg/day L-NAME group and by 69% and 27%, respectively in the 40 mg/kg/day L-NAME group. The protein profile of the left ventricle in both L-NAME groups was characterized by an increased concentration of metabolic proteins. Nevertheless, a significant increase in the concentration of pepsin-soluble collagenous proteins and the concentration of hydroxyproline in pepsin-insoluble collagenous proteins was found only in the group receiving 40 mg/kg/day L-NAME. The morphometric evaluation revealed a significant increase in myocardial fibrosis in both L-NAME groups. However, this was more pronounced in the 40 mg/kg/day L-NAME group. It is concluded that NO deficiency resulted in significant enhancement of fibrotic tissue growth in proportion to the administered L-NAME dose, while SBP was increased similarly in both L-NAME groups. Thus, NO deficiency rather than hemodynamic changes appears to be crucially involved in collagenous protein and fibrotic tissue changes of the left ventricle in hypertension induced by L-NAME.

Animals↗

Quantitative assessment of dictionary-based protein named entity tagging.

OBJECTIVE: Natural language processing (NLP) approaches have been explored to manage and mine information recorded in biological literature. A critical step for biological literature mining is biological named entity tagging (BNET) that identifies names mentioned in text and normalizes them with entries in biological databases. The aim of this study was to provide quantitative assessment of the complexity of BNET on protein entities through BioThesaurus, a thesaurus of gene/protein names for UniProt knowledgebase (UniProtKB) entries that was acquired using online resources. METHODS: We evaluated the complexity through several perspectives: ambiguity (i.e., the number of genes/proteins represented by one name), synonymy (i.e., the number of names associated with the same gene/protein), and coverage (i.e., the percentage of gene/protein names in text included in the thesaurus). We also normalized names in BioThesaurus and measures were obtained twice, once before normalization and once after. RESULTS: The current version of BioThesaurus has over 2.6 million names or 2.1 million normalized names covering more than 1.8 million UniProtKB entries. The average synonymy is 3.53 (2.86 after normalization), ambiguity is 2.31 before normalization and 2.32 after, while the coverage is 94.0% based on the BioCreAtive data set comprising MEDLINE abstracts containing genes/proteins. CONCLUSION: The study indicated that names for genes/proteins are highly ambiguous and there are usually multiple names for the same gene or protein. It also demonstrated that most gene/protein names appearing in text can be found in BioThesaurus.

Dictionaries as Topic↗