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Shot-noise influence on the reconstructed phase image signal-to-noise ratio in digital holographic microscopy.

In digital holographic microscopy, shot noise is an intrinsic part of the recording process with the digital camera. We present a study based on simulations and real measurements describing the shot-noise influence in the quality of the reconstructed phase images. Different configurations of the reference wave and the object wave intensities will be discussed, illustrating the detection limit and the coherent amplification of the object wave. The signal-to-noise ratio (SNR) calculation of the reconstructed phase images based on the decision statistical theory is derived from a model for image quality estimation proposed by Wagner and Brown [Phys. Med. Biol. 30, 489 (1985)]. It will be shown that a phase image with a SNR above 10 can be obtained with a mean intensity lower than 10 photons per pixel and per hologram coming from the observed object. Experimental measurements on a glass-chrome probe will be presented to illustrate the main results of the simulations.

Journal Article↗

Noise-induced hearing loss in the noise-toughened auditory system.

The auditory system, toughened by an interrupted noise exposure, has been shown in several reports to be less affected by (or protected from) a subsequent high-level noise exposure. Exposure to 115 dB peak SPL, 1 kHz narrow band (400 Hz) transients presented l/s, 6 h/day, to four groups of chinchillas produced a 10-28 dB toughening effect across the 0.5-8.0 kHz test frequency range. Following either a 30 day or an 18 h recovery period the animals were exposed to the same impulses but presented at 121 or 127 dB peak SPL for five uninterrupted days, thus producing an asymptotic threshold shift (ATS) condition. Comparisons between toughened and untoughened control subjects showed: (1) During the 121 dB exposure there was a statistically significant reduction of 10-25 dB in ATS across the entire test frequency range. Thirty days following the 121 dB exposure there were no significant differences in the postexposure permanent effects on thresholds and sensory cell loss. (2) During the 127 dB exposure only the group with the 30 day interval between the toughening and traumatic exposures showed a small (approximately 10 dB), statistically significant, frequency-specific (8 kHz), reduction in ATS. Thirty days following the 127 dB exposure a statistically significant protective effect on threshold was measured only at 16.0 kHz. However, both toughened groups showed less inner hair cell loss at and above 1.0 kHz, while only the group with the 18 h interval between the toughening and traumatic exposures showed less outer hair cell loss at and above 1.0 kHz. There were no systematic differences in the response of the toughened animals that could be attributed to the 30 day or 18 h post-toughening interval.

Adaptation, Physiological↗

Assessing the influence of scanner background noise on auditory processing. II. An fMRI study comparing auditory processing in the absence and presence of recorded scanner noise using a sparse design.

Several studies reported decreased signal intensities within auditory areas for experimental designs employing continuous scanner background noise (SBN) in comparison to designs with less or no SBN. This study examined the source for this SBN-induced masking effect of the blood oxygenation level-dependent (BOLD) response by directly comparing two experimental sessions with the same auditory stimulation, which was presented either with or without recorded scanner background noise (RecSBN). Ten subjects listened to a series of four one-syllable words and had to decide whether two of the words were identical. The words were either presented with a silent background or with added RecSBN. This was then contrasted with either silence or RecSBN. A sparse temporal sampling method was used in both sessions, which enabled us to directly assess the influence of RecSBN without varying scanning parameters, acquisition quantities, or auditory stimulations. Our results suggest that previously reported SBN-induced masking of the BOLD response in experimental designs with SBN might be caused by an interaction between increased baseline levels and nonlinearity effects within auditory cortices. Adding SBN to an experimental condition does not enhance signal intensities to the same degree that SBN does when presented with a silent background, and therefore contrasting an experimental and baseline condition that both have SBN may lead to signal decreases. In addition, our study shows this effect is greatest in Heschl's gyrus, but can also be observed in higher-order auditory areas.

Acoustic Stimulation↗

Relationships between acoustic reflex patterns elicited by unfiltered white noise and narrow band white noise stimuli of different duration but of the same intensity.

For the purpose of this study, acoustic signals were generated by an Amplaid MK VI. An Amplaid 702 impedence meter was connected to its averaging section and to its computer. The stimuli were bursts of unfiltered white noise (UWN) and of narrow band white noise (NBWN; 30 db./oct/slope; central frequencies 1,000, 2,000, 4,000 Hz.) lasting 3-1,000 msec., at intensity of 105 db. SPL p.e. The following parameters were evaluated: stapedius contraction latency, amplitude, duration and recruitment time. It was found that latency was independent of the spectrum of the stimulus and its duration. Amplitude and recruitment time, on the other hand, were related to spectrum and duration, while duration of contraction was directly related to the duration of the stimulus only.

Adult↗

Interpreting noise dosimeter results based on different noise standards.

Three types of noise dosimeters were exposed on workers during routine work in a synthetic rubber plant, two refineries, a petrochemical plant, a petroleum marketing terminal and an off-shore producing platform. The dosimeters represent different methods of noise integration.

Ear Protective Devices↗

Development of a quick speech-in-noise test for measuring signal-to-noise ratio loss in normal-hearing and hearing-impaired listeners.

This paper describes a shortened and improved version of the Speech in Noise (SIN) Test (Etymotic Research, 1993). In the first two of four experiments, the level of a female talker relative to that of four-talker babble was adjusted sentence by sentence to produce 50% correct scores for normal-hearing subjects. In the second two experiments, those sentences-in-babble that produced either lack of equivalence or high across-subject variability in scores were discarded. These experiments produced 12 equivalent lists, each containing six sentences, with one sentence at each adjusted signal-to-noise ratio of 25, 20, 15, 10, 5, and 0 dB. Six additional lists were also made equivalent when the scores of particular pairs were averaged. The final lists comprise the "QuickSIN" test that measures the SNR a listener requires to understand 50% of key words in sentences in a background of babble. The standard deviation of single-list scores is 1.4 dB SNR for hearing-impaired subjects, based on test-retest data. A single QuickSIN list takes approximately one minute to administer and provides an estimate of SNR loss accurate to +/-2.7 dB at the 95% confidence level.

Acoustic Stimulation↗

Does the presentation of audiometric test data have a positive effect on the perceptions of workplace noise and noise exposure avoidance?

Research and 'common knowledge' has for many years accepted that education and feedback supplied to individuals during and immediately after workplace health assessments provides valuable information to workers about their health. Further, if more relevant and detailed information could be supplied then awareness and preventative action may increase proportionately. This research carried out with a rural Australian population has shown that preventative action did not increase in proportion to a corresponding increase in the amount and variety of information provided in connection with hearing health status. Two research groups underwent hearing tests, both with pure tone audiometry (PTA) while the second group also underwent otoacoustic emission (OAE) testing. Test results were presented to the subjects at the conclusion of their test session. An analysis of questionnaire responses at six week and twelve months follow up showed that more information did not result in increased preventative action. Barriers seem to exist such that individuals feel that they are not able to effectively act to reduce overall noise exposure. While self-efficacy initially increased, it declined to close to its initial value over the longer period. Other measures such as perceived susceptibility to hearing loss and the benefits of exposure reduction significantly increased and remained at the same increased level after twelve months. So, while overall awareness of noise and the risks of exposure were increased after both types of hearing test there was no increased hearing health benefit due to additional testing and hearing information.

Adult↗

[The NSI (Noise Sensitivity Index)--a method for the demonstration of acute physical symptoms in noise exposure and combination exposure].

The NSI (Noise Sensitive Index) is a method suitable for the single or repeated recording of acute, subjectively perceived bodily complaints caused by exposure against noise alone or combined with additional physical factors (e.g. physical load, high temperature) during the lapse of exposure. The paper describes the application of NSI in 6 experimental investigations. The results are indicative regarding their dependence on components of exposure and personality. If certain rules are taken into consideration, application, scoring and interpretation of NSI is easy, not very time consuming, and profitable.

Adult↗

Speech recognition in noise by hearing-impaired and noise-masked normal-hearing listeners.

A prevailing complaint among individuals with sensorineural hearing loss (SNHL) is difficulty understanding speech, particularly under adverse listening conditions. The present investigation compared the speech-recognition abilities of listeners with mild to moderate degrees of SNHL to normal-hearing individuals with simulated hearing impairments, accomplished using spectrally shaped masking noise. Speech-perception ability was assessed using the predictability-high sentences from the Speech Perception in Noise test. Results revealed significant differences between groups in sentential-recognition ability, with the hearing-impaired subjects performing poorer than the masked-normal listeners. These findings suggest the presence of a secondary distortion degrading sentential-recognition ability in the hearing impaired, implications of these data will be discussed concerning the mechanism(s) responsible for speech perception in the hearing impaired.

Adult↗

Trachea-noise biofeedback in asthma: a comparison of the effect of trachea-noise biofeedback, a bronchodilator, and no treatment on the rate of recovery from exercise- and eucapnic hyperventilation-induced asthma.

We review some of the evidence that supports the existence of psychosomatic triggers to bronchospasm in asthmatics, and hypothesize that it may also be possible to consciously reverse bronchospasm using trachea-noise biofeedback. We precipitated significant levels of bronchospasm in 16 asthmatics using exercise or eucapnic-hyperventilation challenges on five occasions, and administered four different treatments and a no-treatment control. The treatments were trachea-noise biofeedback (TNBF), wrong-information TNBF, an inhaled adrenergic bronchodilator, and a placebo inhaler, all given double blind. Half of the subjects had 3 training days in the use of the TNBF device before study. Our results show that TNBF, in the trained subjects only, is associated with a detectable, but not statistically significant, increase in the rate of recovery from bronchospasm over that found with no treatment. We conclude that, although asthmatics seem to have a strong ability to consciously induce bronchospasm, conscious reversal of a full asthma attack using TNBF is limited. Despite contrary conclusions by other investigators, we believe that this study demonstrated little TNBF-assisted recovery from bronchospasm. We suggest that this is because its effect may be inhibited by humoral mechanisms that sustain the attack, but we believe further work is required to support this.

Adult↗

Measurement of Signal-to-Noise and Contrast-to-Noise in the fBIRN Multicenter Imaging Study.

The ability to analyze and merge data across sites, vendors, and field strengths depends on one's ability to acquire images with the same image quality including image smoothness, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). SNR can be used to compare different magnetic resonance scanners as a measure of comparability between the systems. This study looks at the SNR and CNR ratios in structural fast spin-echo T2-weighted scans acquired in five individuals across ten sites that are part of Functional Imaging Research of Schizophrenia Testbed Biomedical Informatics Research Network (fBIRN). Different manufacturers, field strengths, gradient coils, and RF coils were used at these sites. The SNR of gray matter was fairly uniform (41.3-43.3) across scanners at 1.5 T. The higher field scanners produced images with significantly higher SNR values (44.5-108.7 at 3 T and 50.8 at 4 T). Similar results were obtained for CNR measurements between gray/white matter at 1.5 T (9.5-10.2), again increasing at higher fields (10.1-28.9 at 3 T and 10.9 at 4 T).

Analysis of Variance↗

Changes in signal-to-noise ratios and contrast-to-noise ratios of hypervascular hepatocellular carcinomas on ferucarbotran-enhanced dynamic MR imaging.

PURPOSE: To verify changes in the signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs) of hypervascular hepatocellular carcinomas (HCCs) on ferucarbotran-enhanced dynamic T1-weighted MR imaging. MATERIALS AND METHODS: Fifty-two patients with 61 hypervascular HCCs underwent ferucarbotran-enhanced dynamic MR imaging, and then hepatic resection. Hypervascular HCCs were identified when definite enhancement was noted during the arterial dominant phase of three-phase MDCT. Dynamic MR Images with T1-weighted fast multiplanar spoiled gradient-recalled echo sequence (TR200/TE4.2) were obtained before and 20 s, and 1, 3, 5, and 10 min, after bolus injection of ferucarbotran. We estimated the signal intensities of tumors and livers, and calculated the SNRs and CNRs of the tumors. RESULTS: On ferucarbotran-enhanced dynamic MR imaging, SNR measurements showed a fluctuating pattern, namely, an increase in SNR followed by a decrease and a subsequent increase (or a decrease in SNR followed by a increase and a subsequent decrease) in 50 (82.0%) of 61 tumors, a single-peak SNR pattern (highest SNR on 20 s, 1, 3, or 5 min delayed images followed by a decrease) in seven (11.5%), and a decrease in SNR followed by an increase in four (6.6%). Maximum absolute CNRs with positive value were noted on 10 min delayed images in 41 (67.2%) tumors, and maximum absolute CNRs with negative value were observed on 20 s delayed images in 12 (19.7%) and on 1 min delayed images in eight (13.1%). CONCLUSION: Despite showing various SNR and CNR changes, the majority of hypervascular HCCs demonstrated a fluctuating SNR pattern on ferucarbotran-enhanced dynamic MR imaging and a highest CNR on 10 min delayed image, which differed from the classic enhancement pattern on multiphasic CT.

Adult↗

Open channel noise. I. Noise in acetylcholine receptor currents suggests conformational fluctuations.

The random passage of ions through an open channel is expected to result in shot noise fluctuations in the channel current. The patch-clamp technique now allows fluctuations of this size to be observed in single-channel currents. In the experiments reported here the acetylcholine-induced currents in cultured rat muscle cells were analyzed; fluctuations were found that were considerably larger than expected for shot noise. A low-frequency component, which was fitted with a Lorentzian, was examined in detail; it appears to arise from fluctuations in channel conductance of approximately 3% on a time scale of 1 ms. The characteristic relaxation time is voltage dependent and temperature dependent (Q10 approximately equal to 3) suggesting that the fluctuations arise from conformational fluctuations in the channel protein.

Acetylcholine↗

Comparison of different cardiac MRI sequences at 1.5 T/3.0 T with respect to signal-to-noise and contrast-to-noise ratios - initial experience.

PURPOSE: To compare image quality, signal-to-noise (SNR) and contrast-to-noise ratios (CNR) of different MRI sequences for cardiac imaging at 1.5 T and 3.0 T in volunteers. MATERIAL AND METHODS: 10 volunteers (5 male, 5 female) with a mean age of 33 years (+/- 8) without any history of cardiac diseases were examined on a GE Signa 3.0 T and a GE Signa 1.5 T TwinSpeed Excite (GE Medical Systems, Milwaukee, WI, USA) scanner using a 4-element phased array surface coil (same design) on the same day. For tissue characterization ECG gated Fast Spinecho (FSE) T (1)- (Double IR), T (1)-STIR (Triple IR) and T (2)-weighted sequences in transverse orientation were used. For functional analysis a steady state free precession (SSFP - FIESTA) sequence was performed in the 4-chamber, 2-chamber long axis and short axis view. The flip angle used for the SSFP sequence at 3.0 T was reduced from 45 degrees to 30 degrees to keep short TR times while staying within the pre-defined SAR limitations. All other sequence parameters were kept constant. RESULTS: All acquisitions could successfully be completed for the 10 volunteers. The mean SNR 3.0 T compared to 1.5 T was remarkably increased (p < 0.05) for the T (2) - (160 % SNR increase), the STIR-T (1)- (123 %) and the T (1)- (91 %) weighted FSE. Similar results were found comparing CNR at 3.0 T and 1.5 T. The mean SNR achieved using the SSFP sequences was more than doubled by 3.0 T (150 %), but did not have any significant effect on the CNR. The image quality at 3.0 T did not appear to be improved, and was considered to be significantly worse when using SSFP sequences. Artefacts like shading in the area of the right ventricle (RV) were found to be more present at 3.0 T using FSE sequences. After a localized shim had been performed in 5/10 volunteers at the infero-lateral wall of the left ventricle (LV) with the SSFP sequences at 3.0 T no significant increase in artefacts could be detected. CONCLUSIONS: In all cardiac FSE sequences, SNR and CNR at 3.0 T were found to be increased compared to 1.5 T without any major changes of the sequence parameters. The adjusted SSFP sequences fulfilled the expected increase in SNR at 3.0 T but showed no increase in CNR. On the contrary, the overall image quality did not change or was even found to be significantly lower for the SSFP and the FSE sequences at the free wall of the RV. Nevertheless, the results are encouraging for the use of 3.0 T for cardiac tissue characterization and new applications with progressing use of parallel imaging.

Adult↗

Communicating with noise: How chaos and noise combine to generate secure encryption keys.

An approach for the secure transmission of encrypted messages using chaos and noise is presented in this paper. The method is based on the synchronization of certain types of chaotic oscillators in response to a common noise input. This allows two distant oscillators to generate identical output which can be used as a key for encryption and decryption of a message signal. The noiselike synchronizing input-which contains no message information-is communicated to identical oscillators in the transmitter and the receiver over a public channel. The encrypted message is also sent over a public channel, while the key is never transmitted at all. The chaotic nature of the oscillators which generate the key and the randomness of the signal driving the process combine to make the recovery of the key by an eavesdropper extremely difficult. We evaluate system performance with respect to security and robustness and show that a robust and secure system can be obtained. (c) 1998 American Institute of Physics.

Journal Article↗