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Toward an evolutionary psychology of religiosity.

How can the evolution of religiosity be explained? To answer this question, we attempt to develop an understanding of the psychological domains underlying religious behaviour. We see four evolved domains, the sum and interaction of which constitute religiosity, namely: mysticism, ethics, myths and rituals. Even if the individual content, accents and implementations differ in each specific religion, they nevertheless derive from evolved Darwinian algorithms that are species-specific adaptations of homo sapiens. Mysticism. Intuitive ontologies are the basis for mystical experiences. Usually they serve to classify reality into animate and inanimate objects, animals or plants, for example. For a variety of psychological reasons, supernatural experiences result from a mixture of different ontological categories. Ethics. The basis for ethics lies in the social competency of human beings. Ethics is founded on the concept of social exchange ("social-contract algorithm") with its ideas about reciprocity, fairness, justice, cheater detection, in-group/out-group differentiation, etc. Myths. The basis for myths is the "language instinct". We interpret myths as the verbal expression of the cognitive content of those individual modules that constitute the belief system. Above all, myths document the experience and processing of contingency and thus help social bonding. Rituals. Rituals are based on the handicap principle. By making certain symbols and acts more expensive, they signal commitment for a reliable in-group morale. In conclusion, we argue that human religiosity emerges from a cognitive interaction between these four domains. Religiosity processes contingencies and enhances co-operation through social bonding, norm setting and cheater detection. It fulfils those functions for which the mental modules of its four domains have evolved so that we feel it appears to be justified to attribute to religiosity the evolutionary status of an adaptation.

Algorithms↗

Pardes and PaRDeS: towards a psychotherapeutic theory.

The Hebrew term Pardes has two meanings in Jewish study: the Paradise entered by four eminent Rabbis in search of mystical truth, and PaRDeS, four levels of interpreting Biblical texts. By combining the legend of Pardes with the hermeneutic system of PaRDeS, a psychological theory is presented as a set of propositions which endeavor to demonstrate the following: 1) The combination of Pardes and PaRDeS may be used as a bridge between the rational and mystic approaches to life and death. 2) The rational and the mystic stages each contain two phases: the negative break and the positive possibility of the symbolic "forty years old" more mature active remedy. 3) The "Acher-Akiva" and the "Ben Zoma-Ben Azai" dimensions do not necessarily represent four psychological personality types, but rather inner psychological struggles which may be experienced by one person in part or in full during different phases of his or her life cycle. The successful resolution of these inner psychological struggles may be facilitated by people's ability and motivation to find their one or more personally suitable "faces" from the "seventy" that are available for them. Thus, the road to "Pardes-paradise" is paved by people's own intentions.

Adaptation, Psychological↗

The adolescence of a thirteenth-century visionary nun.

Among the most notable features of the religious revival in western Europe in the early thirteenth century was the development of mysticism among the nuns and religious women of the lowlands. As scholarly attention becomes increasingly focused on this group of remarkable women, the question arises whether a psychiatric viewpoint has something of value to offer to the understanding of such individuals and the culture in which they struggled. The methodological and intellectual problems inherent in examining the life of a thirteenth-century mystic with a twentieth-century empirical frame of reference are illustrated in this study of the adolescence of Beatrice of Nazareth. Beatrice's stormy asceticism, ecstatic states and mood swings lend themselves to potentially competing hypotheses regarding the spiritual and psychopathological significance of her adolescent development and eventual life-course. Common grounds for reconciling these alternative models are discussed.

Adolescent↗

Sahaja: an Indian ideal of mental health.

Sahaja is an Indian ideal of mental and spiritual health that has received special emphasis in the Sikh scriptures--especially, the Adi Granth. Since the concept of sahaja has long been associated with mystical thought and practice, its description has become shrouded in peculiar esoteric terminologies. It is the purpose of this communication to divest sahaja of its esoteric, mystic connotations and to redefine it as a mental health ideal in the context of contemporary conditions.

Behavior↗

The language of altered states.

To compare the subjective experience of different forms of altered states of consciousness, computerized content analysis was applied to 66 autobiographical accounts of schizophrenia, hallucinogenic drug states, or mystical ecstasy and to 28 autobiographical control accounts of important personal experiences. The patterns of lexical choice used by the four groups were significantly different in word frequencies from 49 of 83 lexical categories measured. When data from the 13 most statistically significant categories were used in discriminant and classification analyses, 84% of the samples were correctly identified by their word frequencies. These findings suggest that the subjective experiences of schizophrenia, hallucinogenic drug-induced states, and mystical ecstasy are more different from one another than alike.

Analysis of Variance↗

Results of two worldwide surveys into physician awareness and perceptions of extended-spectrum beta-lactamases.

An omnibus survey of microbiologists (n = 400) and a survey of participants (n = 49) in the Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) programme were conducted to determine the awareness and prevalence of extended-spectrum beta-lactamases (ESBLs), and the regularity and method of screening. Of the omnibus survey participants, 69% screened regularly for ESBLs, compared with 83% of MYSTIC participants. In both surveys, ESBLs were more common in Klebsiella pneumoniae (73% and 79%, respectively) and Escherichia coli (63% and 81%, respectively) than in other bacteria. The surveys demonstrated that awareness of, and testing for, ESBLs is inconsistent.

Anti-Bacterial Agents↗

Detachment: gateway to the world of spirituality.

Mystical states are common cross-culturally. Here we examine the prevalence and general characteristics of these states. We then proceed to critically examine the theories purporting to explain these states: psychoanalytic, cognitive and neurobiological, all of which attempt to explain the breakdown of the boundaries between the self and external world. We conclude by exploring the implications of mystical states for cultural psychiatry.

Attitude↗

Evidence for a common biological basis of the Absorption trait, hallucinogen effects, and positive symptoms: epistasis between 5-HT2a and COMT polymorphisms.

Absorption represents a disposition to experience altered states of consciousness characterized by intensively focused attention. It is correlated with hypnotic susceptibility and includes phenomena ranging from vivid perceptions and imaginations to mystical experiences. Based on the assumption that drug-induced and naturally occurring mystical experiences share common neural mechanisms, we hypothesized that Absorption is influenced by the T102C polymorphism affecting the 5-HT2a receptor, which is known to be an important target site of hallucinogens like LSD. Based on the pivotal role ascribed to the prefrontal executive control network for absorbed attention and positive symptoms in schizophrenia, it was further hypothesized that Absorption is associated with the VAL158MET polymorphism of the catechol-O-methyltransferase (COMT) gene affecting the dopaminergic neurotransmitter system. The Tellegen Absorption Scale was administered to 336 subjects (95 male, 241 female). Statistical analysis revealed that the group with the T/T genotype of the T102C polymorphism, implying a stronger binding potential of the 5-HT2a receptor, indeed had significantly higher Absorption scores (F = 10.00, P = 0.002), while no main effect was found for the COMT polymorphism. However, the interaction between T102C and COMT genotypes yielded significance (F = 3.89; P = 0.049), underlining the known functional interaction between the 5-HT and the dopaminergic system. These findings point to biological foundations of the personality trait of Absorption.

Adult↗

Neurological motor disorders experienced as religious phenomena: role of abnormal movement monitoring.

We describe two cases of neurological motor disorders which were experienced as religious-mystical phenomena by elderly psychotic ladies. One of the patients interpreted a mild hemiparesis as a message from divine forces that changed her left to her right and vice versa. The other patient felt that her perphenazine-induced tardive dyskinesia was the voluntary reading of a silent mantra. Involvement of mystical or religious terms in the interpretation of physical symptoms may lead to the lack of adequate treatment and care. We suggest that a psychosis-related inability to monitor one's own motor behavior is the crucial factor leading to peculiar perception of motor disorders.

Aged↗

An Indian mummy: a case report.

A case of mummification occurring in northwest India (Chandigarh) is described. A middle-aged man developed an abscess on his back and was treated by a mystical man who did not allow him any food or water. After a few days the patient died. On the advice of the mystical man the body was kept in a room which was made hot and dry. The police discovered the body after 2 years. A postmortem examination was conducted and findings are reported.

Forensic Anthropology↗

Neuronal hypersynchronization, creativity and endogenous psychoses.

I have investigated a neuronal hypersynchronism, currently included under the general subject of epilepsy, and termed interictal activity. I suggest that it is a physiological activity of the mammalian brain and propose it be termed Hyperia. After a thorough study of the extraordinary psychic manifestations of this neuronal hypersynchronism shown by mystics and artists, I have reviewed several scientific publications bearing on my hypothesis. I conclude by elaborating on a variety of cerebral hypersynchronous functions whose cause I consider to be physiological. Such behaviour is a common basis for extraordinary psychic manifestations found not only in mystics and artists, but also in patients suffering from endogenous psychoses, especially Bipolar Disorder.

Creativity↗

Values and beliefs of psychedelic drug users: a cross-cultural study.

Psychedelic drugs such as LSD and psilocybin are often claimed to be capable of inducing life-changing experiences described as mystical or transcendental, especially if high doses are taken. The present study examined possible enduring effects of such experiences by comparing users of psychedelic drugs (n = 88), users of nonpsychedelic illegal drugs (e.g., marijuana, amphetamines) (n = 29) and non illicit drug-using social drinkers (n = 66) on questionnaire measures of values, beliefs and emotional empathy. Samples were obtained from Israel (n = 110) and Australia (n = 73) in a cross-cultural comparison to see if values associated with psychedelic drug use transcended culture of origin. Psychedelic users scored significantly higher on mystical beliefs (e.g., oneness with God and the universe) and life values of spirituality and concern for others than the other groups, and lower on the value of financial prosperity, irrespective of culture of origin. Users of nonpsychedelic illegal drugs scored significantly lower on a measure of coping ability than both psychedelic users and non illicit drug users. Both groups of illegal drug users scored significantly higher on empathy than non illicit drug users. Results are discussed in the context of earlier findings from Pahnke (1966) and Doblin (1991) of the transformative effect of psychedelic experiences, although the possibility remains that present findings reflect predrug characteristics of those who chose to take psychedelic drugs rather than effects of the drugs themselves.

Adult↗

Pharmacodynamic modeling of beta-lactam antibiotics for the empiric treatment of secondary peritonitis: a report from the OPTAMA program.

BACKGROUND: In this report of the OPTAMA (Optimizing Pharmacodynamic Target Attainment using the MYSTIC Antibiogram) program, we utilized Monte Carlo simulation to compare the probabilities of achieving bactericidal time above the minimum inhibitory concentration (MIC) (%T > MIC) exposures for imipenem-cilastatin 500 mg q6h and 1000 mg q8h, meropenem 500 mg q6h and 1000 mg q8h and piperacillin/tazobactam 3.375 g q6h and 4.5 g q8h in the empiric treatment of secondary peritonitis. METHODS: The prevalence of pathogens causing secondary peritonitis was identified from the primary surgical and infectious diseases literature. Data for these pathogens with respect to MIC were obtained from the 2003 MYSTIC surveillance study and weighted by the prevalence of each pathogen. A sensitivity analysis varying the prevalence of P. aeruginosa was performed with two additional models to determine the robustness of the data. Pharmacokinetic parameters, obtained from previously published studies in healthy volunteers were used to simulate the %T > MIC for 10,000 patients receiving imipenem-cilastatin, meropenem, and piperacillin/tazobactam. The likelihood of obtaining bactericidal exposure is reported. RESULTS: Empiric utilization of imipenem-cilastatin and meropenem 500 mg q6h and 1000 mg q8h regimens achieved 99.6%-99.7% likelihood of bactericidal exposure. Piperacillin/ tazobactam 3.375 g q6h and 4.5 g q8h produced bactericidal target attainments of 92.9% and 85.2%, respectively. Models simulating higher prevalence of P. aeruginosa reduced the likelihood of bactericidal exposure for piperacillin/tazobactam regimens significantly and had little effect on the carbapenems. CONCLUSION: All of the beta-lactams used in the current analysis were predicted to achieve high target attainment consistently for the empiric treatment of secondary peritonitis. However, imipenem-cilastatin 500 mg q6h and 1000 mg q8h, meropenem 1000 mg q8h and 500 mg q6h, and piperacillin/tazobactam 3.375 g q6h achieved the highest likelihood. These, in particular, would be effective choices for the empiric treatment of secondary peritonitis.

Anti-Bacterial Agents↗

A pathway to spirituality.

The phenomenology of mystical experiences has been described throughout all the ages and in all religions. All mystical traditions identify some sense of union with the absolute as the ultimate spiritual goal. I assume that the pathway to both theistic and secular spirituality and our readiness to seek a solution in a psychological merger with something beyond the self evolves out of our human experience. Spirituality is one of man's strategies for dealing with the limitations of the life cycle, separation and loss, biological fragility, transience, and non-existence. Spirituality may serve as the affective component to a belief system or myth that is not rooted in scientific evidence but is lived as if it is true. Spirituality may take many forms, but I will suggest that in some instances it may serve as a reparative process in which one creates in the external world, through symbolic form, a nuance or facet of an internalized mental representation which has become lost or is no longer available to the self; or it may represent the continuity of the self-representation after death through a self-object merger. Lastly I will illustrate from the writings of two of our greatest poets, Dante Alighieri and William Wordsworth, how their poetry became interwoven with a profound spirituality. In Dante we will see the elaboration of a religious spirituality, while in the writings of Wordsworth a secular spirituality emerges interwoven with nature and belatedly his identification with "tragic man" as his mythos.

Attitude↗

Integrating Escherichia coli antimicrobial susceptibility data from multiple surveillance programs.

Collaboration between networks presents opportunities to increase analytical power and cross-validate findings. Multivariate analyses of 2 large, international datasets (MYSTIC and SENTRY) from the Global Advisory on Antibiotic Resistance Data program explored temporal, geographic, and demographic trends in Escherichia coli resistance from 1997 to 2001. Elevated rates of nonsusceptibility were seen in Latin America, southern Europe, and the western Pacific, and lower rates were seen in North America. For most antimicrobial drugs considered, nonsusceptibility was higher in isolates from men, older patients, and intensive care unit patients. Nonsusceptibility to ciprofloxacin was higher in younger patients, rose with time, and was not associated with intensive care unit status. In univariate analyses, estimates of nonsusceptibility from MYSTIC were consistently higher than those from SENTRY, but these differences disappeared in multivariate analyses, which supports the epidemiologic relevance of findings from the 2 programs, despite differences in surveillance strategies.

Anti-Bacterial Agents↗

Acute gastric dilatation with volvulus in a northern fur seal (Callorhinus ursinus).

Acute gastric dilatation with volvulus occurred in a 4-year-old female northern fur seal (Callorhinus ursinus). The animal had been maintained in an outdoor exhibit at Mystic Marinelife Aquarium (Mystic, Connecticut, USA) from June 1989 to March 1994. On necropsy, we observed a 360 degrees clockwise rotation of the stomach about its mesenteric axis as viewed ventrodorsally. The stomach was markedly distended with gas, fluid, and partially digested fish. The spleen followed the rotation of the stomach 360 degrees and was enlarged and congested with twisted mesentery. This is the first reported case of acute gastric dilatation with volvulus in a pinniped.

Acute Disease↗

Gastric intramural hematoma and hemoperitoneum in a captive northern fur seal.

A 16-yr-old adult male northern fur seal (Callorhinus ursinus) was found dead in its outdoor pool in November 1995. The animal was maintained at Mystic Aquarium (Mystic, Connecticut, USA) from March 1980 to November 1995. Gross necropsy findings included hemoperitoneum and locally extensive gastric intramural hemorrhage that involved the posterior fundic, antral, and pyloric regions and extended into the duodenum. The gastric mural thickening grossly resembled hemangioma, and the gastric serosa was ruptured at the site of maximal mural expansion. In histologic sections of the stomach, a cribiform network of fibrin, which encompassed numerous variably-sized aggregates of closely packed erythrocytes, markedly expanded the submucosa. No vascular endothelium was identified in serial histologic sections of the expanded gastric submucosa stained with hematoxylin and eosin or immunohistochemically with antibodies to vimentin and Factor VIII-related antigen, establishing an absence of hemangioma. Carstairs' and Weigert's histochemical stains confirmed that the framework expanding the submucosa was fibrin. Although the appearance of the gastric wall resembled hemangioma, a population of neoplastic endothelial cells was not identified within the submucosal expansion of hemorrhage and fibrin, and microscopic evidence was most consistent with the diagnosis of gastric intramural hematoma. This lesion is a rare pathologic event that has not been reported in marine mammals, but one that should be included in diagnostic considerations of hemoperitoneum and gastric mural expansion.

Animals↗

A quest for purpose in psychic research.

Metapsychiatry is a term born of necessity to designate the important but hitherto unclassified interface between psychiatry and mysticism. By "mysticism" the author means phenomena experienced by the senses but not explainable by the intellect. Examples of such phenomena are dreams, ESP, faith healing and so forth. The author believes that such phenomena were endowed by nature as life preserving functions. Thus, precognition is a sort of psychic radar, warning an individual of impending danger; dreams are a safety valve for potentially psycholytic repressions; and faith is an important element in the healing process. Such phenomena are probably a primitive acquisition, latent in all of us. They should not be treated merely as divine manifestations requiring no further explanations. Scientists must seek rational answers, and physicians should seriously consider using gifted, reputable psychics as paramedical aides.

Humans↗