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PubMed1995

Family-oriented pediatric care. Taking the next step.

Pediatricians often have more information at their disposal than they use. They are frequently aware of some of the family issues that can contribute to their patient's health. This article has presented a framework for moving beyond a solely biomedical model to one that uses this information to create a more comprehensive picture of the family--one that offers the potential to unlock impasses and increase both physician and family satisfaction.

Family↗
PubMed1997

Respirometer for small samples with automatic registration.

The respiration chamber containing the sample is a small glass test tube with a closure of KOH solution. During registration the gas volume is kept constant by adjusting the pressure through a feedback mechanism: a microscope projects the picture of the meniscus of KOH onto a photodiode connected to a pen recorder with a vertically moving pen. A levelling bulb with water mounted on the pen transmits the pressure adjustments to the KOH solution through a water filled tubing. The accuracy is +/-0.1 mm water column (1 Pa) and the minimum air volume is 10 nl, so that an oxygen consumption down to 1 pl can be seen.

Carbon Dioxide↗
PubMed2004

Rejuvenation of the lithosphere by the Hawaiian plume.

The volcanism responsible for creating the chain of the Hawaiian islands and seamounts is believed to mark the passage of the oceanic lithosphere over a mantle plume. In this picture hot material rises from great depth within a fixed narrow conduit to the surface, penetrating the moving lithosphere. Although a number of models describe possible plume-lithosphere interactions, seismic imaging techniques have not had sufficient resolution to distinguish between them. Here we apply the S-wave 'receiver function' technique to data of three permanent seismic broadband stations on the Hawaiian islands, to map the thickness of the underlying lithosphere. We find that under Big Island the lithosphere is 100-110 km thick, as expected for an oceanic plate 90-100 million years old that is not modified by a plume. But the lithosphere thins gradually along the island chain to about 50-60 km below Kauai. The width of the thinning is about 300 km. In this zone, well within the larger-scale topographic swell, we infer that the rejuvenation model (where the plume thins the lithosphere) is operative; however, the larger-scale topographic swell is probably supported dynamically.

Journal Article↗
PubMed1993

Effect of blade configuration, knife action, and intraocular pressure on keratotomy incision depth and shape.

For the same diamond blade extension, uphill (centripetal) radial keratotomy incision direction achieves greater depth and consequently greater refractive effect than downhill (centrifugal) incisions. To determine which factors may account for this difference, two uphill and two downhill incisions were made with a double-edged diamond blade set to 90% central pachometry in 26 human donor eyes at 15 or 60 mm Hg. Uphill incisions made with the perpendicular blade had greater mean incision depth than downhill incisions made with the oblique blade at 15 mm Hg (83.6 +/- 3.9% and 68.2 +/- 5.2%) (p < 0.0005) and at 60 mm Hg (86.3 +/- 3.1% and 79.7 +/- 1.7%) (p < 0.0005). Uphill and downhill incisions both made with the perpendicular blade had equal depth (85.4 +/- 4.9% and 83.7 +/- 3.5%) (p > 0.1). The perpendicular blade edge created a straight, and the oblique edge an S- or J-shaped, histological incision configuration. Corneal profile pictures taken during each incision showed the knife to tilt opposite of the incision direction and to move at a constant angle to the limbal plane, producing a smaller optical clear zone (OCZ) in the posterior stroma than intended with uphill incisions. Greater refractive effect with uphill incisions may be explained by the perpendicular blade being more effective in incising corneal lamellae, and the creation of a smaller posterior OCZ. Intraocular pressure variations during surgery may affect achieved incision depth of downhill, but not of uphill, incisions.

Aged↗
PubMed1977

The influence of secondary depth cues on the understanding by Nigerian schoolboys of spatial relationships in pictures.

The ability of 105 Nigerian schoolboys to interpret pictures three-dimensionally was studied as a function of changing the number of depth cues on moving from monochrome photographs incorporating the effects of shadow, through fully cued line drawings, to line drawings containing only elevation cues. The experiment also investigated the effects of different amounts of previous formal training in technical drawing on performance in these tasks. The results showed a significant increase in performance as the number of depth cues increased above that contained in the minimum cued line drawings. However, the difference between the effects of fully cued line drawings and the photographs was not significant. Neither the main nor interaction effects relating to levels of formal training in technical drawing were significant.

Adolescent↗
PubMed2006

[Identification of a Meckel's diverticulum bleeding by urgent capsule endoscopy].

A 10 year-old patient was admitted to our hospital due to severe gastrointestinal bleeding. His symptoms included hematochezia and fainting. Neither emergency upper endoscopy nor colonoscopy had identified the site of bleeding. During the colonoscopy they noticed that fresh blood entered the cecum from the ileum. An urgent capsule endoscopy was performed 8 hours after the patient admission. They placed the capsule with specific endoscopic technique into the proximal duodenum under general anesthesia. During 3,5 hours by the small bowel passage the capsule moved to the ileum and a focal bleeding lesion was detected at this site, suggesting the typical picture of bleeding Meckel's diverticulum. The patient was transfused by 1 unit of blood, with a minimum haemoglobin level 95 g/l. By surgery the ulcerated Meckel's diverticulum was identified and resected. Histopathology showed ectopic gastric mucosa. Surgical resection of the diverticulum resulted complete healing of this patient. The capsule endoscopy diagnosis was prompt, precise, and the all examinations were carried out within 24 hours. Involving urgent small bowel capsule endoscopy into the diagnostic workup of the obscure bleeding patient could considerably shorten the time to achieve a correct diagnosis and allowed the early institution of definitive treatment. By this one could spare a great number of costly alternative investigations with low diagnostic yield.

Child↗
PubMed2002

Functional proteomics: The goalposts are moving.

Holistic understanding of protein function is a primary goal of the post-genome sequencing era. Functional genomic approaches are powerful and relatively straightforward but produce an incomplete picture at the protein level. Proteomics offers physiologically enriched insights to protein function, and ongoing advances are enabling proteome analyses to proceed with increased depth and efficiency. Exciting discoveries have emerged recently amidst growing awareness of the power of proteomics. However, while proven as a potent discovery tool, proteomics is under pressure to provide improved functional value particularly in concert with other investigative approaches. As reviewed here for ERp29, a recently discovered endoplasmic reticulum protein, the role of novel proteins can remain elusive even after substantial information has accrued. Thousands more proteins of uncertain function will be unveiled in the near future. Consequently, the goalposts are moving for proteomics both through increasing demand for high-value functional information and improving capacity to deliver.

Animals↗
PubMed1987

Rigidity in cinema seen from the front row, side aisle.

Pictures and cinema seen at a slant present the optics of virtual objects that are distorted and inconsistent with their real counterparts. In particular, it should not be possible for moving objects on slanted film and television screens to be seen as rigid, at least according to rules of linear perspective. Previous approaches to this problem have suggested that some process (perhaps cognitive) rectifies the optics of objects in slanted pictures to derive true shape and preserve shape constancy. The means for this rectification is usually thought to be based on recovery of true screen slant. In three experiments I show that this account is unnecessary and insufficient to explain the perception of rotating, rectangular objects in slanted cinema. I present data in favor of an alternate view, one in which the information is sufficient for perceivers to determine rigidity in an object on slanted screens, at least for parallel projections. In the human visual system, local measurements of objects are apparently made according to projective geometry; in those measurements, small amounts of certain distortions in projection are tolerated. Stimuli that appear nonrigid are ones that violate certain local principles, known as Perkins's laws, of projections of rectangular solids.

Humans↗
PubMed1993

[Can medicine move mountains?].

For the author involvement with Paracelsus demands consideration of both, socio-cultural as well as historico-cultural aspects. Each generation has obtained a different picture of this famous physician from Einsiedeln. Around 1941 the progress initiated by Paracelsus has been emphasized, such as the assumed foundation of chemistry, chemotherapy, and the renewal of surgery, occupational medicine, balneology and many more. For the year 1941 (= 400th anniversary of Paracelsus death) a nationalistic perception of Paracelsus was typical. For National-Socialistic Germany, Paracelsus was the founder of a "German medicine" as a contrast to medicine oriented towards France and Jewish-Arabia. Paracelsus also was seen as a pioneer of the experiment and as opponent of medical dilettantism in a popular direction. The perception of Paracelsus of 1993 is completely different. Today Theophrastus from Hohenheim is seen in a post-modern perspective, not as the man of progress, but as one, who opposed to the medicine of his age a partial ancient natural medicine, including the arts of gypsies, witches and midwives. The magic and psychosomatic informations of Paracelsus are seen as precious compensation for losses that we had to accept in the progress of modern medicine. As a psychiatrist Paracelsus was involved with diseases that originated from a "misuse of credo". He reports about collective psychoses, for example those appearing in the group of anabaptists in St. Gallen. Misuse of credo derives from intended provocation of martyrium. To move mountains with one's faith is another pathologic imagination. A therapy should aim at the restitution of such a "mountain" moved by the ill patient. Paracelsus demands the greatest mercy in dealing with mentally ill patients. This disease is also a challenge for theology: "What gives harm to the body destroys the house of the eternal".(ABSTRACT TRUNCATED AT 250 WORDS)

Culture↗
PubMed1979

Polyps of the urethra in children.

The authors present two cases of polyps of the urethra occurring exclusively in boys: one in a 12-month-old infant, the other in a 15-year-old boy. In both patients the polyp caused dysuria or urinary retention. Diagnosis was based on mictional cystography. This examination usually gives a picture of a filling defect spotted in the area of the bladder neck. During miction the defect may move deeper into the urethra. An endoscopic examination may be also helpful. The authors believe that treatment should consist in total excision of the polyp together with its base through the open urinary bladder. Polyps of the urethra have to be differentiated from a valve of the posterior urethra or a shadowless calculus. After total excision of the polyp prognosis is good.

Adolescent↗
PubMed1999

Estimates of shape by eye, or, the little invariant that could.

Five experiments were conducted to test the hypothesis that observers apprehend specific constancies under change in perspective. The constancies were projective properties of ellipses pictured to slant and tilt in depth. Observers were asked to reproduce the static upright view of a moving pair of ellipses, using a computer graphics display and interface. Projective invariants for pairs of conics were computed on the observers' productions. A few experimental conditions revealed near-perfect performance. When pairs of coplanar ellipses were viewed under dynamic transformation in perspective, then invariants calculated on the observers' productions were a match--in value on average--to the invariants of the transforming ellipse pairs. It is proposed that measures of projective properties afford a family of techniques that can be applied to gauge acuity for complex shapes in the study of visual form perception.

Analysis of Variance↗
PubMed1978

[Toxic rhabdomyolysis after alcohol and drug intoxications (author's transl)].

The clinical picture of toxic rhabdomyolysis after alcohol and drug intoxications is characterized by severe pain, swelling, and inability to move the affected muscle group. The disintegration of necrotic muscle tissue leads to hyperkalaemia, excessive increase of creatine kinase in serum, and a myorenal syndrome with anuria. Pathogenetically the combined effects of toxic vascular damage and local pressure and cold influence are assumed to occur. In anuria, resistant to conventional medication, early and repeated plasma exchanges are considered to be a therapeutic alternative to haemodialysis.

Adult↗
PubMed1984

Transcription of ground-state density-functional theory into a local thermodynamics.

The concepts of local temperature, local entropy, and local free energy density are introduced within the framework of the ground-state density-functional theory of many-electron systems, and a complete local thermodynamic picture is then developed. A view emerges of the electron cloud, as analogous to a classical inhomogeneous fluid moving under gradients of temperature, pressure, and an effective potential, described by a locally Maxwellian distribution.

Kinetics↗
PubMed1987

The diagnosis of schizophrenia.

Diagnosis refers to developing the best methods for classifying disorders and for identifying their characteristic symptoms. Most importantly, however, diagnosis refers to the identification of particular disorders that differ in their underlying mechanisms and causes, and therefore defines them as discrete diseases. Most current work on schizophrenia attempts to identify the best ways to classify it and the best ways to identify and define its characteristic symptoms to improve the ongoing search for mechanisms and causes. One idea that is currently widely discussed is the distinction between positive or florid symptoms and negative or defect symptoms. Much more research needs to be done on this model, however, and we need many more studies that attempt to integrate biological research with the careful work that has been done to date on clinical description. The astute modern investigator must be able to move freely between the biotype and the phenomenotype if he or she is to understand fully the clinical picture and ultimately the cause of schizophrenia.

Humans↗
PubMedDate not supplied

Trend analysis of cigarette smoking by Indiana adolescents, 1991-2000.

OBJECTIVES: To examine the feasibility of using a composite index of smoking behaviors to analyze adolescent smoking. METHODS: A secondary analysis of data from 10 annual surveys (1991-2000), from 566,467 Indiana students in grades 6 through 12. A composite index was calculated, and differences between index scores were analyzed using 1-way ANOVA, Tukey's post hoc tests, and 2-way moving averages. RESULTS: Index scores increased before 1997 and decreased after 1976, with greater change among 7th through 10th graders. CONCLUSIONS: The 2-way moving average comparison of a composite index, used with prevalence-based trend analyses, provides a more complete picture of changes in adolescent cigarette smoking.

Adolescent↗
PubMed1985

The modulation of cortical acetylcholine release by GABA, GABA-like drugs and benzodiazepines in freely moving guinea-pigs.

In order to define the modulatory role played by gamma-aminobutyric acid (GABA) in corticopetal cholinergic projections, the effect of this amino acid and related drugs on gross behaviour, the EEG and the release of acetylcholine (ACh) from the cerebral cortex in freely moving guinea-pigs was studied. gamma Aminobutyric acid, injected intracerebroventricularly (20-50 mumol) induced a three-phase picture: first (5-15 min) behavioural activation and increased release of ACh, then (30-90 min) depression, EEG synchronization and reduced release of ACh, and finally "rebound" stimulation. Ethanolamine-O-sulphate (EOS) injected intraventricularly (28 mumol/kg) or intraperitoneally (14 mmol/kg) reproduced the first two phases of the effects of GABA (i.e. stimulation followed by inhibition), while diazepam (0.7 and 3.5 mumol/kg, i.p.) and flurazepam (32 mumol/kg, i.p.) caused, at first, only depression. Muscimol and 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridine-3-ol (THIP) injected intraventricularly (in the nmol range) or intraperitoneally (in the mumol range) produced behavioural activation and increased release of ACh; the depressant signs appeared only after very large, toxic doses. Picrotoxin and bicuculline, at sub-convulsive doses, reduced the symptomatology caused by GABA and antagonized the sedation produced by diazepam. Methysergide (8-16 mumol/kg, i.p.) prevented the behavioural activation and the increased release of ACh by GABA, unmasked the depression due to subthreshold doses of diazepam (i.c.v., 7-70 nmol) and reversed the stimulation induced by muscimol into sedation and reduced the outflow of ACh. Pretreatment with 5,7-HT also dampened and shortened the stimulation by muscimol.(ABSTRACT TRUNCATED AT 250 WORDS)

Acetylcholine↗
PubMed1975

Various background pattern-effect on saccadic suppression.

It has been proved that the saccadic suppression is a phenomenon closely related to the presence of contours and structures in the visual field. Experiments were performed to clarify whether the structured background influences the pattern of attention distribution (making the stimulus detection more difficult) or whether the elevation of visual threshold is due to the "masking' effect of the moving background image over the retina. Two types of backgrounds were used therefore: those with symbolic meaning in the processing of which "psychological' mechanisms are presumably involved like picture reproductions of famous painters and photographs of nudes, and those lacking semantic significance like computer figures composed of randomly distributed black and white squares with different grain expressed as the entropy of the pattern. The results show that saccadic suppression is primarily a consequence of peripheral mechanisms, probably of lateral inhibition in the visual field occurring in the presence of moving edges over the retina. Psychological factors have to be excluded as being fundamental for saccadic suppression.

Eye Movements↗