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PubMed1991

Preliminary evaluation of a prototype tube-valve-mask ventilator for emergency artificial ventilation.

STUDY OBJECTIVE: The objective was to design a prototype tube-valve-mask ventilator that would permit relatively inexperienced operators to provide adequate emergency artificial ventilation, namely, adequate ventilatory volumes and a high oxygen and low carbon dioxide delivery. DESIGN: The tube-valve-mask ventilator is powered by the exhaled air of the operator and uses a tube to act as an oxygen reservoir (1,300 mL) that is filled between breaths. Mouth-to-mouth breathing was the standard against which the tube-valve-mask ventilator and the other accepted methods of mouth-to-mask and bag-valve-mask were assessed. SETTING: Comparison studies were conducted during simulated two-person CPR using a training mannikin equipped to measure ventilation volume and delivered oxygen and carbon dioxide concentrations. TYPE OF PARTICIPANTS: Seventeen volunteer first-year nursing students were used as operators. INTERVENTIONS: The order in which the pairs of operators performed each of the techniques was randomized. MEASUREMENTS AND MAIN RESULTS: The ventilation volume and the percentage of oxygen and carbon dioxide delivered by each technique were as follows (mean +/- SD): Mouth-to mouth (760 +/- 290 mL, 17 +/- 1% O2, 3.4 +/- 0.4% CO2), mouth-to-mask (910 +/- 350 mL, 41 +/- 8% O2, 2.5 +/- 0.4% CO2), bag-valve-(soft) mask (550 +/- 230 mL, 94 +/- 3% O2, 0.03 +/- 0.02% CO2), bag-valve-(rigid) mask (560 +/- 300 mL, 96 +/- 3% O2, 0.03 +/- 0.02% CO2), and tube-valve-mask (860 +/- 290 mL, 91 +/- 7% O2, 0.2 +/- 0.2% CO2). CONCLUSION: In the hands of relatively inexperienced operators, mouth-to-mouth, mouth-to-mask, and tube-valve-mask techniques provide adequate ventilation volumes to a mannikin. This was not the case with the bag-valve-mask systems (800 mL; P = .05 by t test). Of the systems that provide adequate ventilation volume, the tube-valve-mask appears, superior in that higher oxygen and lower carbon dioxide concentrations can also be obtained (P = .05 by paired t test).

Breath Tests↗
PubMed2002

Comparison of times to achieve tracheal intubation with three techniques using the laryngeal or intubating laryngeal mask airway.

We compared the times to intubate the trachea using three techniques in 60 healthy patients with normal airways: (i) fibreoptic intubation with a 6.0-mm reinforced tracheal tube through a standard laryngeal mask airway (laryngeal mask-fibreoptic group); (ii) fibreoptic intubation with a dedicated 7.0-mm silicone tracheal tube through the intubating laryngeal mask airway (intubating laryngeal mask-fibreoptic group); (iii) blind intubation with the dedicated 7.0-mm silicone tracheal tube through the intubating laryngeal mask airway (intubating laryngeal mask-blind group). Mean (SD) total intubation times were significantly shorter in the intubating laryngeal mask-blind group (49 (20) s) than in either of the other two groups (intubating laryngeal mask-fibreoptic 74 (21) s; laryngeal mask-fibreoptic group 75 (36) s; p < 0.001). However, intubation at the first attempt was less successful with the intubating laryngeal mask-blind technique (15/20 (75%)) than in the other two groups (intubating laryngeal mask-fibreoptic 19/20 (95%) and laryngeal mask-fibreoptic 16/20 (80%)) although these differences were not statistically significant. We conclude that in this patient group, all three techniques yield acceptable results. If there is a choice of techniques available, the intubating laryngeal mask-blind technique would result in the shortest intubation time.

Anesthesia, Dental↗
PubMed1999

The reinforced laryngeal mask in paediatric outpatient dental surgery.

One hundred and twenty ASA I and II grade children aged 2-9 years scheduled for outpatient dental extractions under general anaesthesia were studied. They were allocated randomly to one of three groups for airway management: group R had anaesthesia with a reinforced laryngeal mask airway, group L with a standard laryngeal mask airway and group N with a nasal mask. Anaesthesia was induced in all children using halothane in 50% nitrous oxide with oxygen and maintained on halothane in 67% nitrous oxide with oxygen. An Ayre's T-piece with Jackson-Rees modification was used. The incidence of airway obstruction was significantly lower and surgical access significantly better with the reinforced laryngeal mask airway when compared with the standard laryngeal mask airway. However, the reinforced laryngeal mask airway was significantly more difficult to insert when compared with the standard laryngeal mask airway. On comparing the reinforced laryngeal mask airway with the nasal mask, there were significantly fewer episodes of airway obstruction, better oxygen saturation, less increase in heart rate and fewer arrhythmias in the reinforced laryngeal mask airway group. Total time for the procedures was the same for all three groups. Thus, the reinforced laryngeal mask airway was found to be a favourable alternative to the standard laryngeal mask airway and nasal mask for paediatric outpatient dental extractions.

Airway Obstruction↗
PubMed2003

Position of exhalation port and mask design affect CO2 rebreathing during noninvasive positive pressure ventilation.

OBJECTIVE: Noninvasive positive pressure ventilation may be considered a first line intervention to treat patients with hypercapnic respiratory failure. However, CO2 rebreathing from the ventilator circuit or mask may impair CO2 elimination and load the ventilatory muscles. This study was conducted to evaluate the effect of exhalation port location and mask design on CO2 rebreathing during noninvasive positive pressure ventilation. DESIGN: Lung model evaluation. SETTING: Experimental laboratory of a large university-affiliated hospital. SUBJECTS: A dual-chamber test lung was used to simulate the ventilatory mechanics of a patient with obstructive lung disease. INTERVENTION: Hypercapnic respiratory failure (end-tidal CO2 of 75 mm Hg) and obstructive lung disease were simulated in a double-chamber lung model. A facial mask (inner volume of 165 mL) with exhalation port within the mask (Facial-MEP) or the same mask with exhalation port in the ventilator circuit (Facial-WS) and a total face mask with exhalation port within the mask (inner volume 875 mL, Total Face) were tested during continuous positive airway pressure and pressure support ventilation provided by a single-limb circuit ventilator at the same frequency and tidal volume. MEASUREMENTS AND MAIN RESULTS: A capnometer and a flow transducer were placed in the lung model upper airway to measure the volume of CO2 rebreathed and tidal volume (Vt). The inspiratory load was estimated from the pressure variation in the lung model driving chamber (PDR). Volume of CO2 rebreathed was smaller during Facial-MEP compared with the other masks in all tested conditions (p <.001). The Vt and PDR necessary to decrease end-tidal CO2 20% (from 75 to 60 mm Hg) was different among the tested masks (Facial-MEP, Vt 701 +/- 9 mL, PDR 8.1 +/- 0.1 cm H2O/sec; Facial-WS, Vt 745 +/- 9 mL, PDR 10.2 +/- 0.1 cm H2O/sec; Total Face, Vt 790 +/- 12 mL, PDR 11.4 +/- 0.2 cm H2O/sec, p <.001). CONCLUSION: Facial-MEP with its exhalation port within the mask and the smallest mask volume demonstrated less rebreathed CO2 and a lower PDR than either the Facial-WS or Total Face masks. Additional studies are necessary to confirm if mask design can clinically affect patient's inspiratory effort during noninvasive positive pressure ventilation.

Carbon Dioxide↗
PubMed2001

Asymmetry of masking between noise and iterated rippled noise: evidence for time-interval processing in the auditory system.

This study describes the masking asymmetry between noise and iterated rippled noise (IRN) as a function of spectral region and the IRN delay. Masking asymmetry refers to the fact that noise masks IRN much more effectively than IRN masks noise, even when the stimuli occupy the same spectral region. Detection thresholds for IRN masked by noise and for noise masked by IRN were measured with an adaptive two-alternative, forced choice (2AFC) procedure with signal level as the adaptive parameter. Masker level was randomly varied within a 10-dB range in order to reduce the salience of loudness as a cue for detection. The stimuli were filtered into frequency bands, 2.2-kHz wide, with lower cutoff frequencies ranging from 0.8 to 6.4 kHz. IRN was generated with 16 iterations and with varying delays. The reciprocal of the delay was 16, 32, 64, or 128 Hz. When the reciprocal of the IRN delay was within the pitch range, i.e., above 30 Hz, there was a substantial masking asymmetry between IRN and noise for all filter cutoff frequencies; threshold for IRN masked by noise was about 10 dB larger than threshold for noise masked by IRN. For the 16-Hz IRN, the masking asymmetry decreased progressively with increasing filter cutoff frequency, from about 9 dB for the lowest cutoff frequency to less than 1 dB for the highest cutoff frequency. This suggests that masking asymmetry may be determined by different cues for delays within and below the pitch range. The fact that masking asymmetry exists for conditions that combine very long IRN delays with very high filter cutoff frequencies means that it is unlikely that models based on the excitation patterns of the stimuli would be successful in explaining the threshold data. A range of time-domain models of auditory processing that focus on the time intervals in phase-locked neural activity patterns is reviewed. Most of these models were successful in accounting for the basic masking asymmetry between IRN and noise for conditions within the pitch range, and one of the models produced an exceptionally good fit to the data.

Adult↗
PubMed1989

Vibrotactile masking: effects of stimulus onset asynchrony and stimulus frequency.

Vibrotactile thresholds for the detection of a 50-ms vibratory stimulus on the thenar eminence of the hand were measured in the presence of and in the absence of a 700-ms suprathreshold vibratory masking stimulus. When thresholds were measured in the presence of the masking stimulus, stimulus onset asynchrony (SOA) was varied so that backward, simultaneous, and forward masking could be measured. The amount of masking, expressed as threshold shift, was greatest when the test stimulus was presented near the onset or offset of the masking stimulus. For both backward and forward masking, the amount of masking decreased as a function of increasing stimulus onset asynchrony. Comparisons were made of the amounts of masking measured when the test and masking stimuli were both sinusoids, and when the test stimulus was a sinusoid and the masking stimulus was noise. In all conditions, the masked threshold decreased approximately 4.0 dB when SOA was increased from 100 to 650 ms with reference to the onset of the 700-ms masking stimulus. More simultaneous masking was observed when sinusoidal test stimuli were detected in the presence of noise than when they were detected in the presence of sinusoidal maskers of the same frequency. The functions were essentially identical for detection of a low-frequency (20 Hz) test stimulus mediated by a non-Pacinian channel and detection of a high-frequency (250 Hz) test stimulus mediated by the Pacinian channel.

Adult↗
PubMed1989

Forward masking patterns produced by intracochlear electrical stimulation of one and two electrode pairs in the human cochlea.

Three psychophysical forward masking studies were conducted on a multichannel cochlear implant patient. The first study investigated the masking pattern produced by a bipolar electrode pair at different stimulus currents. It was found that the masking pattern for a single-masker bipolar electrode pair had a maximum located at an electrode position where the masker and probe coincided. The spread of the masking pattern was not symmetrical about the maximum. The amount of masking decreased very rapidly toward the apical direction and less rapidly toward the basal direction from the position of the maximum. As the stimulus current increased, the amount of masking at the maximum increased and the masking pattern broadened toward the base. The second study investigated the masking pattern produced by the activation of single bipolar electrode pairs with different spatial extents. The spatial extent of a bipolar electrode pair is defined as the distance between the apical and basal electrode members of the bipolar pair. With a small spatial extent (1.5 mm), the more basal electrode pairs (higher threshold and smaller dynamic range) produced broader masking patterns than the more apical electrode pairs (lower threshold and wider dynamic range), suggesting that there was more current spread at the basal region. With a larger spatial extent (4.5 mm), an additional secondary masking maximum was observed in the vicinity of the apical electrode member of the masker; this was observed only when the apical electrode member lay within the low-threshold apical region. The third study investigated the masking patterns produced by two loudness balanced bipolar masker electrode pairs activated within a stimulus period (inverse of the pulse repetition rate). The biphasic current pulses delivered to the two electrode pairs were nonoverlapping in time. It was found that, at any probe electrode position, the amount of masking produced by the two combined bipolar electrode pairs approximately followed the greater of the two maskings produced respectively by the two individual bipolar masker electrode pairs.

Cochlea↗
PubMed1990

Physiological mechanisms of psychophysical masking: observations from auditory-nerve fibers.

Masking might be due either to the spread of the excitation produced by the masker to the place of the tone signal along the cochlea or to the suppression of the response to the signal by the masker. In order to identify the contributions of these two mechanisms to tone-on-tone masking, masked thresholds of auditory-nerve fibers were measured in anesthetized cats using the same stimulus paradigms and detection criteria as in psychophysics. Suppressive masking was identified by comparing thresholds for simultaneous masking with those for a nonsimultaneous masking technique resembling pulsation thresholds. These nonsimultaneous thresholds do not include the contribution of suppression to masking because suppression only occurs for stimuli that overlap in time. For each masker and signal frequency, the fibers with the lowest (or "best") masked thresholds had characteristic frequencies (CF) slightly on the opposite side of the masker frequency with respect to the signal frequency, consistent with the psychophysical phenomenon of off-frequency listening. Patterns of best masked thresholds against signal frequency resembled psychophysical masking patterns in that they showed a maximum for signal frequencies close to the masker, and a skew toward high frequencies. Masking was found to be both excitatory and suppressive, with the relative contribution of the two mechanisms depending on the frequency separation between signal and masker. Suppressive masking was large for signal frequencies well above the masker. For these conditions, simultaneous thresholds grew more rapidly with masker level than did nonsimultaneous thresholds, suggesting that the upward spread of masking is largely due to the growth of suppression rather than to that of excitation.

Acoustic Stimulation↗
PubMed1996

Masking by ipsilateral and contralateral maskers.

Contralateral masking occurs when the threshold of a signal in one ear is elevated by the presence of a masker in the other, contralateral ear. The classic data and theory on contralateral masking were provided by Zwislocki [J. Acoust. Soc. Am. 52, 644-659 (1972)] who observed a 3- to 18-dB threshold shift (masking) for a gated pure-tone signal in one ear when a gated pure-tone masker was presented via insert earphones to the other ear. Zwislocki referred to this phenomenon as "central masking." Here, using two psychophysical methods (Yes-No; two-interval forced-choice), Zwislocki's original results, obtained with other psychophysical methods, were successfully replicated. Similar results using several psychophysical methods suggest that contralateral masking is indicative of a sensory phenomenon rather than observer bias and other response proclivities. In a second experiment, psychophysical tuning curves were obtained using either an ipsilateral masker or a contralateral masker. Tuning curves obtained with a contralateral masker had steeper slopes on both the low- and high-frequency sides than tuning curves obtained with an ipsilateral masker. Thus, although substantially smaller in effect than ipsilateral masking, contralateral masking is more sharply tuned. The sharp tuning of contralateral masking reflects a greater compression of the input/output functions for contralateral masking than for ipsilateral masking. The closest correspondence between the tuning curves reported here for contralateral masking and those predicted by Zwislocki's theory and data (on central masking) occurred for tuning curves where the ratio of driven activity to spontaneous activity was about six. A remaining issue is the role, if any, of the efferent auditory system, especially the olivocochlear bundle, in threshold shifts measured using the Zwislocki (central masking) paradigm.

Adult↗
PubMed1997

The role of spread excitation and suppression in simultaneous masking.

This experiment was intended to clarify the relative role of spread of excitation and suppression in simultaneous masking, for masker frequencies just below and well below the signal frequency. The experiment had two stages. In stage 1, growth-of-masking functions were measured in simultaneous masking for a 2200-Hz sinusoidal signal and a sinusoidal masker with frequency of either 1800 Hz or 500 Hz. Straight lines fitted to these data were used to determine masker levels that would give 10, 20, and 30 dB of masking. In stage 2, thresholds for detecting a brief 2200-Hz signal were measured using forward masking. It was reasoned that the threshold of the signal would give an indication of the amount of excitation evoked by the masker in the frequency region of the signal. Three forward maskers were used: (1) a 2200-Hz sinusoid at 10, 20, or 30 dB sensation level (SL); (2) a 2200-Hz sinusoid at the same levels as in (1) together with a sinusoid with frequency 500 or 1800 Hz at a level just sufficient to mask the 2200-Hz sinusoid. We refer to this as the "combined masker," (3) a 500-Hz or 1800-Hz sinusoid at the same levels as in (2) above. The 1800-Hz combined masker produced slightly less forward masking than the 2200-Hz masker (1), which might be explained in terms of suppression or as perceptual cueing. Both the 1800-Hz combined masker and the 1800-Hz component alone (3) gave significant amounts of forward masking (up to 18 dB), indicating that these maskers produced substantial excitation at 2200 Hz. This is consistent with the idea that the simultaneous masking of the 2200-Hz component in stage 1 was produced by spread of excitation rather than by suppression. The 500-Hz combined masker produced much less forward masking than the 2200-Hz component alone, indicating strong suppression of the 2200-Hz component of the combined masker by the 500-Hz component. However, both the 500-Hz combined masker and the 500-Hz component alone produced some forward masking. This is not consistent with the idea that masking of the 2200-Hz component in stage 1 (simultaneous masking) was produced solely by suppression.

Acoustic Stimulation↗
PubMed1992

A mask to modify inspired air temperature and humidity and its effect on exercise induced asthma.

BACKGROUND: Heat and moisture loss from the respiratory tract during exercise are important triggers of exercise induced asthma. METHODS: A new heat and moisture exchange mask has been developed which both recovers exhaled heat and water and has a sufficiently low resistance for use during exercise. The effect of the mask on inspired air temperature was studied in four normal subjects. Eight asthmatic subjects performed identical exercise protocols on three separate days, breathing room air through a conventional mouthpiece, a dummy mask, and the new heat and moisture exchange mask. Seven different asthmatic subjects exercised while breathing cold air at -13 degrees C through a dummy or active mask. RESULTS: All subjects found the new mask comfortable to wear. The mean inspired temperature when the mask was used rose to 32.5 (1.4) degrees C when normal subjects breathed room air at 24 degrees C and to 19.1 (2.7) degrees C when they inhaled subfreezing air at -13 degrees C. The heat and moisture exchange mask significantly reduced the median fall in forced expiratory volume in one second (FEV1) after exercise to 13% (range 0-49%) when asthmatic subjects breathed room air compared with 33% (10-65%) with the dummy mask and 28% (21-70%) with the mouthpiece. The fall in FEV1 when the asthmatic subjects breathed cold air was 10% (0-26%) with the heat and moisture exchange mask compared with 22% (13-51%) with the dummy mask. CONCLUSION: Use of a heat and moisture exchange mask can raise the inspired temperature and humidity and ameliorate the severity of exercise induced asthma. The mask may be of practical value in non-contact sport or for people working in subzero temperatures.

Adolescent↗
PubMed2004

Area summation and masking.

At detection threshold, sensitivity improves as the area of a test grating increases, but not when the test is placed on a pedestal and the task becomes contrast discrimination (G. E. Legge & J. M. Foley, 1980). This study asks whether the abolition of area summation is specific to the situation where mask and test stimuli have the same spatial frequency and orientation ("within-channel" masking) or is more general, also occurring when mask and test stimuli are very different ("cross-channel" masking). Threshold versus contrast masking functions were measured where the test and mask were either both small (SS), both large (LL), or small and large, respectively (SL). For within-channel masking, facilitation and area summation were found at low mask contrasts, but the results for SS and LL converged at intermediate contrasts and above, replicating Legge and Foley (1980). For all three observers, less facilitation was found for SL than for SS. For cross-channel masking, area summation occurred across the entire masking function and results for SS and SL were identical. The results for the entire data set were well fit by an extended version of a contrast masking model (J. M. Foley, 1994) in which the weights of excitatory and suppressive surround terms were free parameters. I conclude that (i) there is no empirical abolition of area summation for cross-channel masking, (ii) within-channel area summation can be abolished empirically without being disabled in the model, (iii) observers are able to select the area of spatial integration, but not suppression, (iv) extending a cross-channel mask to the surround has no effect on contrast detection, and (v) there is a formal similarity between area summation and contrast adaptation.

Adaptation, Ocular↗
PubMed1996

Backward versus forward visual masking deficits in schizophrenic patients: centrally, not peripherally, mediated?

OBJECTIVE: Schizophrenic patients have repeatedly demonstrated the inability to rapidly process information when tasks are timed or the processing load is relatively high. Schizophrenic patients show consistent deficits in the visual backward masking paradigm. In visual backward masking, an informational target stimulus is presented, followed after an interstimulus interval by a masking stimulus that interferes with or interrupts target identification. METHOD: In order to clarify whether the visual backward masking deficits of schizophrenic patients are indeed central rather than peripheral in origin, the authors compared visual backward masking to psychometrically matched visual forward masking performance in 35 normal comparison subjects and then 35 schizophrenic patients. In visual forward masking, the mask precedes the target, and visual forward masking mechanisms are felt to be more peripheral (retinal) than are visual backward masking mechanisms. RESULTS: For psychometrically matched forward and backward masking tasks, the schizophrenic patients had a selective and differential deficit in the backward masking condition. CONCLUSIONS: These results support the interpretation that the observed visual backward masking deficits of schizophrenic patients are centrally mediated.

Adult↗
PubMed2001

Pulmonary peptide delivery: effect of taste-masking excipients on leuprolide suspension metered-dose inhalers.

The purpose of this study was to evaluate the effect of taste-masking excipients on in vitro and in vivo performance of a leuprolide metered-dose inhaler (MDI) suspension formulation. Taste-masking excipients (aspartame and menthol) were added to a leuprolide suspension MDI formulation. The leuprolide MDI formulation with the taste-masking excipients was characterized in terms of milling time, particle size distribution, dose delivery and uniformity, and drug absorption in dogs. The data were compared with a formula that did not contain taste-masking excipients. It was found that the longer milling time for the leuprolide suspension with the taste-masking excipients was required to obtain a similar particle size distribution compared with the formula without taste-masking excipients using a fluid energy mill. Although measurable differences in mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD) were not observed between the two formulations, the percent of particles < or = 5 microns and the actuator retention for the formula with the taste-masking excipients were significantly different from the formula without taste-masking excipients using the Marple-Miller cascade impactor. Taste-masking excipients did not show a significant effect on valve delivery and through-can dose uniformity. However, the mean ex-actuator dose was 150.4 mg for the formula with the taste-masking excipients and 162.2 mg for the reference formula, respectively, indicating a significant difference. In tracheostomized dogs, both formulations showed comparable pharmacokinetic parameters including Cmax, Tmax, AUC0-12 and bioavailability (F%), indicating that the taste-masking excipients do not have an effect on lung absorption of leuprolide acetate. Therefore, inclusion of taste-masking excipients in the leuprolide MDI suspension formulation showed a significant impact on drug micronization, exactuator dose, and particle deposition pattern. Mechanistically, the unfavorable performance of leuprolide MDI in the presence of taste-masking excipients could be due to modification of the properties of the suspension itself and alteration of propellant evaporation following actuation.

Administration, Inhalation↗
PubMed1998

Effect of background components on spatial-frequency masking.

Previous studies of spatial-frequency masking and adaptation have shown that the contrast-detection threshold elevates maximally when the test spatial frequency is the same as the masking (or adapting) frequency but changes only slightly when they are separated by two or more octaves. At low spatial frequencies, however, the peak of the threshold-elevation function does not obey this rule: there is a well-established peak shift in the threshold-elevation functions toward higher spatial frequencies. We investigated whether this shift might be due to the masking effects caused by the background field, which contributes energy at the very low end of the spectrum. We first measured the effect of a 3-cycles/deg (c/deg) mask on detection of a range of test frequencies, compared with unmasked detection thresholds. We then measured the combined effect of a 2-c/deg and a 3-c/deg mask on detection, compared with detection with just the 2-c/deg mask. The comparison in the second case still tests the effect of the 3-c/deg mask, but the presence of the hidden 2-c/deg mask causes the peak masking effect to shift toward higher frequencies. This result provides a proof of concept for the hypothesis that the peak shift at low spatial frequencies is caused by the low-frequency energy in the background field, which is present in both masked and unmasked conditions. A five-parameter quantitative model of frequency masking is presented that describes the pure contrast-detection function, the frequency-masking functions at mask frequencies of 0.25, 0.5, 2, and 3 c/deg, and the peak-shift phenomenon.

Contrast Sensitivity↗
PubMed2006

Protecting staff against airborne viral particles: in vivo efficiency of laser masks.

Laser masks are used to prevent inhalation of viral particles during laser surgery. A crossover trial was performed in eight volunteers to compare the ability of a surgical mask and a laser mask with that of an FFP2 respirator to filter airborne dust particles. The surgical and laser masks were tested when worn normally and when they were taped to the face. The mean reductions in particle counts were 3.0 fold [95% confidence interval (95% CI) 1.8-4.2] for the untaped surgical mask, 3.8 fold (95% CI 2.9-4.6) for the untaped laser mask, 7.5 fold (95% CI 6.5-8.5) for the taped surgical mask, 15.6 fold (95% CI 13.5-17.8) for the taped laser mask, and 102.6 fold (95% CI 41.2-164.1) for the FFP2 half-face respirator. The laser mask provided significantly less protection than the FFP2 respirator (P=0.02), and only marginally more protection than the surgical mask. The continued use of laser masks for respiratory protection is questionable. Taping masks to the face only provided a small improvement in protection.

Cross-Over Studies↗
PubMed1997

Contrast masking effects change with practice.

Contrast detection thresholds are known to increase with background contrast, a phenomenon called contrast masking. We found that, under some conditions, observers improved their masked detection performance by repetitive practice of a masking experiment. This learning effect resulted in a cancellation of suprathreshold contrast masking within the contrast range measured. A two-alternative forced-choice discrimination paradigm was used, with stimuli consisting of Gabor signals as maskers and target, presented at the same location and time. Untrained observers showed increased detection thresholds with increasing mask contrast for suprathreshold mask contrasts, but perceptual learning caused an elimination of this classical effect, with masked thresholds reaching the no-mask level and below. Learning did not decrease, but rather somewhat increased, discrimination thresholds when target and mask shared the same Gabor signal parameters. Performance improvement was found to be specific for orientation and mask configurations, though it did transfer between mirror symmetric mask configurations and between eyes. These results argue against a static transducer function-based account for contrast masking and are consistent with a theory assuming multiple feature-based interactive network capable of long-term gain modifications.

Contrast Sensitivity↗
PubMed2000

[Measurement of mask leakage during CPAP in patients with obstructive sleep apnea].

UNLABELLED: To improve the compliance of patients with obstructive sleep apnoea tight fitting nasal masks are necessary. It would be very useful to to measure the mask leakage during the recommended pressure for the treatment at home. We studied therefore the influence of different sizes and types of masks on the air leaks during the adaptation procedure. We investigated 20 patients, mean age 60.8 +/- 11.9 years, AHI 31 +/- 17, lowest oxygen saturation 81 +/- 10.3% mean CPAP-9.9 +/- 1.6. Randomized cross over we applied CPAP with different masks during wakefulness. The pressure was increased from 6 to 13 mbar by steps of 1 mbar. The mask leak was measured by Autoset. RESULTS: Using the best mask (selected from different sizes and different brands) the mask leak was 0.11 +/- 0.9 L/sec. If the patient used a mask (only one brand but selected from different sizes) or one standard mask the mask leak doubled respectively tripled. To reduce side effects and improve compliance we recommend therefore quantification of the mask leak to find the best fitting mask.

Equipment Failure↗