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PubMed1965

DEAFNESS.

Dr T E T Weston describes his research into the effect of noise on hearing acuity and of deafness in the aged. He found that presbyacusis is associated with a multiplicity of factors, e.g. smoking, circulatory disturbance, urban domicile, heredity and occupational acoustic trauma.Miss W Galbraith describes the social implications of various degrees of deafness and the ways in which they can be overcome by such measures as lipreading, hearing aids and rehabilitation.Sir Terence Cawthorne discusses otosclerosis, nearly 1% of the population being affected by this type of deafness. He describes the modern operation of insertion of an artificial piston through the stapes and states that 90% of cases submitted to this operation will show immediate improvement, whilst 85% should still have retained this improvement at the end of two years.

Audiometry↗
PubMed2006

Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate.

OBJECTIVE: The current study was designed to evaluate the neurobiology of reading in a group of men with nonsyndromic clefts of the lip or palate (NSCLP) compared with healthy controls by positron emission tomography. DESIGN: SUBJECTS included eight men with NSCLP compared with six healthy control men. By using radioactively labeled water (O(15)), regional brain blood flow was obtained during the performance of three simple reading tasks: reading unrelated words, reading unrelated sentences, and reading a story. RESULTS: During each of the reading conditions, NSCLP subjects compared with healthy controls showed increased blood flow in areas previously reported to be involved in language processing and reading (inferior frontal lobe, cerebellum, and occipital lobe). The increased blood flow suggests a possible neural inefficiency. In contrast, when analyzing the brain regions involved in more complex language functioning (reading stories compared with reading only words), control subjects showed an increase in blood flow in a distributed neural circuit, whereas the NSCLP subjects showed a decrease in flow in these regions. Additionally, the NSCLP subjects had activation of several regions not activated in the healthy controls, suggesting a compensatory circuit used for this more complex reading task. CONCLUSIONS: These results indicate that subjects with NSCLP show abnormalities in the function of the distributed neural circuitry used for oral reading.

Adult↗
PubMed1987

[Management of an explosion injury of the face].

A 19 year old soldier suffered an explosion injury of the face. He lost the left cerebral hemisphere, the left eye and ear and the majority of the facial musculature on the left side. Primary surgery with rotational flap and mesh graft. Further local flaps and revision of wound area followed. Inspite of nearly complete destruction of the left cerebral hemisphere the patient could walk with only slight hemiparesis. He learned to write with his left hand, he could read from the lips and stand. An understandable speech could not be obtained. Fitting of an epithesis.

Adult↗
PubMed2005

[NF2: ocular, neural and genetic manifestations].

Neurofibromatosis 2 is an autosomal-dominant disease, which is characterized by vestibular schwannomas, cataract, retinal hamartomas as well as tumors of the peripheral and central nerve system, demonstrating a variety of expression. The ophthalmologist plays an important role in making the diagnosis, as several ocular manifestations may be shown during childhood, before tumors of the central nerve system become symptomatic. An early diagnosis of NF 2 may prevent deafness by early surgical intervention. Due to primary and secondary reasons such as age-related processes, different sensations like hearing or vision may be compromised. Neuropathy may lead to vestibular disturbances and loss of muscle control. Therapeutic options include cataract surgery, implantation of cochlear or brainstem implants as well as conservative therapy of the ocular surface in paresis of the VIIth cranial nerve or learning to read from the lips. The human NF2 gene was cloned from chromosome 22 in 1993. The major part of the genetic alterations described so far are point mutations as well as deletions or insertions in or around the exons. Geno-phenotype correlations allow some predictions of the course of the disease to be made.

Adolescent↗
PubMed2003

Do the reading disabilities of children with cleft fit into current models of developmental dyslexia?

OBJECTIVE: The purpose of this study was to determine whether the reading problems of children with cleft fit models of developmental dyslexia. DESIGN: The study compared children with nonsyndromic cleft lip and palate who had reading disability (n = 46) with those who did not have reading disability (n = 46). The children were matched for age, sex, and grade. The two groups were compared (t tests) on measures of verbal expression, phonemic awareness, and rapid naming. Also, regression analyses compared the relative relationships of these variables to reading disability. PARTICIPANTS: Children were selected from 154 patients originally screened. RESULTS: Children with reading disability scored significantly lower on rapid naming and verbal expression, with no differences found on phonemic awareness. Rapid naming was shown to have the most significant association with reading disability. CONCLUSION: Children with nonsyndromic cleft lip and palate show symptoms similar to a naming-memory deficit model of developmental dyslexia. Reading treatment should avoid sight word approaches and focus on oral phonics treatment.

Anomia↗
PubMed1984

Type of reading disability related to cleft type and neuropsychological patterns.

Two groups of cleft palate subtypes (cleft lip and palate and cleft palate only) with reading disability, matched for intelligence, age, sex, and reading level, were compared on reading and neuropsychological test variables. Subjects included 14 males and 10 females of each cleft type ranging in age from 8 to 13. Results showed a significant difference between groups on most language measures and differences in reading comprehension and type of reading errors. Results suggest that children with cleft palate only constitute a language-disorder group with more severe reading disabilities. Children with cleft lip and palate are more likely to have verbal expressive deficits and milder reading problems, possibly related to peripheral speech mechanisms.

Adolescent↗
PubMed1991

Cloning, nucleotide sequencing, and expression in Escherichia coli of a lipase and its activator genes from Pseudomonas sp. KWI-56.

A lipase gene (lip) and its activator gene (act) on a 2.9 kb BglII-EcoRI fragment from Pseudomonas sp. KWI-56 were cloned in Escherichia coli using pUC19 as a vector plasmid. From the sequencing results, the open reading frames of the lip and the act were found to contain 1092 and 1032 nucleotides, respectively. The act existed downstream of the lip with the same orientation. When the lip was expressed in E. coli using the lac promoter on the pUC plasmid vector, the lipase activity of E. coli carrying both the lip and the act was 200-fold greater than that carrying only the lip. This result suggested the act was important in the expression of the lip in E. coli.

Amino Acid Sequence↗
PubMed1976

Social response to acoustic and visual characteristics of oral cleft.

This study was concerned with societal preference among speech, visual, and speech-visual characteristics of persons with repaired cleft lip and palate. A 16 mm motion film with sound was professionally made of 17 male, adult, cleft lip and palate speakers reading the first paragraph from "The Rainbow Passage." A heterogeneous group of 30 adults rated their preference for each of the conditions-auditory, visual and auditory-visual-on a seven-point equal-appearing intervals scale. A four-factor design analysis of variance with repeated measures was performed to determine whether the thirty judges preferred at least one variable of the three variables tested. Results indicated that this heterogenous population had no preference among auditory, visual, or auditory-visual characteristics of adult males with repaired cleft lip and palate. These variables appear to be considered of equal importance by persons who are representative of the lay public.

Adult↗
PubMed2001

Low-temperature lipase from psychrotrophic Pseudomonas sp. strain KB700A.

We have previously reported that a psychrotrophic bacterium, Pseudomonas sp. strain KB700A, which displays sigmoidal growth even at -5 degrees C, produced a lipase. A genomic DNA library of strain KB700A was introduced into Escherichia coli TG1, and screening on tributyrin-containing agar plates led to the isolation of the lipase gene. Sequence analysis revealed an open reading frame (KB-lip) consisting of 1,422 nucleotides that encoded a protein (KB-Lip) of 474 amino acids with a molecular mass of 49,924 Da. KB-Lip showed 90% identity with the lipase from Pseudomonas fluorescens and was found to be a member of Subfamily I.3 lipase. Gene expression and purification of the recombinant protein were performed. KB-Lip displayed high lipase activity in the presence of Ca2+. Addition of EDTA completely abolished lipase activity, indicating that KB-Lip was a Ca2+-dependent lipase. Addition of Mn2+ and Sr2+ also led to enhancement of lipase activity but to a much lower extent than that produced by Ca2+. The optimal pH of KB-Lip was 8 to 8.5. The addition of detergents enhanced the enzyme activity. When p-nitrophenyl esters and triglyceride substrates of various chain-lengths were examined, the lipase displayed highest activity towards C10 acyl groups. We also determined the positional specificity and found that the activity was 20-fold higher toward the 1(3) position than toward the 2 position. The optimal temperature for KB-Lip was 35 degrees C, lower than that for any previously reported Subfamily I.3 lipase. The enzyme was also thermolabile compared to these lipases. Furthermore, KB-Lip displayed higher levels of activity at low temperatures than did other enzymes from Subfamily I.3, indicating that KB-Lip has evolved to function in cold environments, in accordance with the temperature range for growth of its psychrotrophic host, strain KB700A.

Amino Acid Sequence↗
PubMedDate not supplied

[Control of inner speech and Gilles de la Tourette's syndrome].

UNLABELLED: Inner speech is the little voice in the head which comments on everyday life activities. To some aspect, trouble in monitoring the inner speech has been regarded as relevant in auditory hallucinations in psychosis. Another disorder that may involve inner speech is the difficulty inhibiting its vocal utterance (the so-called verbal impulsion ). Verbal impulsion is a classic feature of Gilles de la Tourette's syndrome, during which patients complain of difficulties inhibiting socially undesirable behaviors, especially vocalization (i.e. coprolalia). In a previous paper, we reported on a patient with frontotemporal dementia, whose pathology was revealed by a difficulty inhibiting the verbal utterance of reading (inability to read silently). Later in the course of the disorder, the patient exhibited a severe frontal lobe syndrome with compulsive activities and coprolalia. Externally triggered inner speech has been proposed by the author to be represented by silent reading. In this setting, loss of silent reading can be regarded as the equivalent of a loss of control of the verbal utterance of the inner speech. CASES REPORT: In the present paper, a loss of control of inner speech is suggested as partly involved in two cases of Gilles de la Tourette's syndrome with coprolalia. Two adult patients with a diagnosis of Gilles de la Tourette's syndrome since age 7 and 10, respectively, have been asked to comment on their present or previous abilities to read silently. The first case never silent read as a child while the second case read silently but had a tendency to move his lips. DISCUSSION: The frequency of observed difficulties in silent reading is likely to be a function of the age at which the subject is asked about such difficulties. Nevertheless, theoretical arguments are presented in this part of the paper which suggest that silent reading, considered as a way to challenge the control of inner speech, has been variably impaired at different stages of the disease. The author speculates that the key role of prefrontal cortex, especially the orbito-frontal areas, in the inhibitory control of current behavior, can be responsible for the deficit in the control of inner speech. In this setting, recent functional brain imaging performed in patients with Gilles de la Tourette's syndrome showed a striking deficit in the activation of these areas during tics. It would be of great interest to address this specific question in determining the frequency of difficulties in silent reading in Gilles de la Tourette's syndrome individuals as compared to those without Gilles de la Tourette's syndrome. In this way, the so-called Stroop-test should be adequate in addressing this pivotal issue. In this well-known neuropsychological test the subject is asked to orally report the color in which the name of color has been written. The discrepancy between the color of the written word and the name of the color that have been read can challenge the ability of the subject to correctly inhibit the reading (in example the word blue ) in order to say another color (in example red , if the word blue is red colored). CONCLUSION: Loss of silent reading observed in such patients is suggestive of the failure of the prefrontal inhibitory control on the verbal utterance of inner speech. Further research is needed to confirm these findings.

Adult↗
PubMed1996

Perioral muscle activity in young and older adults during speech and nonspeech tasks.

Correlations of EMG activity among paired sites surrounding the lips were examined as a measure of muscle coupling during oral movements. Twenty-tow young women (M = 22 years old) and 22 older women (M = 75 years old) performed lip protrusion, chewing, conversational speech, and reading aloud tasks. Surface EMG was recorded from the right and left sides of both the upper and lower lips during 20 s of task performance. Signals from each site, representing the sum of activity from muscle fibers present in the underlying tissue, were correlated with signals from every other site. Positive correlations were pervasive, but the range of values extended from .96 to -.19. Correlation values tended to be high across the upper lip and across the lower lip, regardless of the task. Other sites (right side, left side, and diagonal pairs) were also highly correlated for the protrusion and chewing tasks, but were less highly correlated for the speech tasks. Younger women showed significantly lower correlation values for speech tasks than older women. Results imply an increase in muscle coupling for speech as an effect of the aging process, perhaps reflecting a reduction in flexibility of fine oral motor control. Limits of the correlation technique and issues concerning speech production ability in old age are discussed.

Adolescent↗
PubMed1992

The biosynthesis of lipoic acid. Cloning of lip, a lipoate biosynthetic locus of Escherichia coli.

The lip gene of Escherichia coli has been cloned and sequenced. Subcloning of a 3-kilobase EcoRI/EcoRV restriction fragment from Clark-Carbon plasmid pLC15-5 into pUC18 gives a plasmid that complements two lipoate auxotrophs, W1485-lip2 and JRG33-lip9, and which expresses a protein of approximately 36,000 Da. Sequencing suggests that lip codes for a protein of 281 amino acids (31,350 Da), showing sequence similarity to biotin synthase. It is thus likely that lip encodes a sulfur insertion enzyme analogous to biotin synthase and that the sulfur insertion chemistries of the two systems are related. Unidirectional nested deletion experiments show that both lipoate auxotrophs are complemented by the same 500-base pair region at the 3' terminus of the lip gene, indicating that the mutations affecting lipoate biosynthesis are located in this region of the protein. A small open reading frame located immediately downstream of the lip gene codes for a small protein of unknown function.

Amino Acid Sequence↗
PubMed1988

Reading disability in children with clefts.

The prevalence of reading disability was examined in 172 elementary school children with cleft lip and palate (CLP) or cleft palate only (CPO). Approximately 35 percent of the sample displayed a moderate degree of reading disability, and 17 percent of the group exhibited severe reading disability. Reading disability was more prevalent at younger ages, presumably because of peripheral speech deficits. For older children, those with CLP displayed an incidence of reading disability similar to the general population (9 percent), whereas children with CPO exhibited a much higher rate of reading disability (33 percent). There were no sex differences in the prevalence of reading disability in this sample. The study supports earlier suggestions that children with CPO may be more likely to experience general language disorders leading to long-term reading disabilities. Children with CLP appear to manifest reading problems that tend to resolve with increased age.

Adolescent↗
PubMed1996

Anesthetic efficacy of the periodontal ligament injection after an inferior alveolar nerve block.

The purpose of this study was to determine the contribution of the periodontal ligament injection (PDL) to the inferior aveolar nerve (IAN) block in human first molars. Using a repeated-measures design, 40 subjects randomly received a combination IAN block and PDL injections of the first molar using 2% lidocaine with 1:100,000 epinephrine and a combination IAN block and mock PDL injections (needle penetration only) at two successive appointments. The first molar and adjacent teeth, and contralateral canine (positive and negative controls) were blindly tested with an Analytic Technology pulp tester at 2-min cycles for 60 min. Profound anesthesia was defined as no subject response at an 80 reading. One hundred percent of the subjects had lip numbness with the IAN block. When the combination IAN/PDL injections were compared with the IAN block, the incidence of successful pulpal anesthesia (80 reading) was significantly greater for the combination injections through the first 23 min of pulp testing. However, after 23 min, there was no increase in anesthetic success by adding the PDL to the IAN injection. We concluded that adding the PDL injection to an IAN block increased the incidence of pulpal anesthesia for the first 23 min in the first molar.

Adult↗