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At least 253 records · Page 14Linked to original sources
PubMed1986

Immunoglobulin classes in plasma cells of the synovial membrane in chronic inflammatory joint disease.

The histological features of the synovial membrane in rheumatoid arthritis (RA) are shared by other chronic inflammatory joint diseases, so that diagnostic differentiation is impossible. Examination of the immunoglobulin class in the plasma cells present in inflamed synovial membranes, however, has shown differences. Synovial membranes from 12 patients were seropositive RA, eight with seronegative RA, eight with ankylosing spondylitis, five with psoriatic arthritis, and three with Reiter's syndrome have been compared by peroxidase-antiperoxidase (PAP) staining for immunoglobulin classes on routinely paraffin wax embedded sections. There were no significant differences in the percentages of plasma cells containing IgG of IgA between the diseases studied. There were, however, significantly more plasma cells containing IgM in patients with seropositive RA (2-34%) compared with those with seronegative RA (0-10%; p less than 0.002) and with other chronic synovitides (0-9%; p less than 0.002). The results show that it is possible to distinguish seropositive RA from other chronic inflammatory joint diseases by PAP staining for immunoglobulin classes in the plasma cells present in the inflamed synovial membrane.

Adolescent↗
PubMed1986

Reduction of passive extension and radiographic evidence of degenerative knee joint diseases in cage-raised and free-ranging aged rhesus monkeys (Macaca mulatta).

The knee joints of aged (greater than or equal to 15 years) rhesus macaques raised and maintained in individual cages were compared with those of formerly free-ranging monkeys using radiographs and measures of passive joint flexion and extension. Free-ranging monkeys had a significantly higher prevalence (p less than 0.01) and severity (p less than 0.0003) of degenerative joint diseases (osteoarthritis and/or pseudogout) based on radiographic findings and significantly (p less than 0.02) more restricted passive knee joint extension than caged animals of the same age.

Animals↗
PubMedDate not supplied

Thoracolumbar spinal cord compression due to vertebral process degenerative joint disease in a family of Shiloh Shepherd dogs.

Five young Shiloh Shepherd Dogs (4 males and 1 female) related by a common sire were studied because of progressive pelvic limb weakness and incoordination. All dogs had a spastic paraparesis and pelvic limb ataxia consistent with an upper motor neuron and general proprioceptive lesion between spinal cord segments T3 and L3. Proliferative lesions involving one or more of the articular processes from the 11th thoracic vertebrae to the 2nd lumbar vertebra were observed on radiographs of the thoracolumbar vertebrae. Dorsal compression of the spinal cord was identified during imaging studies at these sites. Abnormalities of the synovial joints and bony proliferation of the involved articular processes were identified at postmortem examination in 2 dogs. The articular processes and associated vertebral arches protruded into the vertebral canal, indenting the dorsal surface of the spinalcord. Degenerative joint disease (DJD) was identified histologically. A compressive myelopathy was diagnosed in the spinal cord. These dogs were affected by a compressive myelopathy as a consequence of vertebral process DJD that likely has a geneticcomponent. The DJD could have been caused by a primary vertebral malformation or an injury to the processes at a young age causing malarticulation.

Animals↗
PubMed1980

Hemophilic arthropathy: effect of home care on treatment patterns and joint disease.

To evaluate the efficacy of home care therapy on hemophilic arthropathy, data were analyzed in 19 patients with hemophilia who had been on home therapy for more than four years. Usage of replacement material, number of bleeding episodes, and clinical and radiographic assessment of joint status were evaluated. Patients were divided into three treatment groups (prophylaxis, combination, and episodic care) for further comparison. In all treatment groups, a significant decrease in product usage occurred with age (P < 0.01). The number of bleeding episodes also decreased significantly with age (P < 0.01). The patients' joints which were clinically and radiographically normal on entry into home therapy remained free of arthropathic changes. The outcome of diseased joints varied across treatment groups, with a majority of these joints remaining stable. Younger patients evidenced new and progressive arthropathy, whereas older patients demonstrated stable arthropathy. Although no single treatment protocol appears to be indicated for all patients with hemophilpia, a treatment goal may be to treat younger patients actively in order to preserve normal joint status, stablize diseased joints, and prevent subsequent disability.

Adolescent↗
PubMed1997

Positioning errors produced by persons with knee joint disease when vision is occluded.

This study examined the effect of occluding static vision on the ability of persons with knee joint disease and impaired position sense to actively reproduce knee angles in a one-legged standing position. The subjects, six women with knee joint disease, ages 54-75 years each performed a series of two knee repositioning tasks in the ranges of 20-40 degrees flexion on two different occasions, both with, and without visual feedback. On each occasion, the leg was marked with reflective markers and the resultant sagittal plane knee angles were photographed. Whilst the absolute differences between the criterion and the matching knee angles calculated from these records showed vision to have an effect on positioning accuracy (p = 0.04), there were no differences in mean absolute constant errors between the two experimental paradigms, indicating similar perceptual judgment in memory. However, variability in performance tended to be greater when vision was occluded (p = 0.08). These findings suggest that while visual sources of information may play a minor role in the knee positioning bias towards target overestimation apparent in this group, supplementary visual cues may help to promote more consistent positioning performance.

Aged↗
PubMed1999

Prognostic factors affecting survival of 507 horses with joint disease: (1983 to 1990).

Between July 1, 1983 and December 31, 1990, risk factors were determined for all horses with joint disease presented to a referral center, of being discharged, of ever becoming sound, or of being alive at 3 mo follow-up. Logistic multiple-regression models were done separately for foals (< or = 4 mo), yearlings (> 4-24 mo) and racing or nonracing adult horses (> 24 mo). The breakdown in this study was 53 foals, 87 yearlings, 141 nonracing adults, and 226 racing adults. Thirty-one foals (58%), 68 yearlings (78%), 119 non-racing adults (84%), and 213 racing adults (94%) were discharged. Foals with a less severe lameness, duration of illness of > 1 d, and infectious arthritis had increased odds of discharge. At follow-up, 12 of 18 (67%) were alive, 10 (56%) of which were sound. Yearlings with osteochondrosis had higher odds of discharge; at follow-up, 38 of 49 (78%) were alive, 32 (65%) of which were sound. For non-racing adults, horses with less severe lameness, without a miscellaneous diagnosis, or intended for pleasure use had increased odds of discharge. At follow-up, 55 of 78 (70%) were alive and 33 of 58 (57%) with soundness data became sound. Risk factors for higher odds of being alive at follow-up were carpal lameness, arthroscopic surgery, a prognosis other than poor, became sound, above-median hospitalization costs, and duration of follow-up. The 161 racing adults (76% of discharges), with follow-up, were more likely to have had osteoarthritis, higher hospital costs, hospitalization > 1 d, and arthroscopy. Sixty-four (60%) of these became sound; the odds increased if the horse was not severely lame at admission or was hospitalized for > 1 d. Risk factors and prognosis differed by age-use group among horses seen at our hospital.

Animals↗
PubMed1991

Evaluation of joint disease in the pediatric hand.

Juvenile rheumatoid arthritis, leukemia, hypertrophic osteoarthropathy, sickle cell disease, and child abuse can all be causes of joint disease in the child's hand. The role of radiology is to diagnose disease and follow disease progression so that therapy can be modified. Because much of the child's hand is unossified cartilage, measurements, bone mineralization, and maturation are important components of the radiologic evaluation.

Arthritis, Juvenile↗
PubMed2002

[Bone and joint diseases in the elderly].

As a current attention of the medical treatment has been paid to improve guality of the life rather than to save the life of the patient, so the treatment of bone and joint diseases, which are not ordinarily fatal and deteriorate quality of the life of the patient, would become important in the aged society of 21 century. In a strategy to improve the quality of life in the patient with osteoarthritis, disease modifying anti-osteothritis drugs are investigated for primary prevention and complete recovery of osteoarthritis. In osteoporosis, a characteristic bone disease of the aged, aims of the treatment have been changed from freeing of pain in the nineteen sixties, increase of bone mass in the nineteen eighties and reduction of the fracture rate in the nineteen nineties to improve of quality of the life through decrease of pain and fracture in 21 century. In conclusion, current management for bone and joint diseases in the elderly is finally designed to enjoy a healthy life of long span by medical intervention.

Aged↗
PubMed1996

Adhesion molecule expression and complement activation in vessel walls in synovial tissue from patients with chronic inflammatory joint disease.

Histopathology demonstrating a manifest vasculitis is a rare event in synovial tissue (ST) from patients with chronic inflammatory joint disease. As a possibly more subtle sign of a vasculitic process, complement activation in vessels in ST was studied. In the same tissues, the expression of the adhesion molecules ICAM-1 and E-selectin in vessel walls was examined, to see if the expression was related to vasculitic processes. The study was performed by use of direct immunofluorescence technique on cryostat sections of ST, using mouse monoclonal antibodies to the terminal complement complex (TCC, C5b-9), ICAM-1 and E-selectin. Expression of ICAM-1 was found in the vessel walls in all of 28 tissues tested, whereas E-selectin was found in 4 cases and TCC in 11. E-selectin and TCC were found together in only 1 tissue. The study supports the view that ICAM-1 is always, or nearly always, present in vessel walls in synovial tissue from patients with chronic inflammatory joint disease. E-selectin and TCC may also be present, but the lack of association between these two proteins suggests that the mechanism leading to a complement mediated vasculitic process is different from that causing expression of E-selectin.

Animals↗
PubMed1991

A prospective review of arthroscopic debridement for degenerative joint disease of the knee.

A prospective review of 254 patients with moderate or severe knee pain due to degenerative joint disease, treated by arthroscopic debridement of menisci, articular cartilage, osteophytes and loose bodies has been made 24 to 140 months (average of 44 months) after surgery. Patients ranged in age from 28 to 82 years with an average of 49 years. At review, 75% had minimal discomfort and improved function and 85% were satisfied with the treatment. Those with less radiographic arthritis, less severe involvement of articular cartilage at operation and of younger age had more worthwhile improvement. This procedure allows worthwhile relief of symptoms, and only 14% had a subsequent operation after an average period of four years.

Adult↗
PubMed2003

Progression of peripheral joint disease in psoriatic arthritis: a 5-yr prospective study.

OBJECTIVE: To assess the evolution of disease subgroups and the frequency of progression of peripheral joint disease in a prospectively studied cohort of patients with psoriatic arthritis (PsA). METHODS: The cohort was identified as the first consecutive 100 patients attending a psoriatic arthritis clinic and who had been the subject of a previously published cross-sectional retrospective study. Nine of the 100 patients had died, three declined follow-up and one could not be traced. The remaining 87 patients (49 females, 38 males) completed the study proforma at a median follow-up interval of 65 months (range 39-90). An analysis of initial plasma viscosity compared with rates of progression of joint score was performed. RESULTS: Eighteen patients changed subgroup; 11 had an increase in the number of joints involved, six a decrease, and one changed from an oligoarticular pattern to predominant spondylitis. Within the polyarticular group 37/51 patients had an increase in the number of joints involved. For the whole population, there were significant increases in the number of joints involved (median 6 vs 11, P < 0.001 Wilcoxon signed rank) and Health Assessment Questionnaire scores (median 0.375 vs 0.5, P < 0.001). The median rate of joint progression was 0.42 peripheral joints per year (range 0-7.2). However, the rate of peripheral joint involvement was highest in the first year of arthritis (median 4.0 joints/yr) as measured in 13 patients who had onset within 12 months of baseline assessment. There were no significant differences in skin and nail scores although nine more patients had developed nail disease. There was a significant correlation between the initial viscosity and rate of progression of joint damage (Spearman correlation, P < 0.011). CONCLUSIONS: Peripheral joint disease is progressive in the majority of patients with PsA and reinforces the need for effective monitoring and treatment.

Adolescent↗
PubMed1981

[Results of leukocyte migration inhibition test against elastin in joint diseases (author's transl)].

UNLABELLED: The purpose of this work was to report the results of the test TML inhibition of leukocytes' migration, using elastin, by Soborg and Bendixen method, modified with elastin rates of 100 micrograms and 200 micrograms/ml, in joints disease. We verified that the test is generally negative in healthy controls (1 TML positive out of 26 cases); we studied 72 patients, and 38 out of them had a positive test. TML is frequently positive in Horton disease, spondylarthritis, rheumatoid polyarthritis without corticoids, collagen disease; in this cases there is a significant difference of migration between patients and controls group. We also noted a positive TML in infections arthritis and other inflammatory but not in joint's diseases with alteration of elastic tissue (scabs and lung's injury). IN CONCLUSION: TML positive test with elastin, is not a specific test of articular injury neither a proof of its immunologic nature but it contributes in diagnostic for joints diseases.

Adult↗
PubMed1989

Degenerative joint disease in ballet dancers.

Forty-four retired dancers were studied with regard to degenerative joint disease in the lower limbs. Six cases of coxarthrosis were found, significantly more than expected in the general population. In addition, there were four cases of tibio-femoral arthrosis, six of knee osteophytosis, four of patellofemoral arthrosis, three of chondrocalcinosis, and one of bilateral ankle arthrosis. More than one-half of the dancers had arthrosis in the metatarsophalangeal joints.

Adult↗
PubMed1977

Severe degenerative joint disease. Mild and moderately severe hemophilia A.

Severe degenerative joint disease developed in three adults with mild to moderately severe hemophilia A, as judged by the clinical course and by levels of factor VIII coagulant. Bilateral total hip arthroplasty was required in one patient, unilateral hip arthroplasty in the second, and a recommendation for bilateral knee replacement in the third. The pathogenesis of the arthropathy may be multifactorial and the result of repeated joint hemorrhage that remains unrecognized and inadequately treated. These observations suggest the need for more careful monitoring of patients who have relatively mild hemophilia.

Adult↗
PubMed2001

Analgesic effect of etidronate on degenerative joint disease.

In the present study, 80 patients with degenerative joint disease, spondylosis deformans, and/or osteoarthritis of the knee with back or joint pain, especially on movement and strain, were randomly divided into four groups. Group A received no etidronate, while groups B, C and D received 66, 133 and 200 mg/day etidronate, respectively, for 12 months. Every 3 months, after evaluating subjective pain on a visual rating scale (VRS), skin impedance was measured with subjects in a quiet sitting position and with the application of various strains on the spine and knee, including standing up from quiet sitting on a chair, bending forward to flex the spine, squatting to flex the knee, walking 20 paces on a flat floor, ascending 10 stair steps and descending 10 stair steps. A dose related improvement of subjective pain on the VRS with a parallel decrease in the percentage fall in skin impedance was noted. The intra-individual coefficients of variation (CV) of L1-L4 bone mineral density (BMD) on dual-energy X-ray absorptiometry were calculated as a possible index for spondylotic changes before and after treatment as an indication of spondylotic deformity, because no established method is yet available to evaluate such changes objectively. A dose-related decrease in CV of BMD was also noted, parallel to the analgesic effect.

Aged↗
PubMed1992

Early degenerative joint disease simulating impingement syndrome: arthroscopic findings.

Eighteen patients who underwent shoulder arthroscopy for impingement syndrome were shown at operation to have coexisting glenohumeral degenerative joint disease (DJD) which was not apparent during preoperative clinical and radiographic evaluation. Because traditional ("open") techniques of anterior acromioplasty do not allow inspection of the glenohumeral joint, it is almost certain that this pathology would have been missed at operation if open acromioplasty had been performed. We conclude that arthroscopic subacromial decompression (ASD), by allowing easy inspection of the glenohumeral joint, offers a distinct advantage over traditional acromioplasty. Furthermore, arthroscopic evaluation of some of these patients' glenohumeral joints provided us with evidence supporting the existence of subluxation arthropathy. We have also developed a new clinical test, the "compression-rotation" test, which has been helpful in distinguishing patients with both impingement syndrome and early DJD syndrome from those with isolated impingement syndrome. Although patients in this study appeared to be doing well at short-term follow-up status post-ASD and glenohumeral debridement, no long-term results are yet available.

Adult↗
PubMed1983

The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint diseases. I. The localization of the major synovial cell populations as detected by monoclonal reagents directed towards Ia and monocyte-macrophage antigens.

Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I, type II and type III synoviocytes that previously had been defined by their cell surface phenotype with regard to the expression of monocyte-macrophage lineage (M theta) and Ia antigens as well as by their phagocytic capacity or the ability to produce glycosaminoglycans. In patients with non-inflammatory joint diseases, cells with the M theta + Ia+ (type I) phenotype constituted the majority of synoviocytes immediately adjacent to the joint cavity; cells with this phenotype were also scattered in the subsynovial tissue and in the perivascular regions. The fibroblastoid type III cells defined by the absence of both M theta and Ia antigens formed the major cell population in the subsynovial tissue in this patient group. In patients with rheumatoid arthritis, the Ia+ M theta + cells were present in a characteristic double configuration forming an intensely positive layer adjacent to the intra-articular space followed by an Ia- M theta - layer that again was succeeded by an intensely Ia+ M theta + layer. Large numbers of synoviocytes bearing M theta + Ia+ antigens were also demonstrated in the diffusely inflamed subsynovial tissue, in the perivascular regions as well as around and within lymphoid infiltrates.(ABSTRACT TRUNCATED AT 250 WORDS)

Antibodies, Monoclonal↗