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Results for “Hemoglobin Level”

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At least 253 records · Page 14Linked to original sources
PubMed2005

Glycated hemoglobin levels and intellectual activity in an aged population.

OBJECTIVES: To examine the association between glycated hemoglobin (GHb) and aspects of daily activities in an elderly population. DESIGN: Cross-sectional population-based survey. SETTING: Nangai village, an agricultural community with a population of about 5,000 located in Akita prefecture in the north of Japan. PARTICIPANTS: Nine hundred thirty-five people aged 65 and older. MEASUREMENTS: GHb percentages, self-reported measures of activities of daily living (ADLs) and instrumental activities of daily living (IADLs), intellectual activity (IA), and social role (SR). RESULTS: An exploratory analysis indicated that nondiabetic subjects in the lowest tertile of GHb tend to have lower IA than those in the middle tertile, if they were aged 70 and older. No consistent association appeared between GHb and ADLs, IADLs, or SR. Linear and logistic regression analyses, controlling for other risk factors, indicated significantly lower IA scores in the low and high GHb tertiles (P<.001 and P=.04, respectively) than in the middle in nondiabetic subjects aged 70 and older and without stroke history or IADL impairments. The value of GHb related to the maximal IA score was 5.0% to 5.2% as the middle tertile; or 5.2%, assuming a logistic regression model including a squared term with GHb as a continuous variable. A similar relationship was observed in the whole nondiabetic sample aged 70 and older but not in the younger counterpart. CONCLUSION: There is an inverted U-shaped relationship between GHb and intellectual activity in older people without diabetes mellitus. One possible interpretation is that suboptimal blood glucose could contribute to intellectual inactivity in older people.

Activities of Daily Living↗
PubMed2002

Hemoglobin level is an important determinant of acid-base status in hemodialysis patients.

BACKGROUND/AIMS: We studied the relationship between hemoglobin (Hb), which is a major buffer of blood, and arterial blood total carbon dioxide (tCO2) levels in maintenance hemodialysis (HD) patients. We also evaluated the difference between the tCO2 measured with a standard Hb value of 15 g/dl, and that assayed with an actual Hb level entered into an analyzer. METHODS/RESULTS: In 105 patients the predialysis tCO2 level of 21.4 +/- 2.84 mEq/l inversely correlated with the Hb level of 9.5 +/- 1.78 g/dl (r = -0.358, p = 0.0002). This indicated that the rise in Hb from 6 to 14 g/dl could result in a decrease of about 5 mEq/l in the tCO2 level. In 20 patients the tCO2 level measured at the Hb of 15 g/dl was 21.0 +/- 2.47 mEq/l, and higher (p = 0.009) than that of 20.8 +/- 2.45 mEq/l estimated at the actual Hb. The difference between these two measurements was inversely associated with the Hb level (r = -0.579, p = 0.007). The measurement of tCO2 at the unadjusted Hb slightly underestimated the degree of acidosis when the actual Hb level was < 11.5 g/dl. CONCLUSION: The degree of anemia and, to some extent, laboratory technique should always be considered when interpreting changes in arterial blood acid-base balance in maintenance HD patients.

Acid-Base Equilibrium↗
PubMed2000

F cells, fetal hemoglobin levels, lymphocyte subsets, and frequency of crises in sickle-cell disease in Kuwait.

In vitro, fetal hemoglobin (Hb F) inhibits the aggregation of Hb S, and this may be clinically significant. Alterations in B and T lymphocytes seen in sickle-cell disease may be important in the immune deficit in these patients. We examined 16 patients with repeated crises (6 females and 10 males, age 9.3 +/- 3.4 years) and 15 patients with infrequent crises (9 females and 6 males, age 7.1 +/- 3.8 years) to determine the relationship between F cells, Hb F levels, lymphocyte subsets, and the frequency of crises. The proportion of CD2 and CD3 lymphocytes was significantly lower (P=0.015 and <0.0001, respectively) in both groups of patients than controls. CD4 lymphocytes were significantly lower (P = 0.018) and CD19 significantly higher (P = 0.007) than controls. CD45RO levels in both groups of patients were comparable with matched controls but significantly lower (P = 0.002) than adult values. Hb F levels in patients with and without frequent crises were comparable (P = 0.067). However, F cells in patients with infrequent crises were significantly higher than in patients with frequent crises (P<0.01). Alteration in the lymphocyte subsets did not correlate with the frequency of crisis in these patients.

Adult↗
PubMed2006

Influence of hemoglobin levels on inpatient rehabilitation outcomes after total knee arthroplasty.

This retrospective study examined the influence of hemoglobin (Hb) on the outcomes of 184 acute inpatient rehabilitation patients admitted to a single university-based inpatient rehabilitation facility after primary total knee arthroplasty between 2001 and 2003. Patient function was measured using the Functional Independence Measure (FIM) instrument. Average length of stay was 9.4 days. Total FIM score increased from 81.5 to 110.8. Mean baseline Hb was 10.5 g/dL. Multivariate analyses demonstrated that a higher Hb at baseline was associated with significantly shorter length of stay (P = .004) and greater FIM efficiency (change in total FIM score/length of stay) (P = .04). Hemoglobin is associated with rehabilitation outcomes after total knee arthroplasty; additional research into the influence of blood management strategies on rehabilitation outcomes is warranted.

Aged↗
PubMed2005

Proteinuria and hemoglobin levels in patients with primary glomerular disease.

BACKGROUND: Anemia in association with nephrotic syndrome has been described in small patient series and case reports. Whether nephrotic patients develop anemia has not been formally investigated. METHODS: We undertook a retrospective cross-sectional study of patients with biopsy-proven primary glomerular disease, various degrees of proteinuria, and creatinine levels less than 2 mg/dL (< 177 micromol/L). In addition to proteinuria, values for hemoglobin (Hb), age, body mass index (BMI), serum albumin and protein, and estimated glomerular filtration rate (eGFR) were derived from patient charts. RESULTS: We studied 297 patients, 187 men and 110 women, aged between 16 and 81 years. Univariate analysis showed no correlation between Hb level and proteinuria in either sex. Stratification of women and men into quartiles according to proteinuria showed no differences in Hb levels among the 4 groups. Three of 52 non-nephrotic women (6%) were anemic (Hb < 12 g/dL [< 120 g/L]) compared with 11 of 58 nephrotic women (19%; P = 0.047). Multiple regression analysis of all patients showed Hb level to have a correlation with sex (P < 0.001), BMI (P < 0.001), and eGFR (P = 0.005); negative correlation with age (P = 0.028); and borderline negative correlation with proteinuria (P = 0.054). In women, BMI showed a positive correlation with Hb level (P = 0.030). Proteinuria did not reach statistical significance (P = 0.093). In men, BMI (P = 0.001) and eGFR (P = 0.013) were associated positively and age (P = 0.031) was associated negatively with Hb level. CONCLUSION: These results indicate that nephrotic syndrome is not associated with anemia in men, but with a tendency to decrease Hb levels in women.

Adolescent↗
PubMed2006

Prognostic significance of hemoglobin level in patients with congestive heart failure and normal ejection fraction.

BACKGROUND: Previous studies have shown low hemoglobin (Hb) to have an adverse effect on survival in patients with congestive heart failure (CHF) and reduced left ventricular (LV) ejection fraction (EF); but its effect on survival in patients with CHF and normal EF is not known. HYPOTHESIS: This study sought to determine whether low Hb has an effect on survival in patients with both CHF and normal EF. METHODS: Detailed chart reviews were performed by medical residents on 2,246 patients (48% with normal EF) with a discharge diagnosis of CHF in a large tertiary care hospital from 1990 to 1999. The CHF diagnosis was validated using the Framingham criteria. Mortality data were obtained from the National Death Index. Survival analysis was performed using Kaplan-Meier and Cox regression models. RESULTS: By Kaplan-Meier analysis, low Hb (< 12 gm/dl) compared with normal hemoglobin was associated with a lower 5-year survival in patients with CHF and both normal (38 vs. 50%, p = 0.0008) and reduced (35 vs. 48%, p = 0.0009) EF. Using the Cox regression model, low Hb was an independent predictor of mortality after adjusting for age, gender, renal dysfunction, diabetes mellitus, hypertension, and EF in both groups of patients. CONCLUSION: Low Hb has an independent adverse effect on survival in patients with CHF and both normal and reduced EF in both groups of patients.

Aged↗
PubMed1992

Is hemoglobin level alone a reliable predictor of outcome in the severely anemic surgical patient?

The relationship between outcome and hemoglobin (Hgb), oxygen extraction ratio (ER), history of cardiac, renal, pulmonary, and/or hepatic disease, diabetes, malignancy, sepsis, hypertension, and active bleeding was analyzed in 47 patients with severe anemia (Hgb less than 7.0 gm/dl, mean = 4.6 +/- .2 gm/dl) to evaluate the effect of Hgb on survival and to look for other predictors of outcome. All patients had refused blood transfusion on religious grounds and were participants in a randomized, controlled study of the blood substitute Fluosol DA-20 per cent. Patients were analyzed as a group and after stratifying by Hgb into four levels: (Hgb less than 3.0 gm/dl, N = 7; Hgb less than 3.5 gm/dl, N = 12; Hgb less than 4.0 gm/dl, N = 17; Hgb less than 4.5 gm/dl, N = 23) and by ER into two levels of less than 50 per cent and greater than 50 per cent. Only Hgb, ER, sepsis and active bleeding were predictors of outcome, with sepsis being the only significant, independent predictor of outcome at all levels (P less than .01). Active bleeding was a predictor for levels of Hgb below 4.0 gm/dl. Hgb level alone was a significant predictor only at levels below 3 gm/dl (P less than .05). Extraction ratio interacted with Hgb only below 3 gm/dl (P less than .05). Multiple independent factors influence outcome in the severely anemic patient, the strongest being sepsis and active bleeding. Prevention of sepsis and early intervention to stop bleeding should improve survival in the patient who refuses transfusion.

Anemia↗