Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Helicobacter”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 253 records · Page 14Linked to original sources
PubMed2001

[Eradication of Helicobacter pylori. Is it necessary to eradicate Helicobacter pylori in gastric reflux?].

POTENTIAL PROTECTIVE EFFECT OF H. PYLORI: Epidemiological studies have not demonstrated an association between H. pylori infection and symptoms of gastroesophageal reflux, reflux esophagitis, or Barrett's esophagus with or without dysplasia or esophageal adenocarcinoma. On the contrary, an apparently favorable negative association has been identified suggested a potential protective effect of H. pylori. An inverse association is also observed between the severity of reflux complications and infection by strains of H. pylori expressing certain virulence markers (cogA) associated with the more severe gastric lesions. The prevalence of gastroesophageal reflux-related disease has increased steadily for more than fifty years while the incidence of H. pylori infection has decreased in developed countries. This observation might suggest that H. pylori infection plays a protective role. In addition, eradication of H. pylori could favor he development of gastroesophageal reflux or reflux esophagitis. The degree of risk is unknown. Pangastritis with significant lesions of the gastric body leading to a reversible decrease in the secretion of acid after H. pylori eradication might lower the risk of gastroesophageal reflux. POTENTIAL PROMOTION EFFECT: The relations between H. pylori and gastroesophageal reflux are complex. Reflux associated with duodenal ulcer appears to be improved by eradication of H. pylori suggesting that infection might promote the development of reflux. The causal mechanism would be increased acid secretion induced by antral gastritis predominantly resulting from the H. pylori infection. Further work is needed to determine the exact role of gastritis and perturbed acid secretion. PERSPECTIVES: Data on the role of H. pylori in transient relaxation of the lower esophageal sphincter, implicated in the pathogenesis of gastroesophageal reflux, are lacking. Antisecretion treatments reduce the quantity of gastric acid favoring H. pylori colonization of the fundic mucosa and possibly aggravating fundic gastritis. The risk of progression from H. pylori gastritis to atrophy or intestinal metaplasia of the fundus under prolonged proton pump inhibitor treatment remains to be determined. Eradication of H. pylori reduces the efficacy of antisecretory drugs according to poorly understood mechanisms. The potential effect of gastroesophageal reflux on the transmission of H. pylori infection remains to be established. PRACTICAL ATTITUDE: Much remains to be learned concerning the beneficial or deleterious effects of eradication of H. pylori on the course of gastroesophageal reflux. In clinical practice, eradication of H. pylori is not useful for patients with gastroesophageal reflux.

Adenocarcinoma↗
PubMedDate not supplied

Effect of anti-Helicobacter pylori IgG antibody titer following eradication of Helicobacter pylori infection.

BACKGROUND/AIMS: We measured the levels of IgG antibody in patients treated for H. pylori infection using four commercially available ELISA (enzyme linked immunosorbent assay) kits. METHODOLOGY: A total of 37 patients with peptic ulcers (21 patients had gastric ulcers and 16 patients had duodenal ulcers) were treated and monitored. These patients were treated for 14 days with either a dual therapy regime consisting of amoxicillin at 1,500 mg per day and omeprazole at 20 mg per day or a triple therapy regime consisting of the same medications as above plus metronidazole at 1,000 mg per day. Of these 37 patients, 24 patients (64.9%) had successful eradication of the H. pylori infection. The other 13 patients (35.5%) remained infected. Infection by H. pylori was confirmed prior to treatment using conventional microbiological (rapid urease test) and histological tests on biopsy specimens obtained by endoscopy. Four commercially available ELIZA kits (GAP-IgG, Hel-P, Helico-G and HM-CAP) were used to measure the serum levels of IgG antibody against H. pylori before treatment and at 3, 6 and 9 months after treatment. A significant decrease in the IgG titer was observed with the successful eradication of the H. pylori infection. RESULTS: In patients whom the H. pylori infection was not eradicated, the IgG titer remained the same throughout the testing period. All the kits showed a significant decrease in the IgG levels (approximately 50% at 3 months) with patients that were successfully treated. The HM-CAP kit had the lowest sensitivity at detection the decrease in antibody levels (approximately 42% decrease at 3 months). The GAP-IgG kit was able to detect whether or not H. pylori was eradicated in shortest time period (100% uniformity ratio at 3 months). CONCLUSIONS: The results of this study suggest that monitoring serum IgG levels after treatment may provide an early indicator of the efficacy of therapy in eradicating H. pylori infection. Additionally, the serum IgG level can provide evidence of infection in chronic gastritis patients even when the biopsy specimens are negative by microbiological and/or histological tests.

Duodenal Ulcer↗
PubMedDate not supplied

Improvement of complete blood count in patients with iron deficiency anemia and Helicobacter pylori infection after the eradication of Helicobacter pylori.

BACKGROUND/AIMS: Recent reports support the possible association between Hp infection and iron deficiency anemia. In the present study, the effects of the eradication therapy on iron deficiency anemia were investigated. METHODOLOGY: Fourteen women with iron deficiency anemia were enrolled (mean age: 36.4 years; range: 20-52 years old). None of the patients received iron supplementation. Several examinations including upper and lower gastrointestinal endoscopy were performed to reveal any gastrointestinal bleeding sites in all patients. Gastric biopsies during endoscopy were taken from the subjects except one whose serum anti-Hp IgG was positive. After diagnosing the Hp infection by means of microbiology, histology and Gram stain, a combination therapy consisting of lansoprosol, clarithromycin and amoxicillin was administered to each patient. Hematologic examinations and the body iron status were evaluated periodically, following the eradication therapy. RESULTS: Endoscopic findings were as follows: Seven patients with antral gastritis, two patients with pangastritis, whereas five patients were found to be endoscopically normal. None of the subjects were found to have gastrointestinal bleeding of any type. Serum hemoglobin, iron and transferrin saturations of the patients were found to be increased at 20-24 weeks of follow-up after the eradication therapy. Serum ferritin levels were not found to be increased. CONCLUSIONS: Hp infection may be involved in cases of iron deficiency anemia of unknown origin, and the eradication of the infection may improve blood parameters other than serum ferritin levels.

Adult↗
PubMed1996

[A comparison of purified urease antigen and whole cell antigen of Helicobacter pylori by ELISA test--study on the application and serum diagnoses of Helicobacter pylori urease diagnostic reagent].

A useful assay for epidemiological survey of H. pylori infection was reported, using the urease antigen of H. pylori to detect the anti-urease antibody in sera from 676 patients suffered from gastropathy with ELISA technique, and compared with whole cell antigen. Results showed that the purified urease antigen was better than whole cell antigen. The partially purified urease antigens rapid diagnostic reagent of H. pylori was examined in hospital/institution and compared with whole-cell antigens. Results of sera from 676 H. pylori-positive gastritis and non-ulcer dyspepsia patients being tested showed that specificity and sensitivity of ELISA were 96% and 98% respectively. It seemed to be very useful for epidemiological studies on H. pylori infection. The use of ELISA in the detection of IgG antibodies against H. pylori was also sensitive, specific and rapid in assessing the improvement of both acute and chronic inflammation, cleaning of bacteria and the antibody titers after treatment, so as recognized an ideal diagnostic method.

Adolescent↗