SEARCH · Search PubMed
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
A patient with an endocrine-active carcinoma of the parathyroid gland was observed. The typical signs of hyperthyroidism could be seen in the skeletal system. Symptoms of bone and kidney diseases dominated the clinical picture. The symptomatology corresponded to a subchronic primary hyperparathyroidism.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The authors have only reported cases responding to the following criteria: A) necessarily: 1) Clinical appearance of algodystrophy. 2) Intense hyperfixation of the bone scan. 3) X rays repeated a sufficient number of times always normal and submitted to the judgement of six rheumatologists not forewarned, to eliminate the subjective factor in the diagnosis of normality. 4) Clinical cure within the usual period. 5) Return to normal of the bone scan. B) Eventually: 6) Proved decalcifying algodystrophy from another joint site in the past history. 7) Histological appearance compatible with algodystrophy on bone biopsy. Four cases are presented (hip one case, knee two cases, ankle one case) which fulfill the five necessary criteria. The course seems shorter than in the classical decalcifying forms: 2 months instead of 4 1/2 months on average for the hip; 5 months instead of 7 months on average for the knee; 5 months instead of 12 months on average for the foot. This short course is in favour of the theory of early and rapid reconstructive bone changes, which do not leave the algodystrophy the time to demineralise the bone more than 30 to 50% which is the time necessary for the increased radiographic bone transparency to become clear.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Paget's disease may in some cases require recourse to surgery: (1) Fractures of bones in patients with the disease mend normally but slowly. Orthopaedic treatment is satisfactory, except for the femur where osteosynthesis is necessary. (2) Severe deformation of the lower limbs should be corrected by osteotomy when it is responsible for serious disablement. With a simple and sure technique functional improvement can be assured. (3) Coxopathy associated with Paget's disease sometimes involves sufficient invalidity to justify total arthroplasty. (4) Malignant degeneration, usually determined by biopsy, is beyond any therapeutic treatment.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Bone mineralization and serum osteocalcin level were evaluated in 15 children with Grave's disease. Two groups were constituted according to the presence (group I: n = 9) or absence (group II: n = 6) of a severe bone demineralization. A spontaneous fracture and a collapsed vertebra were found in one group I patient. Patients in group I were younger than in group II (8.3 +/- 4.9 vs 11.5 +/- 4.3 yrs). One patient in group II and six in group I were prepubertal with advanced bone age and increased growth velocity. Osteocalcin measurement (Oc) was performed in 10 patients (group I: n = 6; group II: n = 4) at the time of biological hyperthyroidism. The six patients with bone demineralization had elevated Oc levels. In group II, two patients had normal Oc levels and two had elevated Oc levels. In treated patients with good control of hyperthyroidism, all group II patients except one, had normal serum Oc levels and bone mineralization remain normal (n = 5) after 0.6 to 4.6 yrs of follow-up. In group I patients, although height velocity was normal, elevated (n = 4) or slightly elevated (n = 1) serum Oc levels and severe bone demineralization (n = 7 cases) persisted after 0.5 to 3 yrs of good control of the hyperthyroidism. Although the method used for measuring bone mineralization is potentially less precise than bone densitometry and not all the patients had serum osteocalcin measurements at the same time of the illness, our results emphasize that skeletal demineralization may be particularly marked in young children with Grave's disease and should be carefully evaluated.
Explore the source record for details and available documents.
Cognitive changes, depression, arthralgia and dermatitis developed in a 33-year-old woman 5 years after a jejunoileal shunt for massive obesity, The dermatitis and low serum carotene and vitamin C values suggested vitamin deficiencies, The serum magnesium concentration also was low. Vitamin and mineral replacement led to amelioration of the physical and psychological symptoms; the improvement has been maintained at 18-month follow-up. The favourable changes were documented with the Wechsler Adult Intelligence Scale, the Minnesota Multiphasic Personality Inventory and test performance ratings. It is concluded that the surgical procedure caused vitamin and magnesium deficiencies and that these resulted in the patient's symptoms.