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Results for “Conjunctival Neoplasms”

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At least 253 records · Page 14Linked to original sources
PubMed1991

Primary subconjunctival lymphoma: an unusual presentation of childhood non-Hodgkin's lymphoma.

Of 806 non-Hodgkin's lymphoma cases, only one primary subconjunctival lymphoma case was observed in Hacettepe Children's Hospital over a period of 16 years. The patient was a 12 year-old-boy with a subconjunctival mass on the upper part of his right eye. Biopsy revealed malignant lymphoma. Extensive investigations disclosed no other site of tumor. He was given the modified LSA2-L2 protocol. He has been in remission for 22 months. This may be the first report of a primary subconjunctival lymphoma in the childhood period.

Child↗
PubMedDate not supplied

Precursor lesions of melanoma: do they exist?

The question of whether definite precursors to melanoma exist is answered in the affirmative. Three cutaneous lesions likely to be such precursors are described and discussed as to their clinical and histologic appearance and incidence. Additionally, a type of conjunctival melanosis that has been associated with malignant melanoma of the conjunctiva is discussed and an attempt is made to define it; a proposed classification of this entity is reviewed. Basic approaches to management and analysis of precursor lesions are elaborated.

Conjunctival Neoplasms↗
PubMed1999

Differential expression of nm23 H-1 protein in conjunctival melanoma and potential precursor lesions.

Loss of nm23 gene expression is believed to enhance metastatic spread in diverse human tumors, including skin melanoma. The purpose of this work was to determine the pattern and prognostic relevance of nm23 protein immunoexpression in conjunctival melanoma and potential precursor lesion. Formaldehyde-fixed, paraffin-embedded conjunctival specimens comprising 85 melanocytic lesions (nevi, primary aquired melanosis with and without atypia and primary and locally recurrent malignant melanomas) from 73 patients were used. Sections from all specimens were examined by light microscopy to assess diverse prognostic parameters. Additional sections were then immunostained for nm23 H-1 protein and the immunoreactivity was assessed semi-quantitatively. Survival data for all patients were retrieved from the National Causes of Death Registry of Sweden.Nm23 H-1 protein was differentially expressed in conjunctival melanocytic lesions, however loss of immunoexpression was not more common in melanocytic lesions asociated with a high risk of malignant transformation. Also, primary and recurrent conjunctival melanomas showed an essentially similar nm23 expression pattern and we could not associate the pattern of nm23 immunoexpression with an increased risk for malignant transformation or locally recurrent disease. While there was a tentative separation between cause-specific survival curves after excision for low and high nm23 expression conjunctival melanoma, there was no statistically significant association with metastatic death of patients. However, loss of nm23 protein immunoexpression may still be of some importance as a marker for prognosis in conjunctival melanoma because the present study could only detect large differences in survival. Our results suggest that any potential prognostic value of nm23 immunoexpression would be independent of other markers, underlining the importance of further studies.

Biomarkers, Tumor↗
PubMed1983

Conjunctival melanomas in The Netherlands: a follow-up study.

In a follow-up study of 45 conjunctival melanoma patients the recurrence rate after local excision was 80% but the mortality rate due to metastasis was low, only 2 out of 25 cases in which the recurrences could be controlled by repeated local excisions. In the 18 cases in which exenteration was required, because of the unfavorable localization of the melanoma or repeated recurrences, the mortality rate due to metastatic disease (7 out of 18) was high.

Aged↗
PubMed1983

Local metastasis in conjunctival melanoma.

After excision of conjunctival melanomas the rate of recidivation is high. This may partly be due to local seeding of tumour cells in the excision wound, as we observed in one patient. We now use a sodiumhypochlorite solution (Dakin's solution) as tumour cell killing agent. Instead of diagnostic biopsy exfoliative cytology is performed; at surgery the tumour is not touched except for cauterisation with formaldehyde.

Conjunctival Neoplasms↗
PubMed1983

Irrigation with mercury chloride and sodium hypochlorite to prevent local recurrence after excision of conjunctival melanoma. An experimental study.

Two chemical agents, sodium hypochlorite 0.5% (Dakin's solution) and mercury chloride 0.1%, capable of killing seeded tumour cells, were used for washing the cornea and conjunctiva of rabbits. Both agents produced considerable superficial lesions in the cornea and conjunctiva after irrigation for 3 and 5 min, but these were restored to normal after 2 weeks.

Animals↗
PubMed1988

Clinical and therapeutical considerations on a case of conjunctival melanoma.

The authors report a case of limbal conjunctival melanoma treated in a conservative manner. The choice of such a therapy was based not only on clinical examinations and review of literature, but also and mainly on the intraoperative histological examination that showed no involvement of the conjunctival deeper layers.

Aged↗
PubMed1986

Kaposi's sarcoma of the conjunctiva and CMV-retinitis in AIDS.

The number of AIDS patients is still increasing. In 30-50% of these patients ocular lesions occur, which are of diagnostic and prognostic significance. If the life-span of AIDS patients lengthens in the future, adequate treatment of the ocular conditions will become increasingly important. The two most important ocular manifestations AIDS are CMV-retinitis and Kaposi's sarcoma of the conjunctiva. DHPG, a new virustatic for human cytomegalovirus, appears promising as treatment for the severe CMV-retinitis, which leads rapidly to blindness. Two case histories illustrate the preliminary results obtained with DHPG treatment. Kaposi's sarcoma of the conjunctiva is relatively benign is AIDS and can be treated successfully by surgical excision, radiotherapy, cryotherapy or local injections of cytostatics.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Primary orbital malignant lymphoma: a clinicopathology study of 17 cases.

We investigated the clinicopathologic characteristics of 17 patients (13 men and 4 women) with primary orbital malignant lymphoma using the Working Formulation. Most of the cases belonged to the low-grade malignancy group, and more women than men were in the histologically high-grade malignancy group. The phenotype of the tumor cells was investigated immunohistochemically. All cases showed the monoclonal feature of a B-cell lineage. All patients received chemotherapy with or without radiotherapy. Of 16 subjects, 15 achieved a complete remission; none of these patients has had a recurrence since the completion of the initial therapy (range of follow-up from 16 months to 10 years). One patient died.

Adult↗
PubMed1992

Krause's end-bulb microtumor of the conjunctiva: optic and ultrastructural description of a case.

Ultrastructural examination of a conjunctival biopsy of a 90-year-old woman with a history of chronic lymphatic leukemia showed numerous densely packed structures located below the epithelial conjunctival layer. They were composed of concentrical flattened lamellae arranged around one or several clear cores containing a large number of mitochondria. The plasma membranes of the lamellae displayed large numbers of pinocytotic vesicles and resembled perineurial cell processes. The central areas were thought to be axons. Because of their conjunctional location and morphological features. The structures were categorized as nerve endings of the Krause's end-bulb type. The aberrant and profuse growth of these structures led to the diagnosis of Krause's end-bulb microtumor of the conjunctiva. We compare our findings with mucosal neuromas, paraneoplastic lesions and age-related alterations are discussed, although they differ morphologically from Krause's end-bulb microtumor.

Aged↗
PubMed1994

Sebaceous gland adenoma of the palpebral conjunctiva in a patient with Muir-Torre-syndrome: a case report.

BACKGROUND: Muir-Torre syndrome (MTS) is a hereditary genodermatosis associated with internal malignancies. METHODS: We report the histological case of an atypical sebaceous gland adenoma of the palpebral conjunctiva in a 42-year-old female patient. RESULTS: The combination of this adenoma with atypical adenomatous hyperplasia of the endometrium and a strong family history of gastrointestinal and urogenital cancers led to the diagnosis of MTS. CONCLUSION: We present a case where the diagnosis of an atypical solitary sebaceous gland adenoma of the palpebral conjunctiva combined with a conspicuous personal and family history led to the diagnosis of MTS.

Adenoma↗
PubMed1996

Malignant melanoma of the conjunctiva: occurrence and survival following surgery and radiotherapy in a Danish population.

PURPOSE: To describe patient characteristics, risk of recurrence, and survival in patients with premalignant and malignant melanocytic lesions of the conjunctiva. METHODS: In a retrospective study, 55 cases with a minimum follow-up of 10 years were reviewed. RESULTS: The actuarial 5-and 10-year survival rates were 86% (95% Cl: 76-96%) and 73% (95% Cl: 60-87%) respectively. The 5-year risk of local recurrence was 35% (95% Cl: 21-49%), and the 10-year risk was 43% (95% Cl: 28-58%). Primary acquired melanosis with atypia was the first manifestation in 13 cases, malignant melanoma in 42 cases. No significant difference in survival and recurrence was found between the two groups or by gender, location of primary lesion, histological characteristics, or extent of surgical procedure. A minimum incidence of 0.052 cases a year per 100 000 in Denmark was calculated. CONCLUSION: The results are estimated to represent a nationwide sample of patients. No prognostic factors of significance were identified.

Adolescent↗
PubMed1990

Clinical course and pathologic features of conjunctival non-Hodgkin's lymphoma. A report of six cases.

Six patients with conjunctival non-Hodgkin's lymphoma (NHL) were evaluated. In all six cases the conjunctiva was the primary site of clinical presentation; four cases involved low-grade malignancy and two, intermediate-grade malignancy, according to the International Working Formulation. The disease developed within a short period of time to stage IV. The poor response to therapy revealed a worse prognosis than would be expected according to the histopathologic classification. Four of the six patients died of NHL, three of them within 15 months. Comparison of these 6 cases with a group of 15 patients with orbital NHL revealed a much better prognosis in the latter patients. In spite of the fact that 4 of the 15 orbital cases showed NHL of high-grade malignancy, only 2 of them died of the lymphoma. Therefore, conjunctival NHL requires a fast and adequate diagnostic and therapeutic approach.

Adrenal Cortex Hormones↗
PubMed1997

Diagnosis of MALT lymphoma by conjunctival biopsy: a case report.

BACKGROUND: Most extranodular lymphatic tissue is found in the intestinal mucosa. Together with similarly structured lymphatic tissue at other locations it has been named mucosa-associated lymphatic tissue (MALT). Malignant transformation of such tissue to lymphoma is well known. Although MALT lymphoma has been described in tissue physiologically void of MALT, lymphoma manifestation in the conjunctiva is rare. METHODS: We report a case of a 47-year-old woman who was referred to our clinic for symptomatic treatment and evaluation of severe symptoms of dry eyes. She was thought to suffer from Sjögren's syndrome because of xerophthalmia and xerostomia, as well as massive bilateral swelling of the parotid gland. Ophthalmological examination revealed marked hyperplasia of the conjunctiva, of which a biopsy was taken. RESULTS: Histological and immunohistochemical examination of the conjunctival biopsy, together with analysis of gene rearrangement by Southern blot, led to the diagnosis of low-grade B-cell lymphoma of the MALT. CONCLUSION: The differential diagnosis of keratoconjunctivitis sicca presenting with conjunctival swelling of unknown origin should include lymphoma, especially since Sjögren's syndrome may be associated with malignant disorders of the lymphatic system. A biopsy of suspicious conjunctival changes can clarify a multisystem disease by providing a tissue diagnosis.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1985

Human papillomavirus DNA in conjunctival papilloma.

A histologically proven conjunctival papilloma was examined for the presence of papillomavirus DNA by nucleic acid hybridization under relaxed conditions. It harbored papilloma-virus-specific DNA, which showed no detectable relationship with that of known virus types when tested under stringent conditions. This demonstrates that conjunctival papillomas are associated with more than one papillomavirus type. Viral diagnosis may turn out to be of prognostic value.

Adult↗
PubMed1986

A prognostic index for patients with malignant melanoma of the conjunctiva.

From 1968 to 1984, 31 patients with histologically proven malignant melanoma of the conjunctiva were treated and followed in the Eye Hospital of the University of München. Histological demonstration of tumor thickness and the mitotic index (number of mitoses per square millimeter) gave a the prognostic index, in which tumor thickness was multiplied by the mitotic index. This index then allowed evaluation of the risk for tumor metastasis. Most tumors measured less than 1.5 mm in thickness, and the metastatic risk was low or medium in these cases. All tumors of the low metastatic risk group had a prognostic index of 1 or less, while all recurrences were associated with a prognostic index that exceeded 1.

Conjunctival Neoplasms↗