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PubMedDate not supplied

Syndromal associations of common origin of the carotid arteries.

The term "common origin of the carotid arteries" (COCA) has been proposed to replace the older terms "origin of the left carotid artery from the innominate stem" and "bicarotid trunk with anomalous right or left subclavian artery." These anatomic patterns are usually reported to occur in about 11% of whites and 20-25% of blacks and have been reported to have increased frequency in patients with esophageal atresia-tracheoesophageal fistula, DiGeorge anomaly, and anomalous origin of the left coronary artery from the pulmonary artery. COCA is a significant, if not invariant, feature of the great arteries in the condition usually called in the more recent literature "anomalous origin of the innominate artery," the most frequent cause of symptomatic tracheal compression by anomalous systemic arteries. Analysis of associations of COCA with various other congenital cardiovascular lesions showed, in addition, significant association with congenital polyvalvular disease, truncus arteriosus, aorticopulmonary window, trisomy 13, 18, and 21 syndromes, acrocephalosyndactyly (especially Apert syndrome), tetralogy of Fallot not associated with DiGeorge anomaly, and clinical Noonan phenotype. Pentalogy of Cantrell was associated with no increase in incidence of COCA.

Carotid Artery, Common↗
PubMedDate not supplied

Effect of feeding tube properties and three irrigants on clogging rates.

An experimental study was conducted on 3 consecutive 12-hour days to determine if selected physical properties of feeding tubes (material and diameter) affect tube clogging. Effectiveness of three irrigant fluids (cranberry juice, Coca-Cola, and water) in preventing tube clogging was studied. One hundred eight tubes were connected to gravity flow feeding bags containing isotonic enteral formula; 54 polyurethane and 54 silicone tubes were equally divided as to external diameters of 8 French (Fr), 10 Fr, and 12 Fr. At 4-hour intervals, flow regulators on the feeding bags were adjusted to a rate of 50 ml/hour. Fluid volumes delivered per minute were measured for each tube at 2-hour intervals. One set of tubes at each station was irrigated periodically with cranberry juice, Coca-Cola, or water. On each of the 3 days, analyses revealed significant, p less than .05, effects for tube material, cranberry juice contrasted with Coca-Cola and water as irrigants, and time. Polyurethane was consistently superior to silicone as a tube material, and cranberry juice was consistently inferior to both Coca-Cola and water as an irrigant. Tube diameter had no significant effect on the incidence of tube clogging.

Beverages↗
PubMed1983

The ethnobotany of chamairo: Mussatia hyacinthina.

Recent fieldwork in the eastern lowlands of Bolivia and Peru has revealed a traditional use of coca (Erythroxylum coca Lam.) as a medicine and stimulant that is distinct from the well-documented customs of the Northwest Amazon and the Andean highlands. In Bolivia some nine indigenous tribes centered mainly in the Rio Beni drainage masticate entire sun-dried coca leaves, yet use as an alkaline additive the crude ash of the spathe or leafbase of the motacú palm (Scheelea princeps (Mart.) Karst.). To the quid they add a piece of the bark of the bignoniaceous liana chamairo (Mussatia sp.), which markedly sweetens the chew. In the montaña of Peru, the liana is also used and a new species is reported from the upper Apurimac river. The ethnobotany of chamairo throughout its range is examined and the need for pharmacological screening is emphasised.

Bolivia↗
PubMed2000

[Consumption of licit and illicit drugs in Chile: results of the 1998 study and comparison with the 1994 and 1996 studies].

The principal results are presented here from the Third National Study of the Consumption of Drugs, which was carried out in Chile by the National Board for Narcotics Control between 1 September 1998 and 15 January 1999. The 1998 study used the same methodological design as the first and second studies, which were done in 1994 and 1996. The 1998 study expanded the sample to 31,665 individuals, who were representative of a population of 6,940,727 people from 12 to 64 years old, both sexes, and five socioeconomic levels and who were residents of urban areas in 62 commune administrative divisions of the 13 regions of the country. Results from the 1998 study are compared with those from 1996 and 1994. The 1998 study shows that 17.5% of Chileans have at some time in their life used one of the three illicit drugs most popular in the country: marijuana (16.8%), coca paste (2.3%), and cocaine hydrochloride (4.0%). The prevalence of use of any of the three drugs, mainly marijuana, during the preceding year was 5.3% and during the preceding month 2.2%. With respect to licit drugs, 28.4% of Chileans have at some time in their lives used antianxiety drugs, 84.4% of them have consumed alcohol, and 71.9% have used tobacco. Most of the people who once used illegal drugs have stopped doing so: 71.6% in the case of marijuana, 64.1% with coca paste, and 66.8% with cocaine hydrochloride. For legal drugs, the percentages were lower: 55.5% for anxiolytics, 16.0% for alcohol, and 34.5% for tobacco. The consumption of licit and illicit drugs was several times greater among men than among women, except for anxiolytics, whose use was three times greater among women. Drug use was more frequent among persons between 19 and 25 years old. Consumption of illegal drugs was more frequent at higher socioeconomic levels, and use of licit drugs was more common in the lower socioeconomic levels. The 50th percentile of the age of initiating drug use was 17 years for alcohol, 15 for tobacco, 30 for antianxiety agents, 17 for marijuana, 20 for coca paste, and 21 for cocaine hydrochloride. Comparing the results of the three studies shows that, after an increase in the use of licit drugs between 1994 and 1996, there was a stabilization in 1998. With illegal drugs there was a modest increase in consumption between 1996 and 1998, following a small reduction between 1994 and 1996.

Adolescent↗
PubMed1993

Cocaine abuse in North America: a milestone in history.

The euphoric effects of coca leaves have been known to mankind for thousands of years. Yet the first epidemic of cocaine use in America occurred during the late 19th century. Initially, there were no laws restricting the consumption or sale of cocaine. In fact, cocaine was freely available in drug stores, saloons, from mail-order vendors, and even in grocery stores. It is reported that one drug manufacturer, in 1885, was selling cocaine in 15 different forms, including cigarettes, cheroots, inhalants, cordials, crystals, and solutions. Many famous imported wines, such as "Vin Mariani," contained a mixture of wine and coca. For consumers on budgets, the wonder drug was available as Coca-Cola and dozens of other soda pops and pick-me-up drinks. One of them even had a simple and direct name, Dope. Soon enough, the ill effects of cocaine became apparent, and by the 1920s cocaine was the most feared of all illicit drugs. Most states began enacting laws against cocaine use. President William Taft proclaimed cocaine as Public Enemy No. 1, and in 1914 the Congress passed the Harrison act, which tightly regulated the distribution and sale of cocaine. By the late 1950s, cocaine use in the United States was simply considered a problem in the past. Unfortunately, the people who were aware of the nation's first cocaine epidemic gradually passed away, and America once again was ready for its fling with cocaine in the 1960s. Today, it is estimated that upwards of 50 million Americans, that is one in four, have used cocaine. In addition, another fifty thousand people use this substance for the first time each day. More than 6 million Americans use cocaine on a regular basis. Little wonder, then, that America as well as the other countries have declared a "War on Drugs." In this review, pharmacology of cocaine, major complications arising from its use, and efforts to curb its abuse are discussed.

Cardiovascular System↗
PubMed2005

Influence of a soft drink with low pH on enamel surfaces: an in vitro study.

INTRODUCTION: The purpose of this study was to investigate, in vitro, the short-term effect of a soft drink (Coca Cola, Coca Cola Company, Atlanta, Ga) with low pH on enamel surfaces at different levels of intake. Effects on labial and palatal surfaces were also compared. METHODS: Thirty human enamel blocks (labial and palatal enamel surfaces) were randomly divided into 5 groups-1 control and 4 experimental. For 7 days, the enamel surfaces in the experimental groups were immersed in Coca-Cola at different frequencies: 1, 2, or 3 times per day for 20 minutes each, with each immersion followed by 1 hour in artificial saliva. Specimens in the fourth group were immersed for 1 minute in the soft drink followed by 3 minutes in artificial saliva, and the cycle repeated for 20 minutes to better simulate drinking habits. Control specimens remained in physiological serum at room temperature. The measurements were made at baseline (T0), day 3 (T1), and day 7 (T2) with a Knoop hardness tester. Analysis of the variance was used to find differences between the groups. For the multiple comparisons, the Dunnett test was used. The statistical level was accepted at P < .05. RESULTS: The experimental groups showed significant reductions in microhardness values. Differences between the test groups were not statistically significant, nor were differences between the labial and the palatal surfaces. CONCLUSIONS: Soft drink intake, even of relatively short duration, can reduce enamel microhardness. The frequency of intake seems not to play a decisive role on enamel microhardness. Care should be taken to avoid soft drinks during orthodontic treatment with fixed appliances.

Analysis of Variance↗
PubMed2000

Resistance of two dentin-bonding agents and a dentin densensitizer to acid erosion in vitro.

OBJECTIVES: To determine the resistance of two dentin-bonding agents (DBAs) and a dentin desensitizer to simulated dental erosion. METHODS: Twenty teeth in each of three groups of selected premolars, with exposed cervical dentin, were treated with one of three dentin surface treatment systems: Gluma Desensitizer (Heraeus Kulzer (UK) Ltd), One Coat Bond (Whaledent (UK) Ltd), and Optibond FL (Kerr (UK) Ltd) and exposed to water (control) and an erosive challenge (Coca Cola) for 14 days. Sequential tracings of the specimens were taken, superimposed and the mean reduction in densensitizer or DBA thickness and or tooth loss determined. RESULTS: A mean loss of 77 microns (s.d. 14.6 microns) of tooth tissue over the untreated sites following 14 days exposure to Coca Cola was observed. The application of DBAs, as opposed to Gluma Desensistizer alone, over exposed dentin surfaces afforded substantial protection against erosion by Coca Cola over the period of study. The mean change in vertical profile of teeth treated with a DBA was 20 microns (s.d. 14.7 microns), almost four times less than that seen over untreated sites. SIGNIFICANCE: With the exception of Gluma Desensitizer, which was lost completely, One Coat Bond and Optibond FL demonstrated levels of acid dissolution resistance, which would be of potential value clinically.

Analysis of Variance↗
PubMed2005

Impact of modified acidic soft drinks on enamel erosion.

OBJECTIVE: To evaluate the enamel erosive potential of modified acidic soft drinks under controlled conditions in an artificial mouth. MATERIALS AND METHODS: From each of 144 bovine incisors one enamel sample was prepared. Labial surfaces of the samples were ground flat, polished and covered with adhesive tape, leaving an exposed area. The samples were distributed among four (A-D) groups for treatment with A: Coca-Cola, B: Sprite; C: Sprite light, D: orange juice. Either 1.0 mmol l(-1) calcium (Ca) or a combination (comb.) of 0.5 mmol l(-1) calcium plus 0.5 mmol l(-1) phosphate plus 0.031 mmol l(-1) fluoride was added to the beverages. Samples of each group were subdivided into three subgroups (-original; -Ca and -comb.) for treatment with original and modified drinks. De- and remineralization cycles were based on a standard protocol described earlier. Surface loss of the specimens was determined using profilometry after test procedure. RESULTS: In all subgroups, loss of enamel was observed. The enamel loss recorded for the samples rinsed with original Sprite and original orange juice was significantly higher compared with all other solutions (P = 0.001). Lowest enamel loss was recorded for the original Coca-Cola group (P = 0.001). With the exception of Coca-Cola, demineralization with the modified beverages led to significantly lower losses compared with the respective original solutions. CONCLUSION: Modification of the test soft drinks with low concentrations of calcium or a combination of calcium, phosphate and fluoride may exert a significant protective potential with respect to dental erosion.

Animals↗
PubMed2005

Erosive effects of common beverages on extracted premolar teeth.

BACKGROUND: Dental erosion is highly prevalent today, and acidic drinks are thought to be an important cause. The aim of the present investigation was to determine the erosive potential of a range of common beverages on extracted human teeth. METHODS: The beverages were tested for their individual pHs using a pH meter. The clinical effects of the most erosive beverages were determined by the degree of etching and Vickers microhardness of enamel. RESULTS: The results showed that many common beverages have pHs sufficiently low to cause enamel erosion. Lime juice concentrate (pH 2.1) had the lowest pH, followed by Coca-cola and Pepsi (both with pH 2.3) and Lucozade (pH 2.5). The erosive potential of these beverages was demonstrated by the deep etching of the enamel after five minutes. The Vickers Hardness of enamel was reduced by about 50 per cent in the case of lime juice (p < 0.001) and 24 per cent in the case of Coca-cola (p < 0.004). Addition of saliva to 50 per cent (v/v) of Coca-cola completely reversed the erosive effects on the enamel. CONCLUSIONS: Although only a few of the beverages with the lowest pHs were tested, the present study showed that the most acidic drinks had the greatest erosive effects on enamel. While saliva was protective against erosion, relatively large volumes were required to neutralize the acidity.

Acids↗
PubMed2004

[Use and attitudes about drugs among nursing students at the Universidad Mayor de San Andrés].

This study presents the results of a research that examined the use and attitudes about alcohol, tobacco, coca leaves, tranquilizers and amphetamines among nursing students at the Universidad Mayor de San Andrés who had not used these substances over the last 12 months. Data were collected in August 2002 by means of a self-administered and distributed questionnaire, which guaranteed anonymity. The following results were obtained: Attitudes related to drugs approve of coca leaf and tranquilizer use and disapprove of cocaine. Personal use of drugs during the last 12 months corresponds to: daily use of coca leaves, alcohol less than once per week and tobacco every day. The main reason for using these drugs is related to religious practice; the students' first contact with drugs occurs through family members and (girl or boy) friends.

Adolescent↗
PubMedDate not supplied

Tailored logistics: the next advantage.

How many top executives have ever visited with managers who move materials from the factory to the store? How many still reduce the costs of logistics to the rent of warehouses and the fees charged by common carriers? To judge by hours of senior management attention, logistics problems do not rank high. But logistics have the potential to become the next governing element of strategy. Whether they know it or not, senior managers of every retail store and diversified manufacturing company compete in logistically distinct businesses. Customer needs vary, and companies can tailor their logistics systems to serve their customers better and more profitably. Companies do not create value for customers and sustainable advantage for themselves merely by offering varieties of goods. Rather, they offer goods in distinct ways. A particular can of Coca-Cola, for example, might be a can of Coca-Cola going to a vending machine, or a can of Coca-Cola that comes with billing services. There is a fortune buried in this distinction. The goal of logistics strategy is building distinct approaches to distinct groups of customers. The first step is organizing a cross-functional team to proceed through the following steps: segmenting customers according to purchase criteria, establishing different standards of service for different customer segments, tailoring logistics pipelines to support each segment, and creating economics of scale to determine which assets can be shared among various pipelines. The goal of establishing logistically distinct businesses is familiar: improved knowledge of customers and improved means of satisfying them.

Commerce↗
PubMedDate not supplied

The implication of phenylketonuria on oral health.

PURPOSE: This study was performed to evaluate the oral health of children with PKU and to assess, in vitro, the erosive potential of 5 amino acid supplements commonly prescribed in the management of these children. METHODS: Forty children with phenylketonuria underwent a full dental examination and were compared with an age and sex matched control group. The erosive potential of the supplements was assessed by comparing their pH and titratable acidity to those of Coca Cola and orange juice. RESULTS: There was no significant difference between the affected and control groups in the level of dental caries, with over 75% of the children examined being caries free. However significantly more (33%) children with phenylketonuria exhibited signs of tooth wear compared with 24% of the controls (P < 0.05). While Coca Cola had the lowest pH (2.46), the titratable acidity of the flavoured supplements (92.86-126.8 mEq/l) was significantly higher than both their unflavored counterparts (4.18-14.0 mEq/l) and Coca Cola (38.56 mEq/l). CONCLUSIONS: Despite the potentially damaging nature of their diet, significantly less children with PKU had ever seen a dentist. Health professionals involved in the care of these patients should be aware of the implications of management and provide appropriate dental advice and referral.

Adolescent↗
PubMedDate not supplied

Influence of different beverages on the microhardness and surface roughness of resin composites.

This study assessed the influence of different beverages on the microhardness and surface roughness of microfilled (A110, 3M/ESPE), hybrid (Z250 3M/ESPE) and flowable (Flow, 3M/ESPE) resin composites, over time. Twenty-four disc-shaped specimens (10 mm; 2-mm thick) of each resin composite were fabricated, thereby forming three groups (n=24). Knoop microhardness and surface roughness (Ra) were analyzed at predetermined evaluation periods: 24 hours, and 7, 30 and 60 days after specimens fabrication. The 24-hour measurements were recorded after storage in artificial saliva. Next, each group (n=24) was divided into four subgroups (n=6) according to the test beverages: Coca-Cola, sugar cane spirit, coffee and artificial saliva (control). Control specimens were kept in saliva throughout the experiment (60 days). For experimental specimens, a 60-day testing cycle was carried out: specimens were initially stored in saliva for four hours, then submitted to a five-minute immersion in the beverages (Coca-Cola, sugar cane spirit, coffee) intercalated by immersions in saliva three times daily. Microhardness/roughness measurements were done at 7-, 30- and 60-day intervals. Data were submitted to three-way ANOVA and Scheffée test (p<0.05). It was observed that the tested beverages somewhat altered (p<0.05) the composites' microhardness and/or surface roughness. Knoop microhardness-for all resin composites, microhardness remained stable up to the 30-day record, decreasing significantly at the 60-day evaluation. During the interaction beverage X evaluation period, it was observed that the microhardness of materials immersed in coffee and Coca-Cola remained stable up to the seven-day measurement, showing a decrease at the 30-day record and a more accentuated drop at the 60-day evaluation (p<0.05). Specimens immersed in sugar cane spirit exhibited no significant change in microhardness up to the seven-day measurement, increasing significantly at the 30-day record and later decreasing at the 60-day evaluation. Surface Roughness--For all resin composites, surface roughness increased at the seven-day measurement, while decreasing at the 30-day record and even more at the 60-day record. In the interaction beverage X evaluation period, the surface roughness of specimens immersed in test beverages increased at the seven-day measurement, showing a gradual decrease at the following records (30- and 60-day evaluations). The findings of the reported research disclosed that all beverages altered, to some degree, the microhardness and/or surface roughness of the tested resin composites. The alterations' effects ranged from slightly adverse to a markedly negative impact on the composites' microhardness and surface roughness, depending on the characteristics of the materials, type of beverage and the evaluated period. Generally, the greater number of immersions in beverages resulted in a more accentuated impact on the resins' properties.

Alcoholic Beverages↗
PubMed2005

Allergenic extracts from Metarhizium canisopliae: obtainment and characterization.

Metarhizium anisopliae is used as a biopesticide for insects that damage agricultural plantations like sugar cane and forage plants. In a previous study the sensitization to this fungus of asthmatic patients coming from sugar cane areas was showed. The aims of this work were: to compare crude extracts obtained with Tris-HCl and Coca liquid from several growth phases of M. anisopliae concerning the total content of proteins and their electrophoretic analysis profile; to evaluate in vivo allergic sensitization in Balb/c mice and allergic patients from a sugar cane area, and to characterize the allergenic fractions in the sera of patients positive for the prick test by means of Western-blotting. The extract obtained with Coca liquid on the 16th day was the one that presented the greatest number of proteic fractions, including all those present in the other extracts. Twelve fractions were verified in this extract with approximate molecular weights from 94 to 14 kDa. The allergenicity of the extract obtained on the 16th day was proven by the production of IgE antibodies in Balb/c mice, with titres of 200. Prick tests carried out with the extract of the 16th day in 79 atopic individuals (from sugar cane area), 35 atopic individuals (from urban area) and 11 non- atopic individuals showed respective positivity of 29%, 9% and 0%. The allergenic characterization in vitro was performed by means of Western blotting, and the fractions that reacted with the positive individuals' sera were those of approximate molecular weights of 67 kDa (95%); 20 kDa (55%); 94 kDa (36%); 34 and 36 kDa (23%); 43 and 48 kDa (14%); 16 kDa (9%) and 54kDa (5%). It was concluded that the crude allergenic extract, obtained with Coca liquid from the 16th day growth of Metarhizium anisopliae, contains allergenic fractions and can be used in diagnostic screening tests.

Allergens↗
PubMed1988

[Pharmacological interactions between dependence-liable drugs].

Pharmacological interactions between morphine (Mor; analgesia), pentobarbital (Pent; hypnosis), ethanol (EtOH; rotarod adaptability), amphetamine (AMP; ambulation), and cocaine (Coca; ambulation) were examined in mice after a single or repeated administrations. Pretreatment with each drug, even a single dose, resulted in a modification of the effect of succeeding drugs. After 6-day daily treatment with drugs, tolerance developed to Mor, Pent, and EtOH, while reverse tolerance was developed to AMP and Coca. Development of tolerance to Pent was accelerated in the animals that were chronically treated with other drugs. Cross reverse-tolerance was obtained between AMP and Coca, on the other hand, one-way cross tolerance was observed between Mor and EtOH. A marked change was observed in the effect of each drug when administered at the peak time of withdrawal signs of Mor, barbital (Barb), and EtOH. The development of physical dependence on Mor, Barb, and EtOH was not modified by the pretreatment with other drugs. These results may serve to predict the risk of the interactions between various dependence-liable drugs in humans.

Amphetamine↗
PubMed2005

Cocaine distribution in wild Erythroxylum species.

Cocaine distribution was studied in leaves of wild Erythroxylum species originating from Bolivia, Brazil, Ecuador, Paraguay, Peru, Mexico, USA, Venezuela and Mauritius. Among 51 species, 28 had never been phytochemically investigated before. Cocaine was efficiently and rapidly extracted with methanol, using focused microwaves at atmospheric pressure, and analysed without any further purification by capillary gas chromatography coupled to mass spectrometry. Cocaine was reported for the first time in 14 species. Erythroxylum laetevirens was the wild species with the highest cocaine content. Its qualitative chromatographic profile also revealed other characteristic tropane alkaloids. Finally, its cocaine content was compared to those of two cultivated coca plants as well as with a coca tea bag sample.

Coca↗
PubMed1991

[Cocaine: half a century of therapeutic use (1880-1930)].

After observations concerning the cultivation, the trade and the use of coca by the Peruvian population, several Spanish physicians--among whom MONARDES--had already in the XVIth century, proposed to use this plant as a medicine. Therapeutical experiments however were not effected until the second half of the XIXth century. In 1559 the Italian neurologist MANTEGAZZA was the first to try out the remedy on himself and to advocate the use of coca as an internal medicine. Experiments with cocaine were still made during about twenty years, until more and more therapeutical applications clearly appeared. In psychiatry cocaine was used--also on Freud's recommendation--as an euphoriant excitant in cases of melancholia, both physical and psychic exhaustion and of cachexia. It was further used as a substitution therapy for morphine-addicts. 1884 also meant a break-through for the use of cocaine as a local anesthetic. It was first used in eye-surgery and was applied later on in dentistry and in cases of minor surgery. Local pain-killing injections seems to have been used at the beginning of our century in all sorts of indications. Cocaine was also applied to cure asthma, mountain-sickness, sea-sickness, pregnancy vomiting and all possible sorts of cramping pains. Although in the last years of the XIXth century the medical literature already clearly warned against the danger of therapeutically induced cocaine mania, it is only several years after World War I that the use of cocaine pills for painful diseases of the mouth and of the upper digestion organs still appeared. Between 1880 and 1930, we may assert that cocaine had taken the place of the universal panacea of the Middle Ages, the Theriaca.

Antidotes↗
PubMed2002

Novel 2D triple-resonance NMR experiments for sequential resonance assignments of proteins.

We present 2D versions of the popular triple resonance HN(CO) CACB, HN(COCA)CACB, HN(CO)CAHA, and HN(COCA) CAHA experiments, commonly used for sequential resonance assignments of proteins. These experiments provide information about correlations between amino proton and nitrogen chemical shifts and the alpha- and beta-carbon and alpha-proton chemical shifts within and between amino acid residues. Using these 2D spectra, sequential resonance assignments of H(N), N, C(alpha), C(beta), and H(alpha) nuclei are easily achieved. The resolution of these spectra is identical to the well-resolved 2D (15)N-(1)H HSQC and H(NCO)CA spectra, with slightly reduced sensitivity compared to their 3D and 4D versions. These types of spectra are ideally suited for exploitation in automated assignment procedures and thereby constitute a fast and efficient means for NMR structural determination of small and medium-sized proteins in solution in structural genomics programs.

Carbon Isotopes↗