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Tumours in the conus medullaris, the cauda equina and filum terminale are rare, and present a varied clinical picture. There is often a delay between onset of symptoms and diagnosis. However, in most cases, a detailed history and clinical examination will indicate further investigation.
Peripheral primitive neuroectodermal tumour (pPNET or peripheral neuroepithelioma) is one of the malignant small round cell tumours of peripheral nerves, soft tissues and bones, but rarely originates in the spinal canal. We report an example of pPNET arising in the cauda equina of a 14-year-old Japanese boy. At surgery, a well-demarcated tumour measuring 2 x 4 cm in diameter and involving one of the nerve roots of the cauda equina was located within the intradural space with no evidence of extradural extension. Microscopically the tumour was made up of sheets of closely packed small round cells, associated with ganglioneuroma-like islands. Immunohistochemically, the small round tumour cells were intensely positive for neuron-specific enolase (NSE), an MIC2 gene product (O13) and beta 2-microglobulin, whereas the foci with ganglion cell-like cells reacted positively to NSE, synaptophysin and beta 2-microglobulin but were negative for O13. A chimeric transcript of the EWS/FLI-1 fusion gene detected by a nested reverse transcriptase-polymerase chain reaction using formalin-fixed paraffin-embedded tissue justified the diagnosis of pPNET. Only 6 cases of PNET in the cauda equina have been described in the literature, and this is the first case of a pPNET with ganglio-neuroma-like areas. This finding suggests that the primitive tumour cells of pPNET may respond to unknown inductive effects and express a ganglion cell-like morphology.
Two cases of intradural cavernous angioma of the cauda equina are reported, one of which presented with symptoms of subarachnoid hemorrhage. The clinical and therapeutic aspects of intradural angiomas, in particular those of the cauda equina, are discussed.
Malignant lymphoma compression of the cauda equina is rare. In the literature only a few cases have been described with occasional long term survivors. We report another case of non-Hodgkin's lymphoma presenting with cauda equina compression. Significant palliation and long-term survival were achieved after therapy by decompressive, cytoreductive surgery; local irradiation; and chemotherapy.
A case of subarachnoid hematoma of the cauda equina is described. The lesion developed in a patient receiving anti-coagulant treatment after a seemingly ordinary fall from a ladder. Neurosurgery achieved complete regression of the neurological defects in two weeks. The mechanism of development of the lesions is discussed. This form of complication of spinal trauma is fortunately exceptional.
Seven patients with redundant roots of the cauda equina were followed 2 1/2-10 years after surgical decompression. Improvement of signs and symptoms occurred in all patients. However, none of them was neurologically intact at the time of the last physical examination, although persistence of minimal neurological signs and/or occasional pain did not prevent a useful occupational activity.
During routine autopsies in 11 cadavers, the intact dural sac, including its nerve roots, was circumferentially constricted by a clamp while the pressure under the clamp among the nerve roots was recorded simultaneously. The first sign of a pressure increase--the critical size--occurred at a cross-sectional area of the cauda equina of 77 +/- 13 mm2. To achieve a pressure increase of 50 mm Hg, the cross-sectional area of the cauda equina had to be further constricted at an average of 19 +/- 8%. The corresponding constriction needed to achieve a pressure of 100 mm Hg was 26 +/- 8%. The results indicated that constriction of the cauda equina to a size less than 75 mm2 probably will affect the normal function of the nerve roots of the cauda.
The clinical and radiological characteristics together with the therapeutic results in 12 cases of Cauda Equina neurinomas are analyzed. In a high percentage of cases, Cauda Equina neurinomas manifest initially as a simple lumbar sciatic syndrome, frequently not different from those caused by other more common pathologies such as lumbar discal hernia. This article discusses the possible diagnostic problems encountered with the most common currently used radiologic procedures in this type of lesions such as CT scan, myelography and NMR.
Neurologic sequelae of Paget's disease of bone include involvement of the spinal cord or cauda equina due to mechanical compression by enlarged vertebrae, ischemia caused by a spinal artery, steal syndrome or neoplasm. We describe a patient with Paget's disease of bone who presented with acute cauda equina syndrome due to a spinal epidural hematoma. Clinicians need to recognize this entity since surgical intervention may result in a favorable outcome.
Cauda Equina Compression (CEC) is a clinical syndrome consisting of low back pain, bilateral sciatica, saddle anesthesia, bilateral lower extremity weakness, and even frank paraplegia with bowel and bladder incontinence. At the onset of CEC, the clinical picture may resemble typical intervertebral disk disease with low back pain and unilateral sciatica. The back pain is severe, overshadowing the leg pain, and should alert the physician to the periodic evaluation of the patient and evidence of a progressive neurologic deficit. Early discovery of CEC is necessary if neurologic recovery is to be expected from decompressive laminectomy.
Suspected spinal cord or cauda equina pathology is an emergency that must be dealt with swiftly, with appropriate referral and investigations. Constipation is a clinical diagnosis of exclusion, but should not be forgotten as a cause of major morbidity when severe in nature. It can mimic an acute abdomen, sepsis and even spinal cord pathology. We describe a case of cauda equina syndrome in a young man. The pathology responsible was found to be constipation with faecal impaction, once nerve and bony pathology were excluded. When treated, there was almost immediate resolution of the neurologic signs and urinary retention.
We report a case of paraganglioma of the cauda equina and review the MRI features in 11 previously published cases with MRI description. On T1-weighted images, paraganglioma is isointense relative to spinal cord and shows moderate to intense enhancement after Gd-DTPA application, usually with heterogeneous texture. On T2-weighted images, different findings were found. MRI features do not allow to distinguish paraganglioma of the cauda equina from majority of other tumors in this region.
BACKGROUND: Cavernous hemangiomas of the spine and spinal cord are relatively uncommon lesions that are being discovered more frequently because of the increased use of magnetic resonance imaging (MRI). We present a rare case of a symptomatic cavernous hemangioma of the cauda equina. CASE DESCRIPTION: A 49-year-old woman presented to our institution with the chief complaint of low back pain of acute onset. On physical examination the patient was found to be tender to percussion over the lumbar spine, had tenderness over the sciatic nerve, loss of pinprick sensation over the right lateral foot and loss of the Achilles' reflex on the right. In addition, she was found to have a large postvoid urinary bladder residual volume. MRI revealed a 20 mm x 11 mm nonenhancing, heterogenous mass obliterating the spinal canal at the L4 level. At operation, this lesion was found to be adherent to the nerve roots and was completely resected. Pathology revealed this lesion to be a cavernous angioma of the cauda equina. A review of the pertinent literature is presented. CONCLUSIONS: Cavernous hemangiomas of the cauda equina are extremely rare lesions that may present as low back pain, neurologic deficit, or as subarachnoid hemorrhage. They can be successfully treated with surgical excision.
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Hemangioblastomas of the spinal cord are rare lesions, and those located at the cauda equina are even rarer. Most commonly these tumors are present in patients with von Hippel-Lindau (VHL) syndrome. We describe here the case of a 48 years old woman with a pure radicular hemangioblastoma, not associated with VHL, presenting with radicular pain, diagnosed with magnetic ressonance imaging (MRI) and submitted to total resection with a very good outcome. To our knownledge, this is the second report to describe the MRI aspect of histologically proved hemangioblastoma of the cauda equina in a patient without clinical criteria for VHL.
Low back pain is an extremely common complaint encountered by emergency and primary care physicians. Although the majority of patients have uncomplicated benign presentations, there is a small subset who has a much more severe disease process called cauda equina syndrome, which entails acute compression of the nerve roots of the cauda equina. These patients usually present posttraumatically with the triad of saddle anesthesia, bowel or bladder dysfunction, and lower extremity weakness. Significant morbidity can result from delayed diagnosis and treatment; therefore, the emergency physician should remain aware of this potential orthopedic pitfall. This case report discusses the clinical presentation, diagnosis, and relevant treatment of cauda equina syndrome in the ED.
A 35-year-old white male presented with erectile dysfunction and areflexic bladder secondary to an intrathecal paraganglioma of the cauda equina. Erectile dysfunction has not been emphasized as a component of the cauda equina syndrome.
Six patients with ankylosing spondylitis and features of a cauda equina syndrome are described. The myelographic findings are discussed in relation to the pathogenesis of the disorder and its natural history. Present experience suggests that the cauda equina syndrome is a more common complication of ankylosing spondylitis than is usually thought.