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At least 253 records · Page 14Linked to original sources
PubMed1988

Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide.

A case-control study of cataract in Oxfordshire explored the risks and benefits associated with a variety of drugs. Steroids including the diuretic spironolactone, nifedipine, heavy smoking, and beer drinking were associated with a raised risk. On the other hand aspirin-like analgesics (paracetamol, ibuprofen, aspirin, etc. appeared to protect against cataract. Cyclopenthiazide appeared to provide a similar protection.

Aged↗
PubMed2003

Is manual small incision cataract surgery affordable in the developing countries? A cost comparison with extracapsular cataract extraction.

AIM: To compare the cost of manual small incision cataract surgery (MSICS) with conventional extracapsular cataract surgery (ECCE) in community eye care settings. METHOD: A single masked randomised trial was used to compare the safety, efficacy, time, and patient satisfaction of surgery by both the techniques. The fixed facility and recurrent cost for the two procedures was calculated based on information collected from different sources. Average cost per procedure was calculated by dividing the total cost by the number of procedures performed. RESULT: The average cost of an ECCE procedure for the hospital was Rs 727.76 (US$15.82) and the average cost of a MSICS procedure was Rs 721.40 ($15.68), of which Rs. 521.51 ($11.34) was the fixed facility cost common to both. CONCLUSION: Both ECCE and MSICS are economical in community eye care settings, but MSICS is economical and gives better uncorrected visual acuity in a greater proportion of patients.

Cataract Extraction↗
PubMed1992

Age-related cataract in the hereditary cataract rat (ICR/1): development and classification.

Lens opacification of the Ihara hereditary cataract rat (ICR/1 rat) was followed up with slit lamp biomicroscopy and photography up to 1 year after birth. The development of lens opacities was first recognized in the anterior superficial cortex of the equatorial region between 30 and 44 days of age. It progressed to maturity around 93-107 days after birth. Cataract development was classified into six stages. The increase of lens weight indicated a continuous lens growth after birth which seemingly even continued after the occurrence of lens opacities. After around 60 days of age, the lens showed a continuous increase of water content, suggesting a participation of increased water content in lens opacification.

Aging↗
PubMed1996

Comparative study of intraocular pressure change after cataract surgery: phacoemulsification and extracapsular cataract extraction.

A randomized prospective study was performed to evaluate intraocular pressure (IOP) change after extracapsular cataract extraction (ECCE) or phacoemulsification and aspiration (PEA) with implantation of posterior chamber intraocular lens in otherwise normal cataract patients. IOP was measured preoperatively and postoperatively at up to 6 months. There was a mean fall in pressure of 1.1mmHg (5.72%) in the ECCE group (15 eyes) and of 0.6mmHg (4.16%) in the PEA group (24 eyes) after 6 months. The decrease in mean IOP was significant at 2 months in the PEA group and at 4 to 6 months in the ECCE group, but there was no statistically significant difference between the two groups during the follow-up periods (p < 0.05). The present study shows that there was some postoperative IOP reduction in both the ECCE and PEA group, but the amount of reduction was not significantly different between the two groups.

Aged↗
PubMedDate not supplied

[Vitrectomy in traumatic cataracts and in the complications of surgery in congenital cataract in children].

Vitrectomies were carried out in 35 children with traumatic cataracts and complications of surgery for cataracts, caused by injury to the posterior lenticular capsule and incorporation of its fragments to the vitreous. Complete removal of lenticular rudiments rapidly eliminated phacogenic iridocyclitis and improved visual acuity. Improvement of visual functions was attained in 66.6% cases; in 33.4% cases visual acuity did not change. Hemorrhages to the vitreous cavity occurred in 4 cases with pronounced iridocyclitis; therefore, a corneal approach is preferable for cases with pronounced iridocyclitis.

Adolescent↗
PubMedDate not supplied

Comparison of intraocular pressure profiles during cataract surgery by phacoemulsification and extracapsular cataract extraction.

BACKGROUND AND OBJECTIVE: In view of reports of fluctuations in intraocular pressure (IOP) during phacoemulsification, real-time IOP during small-incision, manual extracapsular cataract extraction (ECCE) and phacoemulsification was measured to determine the effect of anterior chamber maintainer infusion on intraoperative IOP dynamics. PATIENTS AND METHODS: A comparative study of IOP during cataract surgery was conducted by these two methods in 29 patients. An anterior chamber maintainer infused balanced salt solution continuously into the eye throughout ECCE. The anterior chamber maintainer was open in 7 cases throughout phacoemulsification and switched off during phacoemulsification in 7 cases. RESULTS: IOP measurements during small-incision ECCE were physiologic (range, 5 to 20 mm Hg) during most of the operation and coincided with the value of hydrostatic pressure established by the height of the anterior chamber maintainer infusion bottle. During phacoemulsification without concomitant anterior chamber maintainer, IOP was positive (> 2 to 3 mm Hg) as long as the phacoemulsification infusion line was activated (position 1). Moving to position 0 caused hypotony. Occlusion breaks occasionally caused wide fluctuations in IOP. Concomitant anterior chamber maintainer and phacoemulsification infusion did not prevent surges, but may account for the lower range of fluctuation. The anterior chamber maintainer also maintained a positive IOP at position 0 during phacoemulsification. CONCLUSIONS: An anterior chamber maintainer in conjunction with a self-sealing incision can maintain stable physiologic IOP during small-incision ECCE. The IOP fluctuations during phacoemulsification, especially during occlusion breaks, can be attenuated by an anterior chamber maintainer.

Aged↗
PubMedDate not supplied

Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.

We undertook a prospective study in senile cataract patients using systemic aspirin and systemic vitamin E. Vitamin E treated eyes did show less progression of PSC opacities extent and less new nuclear opacities during the follow-up, but overall vitamin E treated eyes did no better than the control group eyes. More eyes in systemic aspirin treated group maintained the initial vision and loss of vision in the aspirin group was also less marked. Aspirin also caused a significant less mean increase in cortical opacity extent, nuclear/opacity and density and PSC opacity extent and density as well as in ophthalmoscopically graded opacity extent and density. We suggest that aspirin is a potential drug which should be further evaluated in large double blind photodocumentated studies. The present data does not justify the recommendation that aspirin be prescribed for slowing down cataract progression. This must await large studies and confirmation.

Administration, Oral↗
PubMed1984

A lipid peroxidative mechanism for posterior subcapsular cataract formation in the rabbit: a possible model for cataract formation in tapetoretinal diseases.

Posterior subcapsular cataracts developed in rabbits following injection of docosahexenoic acid. Autoxidation of docosahexenoic acid in rabbit vitreous was demonstrated by the formation of malondialdehyde and vitreous fluorescence. The onset of posterior subcapsular cataract formation was temporally correlated with declining levels of vitreous malondialdehyde.

Animals↗
PubMed1984

Sodium hyaluronate in cataract surgery. I. Report on the use of Healon in two different types of intracapsular cataract surgery.

Healon has been used in a prospective study as a surgical device for two cataract surgical methods. The study comprised 80 patients divided into two groups. In each group Healon and balanced salt solution (BSS) was randomly applied in two age-matched patient subgroups. The surgical procedures were intracapsular cataract extraction (ICCE) with corneoscleral incision and ICCE with corneal incision. Healon is shown to have a protective effect on the cornea as judged by corneal thickness measurements and by endothelial cell counts. Healon facilitated the surgical procedure in several ways. No side effects, either with regard to intraocular pressure or to postoperative inflammatory reaction have been observed.

Aged↗
PubMed1998

[Indications for cataract surgery in Denmark in 1980 and 1992. Results from the Danish Cataract Surgery Outcomes Study].

In Denmark the number of cataract extractions has increased to 350% from 1980 to 1991. During the same period the elderly population at risk has only increased to 117%, and thus cannot account for the large increase in the number of extractions. In order to investigate whether more comprehensive clinical indications could be a possible explanation, we compared pre-operative visual acuity and visual impairment in two consecutive samples of Danish cataract surgery patients obtained in 1980 (n = 73) and in 1992 (n = 270). Criteria for inclusion were similar and both samples were representative for the whole country. During the period mean pre-operative visual acuity increased from 0.04 to 0.16 in the eye enlisted for surgery (p < 0.001). Visual functional impairment could be compared by using the same questionnaire for patient interview in 1992 as was used in 1980. In 1992, the degree of impairment was significantly less for reading, outdoor orientation and self care activities. A change in surgical threshold or clinical indications for surgery appears to be a major contributing factor to the large increase in surgical rates.

Aged↗
PubMed2003

A comparison of anterior chamber and posterior chamber intraocular lenses after vitreous presentation during cataract surgery: the Department of Veterans Affairs Cooperative Cataract Study.

PURPOSE: To compare the efficacy and safety of anterior chamber (AC) intraocular lenses (IOLs) and posterior chamber (PC) IOLs implanted after vitreous presentation during extracapsular cataract extraction (ECCE). DESIGN: The study was a prospective, long-term, randomized clinical trial conducted at 19 Department of Veterans Affairs medical centers across the United States. METHODS: There were 438 eyes (438 patients) that met preliminary eligibility criteria, suffered vitreous presentation during ECCE (phacoemulsification or classical extracapsular technique), and had sufficient capsular support for a PC IOL without sutures after anterior vitrectomy randomized to either a PC IOL (230 patients) or an AC IOL (208 patients). Patients were examined at 3, 6, and 12 months post-surgery and yearly thereafter. Minimum follow-up was 1 year. The primary outcome measure of best-corrected visual acuity at 1 year was obtained by a masked certified examiner. RESULTS: More PC IOL patients (91%) achieved visual acuity of 20/40 or better at 1 year than AC IOL patients (79%), a highly significant difference (P =.003). There was no significant difference between the two groups for patient's rating of vision or adverse events. Over 84% of the PC IOL patients and over 77% of the AC IOL patients rated their vision as good or better at 1 year as opposed to only 7% giving such ratings before surgery. For at least one rating period during the first year, 13.2% of the combined study patients had cystoid macular edema, 8.5% had posterior capsule opacification, 5.7% had glaucoma, and 3.7% had retinal detachment. CONCLUSION: In the presence of sufficient capsular support, a PC IOL should be implanted after vitreous presentation during ECCE.

Aged↗
PubMed1980

Cataract extraction in cases of cataract with vitreous abnormality.

Since good visibility of the deeper structures of the eye is a prerequisite for vitreous surgery, a lentectomy is often performed in combination with vitreous surgery even when the lens is only slightly cataractous. Clear lenses may have to be removed when complete intraocular gas tamponade is utilized (treatment of giant tears 180 degrees and larger). A pars plana approach is recommended, and the lens is removed with the vitrectomy instruments as long as the nucleus is not too hard. Otherwise, phacoemulsifying instruments are needed. The techniques are described. The worst complication of posterior lentectomy is loss of lens material into the vitreous cavity.

Cataract↗
PubMed2000

Creating cataracts of varying hardness to practice extracapsular cataract extraction and phacoemulsification(2).

We describe a method to harden the nucleus of crystalline lenses in postmortem human globes by intralenticular injection of a mixture of paraformaldehyde and glutaraldehyde (Karnovsky's solution). Evaluation of the nuclear manipulations, using the Miyake-Apple posterior video/photographic technique, shows that the method provides suitable specimens for practicing extracapsular cataract extraction and phacoemulsification.

Cataract↗
PubMed1987

Subjective assessment of the effect of cataract surgery and a review of long term aims. Oxford Cataract Treatment and Evaluation Team (O.C.T.E.T.).

A questionnaire designed to test subjective assessment of functional improvement was given to 327 patients in a randomised controlled trial one year after operation for cataract. Approximately one-third of the patients had a contact lens fitted after intracapsular extraction (I/C) and two-thirds had intraocular implants after both I/C and extracapsular extraction. The great majority of patients admitted to functional improvement irrespective of treatment mode. A review of objective data from the study suggests that the beneficial effects of surgery are likely to be long lasting.

Aged↗
PubMed1981

Antibodies to lens antigens in cataract and after cataract surgery.

By means of an enzyme-linked immunosorbent assay (ELISA) antibodies to whole lens homogenate were found in 50.0% of 38 patients with senile cataract and in 57.3% of 75 controls. The antibody titres were in the range of 10-160 in both groups. IgG antibodies occurred in 44.7% of patients and in 45.3% of controls, whereas IgM antibodies were found in 21.1% of the patients and in 40.0% of the controls (not significant). Postoperative uveitis occurred in 5 (31.6%) of 19 patients, who had antibodies in serum prior to the operation and in only 2 (10.5%) of 19 antibody-negative patients (P = 0.10).

Adult↗
PubMed1995

The South Asian Cataract Management Study. I. The first 662 cataract surgeries: a preliminary report.

AIMS: The first 662 cases of a multicentre randomised clinical trial of intracapsular cataract extraction (ICCE) with and without implantation of a four point multiflex (Cilco Kelman Choyce Modification) anterior chamber intraocular lens (AC IOL) were studied after 6 weeks to compare frequency of surgical complications, short term clinical outcomes, and corneal endothelial cell loss between groups. METHODS: Randomisation was performed after screening for predetermined inclusion and exclusion criteria. Demographics, visual acuities, intraocular pressures, and corneal endothelium cell data were recorded preoperatively and at 6 weeks. Details of surgical procedure, complications, and postoperative adverse reactions were recorded. Monitoring of the study was secured by a standardised image documentation procedure on all patients using the IMAGEnet digital imaging system. Analysis of corneal endothelial cell images was done using the CELL SOFT software analysis program. RESULTS: 343 patients were randomised to IOL and 319 to no IOL. Twelve IOL implantations (3.5%) were aborted because of complications. A complication was reported in 103 (15.6%) of the surgical procedures (IOL = 16.9%, no IOL = 14.1%, p = 0.37). The most frequent complication observed was vitreous loss followed by plain capsular rupture, unplanned ECCE, and iris dialysis. Mean corneal endothelial cell loss 6 weeks after surgery was 17.2% (SD 13.1%) in the total study population (IOL = 18.5% no IOL = 16.1%, p = 0.05). The postoperative complications registered until 6 week follow up were significantly higher in the IOL group (IOL = 6.9%, no IOL = 2.6%, p = 0.02), mainly due to mild to moderate iritis needing prolonged use of steroids. Eighty nine per cent of the patients had a best corrected visual acuity of 6/18 or better. There was no significant difference in visual outcome between study groups. CONCLUSIONS: The implantation of a multiflex AC IOL in primary ICCE surgery in the centres of this study did not increase the risk of surgical complications or short term sight threatening adverse clinical outcomes compared with ICCE without lens. Comparisons of corneal endothelial cell loss after 6 weeks between study groups showed no clinically significant difference. The difference in mean cell loss between groups was statistically significant.

Adult↗
PubMedDate not supplied

Midterm visual outcome and progression of diabetic retinopathy following cataract surgery. Midterm outcome of cataract surgery in diabetes.

OBJECTIVE: To assess the influence of cataract surgery on progression of diabetic retinopathy and visual acuity. METHODS: 37 patient eyes with mild to moderate diabetic retinopathy at baseline underwent phacoemulsification and intraocular posterior chamber lens implantation. They were examined 3.3 +/- (SD) 0.7 years after surgery. RESULTS: 83.8% of the eyes showed a better final visual acuity, and 67.6% achieved a final visual acuity of 0.5 or better. The retinopathy remained unchanged in 83.8% and progressed in 16.2% of the eyes. No eye progressed to proliferative retinopathy. CONCLUSION: Phacoemulsification and implantation of a posterior chamber intraocular lens is a safe procedure for patients with mild to moderate diabetic retinopathy.

Aged↗