Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “CALCINOSIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 253 records · Page 14Linked to original sources
PubMed1984

A case report of calcinosis universalis.

Calcium deposits in soft tissues without previous trauma may represent calcinosis universalis, a condition without systemic manifestations and with laboratory values of blood and urine that are consistently normal. Radiographs reveal areas of calcification with homogenous density, and microscopic examination of these deposits shows foreign body giant cell reaction without capsule formation. In this case of calcinosis universalis, wide excision and lavage of the calcium deposits were temporarily beneficial, but the deposits recurred in this patient.

Adult↗
PubMedDate not supplied

MR imaging findings of recurrent tumoral calcinosis.

Tumoral calcinosis is an uncommon disorder and characterized by development of calcified masses within the soft tissues near the large joints. We present a recurrent tumoral calcinosis case with radiographic and magnetic resonance (MR) imaging findings.

Calcinosis↗
PubMedDate not supplied

Angiographic findings in tumoral calcinosis.

Tumor calcinosis is uncommon, typically manifesting as paraarticular, extracapsular soft tissue deposits containing amorphous calcium phosphate and calcium carbonate, with associated hydroxyapatite crystal. CT and MRI are the primary diagnostic radiological tools evaluating these lesions. Primary treatment is early surgical excision with wide margins, as there is a high recurrence rate. We describe the angiographic findings in tumoral calcinosis, demonstrating hypervascularity beyond the calcified mass periphery. Exact margin definition with angiography may influence management and surgical approach.

Adult↗
PubMed1999

Tumoral calcinosis in the premaxillary region.

Tumoral calcinosis, an uncommon pathologic condition that manifests itself in many forms, has rarely been described in the craniofacial region. This report describes a case of tumoral calcinosis affecting the premaxillary region.

Aged↗
PubMed2005

[Tumoral calcinosis in childhood].

In 1943, Inclan described for the first time tumoral calcinosis as a disease of its own. More than 80 examples of these lesions were described in the literature under different names. Tumoral calcinosis is a rare disease characterized by massive deposition of calcium phosphate in the soft tissue of large joints pathogenesis is unclear. The microscopic characterization shows a complex composition of phospholipids with deposits of hydroxyapatite. An infiltration of the surrounding tissue with giant cells, histiocytes and lymphocytes were often found. Complete excision of the tumor is the treatment of choice.

Adolescent↗
PubMed2000

Tumoral calcinosis of the temporomandibular joint region.

A rare case of tumoral calcinosis, discovered in the medial pterygoid muscle and around the temporomandibular joint on a routine panoramic radiograph is presented. CT was found to be ideal for the determination of the exact location of the calcifications. The differential diagnosis of tumoral calcinosis is discussed.

Adult↗
PubMed2001

An extremely severe case of cutaneous calcinosis with juvenile dermatomyositis, and successful treatment with diltiazem.

A case of cutaneous calcinosis associated with juvenile dermatomyositis is described. The patient was a 3-year-old girl who had been diagnosed as having dermatomyositis at age 1 year. She was treated with prednisolone, but developed multiple calcified nodules in the subcutaneous tissues and intermuscular fascia. These nodules gradually increased in size despite continual therapy with steroids and aluminium hydroxide. Treatment with diltiazem completely suppressed the development of calcinosis.

Calcinosis↗
PubMed2002

Aspiration cytodiagnosis of the breast with abundant acellular calcific material indicative of soft tissue calcinosis (a study of 3 cases).

Calcific deposits in soft tissue are rare and may clinically resemble a tumour. It seems feasible, therefore, to investigate them by the non-invasive technique of fine needle aspiration cytology (FNAC). In this study three cases with extensive accumulation of acellular calcific material in the breast are described in which FNAC was indicative of soft tissue calcinosis. In all cases routine mammogram had shown a partially cystic opacity. All other investigations were normal and no significant family or medical history was present. Cytopreparations in all cases showed only abundant acellular calcium. The patients had no further treatment and on follow up were clinically well with no changes. The cases are interesting, since the cytohistological findings in the aspirate sample appeared to be strongly indicative of soft tissue calcinosis.

Biopsy, Needle↗
PubMed2002

Calcinosis cutis universalis.

We report the case of a 49-year-old female who complained of hardening of the skin, with onset about 1.5 years before presentation. The laboratory data showed normal biochemistry profile. Routine haematochemical examinations showed slight anaemia, an increased erythrocyte sedimentation rate and negative rheumatological markers. Calcium excretion in a 24-h urine sample was normal, but the phosphate excretion was slightly low. The clinical diagnosis was verified by soft tissue ultrasound examination showing subcutaneous calcifications. X-ray examination of bones evidenced no abnormal calcification. Mammography revealed deep seated bilateral reticular calcifications, even in the axillary region. Histological examination showed calcinosis cutis. On these grounds, the diagnosis of idiopathic universal calcinosis cutis was made. The authors describe the clinical and histological picture and discuss the laboratory findings.

Calcinosis↗
PubMedDate not supplied

Calcinosis cutis following liver transplantation in a pediatric patient.

We report the occurrence of calcinosis cutis in a 3-year-old girl after liver transplantation. The cutaneous lesions consisted of 5 mm white papules on an erythematous base in linear and rosette configurations that developed in the abdominal and lumbar areas 10 days after transplantation. The patient had received calcium chloride solution intravenously during surgery. We excluded other causes of ectopic calcification such as hyperparathyroidism, renal failure, and extravasation of calcium solution. We discuss the etiology of calcinosis cutis after liver transplantation. This sequence of events has not been previously described in pediatric patients.

Biliary Atresia↗
PubMed2002

Tumoral calcinosis after an injection of recombinant human erythropoietin in a dialysis patient.

Tumoral calcinosis is a rare form of soft tissue calcifications, initially described as an idiopathic condition, which could occur in uremic patients. Despite its distinct clinical and morphologic presentations, the underlying pathogenesis is unknown. We present a dialysis patient who developed tumoral calcinosis over the right shoulder after receiving a misplaced injection of human recombinant erythropoietin probably into the periarticular tissue. This case serves as an example highlighting the importance of periarticular inflammatory reaction in precipitating the development of the lesion in predisposed patients.

Administration, Oral↗
PubMed2003

Solitary intra-articular tumoral calcinosis of the knee.

An unusual case of symptomatic, solitary, intra-articular tumoral calcinosis of the knee in a 39-year-old man is presented. This is the first reported case of intra-articular tumoral calcinosis with no associated underlying systemic diseases. Magnetic resonance imaging was helpful in delineating the lesion. Surgical excision resulted in resolution of symptoms and was not followed by recurrence of the lesion.

Adult↗
PubMedDate not supplied

[Tumoral calcinosis of the ischium].

The authors report on a case of tumoral calcinosis of the ischium in a 63 year old female. A general review of the literature on pathogenesis, histological characteristics and the way of treatment is given and the prognosis of tumoral calcinosis pointed out.

Bone Neoplasms↗
PubMed2003

Congenital calcinosis cutis of the ear.

Congenital calcinosis cutis is a relatively rare event. Herein we report 3 cases of congenital calcinosis cutis that all appeared in the exact same location on the ear. A possible mechanism of pathogenesis is discussed.

Calcinosis↗
PubMed2001

Hepatic vascular calcification: an early second trimester sonographic feature of idiopathic infantile arterial calcinosis.

Prenatal sonographic diagnosis of idiopathic infantile arterial calcinosis has been limited to the third trimester. We report a monozygotic twin gestation for which an 18-week ultrasound detected the unique finding of hepatic vascular calcification as the earliest feature of the disorder. In contrast to previous reports, second-trimester ultrasound may permit timely diagnosis of idiopathic infantile arterial calcinosis.

Adult↗
PubMed2001

New insight into calcinosis of juvenile dermatomyositis: a study of composition and treatment.

Milk of calcium developed in 2 children with juvenile dermatomyositis. The fluid of the collection contained macrophages, interleukin-6, IL-1, and tumor necrosis factor. The patient who had dystrophic calcinosis had a dramatic improvement with the introduction of alendronate. These findings suggest that calcinosis of juvenile dermatomyositis may be mediated by activated macrophages and that alendronate can be an effective treatment for this condition.

Adolescent↗
PubMed1996

A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.

Dystrophic cardiac calcinosis, an age-related cardiomyopathy that occurs among certain inbred strains of mice, involves myocardial injury, necrosis, and calcification. Using a complete linkage map approach and quantitative trait locus analysis, we sought to identify genetic loci determining dystrophic cardiac calcinosis in an F2 intercross of resistant C57BL/6J and susceptible C3H/HeJ inbred strains. We identified a single major locus, designated Dyscalc, located on proximal chromosome 7 in a region syntenic with human chromosomes 19q13 and 11p15. The statistical significance of Dyscalc (logarithm of odds score 14.6) was tested by analysis of permuted trait data. Analysis of BxH recombinant inbred strains confirmed the mapping position. The inheritance pattern indicated that this locus influences susceptibility of cells both to enter necrosis and to subsequently undergo calcification.

Animals↗
PubMed2006

Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation.

Mutations in the gene encoding the glycosyltransferase polypeptide GalNAc-T3, which is involved in initiation of O-glycosylation, were recently identified as a cause of the rare autosomal recessive metabolic disorder familial tumoral calcinosis (OMIM 211900). Familial tumoral calcinosis is associated with hyperphosphatemia and massive ectopic calcifications. Here, we demonstrate that the secretion of the phosphaturic factor fibroblast growth factor 23 (FGF23) requires O-glycosylation, and that GalNAc-T3 selectively directs O-glycosylation in a subtilisin-like proprotein convertase recognition sequence motif, which blocks processing of FGF23. The study suggests a novel posttranslational regulatory model of FGF23 involving competing O-glycosylation and protease processing to produce intact FGF23.

Amino Acid Motifs↗